An implementation for estimating Effective control to 50% of growth inhibition (EC50) for multi isolates and stratified datasets. It implements functions from the drc package in a way that is displayed a tidy data.frame as output. Info about the drc package is available in Ritz C, Baty F, Streibig JC, Gerhard D (2015) <doi:10.1371/journal.pone.0146021>.

This package provides a small group of functions to read in a data dictionary and the corresponding data table from Excel and to automate the cleaning, re-coding and creation of simple calculated variables. This package was designed to be a companion to the macro-enabled Excel template available on the GitHub site, but works with any similarly-formatted Excel data.

Estimates RxC (R by C) vote transfer matrices (ecological contingency tables) from aggregate data using the model described in Forcina et al. (2012), as extension of the model proposed in Brown and Payne (1986). Allows incorporation of covariates. References: Brown, P. and Payne, C. (1986). Aggregate data, ecological regression and voting transitions''. Journal of the American Statistical Association, 81, 453â 460. <DOI:10.1080/01621459.1986.10478290>. Forcina, A., Gnaldi, M. and Bracalente, B. (2012). A revised Brown and Payne model of voting behaviour applied to the 2009 elections in Italy''. Statistical Methods & Applications, 21, 109â 119. <DOI:10.1007/s10260-011-0184-x>.

Process and analyze electronic health record (EHR) data. The EHR package provides modules to perform diverse medication-related studies using data from EHR databases. Especially, the package includes modules to perform pharmacokinetic/pharmacodynamic (PK/PD) analyses using EHRs, as outlined in Choi, Beck, McNeer, Weeks, Williams, James, Niu, Abou-Khalil, Birdwell, Roden, Stein, Bejan, Denny, and Van Driest (2020) <doi:10.1002/cpt.1787>. Additional modules will be added in future. In addition, this package provides various functions useful to perform Phenome Wide Association Study (PheWAS) to explore associations between drug exposure and phenotypes obtained from EHR data, as outlined in Choi, Carroll, Beck, Mosley, Roden, Denny, and Van Driest (2018) <doi:10.1093/bioinformatics/bty306>.

Companion package to the paper: An analytic approach for interpretable predictive models in high dimensional data, in the presence of interactions with exposures. Bhatnagar, Yang, Khundrakpam, Evans, Blanchette, Bouchard, Greenwood (2017) <DOI:10.1101/102475>. This package includes an algorithm for clustering high dimensional data that can be affected by an environmental factor.

This package creates simple to highly customized tables for a wide selection of descriptive statistics, with or without weighting the data.

Implementation of an Event Categorization Matrix (ECM) detonation detection model and a Bayesian variant. Functions are provided for importing and exporting data, fitting models, and applying decision criteria for categorizing new events. This package implements methods described in the paper "Bayesian Event Categorization Matrix Approach for Nuclear Detonations" Koermer, Carmichael, and Williams (2024) available on arXiv at <doi:10.48550/arXiv.2409.18227>.

Automatic generation of exams based on exercises in Markdown or LaTeX format, possibly including R code for dynamic generation of exercise elements. Exercise types include single-choice and multiple-choice questions, arithmetic problems, string questions, and combinations thereof (cloze). Output formats include standalone files (PDF, HTML, Docx, ODT, ...), Moodle XML, QTI 1.2, QTI 2.1, Blackboard, Canvas, OpenOlat, ILIAS, TestVision, Particify, ARSnova, Kahoot!, Grasple, and TCExam. In addition to fully customizable PDF exams, a standardized PDF format (NOPS) is provided that can be printed, scanned, and automatically evaluated.

This extension of the pattern-oriented modeling framework of the poems package provides a collection of modules and functions customized for modeling disease transmission on a population scale in a spatiotemporally explicit manner. This includes seasonal time steps, dispersal functions that track disease state of dispersers, results objects that store disease states, and a population simulator that includes disease dynamics.

Create forecasts from multiple predictions using ensemble Bayesian model averaging (EBMA). EBMA models can be estimated using an expectation maximization (EM) algorithm or as fully Bayesian models via Gibbs sampling. The methods in this package are Montgomery, Hollenbach, and Ward (2015) <doi:10.1016/j.ijforecast.2014.08.001> and Montgomery, Hollenbach, and Ward (2012) <doi:10.1093/pan/mps002>.

Utilities for building certain kinds of common matrices and models in the extended structural equation modeling package, OpenMx'.

Provide an optimal histogram, in the sense of probability density estimation and features detection, by means of multiscale variational inference. In other words, the resulting histogram servers as an optimal density estimator, and meanwhile recovers the features, such as increases or modes, with both false positive and false negative controls. Moreover, it provides a parsimonious representation in terms of the number of blocks, which simplifies data interpretation. The only assumption for the method is that data points are independent and identically distributed, so it applies to fairly general situations, including continuous distributions, discrete distributions, and mixtures of both. For details see Li, Munk, Sieling and Walther (2016) <arXiv:1612.07216>.

