Builds both ROC (Receiver Operating Characteristic) and DET (Detection Error Tradeoff) curves from a set of predictors, which are the results of a binary classification system. The curves give a general vision of the performance of the classifier, and are useful for comparing performance of different systems.

Orders a data-set consisting of an ensemble of probability density functions on the same x-grid. Visualizes a box-plot of these functions based on the notion of distance determined by the user. Reports outliers based on the distance chosen and the scaling factor for an interquartile range rule. For further details, see: Alexander C. Murph et al. (2023). "Visualization and Outlier Detection for Probability Density Function Ensembles." <https://sirmurphalot.github.io/publications>.

Cancer genomes contain large numbers of somatic alterations but few genes drive tumor development. Identifying cancer driver genes is critical for precision oncology. Most of current approaches either identify driver genes based on mutational recurrence or using estimated scores predicting the functional consequences of mutations. driveR is a tool for personalized or batch analysis of genomic data for driver gene prioritization by combining genomic information and prior biological knowledge. As features, driveR uses coding impact metaprediction scores, non-coding impact scores, somatic copy number alteration scores, hotspot gene/double-hit gene condition, phenolyzer gene scores and memberships to cancer-related KEGG pathways. It uses these features to estimate cancer-type-specific probability for each gene of being a cancer driver using the related task of a multi-task learning classification model. The method is described in detail in Ulgen E, Sezerman OU. 2021. driveR: driveR: a novel method for prioritizing cancer driver genes using somatic genomics data. BMC Bioinformatics <doi:10.1186/s12859-021-04203-7>.

Use numerical optimization to fit ordinary differential equations (ODEs) to time series data to examine the dynamic relationships between variables or the characteristics of a dynamical system. It can now be used to estimate the parameters of ODEs up to second order, and can also apply to multilevel systems. See <https://github.com/yueqinhu/defit> for details.

Build a Dockerfile straight from your R session. dockerfiler allows you to create step by step a Dockerfile, and provide convenient tools to wrap R code inside this Dockerfile.

Fits dose-response models utilizing a Bayesian model averaging approach as outlined in Gould (2019) <doi:10.1002/bimj.201700211> for both continuous and binary responses. Longitudinal dose-response modeling is also supported in a Bayesian model averaging framework as outlined in Payne, Ray, and Thomann (2024) <doi:10.1080/10543406.2023.2292214>. Functions for plotting and calculating various posterior quantities (e.g. posterior mean, quantiles, probability of minimum efficacious dose, etc.) are also implemented. Copyright Eli Lilly and Company (2019).

Fit a Poisson regression to carcass distance data and integrate over the searched area at a wind farm to estimate the fraction of carcasses falling in the searched area and format the output for use as the dwp parameter in the GenEst or eoa package for estimating bird and bat mortality, following Dalthorp, et al. (2024) <doi:10.3133/tm7A3>.

Bayesian networks with continuous and/or discrete variables can be learned and compared from data. The method is described in Boettcher and Dethlefsen (2003), <doi:10.18637/jss.v008.i20>.

For an observational study with binary treatment, binary outcome and K strata, implements a d-statistic that uses those strata most insensitive to unmeasured bias in treatment assignment.<doi:10.1093/biomet/asaa032> The package has one function, dstat2x2xk.

Implementation of three methods based on the diversity forest (DF) algorithm (Hornung, 2022, <doi:10.1007/s42979-021-00920-1>), a split-finding approach that enables complex split procedures in random forests. The package includes: 1. Interaction forests (IFs) (Hornung & Boulesteix, 2022, <doi:10.1016/j.csda.2022.107460>): Model quantitative and qualitative interaction effects using bivariable splitting. Come with the Effect Importance Measure (EIM), which can be used to identify variable pairs that have well-interpretable quantitative and qualitative interaction effects with high predictive relevance. 2. Two random forest-based variable importance measures (VIMs) for multi-class outcomes: the class-focused VIM, which ranks covariates by their ability to distinguish individual outcome classes from the others, and the discriminatory VIM, which measures overall covariate influence irrespective of class-specific relevance. 3. The basic form of diversity forests that uses conventional univariable, binary splitting (Hornung, 2022). Except for the multi-class VIMs, all methods support categorical, metric, and survival outcomes. The package includes visualization tools for interpreting the identified covariate effects. Built as a fork of the ranger R package (main author: Marvin N. Wright), which implements random forests using an efficient C++ implementation.

Finds the k nearest neighbours in a dataset of specified points, adding the option to wrap certain variables on a torus. The user chooses the algorithm to use to find the nearest neighbours. Two such algorithms, provided by the packages RANN <https://cran.r-project.org/package=RANN>, and nabor <https://cran.r-project.org/package=nabor>, are suggested.

