This package provides a native R client library for querying the Prometheus time-series database, using the PromQL query language.

Fill missing symmetrical data with mirroring, calculate Procrustes alignments with or without scaling, and compute standard or vector correlation and covariance matrices (congruence coefficients) of 3D landmarks. Tolerates missing data for all analyses.

Helpers for preparing ecommerce product photo planning tables, prompt sheets, and public ProductShot AI workflow URLs. The package works offline and focuses on data-frame preparation for product image batches.

Evaluate or optimize designs for nonlinear mixed effects models using the Fisher Information matrix. Methods used in the package refer to Mentré F, Mallet A, Baccar D (1997) <doi:10.1093/biomet/84.2.429>, Retout S, Comets E, Samson A, Mentré F (2007) <doi:10.1002/sim.2910>, Bazzoli C, Retout S, Mentré F (2009) <doi:10.1002/sim.3573>, Le Nagard H, Chao L, Tenaillon O (2011) <doi:10.1186/1471-2148-11-326>, Combes FP, Retout S, Frey N, Mentré F (2013) <doi:10.1007/s11095-013-1079-3> and Seurat J, Tang Y, Mentré F, Nguyen TT (2021) <doi:10.1016/j.cmpb.2021.106126>.

Bland (2009) <doi:10.1136/bmj.b3985> recommended to base study sizes on the width of the confidence interval rather the power of a statistical test. The goal of presize is to provide functions for such precision based sample size calculations. For a given sample size, the functions will return the precision (width of the confidence interval), and vice versa.

Generates simple and beautiful one-page HTML reference manuals with package documentation. Math rendering and syntax highlighting are done server-side in R such that no JavaScript libraries are needed in the browser, which makes the documentation portable and fast to load.

Conduct internal validation of a clinical prediction model for a binary outcome. Produce bias corrected performance metrics (c-statistic, Brier score, calibration intercept/slope) via bootstrap (simple bootstrap, bootstrap optimism, .632 optimism) and cross-validation (CV optimism, CV average). Also includes functions to assess model stability via bootstrap resampling. See Steyerberg et al. (2001) <doi:10.1016/s0895-4356(01)00341-9>; Harrell (2015) <doi:10.1007/978-3-319-19425-7>; Riley and Collins (2023) <doi:10.1002/bimj.202200302>.

An R interface to pikchr (<https://pikchr.org>, pronounced "picture"), a PIC'-like markup language for creating diagrams within technical documentation. Originally developed by Brian Kernighan, PIC has been adapted into pikchr by D. Richard Hipp, the creator of SQLite'. pikchr is designed to be embedded in fenced code blocks of Markdown or other documentation markup languages, making it ideal for generating diagrams in text-based formats. This package allows R users to seamlessly integrate the descriptive syntax of pikchr for diagram creation directly within the R environment.

Puzzle game that can be played in the R console. Restore the pixel art by shifting rows.

Calculates the pooled mean group (PMG) estimator for dynamic panel data models, as described by Pesaran, Shin and Smith (1999) <doi:10.1080/01621459.1999.10474156>.

Inspired by Moreira and Gamerman (2022) <doi:10.1214/21-AOAS1569>, this methodology expands the idea by including Marks in the point process. Using efficient C++ code, the estimation is possible and made faster with OpenMP <https://www.openmp.org/> enabled computers. This package was developed under the project PTDC/MAT-STA/28243/2017, supported by Portuguese funds through the Portuguese Foundation for Science and Technology (FCT).

This package implements the Principal Components Difference-in-Differences estimators as described in Chan, M. K., & Kwok, S. S. (2022) <doi:10.1080/07350015.2021.1914636>.

This package provides functions for landscape analysis and data retrieval. The package allows users to download environmental variables from global datasets (e.g., WorldClim, CHELSA, ESA WorldCover, Nighttime Lights), and to compute spatial and landscape metrics using a hexagonal grid system based on the H3 spatial index. It is useful for ecological modeling, biodiversity studies, and spatial data processing in landscape ecology. Fick and Hijmans (2017) <doi:10.1002/joc.5086>. Zanaga et al. (2022) <doi:10.5281/zenodo.7254221>. Uber Technologies Inc. (2022) "H3: Hexagonal hierarchical spatial index". Román et al. (2018) <doi:10.1016/j.rse.2018.03.017>. Karger et al. (2017) <doi:10.1038/sdata.2017.122>. Brun et al. (2022) <doi:10.5194/essd-14-5573-2022>.

