This package provides functions for constructing near-optimal generalized full matching. Generalized full matching is an extension of the original full matching method to situations with more intricate study designs. The package is made with large data sets in mind and derives matches more than an order of magnitude quicker than other methods.

Select optimal functional regression or dichotomized quantile predictors for survival/logistic/numeric outcome and perform optimistic bias correction for any optimally dichotomized numeric predictor(s), as in Yi, et. al. (2023) <doi:10.1016/j.labinv.2023.100158>.

This package provides a method for prediction of environmental conditions based on transcriptome data linked with the environmental gradients. This package provides functions to overview gene-environment relationships, to construct the prediction model, and to predict environmental conditions where the transcriptomes were generated. This package can quest for candidate genes for the model construction even in non-model organisms transcriptomes without any genetic information.

For QTL mapping, this package comprises several functions designed to execute diverse tasks, such as simulating or analyzing data, calculating significance thresholds, and visualizing QTL mapping results. The single-QTL or multiple-QTL method, which enables the fitting and comparison of various statistical models, is employed to analyze the data for estimating QTL parameters. The models encompass linear regression, permutation tests, normal mixture models, and truncated normal mixture models. The Gaussian stochastic process is utilized to compute significance thresholds for QTL detection on a genetic linkage map within experimental populations. Two types of data, complete genotyping, and selective genotyping data from various experimental populations, including backcross, F2, recombinant inbred (RI) populations, and advanced intercrossed (AI) populations, are considered in the QTL mapping analysis. For QTL hotspot detection, statistical methods can be developed based on either utilizing individual-level data or summarized data. We have proposed a statistical framework capable of handling both individual-level data and summarized QTL data for QTL hotspot detection. Our statistical framework can overcome the underestimation of thresholds resulting from ignoring the correlation structure among traits. Additionally, it can identify different types of hotspots with minimal computational cost during the detection process. Here, we endeavor to furnish the R codes for our QTL mapping and hotspot detection methods, intended for general use in genes, genomics, and genetics studies. The QTL mapping methods for the complete and selective genotyping designs are based on the multiple interval mapping (MIM) model proposed by Kao, C.-H. , Z.-B. Zeng and R. D. Teasdale (1999) <doi: 10.1534/genetics.103.021642> and H.-I Lee, H.-A. Ho and C.-H. Kao (2014) <doi: 10.1534/genetics.114.168385>, respectively. The QTL hotspot detection analysis is based on the method by Wu, P.-Y., M.-.H. Yang, and C.-H. Kao (2021) <doi: 10.1093/g3journal/jkab056>.

Conduct multiple quantitative trait loci (QTL) mapping under the framework of random-QTL-effect linear mixed model. First, each position on the genome is detected in order to obtain a negative logarithm P-value curve against genome position. Then, all the peaks on each effect (additive or dominant) curve are viewed as potential QTL, all the effects of the potential QTL are included in a multi-QTL model, their effects are estimated by empirical Bayes in doubled haploid population or by adaptive lasso in F2 population, and true QTL are identified by likelihood radio test. See Wen et al. (2018) <doi:10.1093/bib/bby058>.

This package provides functions for assigning treatments in randomized experiments using near-optimal threshold blocking. The package is made with large data sets in mind and derives blocks more than an order of magnitude quicker than other methods.

This package provides functions for quickly writing (and reading back) a data.frame to file in SQLite format. The name stands for *Store Tables using SQLite'*, or alternatively for *Quick Store Tables* (either way, it could be pronounced as *Quest*). For data.frames containing the supported data types it is intended to work as a drop-in replacement for the write_*() and read_*() functions provided by similar packages.

This package provides a copula-based measure for quantifying asymmetry in dependence and associations. Documentation and theory about qad is provided by the paper by Junker, Griessenberger & Trutschnig (2021, <doi:10.1016/j.csda.2020.107058>), and the paper by Trutschnig (2011, <doi:10.1016/j.jmaa.2011.06.013>).

