This package provides a fast, vectorized hashmap that is built on top of C++ std::unordered_map <https://en.cppreference.com/w/cpp/container/unordered_map.html>. The map can hold any R object as key / value as long as it is serializable and supports vectorized insertion, lookup, and deletion.

Empirical value of the Hellinger correlation, a measure of dependence between two continuous random variables. More details can be found in Geenens and Lafaye De Micheaux (2019) <arXiv:1810.10276v4>.

Fits sparse interaction models for continuous and binary responses subject to the strong (or weak) hierarchy restriction that an interaction between two variables only be included if both (or at least one of) the variables is included as a main effect. For more details, see Bien, J., Taylor, J., Tibshirani, R., (2013) "A Lasso for Hierarchical Interactions." Annals of Statistics. 41(3). 1111-1141.

This package provides a scalable implementation of the highly adaptive lasso algorithm, including routines for constructing sparse matrices of basis functions of the observed data, as well as a custom implementation of Lasso regression tailored to enhance efficiency when the matrix of predictors is composed exclusively of indicator functions. For ease of use and increased flexibility, the Lasso fitting routines invoke code from the glmnet package by default. The highly adaptive lasso was first formulated and described by MJ van der Laan (2017) <doi:10.1515/ijb-2015-0097>, with practical demonstrations of its performance given by Benkeser and van der Laan (2016) <doi:10.1109/DSAA.2016.93>. This implementation of the highly adaptive lasso algorithm was described by Hejazi, Coyle, and van der Laan (2020) <doi:10.21105/joss.02526>.

For supersonic aircraft, flying subsonic over land, find the best route between airports. Allow for coastal buffer and potentially closed regions. Use a minimal model of aircraft performance: the focus is on time saved versus subsonic flight, rather than on vertical flight profile. For modelling and forecasting, not for planning your flight!

An implementation for high-dimensional time series analysis methods, including factor model for vector time series proposed by Lam and Yao (2012) <doi:10.1214/12-AOS970> and Chang, Guo and Yao (2015) <doi:10.1016/j.jeconom.2015.03.024>, martingale difference test proposed by Chang, Jiang and Shao (2023) <doi:10.1016/j.jeconom.2022.09.001>, principal component analysis for vector time series proposed by Chang, Guo and Yao (2018) <doi:10.1214/17-AOS1613>, cointegration analysis proposed by Zhang, Robinson and Yao (2019) <doi:10.1080/01621459.2018.1458620>, unit root test proposed by Chang, Cheng and Yao (2022) <doi:10.1093/biomet/asab034>, white noise tests proposed by Chang, Yao and Zhou (2017) <doi:10.1093/biomet/asw066> and Chang et al. (2026+), CP-decomposition for matrix time series proposed by Chang et al. (2023) <doi:10.1093/jrsssb/qkac011> and Chang et al. (2026+) <doi:10.48550/arXiv.2410.05634>, CP-decomposition for tensor time series proposed by Chang et al. (2026+) <doi:10.48550/arXiv.2606.08560>, and statistical inference for spectral density matrix proposed by Chang et al. (2025) <doi:10.1080/01621459.2025.2468013>.

Fits Hierarchical Bayesian space-Time models for Gaussian data. Furthermore, its functions have been implemented for analysing the fitting qualities of those models.

The hydReng package provides a set of functions for hydraulic engineering tasks and natural hazard assessments. It includes basic hydraulics (wetted area, wetted perimeter, flow, flow velocity, flow depth, and maximum flow) for open channels with arbitrary geometry under uniform flow conditions. For structures such as circular pipes, weirs, and gates, the package includes calculations for pressure flow, backwater depth, and overflow over a weir crest. Additionally, it provides formulas for calculating bedload transport. The formulas used can be found in standard literature on hydraulics, such as Bollrich (2019, ISBN:978-3-410-29169-5) or Hager (2011, ISBN:978-3-642-77430-0).

This package provides a toolkit for the analysis and management of data for genes in the so-called "Human Leukocyte Antigen" (HLA) region. Functions extract reference data from the Anthony Nolan HLA Informatics Group/ImmunoGeneTics HLA GitHub repository (ANHIG/IMGTHLA) <https://github.com/ANHIG/IMGTHLA>, validate Genotype List (GL) Strings, convert between UNIFORMAT and GL String Code (GLSC) formats, translate HLA alleles and GLSCs across ImmunoPolymorphism Database (IPD) IMGT/HLA Database release versions, identify differences between pairs of alleles at a locus, generate customized, multi-position sequence alignments, trim and convert allele-names across nomenclature epochs, and extend existing data-analysis methods.

Identifying labeled compounds in a 13C-tracer experiment in non-targeted fashion is a cumbersome process. This package facilitates such type of analyses by providing high level quality control plots, deconvoluting and evaluating spectra and performing a multitude of tests in an automatic fashion. The main idea is to use changing intensity ratios of ion pairs from peak list generated with xcms as candidates and evaluate those against base peak chromatograms and spectra information within the raw measurement data automatically. The functionality is described in Hoffmann et al. (2018) <doi:10.1021/acs.analchem.8b00356>.

