Publication-ready regional gene locus plots similar to those produced by the web interface LocusZoom <https://my.locuszoom.org>, but running locally in R. Genetic or genomic data with gene annotation tracks are plotted via R base graphics, ggplot2 or plotly', allowing flexibility and easy customisation including laying out multiple locus plots on the same page. It uses the LDlink API <https://ldlink.nih.gov/?tab=apiaccess> to query linkage disequilibrium data from the 1000 Genomes Project and can overlay this on plots <doi:10.1093/bioadv/vbaf006>.

Split your rmarkdown or quarto files by sections into a tibble: titles, text, chunks. Rebuild the file from the tibble.

Back-end connections to LattE (<https://www.math.ucdavis.edu/~latte/>) for counting lattice points and integration inside convex polytopes and 4ti2 (<http://www.4ti2.de/>) for algebraic, geometric, and combinatorial problems on linear spaces and front-end tools facilitating their use in the R ecosystem.

This package provides a set of tools designed to enhance transparency and understanding of date-time manipulation functions from the lubridate package. It provides detailed feedback about the operations performed by lubridate functions, allowing users to better comprehend and debug their code. These insights serve as both a learning tool for newcomers and a debugging aid for programmers working with date-time data.

Brings together a comprehensive collection of R packages providing access to API functions and curated datasets from Argentina, Brazil, Chile, Colombia, and Peru. Includes real-time and historical data through public RESTful APIs ('Nager.Date', World Bank API, REST Countries API, and country-specific APIs) and extensive curated collections of open datasets covering economics, demographics, public health, environmental data, political indicators, social metrics, and cultural information. Designed to provide researchers, analysts, educators, and data scientists with centralized access to Latin American data sources, facilitating reproducible research, comparative analysis, and teaching applications focused on these five major Latin American countries. Included packages: - ArgentinAPI': API functions and curated datasets for Argentina covering exchange rates, inflation, political figures, national holidays and more. - BrazilDataAPI': API functions and curated datasets for Brazil covering postal codes, banks, economic indicators, holidays, company registrations and more. - ChileDataAPI': API functions and curated datasets for Chile covering financial indicators ('UF', UTM, Dollar, Euro, Yen, Copper, Bitcoin, IPSA index), holidays and more. - ColombiAPI': API functions and curated datasets for Colombia covering geographic locations, cultural attractions, economic indicators, demographic data, national holidays and more. - PeruAPIs': API functions and curated datasets for Peru covering economic indicators, demographics, national holidays, administrative divisions, electoral data, biodiversity and more. For more information on the APIs, see: Nager.Date <https://date.nager.at/Api>, World Bank API <https://datahelpdesk.worldbank.org/knowledgebase/articles/889392>, REST Countries API <https://restcountries.com/>, ArgentinaDatos API <https://argentinadatos.com/>, BrasilAPI <https://brasilapi.com.br/>, FINDIC <https://findic.cl/>, and API-Colombia <https://api-colombia.com/>.

This package provides tools for detecting and correcting sample mix-ups between two sets of measurements, such as between gene expression data on two tissues. Broman et al. (2015) <doi:10.1534/g3.115.019778>.

This package provides methods for estimating borders of uniform distribution on the interval (one-dimensional) and on the elliptical domain (two-dimensional) under measurement errors. For one-dimensional case, it also estimates the length of underlying uniform domain and tests the hypothesized length against two-sided or one-sided alternatives. For two-dimensional case, it estimates the area of underlying uniform domain. It works with numerical inputs as well as with pictures in JPG format.

This package provides access to the LDlink API (<https://ldlink.nih.gov/?tab=apiaccess>) using the R console. This programmatic access facilitates researchers who are interested in performing batch queries in 1000 Genomes Project (2015) <doi:10.1038/nature15393> data using LDlink'. LDlink is an interactive and powerful suite of web-based tools for querying germline variants in human population groups of interest. For more details, please see Machiela et al. (2015) <doi:10.1093/bioinformatics/btv402>.

This package provides a joint latent class model where a hierarchical structure exists, with an interaction between female and male partners of a couple. A Bayesian perspective to inference and Markov chain Monte Carlo algorithms to obtain posterior estimates of model parameters. The reference paper is: Beom Seuk Hwang, Zhen Chen, Germaine M.Buck Louis, Paul S. Albert, (2018) "A Bayesian multi-dimensional couple-based latent risk model with an application to infertility". Biometrics, 75, 315-325. <doi:10.1111/biom.12972>.

This package performs adjusted inferences based on model objects fitted, using maximum likelihood estimation, by the extreme value analysis packages eva <https://cran.r-project.org/package=eva>, evd <https://cran.r-project.org/package=evd>, evir <https://cran.r-project.org/package=evir>, extRemes <https://cran.r-project.org/package=extRemes>, fExtremes <https://cran.r-project.org/package=fExtremes>, ismev <https://cran.r-project.org/package=ismev>, mev <https://cran.r-project.org/package=mev>, POT <https://cran.r-project.org/package=POT> and texmex <https://cran.r-project.org/package=texmex>. Adjusted standard errors and an adjusted loglikelihood are provided, using the chandwich package <https://cran.r-project.org/package=chandwich> and the object-oriented features of the sandwich package <https://cran.r-project.org/package=sandwich>. The adjustment is based on a robust sandwich estimator of the parameter covariance matrix, based on the methodology in Chandler and Bate (2007) <doi:10.1093/biomet/asm015>. This can be used for cluster correlated data when interest lies in the parameters of the marginal distributions, or for performing inferences that are robust to certain types of model misspecification. Univariate extreme value models, including regression models, are supported.