This package provides a set of functions to estimate the controlled direct effect of treatment fixing a potential mediator to a specific value. Implements the sequential g-estimation estimator described in Vansteelandt (2009) <doi:10.1097/EDE.0b013e3181b6f4c9> and Acharya, Blackwell, and Sen (2016) <doi:10.1017/S0003055416000216> and the telescope matching estimator described in Blackwell and Strezhnev (2020) <doi:10.1111/rssa.12759>.

Go beyond standard probability distributions such as the Normal or Exponential by combining, shifting, maximizing, and otherwise transforming distributions with simple, verb-based functions. Provides easy access to a broader space of distributions more representative of real-world systems such as river flows or insurance claims. Part of the probaverse framework of packages to support advanced statistical modeling and simulations with an intuitive workflow.

This package provides a general framework using mixture Weibull distributions to accurately predict biomarker-guided trial duration accounting for heterogeneous population. Extensive simulations are performed to evaluate the impact of heterogeneous population and the dynamics of biomarker characteristics and disease on the study duration. Several influential parameters including median survival time, enrollment rate, biomarker prevalence and effect size are identified. Efficiency gains of biomarker-guided trials can be quantitatively compared to the traditional all-comers design. For reference, see Zhang et al. (2024) <arXiv:2401.00540>.

This package provides a set of algorithms based on Quinn et al. (1991) <doi:10.1002/hyp.3360050106> for processing river network and digital elevation data to build implementations of Dynamic TOPMODEL, a semi-distributed hydrological model proposed in Beven and Freer (2001) <doi:10.1002/hyp.252>. The dynatop package implements simulation code for Dynamic TOPMODEL based on the output of dynatopGIS'.

Developed to Solve the Multi-Criteria Decision Making Problems with Decision Making Trial and Evaluation Laboratory Technique in R.

This package provides sample size and power calculations when the treatment time-lag effect is present and the lag duration is either homogeneous across the individual subject, or varies heterogeneously from individual to individual within a certain domain and following a specific pattern. The methods used are described in Xu, Z., Zhen, B., Park, Y., & Zhu, B. (2017) <doi:10.1002/sim.7157>.

Simulation models (apps) of various within-host immune response scenarios. The purpose of the package is to help individuals learn about within-host infection and immune response modeling from a dynamical systems perspective. All apps include explanations of the underlying models and instructions on what to do with the models.

Shows you which rows have changed between two data frames with the same column structure. Useful for diffing slowly mutating data.

This package provides a `.` object which can be used for unpacking assignments. For example, `.[rows, columns] <- dim(cars)` could be used to pull the number of rows and number of columns from `dim(cars)` into individual variables `rows` and `columns` in a single step.

Create and manage fault-tolerant task queues for the foreach package using the Redis key/value database.

This package creates interactive genome browser. It joins the data analysis power of R and the visualization libraries of JavaScript in one package. Barrios, D. & Prieto, C. (2017) <doi:10.1089/cmb.2016.0213>.

Creating, and refining data nuggets. Data nuggets reduce a large dataset into a small collection of nuggets of data, each containing a center (location), weight (importance), and scale (variability) parameter. Data nugget centers are created by choosing observations in the dataset which are as equally spaced apart as possible. Data nugget weights are created by counting the number observations closest to a given data nugget center. We then say the data nugget contains these observations and the data nugget center is recalculated as the mean of these observations. Data nugget scales are created by calculating the trace of the covariance matrix of the observations contained within a data nugget divided by the dimension of the dataset. Data nuggets are refined by splitting data nuggets which have scales or shapes (defined as the ratio of the two largest eigenvalues of the covariance matrix of the observations contained within the data nugget) Reference paper: [1] Beavers, T. E., Cheng, G., Duan, Y., Cabrera, J., Lubomirski, M., Amaratunga, D., & Teigler, J. E. (2024). Data Nuggets: A Method for Reducing Big Data While Preserving Data Structure. Journal of Computational and Graphical Statistics, 1-21. [2] Cherasia, K. E., Cabrera, J., Fernholz, L. T., & Fernholz, R. (2022). Data Nuggets in Supervised Learning. \emphIn Robust and Multivariate Statistical Methods: Festschrift in Honor of David E. Tyler (pp. 429-449). Cham: Springer International Publishing.

This package provides methods for estimating multi-stage optimal dynamic treatment regimes for survival outcomes with dependent censoring. Cho, H., Holloway, S. T., and Kosorok, M. R. (2022) <doi:10.1093/biomet/asac047>.