Generates image data for fractals (Julia and Mandelbrot sets) on the complex plane in the given region and resolution. Benoit B Mandelbrot (1982).

This package provides methods for fast segmentation of multivariate signals into piecewise constant profiles and for generating realistic copy-number profiles. A typical application is the joint segmentation of total DNA copy numbers and allelic ratios obtained from Single Nucleotide Polymorphism (SNP) microarrays in cancer studies. The methods are described in Pierre-Jean, Rigaill and Neuvial (2015) <doi:10.1093/bib/bbu026>.

This package provides an interface to Jamendo API <https://developer.jamendo.com/v3.0>. Pull audio, features and other information for a given Jamendo user (including yourself!) or enter an artist's -, album's -, or track's name and retrieve the available information in seconds.

This package implements an S4 distribution system and estimation methods for parameters of common distribution families. The common d, p, q, r function family for each distribution is enriched with the ll, e, and v counterparts, computing the log-likelihood, performing estimation, and calculating the asymptotic variance - covariance matrix, respectively. Parameter estimation is performed analytically whenever possible.

Implementation of a parametric joint model for modelling recurrent and competing event processes using generalised survival models as described in Entrop et al., (2025) <doi:10.1002/bimj.70038>. The joint model can subsequently be used to predict the mean number of events in the presence of competing risks at different time points. Comparisons of the mean number of event functions, e.g. the differences in mean number of events between two exposure groups, are also available.

Simply and efficiently simulates (i) variants from reference genomes and (ii) reads from both Illumina <https://www.illumina.com/> and Pacific Biosciences (PacBio) <https://www.pacb.com/> platforms. It can either read reference genomes from FASTA files or simulate new ones. Genomic variants can be simulated using summary statistics, phylogenies, Variant Call Format (VCF) files, and coalescent simulationsâ the latter of which can include selection, recombination, and demographic fluctuations. jackalope can simulate single, paired-end, or mate-pair Illumina reads, as well as PacBio reads. These simulations include sequencing errors, mapping qualities, multiplexing, and optical/polymerase chain reaction (PCR) duplicates. Simulating Illumina sequencing is based on ART by Huang et al. (2012) <doi:10.1093/bioinformatics/btr708>. PacBio sequencing simulation is based on SimLoRD by Stöcker et al. (2016) <doi:10.1093/bioinformatics/btw286>. All outputs can be written to standard file formats.

Evaluation of the Jacobi theta functions and related functions: Weierstrass elliptic function, Weierstrass sigma function, Weierstrass zeta function, Klein j-function, Dedekind eta function, lambda modular function, Jacobi elliptic functions, Neville theta functions, Eisenstein series, lemniscate elliptic functions, elliptic alpha function, Rogers-Ramanujan continued fractions, and Dixon elliptic functions. Complex values of the variable are supported.

This package provides a highly configurable jQuery plugin offering a simple interface to create complex queries/filters in Shiny'. The outputted rules can easily be parsed into a set of R and/or SQL queries and used to filter data. Custom parsing of the rules is also supported. For more information about jQuery QueryBuilder see <https://querybuilder.js.org/>.

Aids in the calculation and visualization of regions of non-significance using the Johnson-Neyman technique and its extensions as described by Bauer and Curran (2005) <doi:10.1207/s15327906mbr4003_5> to assess the influence of categorical and continuous moderators. Allows correcting for phylogenetic relatedness.

This package provides a gridded classification of weather types by applying the Jenkinson and Collison classification. For a given region (it can be either local region or the whole map),it computes at each grid the 11 weather types during the period considered for the analysis. See Otero et al., (2017) <doi:10.1007/s00382-017-3705-y> for more information.

This package provides a small package containing functions to perform a joint calibration of totals and quantiles. The calibration for totals is based on Deville and Särndal (1992) <doi:10.1080/01621459.1992.10475217>, the calibration for quantiles is based on Harms and Duchesne (2006) <https://www150.statcan.gc.ca/n1/en/catalogue/12-001-X20060019255>. The package uses standard calibration via the survey', sampling or laeken packages. In addition, entropy balancing via the ebal package and empirical likelihood based on codes from Wu (2005) <https://www150.statcan.gc.ca/n1/pub/12-001-x/2005002/article/9051-eng.pdf> can be used. See the paper by BerÄ sewicz and Szymkowiak (2023) for details <arXiv:2308.13281>.