This package provides a SQLite database is designed to store all information of experiment-based data including metadata, experiment design, managements, phenotypic values and climate records. The dataset can be imported from an Excel file.

Fits a variety of hidden Markov models, structured in an extended generalized linear model framework. See T. Rolf Turner, Murray A. Cameron, and Peter J. Thomson (1998) <doi:10.2307/3315677>, and Rolf Turner (2008) <doi:10.1016/j.csda.2008.01.029> and the references cited therein.

Perform a Bayesian estimation of the exploratory deterministic input, noisy and gate (EDINA) cognitive diagnostic model described by Chen et al. (2018) <doi:10.1007/s11336-017-9579-4>.

Produce maximum likelihood estimates of common accuracy statistics for multiple measurement methods when a gold standard is not available. An R implementation of the expectation maximization algorithms described in Zhou et al. (2011) <doi:10.1002/9780470906514> with additional functions for creating simulated data and visualizing results. Supports binary, ordinal, and continuous measurement methods.

This package provides tools for fitting the Extended Empirical Saddlepoint (EES) density of Fasiolo et al. (2018) <doi:10.1214/18-EJS1433>.

Current layout algorithms such as Kamada Kawai do not take into consideration disjoint clusters in a network, often resulting in a high overlap among the clusters, resulting in a visual â hairballâ that often is uninterpretable. The ExplodeLayout algorithm takes as input (1) an edge list of a unipartite or bipartite network, (2) node layout coordinates (x, y) generated by a layout algorithm such as Kamada Kawai, (3) node cluster membership generated from a clustering algorithm such as modularity maximization, and (4) a radius to enable the node clusters to be â explodedâ to reduce their overlap. The algorithm uses these inputs to generate new layout coordinates of the nodes which â explodesâ the clusters apart, such that the edge lengths within the clusters are preserved, while the edge lengths between clusters are recalculated. The modified network layout with nodes and edges are displayed in two dimensions. The user can experiment with different explode radii to generate a layout which has sufficient separation of clusters, while reducing the overall layout size of the network. This package is a basic version of an earlier version called [epl]<https://github.com/UTMB-DIVA-Lab/epl> that searched for an optimal explode radius, and offered multiple ways to separate clusters in a network (Bhavnani et al(2017) <https://pmc.ncbi.nlm.nih.gov/articles/PMC5543384/>). The example dataset is for a bipartite network, but the algorithm can work also for unipartite networks.

Runs an evolutionary algorithm using the AlphaSimR machinery <doi:10.1093/g3journal/jkaa017> .

Ensemble correlation-based low-rank matrix completion method (ECLRMC) is an extension to the LRMC based methods. Traditionally, the LRMC based methods give identical importance to the whole data which results in emphasizing on the commonality of the data and overlooking the subtle but crucial differences. This method aims to overcome the equality assumption problem that exists in the current LRMS based methods. Ensemble correlation-based low-rank matrix completion (ECLRMC) takes consideration of the specific characteristic of each sample and performs LRMC on the set of samples with a strong correlation. It uses an ensemble learning method to improve the imputation performance. Since each sample is analyzed independently this method can be parallelized by distributing imputation across many computation units or GPU platforms. This package provides three different methods (LRMC, CLRMC and ECLRMC) for data imputation. There is also an NRMS function for evaluating the result. Chen, Xiaobo, et al (2017) <doi:10.1016/j.knosys.2017.06.010>.

This package provides a function (echo_find()) designed to find rhythms from data using extended harmonic oscillators. For more information, see H. De los Santos et al. (2020) <doi:10.1093/bioinformatics/btz617> .

Errors in data can be located and removed using validation rules from package validate'. See also Van der Loo and De Jonge (2018) <doi:10.1002/9781118897126>, chapter 7.

Total Time on Test plot and routines for parameter estimation of any lifetime distribution implemented in R via maximum likelihood (ML) given a data set. It is implemented thinking on parametric survival analysis, but it feasible to use in parameter estimation of probability density or mass functions in any field. The main routines maxlogL and maxlogLreg are wrapper functions specifically developed for ML estimation. There are included optimization procedures such as nlminb and optim from base package, and DEoptim Mullen (2011) <doi:10.18637/jss.v040.i06>. Standard errors are estimated with numDeriv Gilbert (2011) <https://CRAN.R-project.org/package=numDeriv> or the option Hessian = TRUE of optim function.

This framework enables forecasting and extrapolating measures of conditional risk (e.g. of extreme or unprecedented events), including quantiles and exceedance probabilities, using extreme value statistics and flexible neural network architectures. It allows for capturing complex multivariate dependencies, including dependencies between observations, such as sequential dependence (time-series). The methodology was introduced in Pasche and Engelke (2024) <doi:10.1214/24-AOAS1907> (also available in preprint: Pasche and Engelke (2022) <doi:10.48550/arXiv.2208.07590>).