The t-designs represent a generalized class of balanced incomplete block designs in which the number of blocks in which any t-tuple of treatments (t >= 2) occur together is a constant. When the focus of an experiment lies in grading and selecting treatment subgroups, t-designs would be preferred over the conventional ones, as they have the additional advantage of t-tuple balance. t-designs can be advantageously used in identifying the best crop-livestock combination for a particular location in Integrated Farming Systems that will help in generating maximum profit. But as the number of components increases, the number of possible t-component combinations will also increase. Most often, combinations derived from specific components are only practically feasible, for example, in a specific locality, farmers may not be interested in keeping a pig or goat and hence combinations involving these may not be of any use in that locality. In such situations partially balanced t-designs with few selected combinations appearing in a constant number of blocks (while others not at all appearing) may be useful (Sayantani Karmakar, Cini Varghese, Seema Jaggi & Mohd Harun (2021)<doi:10.1080/03610918.2021.2008436>). Further, every location may not have the resources to form equally sized homogeneous blocks. Partially balanced t-designs with unequal block sizes (Damaraju Raghavarao & Bei Zhou (1998)<doi:10.1080/03610929808832657>. Sayantani Karmakar, Cini Varghese, Seema Jaggi & Mohd Harun (2022)." Partially Balanced t-designs with unequal block sizes") prove to be more suitable for such situations.This package generates three series of partially balanced t-designs namely Series 1, Series 2 and Series 3. Series 1 and Series 2 are designs having equal block sizes and with treatment structures 4(t + 1) and a prime number, respectively. Series 3 consists of designs with unequal block sizes and with treatment structure n(n-1)/2. This package is based on the function named PBtD() for generating partially balanced t-designs along with their parameters, information matrices, average variance factors and canonical efficiency factors.

This uses a mixed integer mathematical programming (MIP) approach for building and solving multi-action planning problems, where the goal is to find an optimal combination of management actions that abate threats, in an efficient way while accounting for spatial aspects. Thus, optimizing the connectivity and conservation effectiveness of the prioritized units and of the deployed actions. The package is capable of handling different commercial (gurobi, CPLEX) and non-commercial (symphony, CBC) MIP solvers. Gurobi optimization solver can be installed using comprehensive instructions in the gurobi installation vignette of the prioritizr package (available in <https://prioritizr.net/articles/gurobi_installation_guide.html>). Instead, CPLEX optimization solver can be obtain from IBM CPLEX web page (available here <https://www.ibm.com/es-es/products/ilog-cplex-optimization-studio>). Additionally, the rcbc R package (available at <https://github.com/dirkschumacher/rcbc>) can be used to obtain solutions using the CBC optimization software (<https://github.com/coin-or/Cbc>). Methods used in the package refers to Salgado-Rojas et al. (2020) <doi:10.1016/j.ecolmodel.2019.108901>, Beyer et al. (2016) <doi:10.1016/j.ecolmodel.2016.02.005>, Cattarino et al. (2015) <doi:10.1371/journal.pone.0128027> and Watts et al. (2009) <doi:10.1016/j.envsoft.2009.06.005>. See the prioriactions website for more information, documentations and examples.

This package implements the Penalized Youden Index Estimator (PYE) and the Covariate-Adjusted Youden Index Estimator (covYI), providing a novel framework for feature and covariate selection and combination in high-dimensional binary classification problems. Methodologies are based on Salaroli and Pardo (2023) <doi:10.1016/j.chemolab.2023.104786> and an unpublished manuscript by Salaroli and Pardo (2026) under review.

