Full dynamic system to describe and forecast the spread and the severity of a developing pandemic, based on available data. These data are number of infections, hospitalizations, deaths and recoveries notified each day. The system consists of three transitions, infection-infection, infection-hospital and hospital-death/recovery. The intensities of these transitions are dynamic and estimated using non-parametric local linear estimators. The package can be used to provide forecasts and survival indicators such as the median time spent in hospital and the probability that a patient who has been in hospital for a number of days can leave it alive. Methods are described in Gámiz, Mammen, Martà nez-Miranda, and Nielsen (2024) <doi:10.48550/arXiv.2308.09918> and <doi:10.48550/arXiv.2308.09919>.

Generic code for estimating treatment effects with panel data. The idea is to break into separate steps organizing the data, looping over groups and time periods, computing group-time average treatment effects, and aggregating group-time average treatment effects. Often, one is able to implement a new identification/estimation procedure by simply replacing the step on estimating group-time average treatment effects. See several different examples of this approach in the package documentation.

This package provides tools for extracting and processing structured annotations from R and Python source files to facilitate workflow visualization. The package scans source files for special PUT annotations that define nodes, connections, and metadata within a data processing workflow. These annotations can then be used to generate visual representations of data flows and processing steps across polyglot software environments. Builds on concepts from literate programming Knuth (1984) <doi:10.1093/comjnl/27.2.97> and utilizes directed acyclic graph (DAG) theory for workflow representation Foraita, Spallek, and Zeeb (2014) <doi:10.1007/978-0-387-09834-0_65>. Diagram generation powered by Mermaid Sveidqvist (2014) <https://mermaid.js.org/>.

This package provides functions for creating color palettes, visualizing palettes, modifying colors, and assigning colors for plotting.

This package provides an implementation of a rare variant association test that utilizes protein tertiary structure to increase signal and to identify likely causal variants. Performs structure-guided collapsing, which leads to local tests that borrow information from neighboring variants on a protein and that provide association information on a variant-specific level. For details of the implemented method see West, R. M., Lu, W., Rotroff, D. M., Kuenemann, M., Chang, S-M., Wagner M. J., Buse, J. B., Motsinger-Reif, A., Fourches, D., and Tzeng, J-Y. (2019) <doi:10.1371/journal.pcbi.1006722>.

Calculates, via simulation, power and appropriate stopping alpha boundaries (and/or futility bounds) for sequential analyses (i.e., group sequential design) as well as for multiple hypotheses (multiple tests included in an analysis), given any specified global error rate. This enables the sequential use of practically any significance test, as long as the underlying data can be simulated in advance to a reasonable approximation. Lukács (2022) <doi:10.21105/joss.04643>.

This package provides (weighted) Partial least squares Regression for generalized linear models and repeated k-fold cross-validation of such models using various criteria <doi:10.48550/arXiv.1810.01005>. It allows for missing data in the explanatory variables. Bootstrap confidence intervals constructions are also available.

An enterprise-targeted scalable and UI-standardized shiny framework including a variety of developer convenience functions with the goal of both streamlining robust application development while assisting with creating a consistent user experience regardless of application or developer.

The Piece-wise exponential (Additive Mixed) Model (PAMM; Bender and others (2018) <doi: 10.1177/1471082X17748083>) is a powerful model class for the analysis of survival (or time-to-event) data, based on Generalized Additive (Mixed) Models (GA(M)Ms). It offers intuitive specification and robust estimation of complex survival models with stratified baseline hazards, random effects, time-varying effects, time-dependent covariates and cumulative effects (Bender and others (2019)), as well as support for left-truncated data as well as competing risks, recurrent events and multi-state settings. pammtools provides tidy workflow for survival analysis with PAMMs, including data simulation, transformation and other functions for data preprocessing and model post-processing as well as visualization.

This package provides an R interface to the PCATS API <https://pcats.research.cchmc.org/api/__docs__/>, allowing R users to submit tasks and retrieve results.

This package provides essential checklists for R package developers, whether you're creating your first package or beginning a new project. This tool guides you through each step of the development process, including specific considerations for submitting your package to the Comprehensive R Archive Network (CRAN). Simplify your workflow and ensure adherence to best practices with packagepal'.

Matches cases to controls based on genotype principal components (PC). In order to produce better results, matches are based on the weighted distance of PCs where the weights are equal to the % variance explained by that PC. A weighted Mahalanobis distance metric (Kidd et al. (1987) <DOI:10.1016/0031-3203(87)90066-5>) is used to determine matches.