Different algorithms to perform approximate joint diagonalization of a finite set of square matrices. Depending on the algorithm, orthogonal or non-orthogonal diagonalizer is found. These algorithms are particularly useful in the context of blind source separation. Original publications of the algorithms can be found in Ziehe et al. (2004), Pham and Cardoso (2001) <doi:10.1109/78.942614>, Souloumiac (2009) <doi:10.1109/TSP.2009.2016997>, Vollgraff and Obermayer <doi:10.1109/TSP.2006.877673>. An example of application in the context of Brain-Computer Interfaces EEG denoising can be found in Gouy-Pailler et al (2010) <doi:10.1109/TBME.2009.2032162>.

Used to create dynamic, interactive D3.js based parallel coordinates and principal component plots in R'. The plots make visualizing k-means or other clusters simple and informative.

We developed a package Keyboard for designing single-agent, drug-combination, or phase I/II dose-finding clinical trials. The Keyboard designs are novel early phase trial designs that can be implemented simply and transparently, similar to the 3+3 design, but yield excellent performance, comparable to those of more-complicated, model-based designs (Yan F, Mandrekar SJ, Yuan Y (2017) <doi:10.1158/1078-0432.CCR-17-0220>, Li DH, Whitmore JB, Guo W, Ji Y. (2017) <doi:10.1158/1078-0432.CCR-16-1125>, Liu S, Johnson VE (2016) <doi:10.1093/biostatistics/kxv040>, Zhou Y, Lee JJ, Yuan Y (2019) <doi:10.1002/sim.8475>, Pan H, Lin R, Yuan Y (2020) <doi:10.1016/j.cct.2020.105972>). The Keyboard package provides tools for designing, conducting, and analyzing single-agent, drug-combination, and phase I/II dose-finding clinical trials. For more details about how to use this packge, please refer to Li C, Sun H, Cheng C, Tang L, and Pan H. (2022) "A software tool for both the maximum tolerated dose and the optimal biological dose finding trials in early phase designs". Manuscript submitted for publication.

This package provides a shiny app to visualize the knowledge networks for the code concepts. Using co-occurrence matrices of EHR codes from Veterans Affairs (VA) and Massachusetts General Brigham (MGB), the knowledge extraction via sparse embedding regression (KESER) algorithm was used to construct knowledge networks for the code concepts. Background and details about the method can be found at Chuan et al. (2021) <doi:10.1038/s41746-021-00519-z>.

Computes group centrality scores and identifies the most central group of players in a network.

This is a stochastic framework that combines biochemical reaction networks with extended Kalman filter and Rauch-Tung-Striebel smoothing. This framework allows to investigate the dynamics of cell differentiation from high-dimensional clonal tracking data subject to measurement noise, false negative errors, and systematically unobserved cell types. Our tool can provide statistical support to biologists in gene therapy clonal tracking studies for a deeper understanding of clonal reconstitution dynamics. Further details on the methods can be found in L. Del Core et al., (2022) <doi:10.1101/2022.07.08.499353>.

Helper functions for creating formatted summary of regression models, writing publication-ready tables to latex files, and running Monte Carlo experiments.

Routines to handle family data with a pedigree object. The initial purpose was to create correlation structures that describe family relationships such as kinship and identity-by-descent, which can be used to model family data in mixed effects models, such as in the coxme function. Also includes a tool for pedigree drawing which is focused on producing compact layouts without intervention. Recent additions include utilities to trim the pedigree object with various criteria, and kinship for the X chromosome.

Interface to Keras <https://keras.io>, a high-level neural networks API'. Keras was developed with a focus on enabling fast experimentation, supports both convolution based networks and recurrent networks (as well as combinations of the two), and runs seamlessly on both CPU and GPU devices.

Attempts to remove vocals from a stereo .wav recording of a song.

This package provides useful functions which are needed for bioinformatic analysis such as calculating linear principal components from numeric data and Single-nucleotide polymorphism (SNP) dataset, calculating fixation index (Fst) using Hudson method, creating scatter plots in 3 views, handling with PLINK binary file format, detecting rough structures and outliers using unsupervised clustering, and calculating matrix multiplication in the faster way for big data.

This package provides fast implementations of kernel smoothing techniques for bivariate copula densities, in particular density estimation and resampling, see Nagler (2018) <doi:10.18637/jss.v084.i07>.

Detect and test for changes in covariance structures of functional data, as well as changepoint detection for multivariate data more generally. Method for detecting non-stationarity in resting state functional Magnetic Resonance Imaging (fMRI) scans as seen in Ramsay, K., & Chenouri, S. (2025) <doi:10.1080/10485252.2025.2503891> is implemented in fmri_changepoints(). Also includes depth- and rank-based implementation of the wild binary segmentation algorithm for detecting multiple changepoints in multivariate data.