This package provides a tool for inferring kinase activity changes from phosphoproteomics data. pKSEA uses kinase-substrate prediction scores to weight observed changes in phosphopeptide abundance to calculate a phosphopeptide-level contribution score, then sums up these contribution scores by kinase to obtain a phosphoproteome-level kinase activity change score (KAC score). pKSEA then assesses the significance of changes in predicted substrate abundances for each kinase using permutation testing. This results in a permutation score (pKSEA significance score) reflecting the likelihood of a similarly high or low KAC from random chance, which can then be interpreted in an analogous manner to an empirically calculated p-value. pKSEA contains default databases of kinase-substrate predictions from NetworKIN (NetworKINPred_db) <http://networkin.info> Horn, et. al (2014) <doi:10.1038/nmeth.2968> and of known kinase-substrate links from PhosphoSitePlus (KSEAdb) <https://www.phosphosite.org/> Hornbeck PV, et. al (2015) <doi:10.1093/nar/gku1267>.

Several functions are provided to implement a MBPLSDA : components search, optimal model components number search, optimal model validity test by permutation tests, observed values evaluation of optimal model parameters and predicted categories, bootstrap values evaluation of optimal model parameters and predicted cross-validated categories. The use of this package is described in Brandolini-Bunlon et al (2019. Multi-block PLS discriminant analysis for the joint analysis of metabolomic and epidemiological data. Metabolomics, 15(10):134).

Automatically create a web server from annotated R files or by building it up programmatically. Provides automatic OpenAPI documentation, input handling, asynchronous evaluation, and plugin support.

This package implements the method described at the UCLA Statistical Consulting site <https://stats.idre.ucla.edu/r/dae/ordinal-logistic-regression/> for checking if the proportional odds assumption holds for a cumulative logit model.

Perform 1-dim/2-dim projection pursuit, grand tour and guided tour for big data based on data nuggets. Reference papers: [1] Beavers et al., (2024) <doi:10.1080/10618600.2024.2341896>. [2] Duan, Y., Cabrera, J., & Emir, B. (2023). "A New Projection Pursuit Index for Big Data." <doi:10.48550/arXiv.2312.06465>.

Given an arbitrary set of spatial regions and road networks, generate a set of representative points, or pseudohouseholds, that can be used for travel burden analysis. Parallel processing is supported.

Implementations of Power Fuzzy Clustering (PFC) and Power Fuzzy Cluster-wise Regression (PFCR) for multivariate data. The package supports Minkowski distances, with the L1 case solved via iteratively re-weighted least squares and the case p > 1 solved via coordinate-wise root finding, as well as an adaptive, regularised Mahalanobis distance with per-cluster covariance matrices. Both plain fuzzy clustering and cluster-wise linear regression are provided. The corresponding paper can be found at Nguyen P.T., Tortora C., and Punzo A. (2026) <doi:10.1109/TFUZZ.2026.3683998>.

Interface to the Pharmpy pharmacometrics library. The Reticulate package is used to interface Python from R.

This package contains the functions for construction and visualization of various families of the proximity catch digraphs (PCDs), see (Ceyhan (2005) ISBN:978-3-639-19063-2), for computing the graph invariants for testing the patterns of segregation and association against complete spatial randomness (CSR) or uniformity in one, two and three dimensional cases. The package also has tools for generating points from these spatial patterns. The graph invariants used in testing spatial point data are the domination number (Ceyhan (2011) <doi:10.1080/03610921003597211>) and arc density (Ceyhan et al. (2006) <doi:10.1016/j.csda.2005.03.002>; Ceyhan et al. (2007) <doi:10.1002/cjs.5550350106>). The PCD families considered are Arc-Slice PCDs, Proportional-Edge PCDs, and Central Similarity PCDs.

Build your own universe of packages similar to the tidyverse package <https://tidyverse.org/> with this meta-package creator. Create a package-verse, or meta package, by supplying a custom name for the collection of packages and the vector of desired package names to includeâ and optionally supply a destination directory, an indicator of whether to keep the created package directory, and/or a vector of verbs implement via the usethis <http://usethis.r-lib.org/> package.

This package provides data set and function for exploration of Multiple Indicator Cluster Survey (MICS) 2017-18 Household questionnaire data for Punjab, Pakistan. The results of the present survey are critically important for the purposes of Sustainable Development Goals (SDGs) monitoring, as the survey produces information on 32 global Sustainable Development Goals (SDGs) indicators. The data was collected from 53,840 households selected at the second stage with systematic random sampling out of a sample of 2,692 clusters selected using probability proportional to size sampling. Six questionnaires were used in the survey: (1) a household questionnaire to collect basic demographic information on all de jure household members (usual residents), the household, and the dwelling; (2) a water quality testing questionnaire administered in three households in each cluster of the sample; (3) a questionnaire for individual women administered in each household to all women age 15-49 years; (4) a questionnaire for individual men administered in every second household to all men age 15-49 years; (5) an under-5 questionnaire, administered to mothers (or caretakers) of all children under 5 living in the household; and (6) a questionnaire for children age 5-17 years, administered to the mother (or caretaker) of one randomly selected child age 5-17 years living in the household (<http://www.mics.unicef.org/surveys>).