This package provides functions for estimating ploidy levels and detecting aneuploidy in individuals using allele intensities or allele count data from high-throughput genotyping platforms, including single nucleotide polymorphism (SNP) arrays and sequencing-based technologies. Implements an extended version of the PennCNV signal standardization method by Wang et al. (2007) <doi:10.1101/gr.6861907> for higher ploidy levels. Computes B-allele frequencies (BAF), z-scores, and identifies copy number variation patterns.

This package implements the robust algorithm for fitting finite mixture models based on quantile regression proposed by Emir et al., 2017 (unpublished).

This package implements the Quantile Composite-based Path Modeling approach (Davino and Vinzi, 2016 <doi:10.1007/s11634-015-0231-9>; Dolce et al., 2021 <doi:10.1007/s11634-021-00469-0>). The method complements the traditional PLS Path Modeling approach, analyzing the entire distribution of outcome variables and, therefore, overcoming the classical exploration of only average effects. It exploits quantile regression to investigate changes in the relationships among constructs and between constructs and observed variables.

Analysis of Q methodology, used to identify distinct perspectives existing within a group. This methodology is used across social, health and environmental sciences to understand diversity of attitudes, discourses, or decision-making styles (for more information, see <https://qmethod.org/>). A single function runs the full analysis. Each step can be run separately using the corresponding functions: for automatic flagging of Q-sorts (manual flagging is optional), for statement scores, for distinguishing and consensus statements, and for general characteristics of the factors. The package allows to choose either principal components or centroid factor extraction, manual or automatic flagging, a number of mathematical methods for rotation (or none), and a number of correlation coefficients for the initial correlation matrix, among many other options. Additional functions are available to import and export data (from raw *.CSV, HTMLQ and FlashQ *.CSV, PQMethod *.DAT and easy-htmlq *.JSON files), to print and plot, to import raw data from individual *.CSV files, and to make printable cards. The package also offers functions to print Q cards and to generate Q distributions for study administration. See further details in the package documentation, and in the web pages below, which include a cookbook, guidelines for more advanced analysis (how to perform manual flagging or change the sign of factors), data management, and a graphical user interface (GUI) for online and offline use.

Calculates the number of four-taxon subtrees consistent with a pair of cladograms, calculating the symmetric quartet distance of Bandelt & Dress (1986), Reconstructing the shape of a tree from observed dissimilarity data, Advances in Applied Mathematics, 7, 309-343 <doi:10.1016/0196-8858(86)90038-2>, and using the tqDist algorithm of Sand et al. (2014), tqDist: a library for computing the quartet and triplet distances between binary or general trees, Bioinformatics, 30, 2079â 2080 <doi:10.1093/bioinformatics/btu157> for pairs of binary trees.

This package provides a brms'-like interface for fitting Bayesian regression models using INLA (Integrated Nested Laplace Approximations) and TMB (Template Model Builder). The package offers faster model fitting while maintaining familiar brms syntax and output formats. Supports fixed and mixed effects models, multiple probability distributions, conditional effects plots, and posterior predictive checks with summary methods compatible with brms'. TMB integration provides fast ordinal regression capabilities. Implements methods adapted from emmeans for marginal means estimation and bayestestR for Bayesian inference assessment. Methods are based on Rue et al. (2009) <doi:10.1111/j.1467-9868.2008.00700.x>, Kristensen et al. (2016) <doi:10.18637/jss.v070.i05>, Lenth (2016) <doi:10.18637/jss.v069.i01>, Bürkner (2017) <doi:10.18637/jss.v080.i01>, Makowski et al. (2019) <doi:10.21105/joss.01541>, and Kruschke (2014, ISBN:9780124058880).

This package implements indices of qualitative variation proposed by Wilcox (1973).

This package provides a re-implementation of quantile kriging. Quantile kriging was described by Plumlee and Tuo (2014) <doi:10.1080/00401706.2013.860919>. With computational savings when dealing with replication from the recent paper by Binois, Gramacy, and Ludovski (2018) <doi:10.1080/10618600.2018.1458625> it is now possible to apply quantile kriging to a wider class of problems. In addition to fitting the model, other useful tools are provided such as the ability to automatically perform leave-one-out cross validation.