This package provides a modular and computationally efficient R package for parameterizing, simulating, and analyzing health economic simulation models. The package supports cohort discrete time state transition models (Briggs et al. 1998) <doi:10.2165/00019053-199813040-00003>, N-state partitioned survival models (Glasziou et al. 1990) <doi:10.1002/sim.4780091106>, and individual-level continuous time state transition models (Siebert et al. 2012) <doi:10.1016/j.jval.2012.06.014>, encompassing both Markov (time-homogeneous and time-inhomogeneous) and semi-Markov processes. Decision uncertainty from a cost-effectiveness analysis is quantified with standard graphical and tabular summaries of a probabilistic sensitivity analysis (Claxton et al. 2005, Barton et al. 2008) <doi:10.1002/hec.985>, <doi:10.1111/j.1524-4733.2008.00358.x>. Use of C++ and data.table make individual-patient simulation, probabilistic sensitivity analysis, and incorporation of patient heterogeneity fast.

Detection of haplotype patterns that include single nucleotide polymorphisms (SNPs) and non-contiguous haplotypes that are associated with a phenotype. Methods for implementing HTRX are described in Yang Y, Lawson DJ (2023) <doi:10.1093/bioadv/vbad038> and Barrie W, Yang Y, Irving-Pease E.K, et al (2024) <doi:10.1038/s41586-023-06618-z>.

Univariate agglomerative hierarchical clustering with a comprehensive list of choices of a linkage function in O(n*log n) time. The better algorithmic time complexity is paired with an efficient C++ implementation.

Identification of recombination events, haplotype reconstruction, sire imputation and pedigree reconstruction using half-sib family SNP data.

Generates high-entropy integer synthetic populations from marginal and (optionally) seed data using quasirandom sampling, in arbitrary dimensionality (Smith, Lovelace and Birkin (2017) <doi:10.18564/jasss.3550>). The package also provides an implementation of the Iterative Proportional Fitting (IPF) algorithm (Zaloznik (2011) <doi:10.13140/2.1.2480.9923>).

In streaming data analysis, it is crucial to detect significant shifts in the data distribution or the accuracy of predictive models over time, a phenomenon known as concept drift. The package aims to identify when concept drift occurs and provide methodologies for adapting models in non-stationary environments. It offers a range of state-of-the-art techniques for detecting concept drift and maintaining model performance. Additionally, the package provides tools for adapting models in response to these changes, ensuring continuous and accurate predictions in dynamic contexts. Methods for concept drift detection are described in Tavares (2022) <doi:10.1007/s12530-021-09415-z>.

This package provides a set of R functions which implements Hotelling's T^2 test and some variants of it. Functions are also included for Aitchison's additive log ratio and centred log ratio transformations.

Core set of low-level utilities common across the hubverse'. Used to interact with hubverse schema, Hub configuration files and model outputs and designed to be primarily used internally by other hubverse packages. See Reich et al. (2022) <doi:10.2105/AJPH.2022.306831> for an overview of Collaborative Hubs.

User-friendly functions for leveraging (multiple) historical data set(s) in Bayesian analysis of generalized linear models (GLMs) and survival models, along with support for Bayesian model averaging (BMA). The package provides functions for sampling from posterior distributions under various informative priors, including the prior induced by the Bayesian hierarchical model, power prior by Ibrahim and Chen (2000) <doi:10.1214/ss/1009212673>, normalized power prior by Duan et al. (2006) <doi:10.1002/env.752>, normalized asymptotic power prior by Ibrahim et al. (2015) <doi:10.1002/sim.6728>, commensurate prior by Hobbs et al. (2011) <doi:10.1111/j.1541-0420.2011.01564.x>, robust meta-analytic-predictive prior by Schmidli et al. (2014) <doi:10.1111/biom.12242>, latent exchangeability prior by Alt et al. (2024) <doi:10.1093/biomtc/ujae083>, and a normal (or half-normal) prior. The package also includes functions for computing model averaging weights, such as BMA, pseudo-BMA, pseudo-BMA with the Bayesian bootstrap, and stacking (Yao et al., 2018 <doi:10.1214/17-BA1091>), as well as for generating posterior samples from the ensemble distributions to reflect model uncertainty. In addition to GLMs, the package supports survival models including: (1) accelerated failure time (AFT) models, (2) piecewise exponential (PWE) models, i.e., proportional hazards models with piecewise constant baseline hazards, and (3) mixture cure rate models that assume a common probability of cure across subjects, paired with a PWE model for the non-cured population. Functions for computing marginal log-likelihoods under each implemented prior are also included. The package compiles all the CmdStan models once during installation using the instantiate package.