This package provides functions to simulate point prevalence studies (PPSs) of healthcare-associated infections (HAIs) and to convert prevalence to incidence in steady state setups. Companion package to the preprint Willrich et al., From prevalence to incidence - a new approach in the hospital setting; <doi:10.1101/554725> , where methods are explained in detail.

Utilizes the lme4 and optimx packages (previously the optim() function from stats') to estimate (generalized) linear mixed models (GLMM) with factor structures using a profile likelihood approach, as outlined in Jeon and Rabe-Hesketh (2012) <doi:10.3102/1076998611417628> and Rockwood and Jeon (2019) <doi:10.1080/00273171.2018.1516541>. Factor analysis and item response models can be extended to allow for an arbitrary number of nested and crossed random effects, making it useful for multilevel and cross-classified models.

This package provides a comprehensive set of tools to simulate, evaluate, and compare model-assisted designs for early-phase (Phase I/II) clinical trials, including: - BOIN12 (Bayesian optimal interval phase 1/11 trial design; Lin et al. (2020) <doi:10.1200/PO.20.00257>), - BOIN-ET (Takeda, K., Taguri, M., & Morita, S. (2018) <doi:10.1002/pst.1864>), - EffTox (Thall, P. F., & Cook, J. D. (2004) <doi:10.1111/j.0006-341X.2004.00218.x>), - Ji3+3 (Joint i3+3 design; Lin, X., & Ji, Y. (2020) <doi:10.1080/10543406.2020.1818250>), - PRINTE (probability intervals of toxicity and efficacy design; Lin, X., & Ji, Y. (2021) <doi:10.1177/0962280220977009>), - STEIN (simple toxicity and efficacy interval design; Lin, R., & Yin, G. (2017) <doi:10.1002/sim.7428>), - TEPI (toxicity and efficacy probability interval design; Li, D. H., Whitmore, J. B., Guo, W., & Ji, Y. (2017) <doi:10.1158/1078-0432.CCR-16-1125>), - uTPI (utility-based toxicity Probability interval design; Shi, H., Lin, R., & Lin, X. (2024) <doi:10.1002/sim.8922>). Includes flexible simulation parameters that allow researchers to efficiently compute operating characteristics under various fixed and random trial scenarios and export the results.

This package provides data sets and functions for exploration of Pakistan Population Census 2023 (<https://www.pbs.gov.pk/>).

High-quality real-world data can be transformed into scientific real-world evidence for regulatory and healthcare decision-making using proven analytical methods and techniques. For example, propensity score (PS) methodology can be applied to select a subset of real-world data containing patients that are similar to those in the current clinical study in terms of baseline covariates, and to stratify the selected patients together with those in the current study into more homogeneous strata. Then, statistical methods such as the power prior approach or composite likelihood approach can be applied in each stratum to draw inference for the parameters of interest. This package provides functions that implement the PS-integrated real-world evidence analysis methods such as Wang et al. (2019) <doi:10.1080/10543406.2019.1657133>, Wang et al. (2020) <doi:10.1080/10543406.2019.1684309>, and Chen et al. (2020) <doi:10.1080/10543406.2020.1730877>.

Disk-based implementation of Functional Pruning Optimal Partitioning with up-down constraints <doi:10.18637/jss.v101.i10> for single-sample peak calling (independently for each sample and genomic problem), can handle huge data sets (10^7 or more).

Determine the chlorophyll a (Chl a) concentrations of different phytoplankton groups based on their pigment biomarkers. The method uses non-negative matrix factorisation and simulated annealing to minimise error between the observed and estimated values of pigment concentrations (Hayward et al. (2023) <doi:10.1002/lom3.10541>). The approach is similar to the widely used CHEMTAX program (Mackey et al. 1996) <doi:10.3354/meps144265>, but is more straightforward, accurate, and not reliant on initial guesses for the pigment to Chl a ratios for phytoplankton groups.

Generates random samples from the Polya-Gamma distribution using an implementation of the algorithm described in J. Windle's PhD thesis (2013) <https://repositories.lib.utexas.edu/bitstream/handle/2152/21842/WINDLE-DISSERTATION-2013.pdf>. The underlying implementation is in C.