This package provides a comprehensive set of tools for describing and visualizing panel data structures, as well as for summarizing and visualizing variables within a panel data context.

This package provides a customisable R shiny app for immersively visualising, mapping and annotating panospheric (360 degree) imagery. The flexible interface allows annotation of any geocoded images using up to 4 user specified drop-down menus. The app uses leaflet to render maps that display the geo-locations of images and Panellum <https://pannellum.org/>, a lightweight panorama viewer for the web, to render images in virtual 360 degree viewing mode. Key functions include the ability to draw on & export parts of 360 images for downstream applications. Users can also draw polygons and points on map imagery related to the panoramic images and export them for further analysis. Downstream applications include using annotations to train Artificial Intelligence/Machine Learning (AI/ML) models and geospatial modelling and analysis of camera based survey data.

This package provides an interface to the GenderAPI.io Phone Number Validation & Formatter API (<https://www.genderapi.io>) for validating international phone numbers, detecting number type (mobile, landline, Voice over Internet Protocol (VoIP)), retrieving region and country metadata, and formatting numbers to E.164 or national format. Designed to simplify integration into R workflows for data validation, Customer Relationship Management (CRM) data cleaning, and analytics tasks. Full documentation is available at <https://www.genderapi.io/docs-phone-validation-formatter-api>.

Survey sampling using permanent random numbers (PRN's). A solution to the problem of unknown overlap between survey samples, which leads to a low precision in estimates when the survey is repeated or combined with other surveys. The PRN solution is to supply the U(0, 1) random numbers to the sampling procedure, instead of having the sampling procedure generate them. In Lindblom (2014) <doi:10.2478/jos-2014-0047>, and therein cited papers, it is shown how this is carried out and how it improves the estimates. This package supports two common fixed-size sampling procedures (simple random sampling and probability-proportional-to-size sampling) and includes a function for transforming the PRN's in order to control the sample overlap.

High-performance Unicode and Punycode encoding/decoding for internationalized domain names. Provides RFC 3492 compliant conversion functions with a focus on URL processing and data analysis workflows. Addresses limitations in existing R packages for handling international domain names in web scraping and URL parsing applications.

This package provides a comprehensive, user-friendly package for label-free proteomics data analysis and machine learning-based modeling. Data generated from MaxQuant can be easily used to conduct differential expression analysis, build predictive models with top protein candidates, and assess model performance. promor includes a suite of tools for quality control, visualization, missing data imputation (Lazar et. al. (2016) <doi:10.1021/acs.jproteome.5b00981>), differential expression analysis (Ritchie et. al. (2015) <doi:10.1093/nar/gkv007>), and machine learning-based modeling (Kuhn (2008) <doi:10.18637/jss.v028.i05>).

This package provides a function PWI() that calculates prize winner indices based on bibliometric data is provided. The default is the Derek de Solla Price Memorial Medal'. Users can provide recipients of other prizes.

Simulate the dynamic of lion populations using a specific Individual-Based Model (IBM) compiled in C.

An implementation of Bayesian single-arm phase II design methods for binary outcome based on posterior probability (Thall and Simon (1994) <doi:10.2307/2533377>) and predictive probability (Lee and Liu (2008) <doi:10.1177/1740774508089279>).

Code to identify functional enrichments across diverse taxa in phylogenetic tree, particularly where these taxa differ in abundance across samples in a non-random pattern. The motivation for this approach is to identify microbial functions encoded by diverse taxa that are at higher abundance in certain samples compared to others, which could indicate that such functions are broadly adaptive under certain conditions. See GitHub repository for tutorial and examples: <https://github.com/gavinmdouglas/POMS/wiki>. Citation: Gavin M. Douglas, Molly G. Hayes, Morgan G. I. Langille, Elhanan Borenstein (2022) <doi:10.1093/bioinformatics/btac655>.

Two functions for financial portfolio optimization by linear programming are provided. One function implements Benders decomposition algorithm and can be used for very large data sets. The other, applicable for moderate sample sizes, finds optimal portfolio which has the smallest distance to a given benchmark portfolio.

This package provides a C++ reimplementation of poLCA - latent class analysis and latent class regression models for polytomous outcome variables, also known as latent structure analysis. It attempts to reproduce results and be as similar as possible to the original code, while running faster, especially with multiple repetitions, by utilising multiple threads. Further reading is available on the Queen Mary, University of London, IT Services Research blog <https://blog.hpc.qmul.ac.uk/speeding_up_r_packages/>.

Parallelized version of the "segment" function from Bioconductor package "DNAcopy", utilizing multi-core computation on host CPU.