The theoretical covariance between pairs of markers is calculated from either paternal haplotypes and maternal linkage disequilibrium (LD) or vise versa. A genetic map is required. Grouping of markers is based on the correlation matrix and a representative marker is suggested for each group. Employing the correlation matrix, optimal sample size can be derived for association studies based on a SNP-BLUP approach. The implementation relies on paternal half-sib families and biallelic markers. If maternal half-sib families are used, the roles of sire/dam are swapped. Multiple families can be considered. Wittenburg, Bonk, Doschoris, Reyer (2020) "Design of Experiments for Fine-Mapping Quantitative Trait Loci in Livestock Populations" <doi:10.1186/s12863-020-00871-1>. Carlson, Eberle, Rieder, Yi, Kruglyak, Nickerson (2004) "Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium" <doi:10.1086/381000>.

Machine learning hierarchical risk clustering portfolio allocation strategies. The implemented methods are: Hierarchical risk parity (De Prado, 2016) <DOI: 10.3905/jpm.2016.42.4.059>. Hierarchical clustering-based asset allocation (Raffinot, 2017) <DOI: 10.3905/jpm.2018.44.2.089>. Hierarchical equal risk contribution portfolio (Raffinot, 2018) <DOI: 10.2139/ssrn.3237540>. A Constrained Hierarchical Risk Parity Algorithm with Cluster-based Capital Allocation (Pfitzingera and Katzke, 2019) <https://www.ekon.sun.ac.za/wpapers/2019/wp142019/wp142019.pdf>.

Estimating heterogeneous treatment effects with tree-based machine learning algorithms and visualizing estimated results in flexible and presentation-ready ways. For more information, see Brand, Xu, Koch, and Geraldo (2021) <doi:10.1177/0081175021993503>. Our current package first started as a fork of the causalTree package on GitHub and we greatly appreciate the authors for their extremely useful and free package.

This package provides inverse-free high-dimensional location tests for two-sample and general linear hypothesis testing (GLHT) problems under equal or unequal covariance structures. The package implements classical normal-approximation procedures, scale-invariant procedures, normal-reference procedures based on covariance-matched Gaussian companions, and F-type normal-reference calibrations for heteroscedastic Behrens-Fisher and GLHT settings. Implemented two-sample normal-approximation and scale-invariant procedures include Bai and Saranadasa (1996) <https://www.jstor.org/stable/24306018>, Chen and Qin (2010) <doi:10.1214/09-aos716>, Srivastava and Du (2008) <doi:10.1016/j.jmva.2006.11.002>, and Srivastava et al. (2013) <doi:10.1016/j.jmva.2012.08.014>. Implemented two-sample normal-reference procedures include Zhang, Guo, Zhou and Cheng (2020) <doi:10.1080/01621459.2019.1604366>, Zhang, Zhou, Guo and Zhu (2021) <doi:10.1016/j.jspi.2020.11.008>, Zhang, Zhu and Zhang (2020) <doi:10.1016/j.ecosta.2019.12.002>, Zhang, Zhu and Zhang (2023) <doi:10.1080/02664763.2020.1834516>, Zhang and Zhu (2022) <doi:10.1080/10485252.2021.2015768>, Zhang and Zhu (2022) <doi:10.1007/s42519-021-00232-w>, and Zhu, Wang and Zhang (2023) <doi:10.1007/s00180-023-01433-6>. Implemented GLHT normal-approximation procedures include Fujikoshi et al. (2004) <doi:10.14490/jjss.34.19>, Srivastava and Fujikoshi (2006) <doi:10.1016/j.jmva.2005.08.010>, Yamada and Srivastava (2012) <doi:10.1080/03610926.2011.581786>, Schott (2007) <doi:10.1016/j.jmva.2006.11.007>, and Zhou, Guo and Zhang (2017) <doi:10.1016/j.jspi.2017.03.005>. Implemented GLHT normal-reference procedures include Zhang, Guo and Zhou (2017) <doi:10.1016/j.jmva.2017.01.002>, Zhang, Zhou and Guo (2022) <doi:10.1016/j.jmva.2021.104816>, Zhu, Zhang and Zhang (2022) <doi:10.5705/ss.202020.0362>, Zhu and Zhang (2022) <doi:10.1007/s00180-021-01110-6>, Zhang and Zhu (2022) <doi:10.1016/j.csda.2021.107385>, and Cao et al. (2024) <doi:10.1007/s00362-024-01530-8>. The package also includes the random-integration normal-approximation GLHT procedure of Li et al. (2025) <doi:10.1007/s00362-024-01624-3>. A package-level overview is given in Wang, Zhu and Zhang (2026) <doi:10.1016/j.csda.2025.108269>.

This package provides a procedure that fits derivative curves based on a sequence of quotient differences. In a hierarchical setting the package produces estimates of subject-specific and group-specific derivative curves. In a non-hierarchical setting the package produces a single derivative curve.