This package provides functions that compute the lattice-based density and regression estimators for two-dimensional regions with irregular boundaries and holes. The density estimation technique is described in Barry and McIntyre (2011) <doi:10.1016/j.ecolmodel.2011.02.016>, while the non-parametric regression technique is described in McIntyre and Barry (2018) <doi:10.1080/10618600.2017.1375935>.

Reusable Shiny user interface and server components from which the graphical applications in the LLMR package family are assembled.

Automatically install, update, and load CRAN', GitHub', and Bioconductor packages in a single function call. By accepting bare unquoted names for packages, it's easy to add or remove packages from the list.

Simplex optimization algorithms as firstly proposed by Spendley et al. (1962) <doi:10.1080/00401706.1962.10490033> and later modified by Nelder and Mead (1965) <doi:10.1093/comjnl/7.4.308> for laboratory and manufacturing processes. The package also provides tools for graphical representation of the simplexes and some example response surfaces that are useful in illustrating the optimization process.

This package provides functions that allow for convenient working with vector space models of semantics/distributional semantic models/word embeddings. Originally built for LSA models (hence the name), but can be used for all such vector-based models. For actually building a vector semantic space, use the package lsa or other specialized software. Downloadable semantic spaces can be found at <https://sites.google.com/site/fritzgntr/software-resources>.

Testing differential abundance at individual taxa and in a whole microbial community. The tests are based on the log-ratio of relative abundances. The tests accommodate continuous, discrete (binary, categorical), and multivariate traits, and allow adjustment of confounders. For more details see He (2026) <doi:10.64898/2026.04.07.716976>.

Instrumental variables (IVs) are a popular and powerful tool for estimating causal effects in the presence of unobserved confounding. However, classical methods rely on strong assumptions such as the exclusion criterion, which states that instrumental effects must be entirely mediated by treatments. In the so-called "leaky" IV setting, candidate instruments are allowed to have some direct influence on outcomes, rendering the average treatment effect (ATE) unidentifiable. But with limits on the amount of information leakage, we may still recover sharp bounds on the ATE, providing partial identification. This package implements methods for ATE bounding in the leaky IV setting with linear structural equations. For details, see Watson et al. (2024) <doi:10.48550/arXiv.2404.04446>.

"Lessons in Statistical Thinking" D.T. Kaplan (2014) <https://dtkaplan.github.io/Lessons-in-statistical-thinking/> is a textbook for a first or second course in statistics that embraces data wrangling, causal reasoning, modeling, statistical adjustment, and simulation. LSTbook supports the student-centered, tidy, pipeline-oriented computing style featured in the book.

Identifying latent genetic interactions in genome-wide association studies using the Latent Interaction Testing (LIT) framework. LIT is a flexible kernel-based approach that leverages information across multiple traits to detect latent genetic interactions without specifying or observing the interacting variable (e.g., environment). LIT accepts standard PLINK files as inputs to analyze large genome-wide association studies.

This package provides a Low Rank Correction Variational Bayesian algorithm for high-dimensional multi-source heterogeneous quantile linear models. More details have been written up in a paper submitted to the journal Statistics in Medicine, and the details of variational Bayesian methods can be found in Ray and Szabo (2021) <doi:10.1080/01621459.2020.1847121>. It simultaneously performs parameter estimation and variable selection. The algorithm supports two model settings: (1) local models, where variable selection is only applied to homogeneous coefficients, and (2) global models, where variable selection is also performed on heterogeneous coefficients. Two forms of parameter estimation are output: one is the standard variational Bayesian estimation, and the other is the variational Bayesian estimation corrected with low-rank adjustment.

Plots path diagrams from models in lavaan using the plotting functionality from the DiagrammeR package. DiagrammeR provides nice path diagrams via Graphviz', and these functions make it easy to generate these diagrams from a lavaan path model without having to write the DOT language graph specification.

We present a method based on filtering algorithms to estimate the parameters of linear, i.e. the coefficients and the variance of the error term. The proposed algorithms make use of Particle Filters following Ristic, B., Arulampalam, S., Gordon, N. (2004, ISBN: 158053631X) resampling methods. Parameters of logistic regression models are also estimated using an evolutionary particle filter method.

This package produces a group screening procedure that is based on maximum Lq-likelihood estimation, to simultaneously account for the group structure and data contamination in variable screening. The methods are described in Li, Y., Li, R., Qin, Y., Lin, C., & Yang, Y. (2021) Robust Group Variable Screening Based on Maximum Lq-likelihood Estimation. Statistics in Medicine, 40:6818-6834.<doi:10.1002/sim.9212>.

This package provides functions for regional frequency analysis using the methods of J. R. M. Hosking and J. R. Wallis (1997), "Regional frequency analysis: an approach based on L-moments".