Developed to perform the estimation and inference for regression coefficient parameters in longitudinal marginal models using the method of quadratic inference functions. Like generalized estimating equations, this method is also a quasi-likelihood inference method. It has been showed that the method gives consistent estimators of the regression coefficients even if the correlation structure is misspecified, and it is more efficient than GEE when the correlation structure is misspecified. Based on Qu, A., Lindsay, B.G. and Li, B. (2000) <doi:10.1093/biomet/87.4.823>.

This package provides functions for estimating the potential dispersal of tree species using regeneration densities and dispersal distances to nearest seed trees. A quantile regression is implemented to determine the dispersal potential. Spatial prediction can be used to identify natural regeneration potential for forest restoration as described in Axer et al (2021) <doi:10.1016/j.foreco.2020.118802>.

Fit quantile regression neural network models with optional left censoring, partial monotonicity constraints, generalized additive model constraints, and the ability to fit multiple non-crossing quantile functions following Cannon (2011) <doi:10.1016/j.cageo.2010.07.005> and Cannon (2018) <doi:10.1007/s00477-018-1573-6>.

Scaling models and classifiers for sparse matrix objects representing textual data in the form of a document-feature matrix. Includes original implementations of Laver', Benoit', and Garry's (2003) <doi:10.1017/S0003055403000698>, Wordscores model, the Perry and Benoit (2017) <doi:10.48550/arXiv.1710.08963> class affinity scaling model, and the Slapin and Proksch (2008) <doi:10.1111/j.1540-5907.2008.00338.x> wordfish model, as well as methods for correspondence analysis, latent semantic analysis, and fast Naive Bayes and linear SVMs specially designed for sparse textual data.

This package implements an adaptively weighted group Lasso procedure for simultaneous variable selection and structure identification in varying coefficient quantile regression models and additive quantile regression models with ultra-high dimensional covariates. The methodology, grounded in a strong sparsity condition, establishes selection consistency under certain weight conditions. To address the challenge of tuning parameter selection in practice, a BIC-type criterion named high-dimensional information criterion (HDIC) is proposed. The Lasso procedure, guided by HDIC-determined tuning parameters, maintains selection consistency. Theoretical findings are strongly supported by simulation studies. (Toshio Honda, Ching-Kang Ing, Wei-Ying Wu, 2019, <DOI:10.3150/18-BEJ1091>).

This package provides a Quantile Rank-score based test for the identification of expression quantitative trait loci.

Implementation of the food safety restaurant grading system adopted by Public Health - Seattle & King County (see Ashwood, Z.C., Elias, B., and Ho. D.E. "Improving the Reliability of Food Safety Disclosure: A Quantile Adjusted Restaurant Grading System for Seattle-King County" (working paper)). As reported in the accompanying paper, this package allows jurisdictions to easily implement refinements that address common challenges with unadjusted grading systems. First, in contrast to unadjusted grading, where the most recent single routine inspection is the primary determinant of a grade, grading inputs are allowed to be flexible. For instance, it is straightforward to base the grade on average inspection scores across multiple inspection cycles. Second, the package can identify quantile cutoffs by inputting substantively meaningful regulatory thresholds (e.g., the proportion of establishments receiving sufficient violation points to warrant a return visit). Third, the quantile adjustment equalizes the proportion of establishments in a flexible number of grading categories (e.g., A/B/C) across areas (e.g., ZIP codes, inspector areas) to account for inspector differences. Fourth, the package implements a refined quantile adjustment that addresses two limitations with the stats::quantile() function when applied to inspection score datasets with large numbers of score ties. The quantile adjustment algorithm iterates over quantiles until, over all restaurants in all areas, grading proportions are within a tolerance of desired global proportions. In addition the package allows a modified definition of "quantile" from "Nearest Rank". Instead of requiring that at least p[1]% of restaurants receive the top grade and at least (p[1]+p[2])% of restaurants receive the top or second best grade for quantiles p, the algorithm searches for cutoffs so that as close as possible p[1]% of restaurants receive the top grade, and as close as possible to p[2]% of restaurants receive the second top grade.

Nonlinear and Penalized parametric modeling of quantile regression coefficient functions. Sottile G, Frumento P, Chiodi M and Bottai M (2020) <doi:10.1177/1471082X19825523>.