This package provides a comprehensive, user-friendly package for label-free proteomics data analysis and machine learning-based modeling. Data generated from MaxQuant can be easily used to conduct differential expression analysis, build predictive models with top protein candidates, and assess model performance. promor includes a suite of tools for quality control, visualization, missing data imputation (Lazar et. al. (2016) <doi:10.1021/acs.jproteome.5b00981>), differential expression analysis (Ritchie et. al. (2015) <doi:10.1093/nar/gkv007>), and machine learning-based modeling (Kuhn (2008) <doi:10.18637/jss.v028.i05>).

Prepares data for statistical analysis (e.g., analysis of variance ;ANOVA) by enabling the user to easily and quickly merge (using the file_merge() function) raw data files into one merged table and then aggregate the merged table (using the prep() function) into a finalized table while keeping track and summarizing every step of the preparation. The finalized table contains several possibilities for dependent measures of the dependent variable. Most suitable when measuring variables in an interval or ratio scale (e.g., reaction-times) and/or discrete values such as accuracy. Main functions included are file_merge() and prep(). The file_merge() function vertically merges individual data files (in a long format) in which each line is a single observation to one single dataset. The prep() function aggregates the single dataset according to any combination of grouping variables (i.e., between-subjects and within-subjects independent variables, respectively), and returns a data frame with a number of dependent measures for further analysis for each cell according to the combination of provided grouping variables. Dependent measures for each cell include among others means before and after rejecting all values according to a flexible standard deviation criteria, number of rejected values according to the flexible standard deviation criteria, proportions of rejected values according to the flexible standard deviation criteria, number of values before rejection, means after rejecting values according to procedures described in Van Selst & Jolicoeur (1994; suitable when measuring reaction-times), standard deviations, medians, means according to any percentile (e.g., 0.05, 0.25, 0.75, 0.95) and harmonic means. The data frame prep() returns can also be exported as a txt file to be used for statistical analysis in other statistical programs.

This package contains common univariate and multivariate portmanteau test statistics for time series models. These tests are based on using asymptotic distributions such as chi-square distribution and based on using the Monte Carlo significance tests. Also, it can be used to simulate from univariate and multivariate seasonal time series models.

Create a project directory structure, along with typical files for that project. This allows projects to be quickly and easily created, as well as for them to be standardized. Designed specifically with scientists in mind (mainly bio-medical researchers, but likely applies to other fields).

Calculating Pst values to assess differentiation among populations from a set of quantitative traits is the primary purpose of such a package. The bootstrap method provides confidence intervals and distribution histograms of Pst. Variations of Pst in function of the parameter c/h^2 are studied as well. Finally, the package proposes different transformations especially to eliminate any variation resulting from allometric growth (calculation of residuals from linear regressions, Reist standardizations or Aitchison transformation).

This package provides methods for plotting potentially large (raster) images interactively on a plain HTML canvas. In contrast to package mapview data are plotted without background map, but data can be projected to any spatial coordinate reference system. Supports plotting of classes RasterLayer', RasterStack', RasterBrick (from package raster') as well as png files located on disk. Interactivity includes zooming, panning, and mouse location information. In case of multi-layer RasterStacks or RasterBricks', RGB image plots are created (similar to raster::plotRGB - but interactive).

Structured fusion Lasso penalized estimation of multi-state models with the penalty applied to absolute effects and absolute effect differences (i.e., effects on transition-type specific hazard rates).

Collection of functions to get files in parquet format. Parquet is a columnar storage file format <https://parquet.apache.org/>. The files to convert can be of several formats ("csv", "RData", "rds", "RSQLite", "json", "ndjson", "SAS", "SPSS"...).

This package provides tools for downloading, reading and analyzing the National Survey of Demographic and Health - PNDS, a household survey from Brazilian Institute of Geography and Statistics - IBGE. The data must be downloaded from the official website <https://www.ibge.gov.br/>. Further analysis must be made using package survey'.

This package provides tools for calculating and viewing topological properties of phylogenetic trees.

Implementation of T. Hailperin's procedure to calculate lower and upper bounds of the probability for a propositional-logic expression, given equality and inequality constraints on the probabilities for other expressions. Truth-valuation is included as a special case. Applications range from decision-making and probabilistic reasoning, to pedagogical for probability and logic courses. For more details see T. Hailperin (1965) <doi:10.1080/00029890.1965.11970533>, T. Hailperin (1996) "Sentential Probability Logic" ISBN:0-934223-45-9, and package documentation. Requires the lpSolve package.

Programs to determine student grades and create examinations from Question banks. Programs will create numerous multiple choice exams, randomly shuffled, for different versions of same question list.