Conducts maximum likelihood analysis and simulation of the protracted birth-death model of diversification. See Etienne, R.S. & J. Rosindell 2012 <doi:10.1093/sysbio/syr091>; Lambert, A., H. Morlon & R.S. Etienne 2014, <doi:10.1007/s00285-014-0767-x>; Etienne, R.S., H. Morlon & A. Lambert 2014, <doi:10.1111/evo.12433>.

This package provides tools for statistical testing of correlation coefficients through robust permutation method and large sample approximation method. Tailored to different types of correlation coefficients including Pearson correlation coefficient, weighted Pearson correlation coefficient, Spearman correlation coefficient, and Lin's concordance correlation coefficient.The robust permutation test controls type I error under general scenarios when sample size is small and two variables are dependent but uncorrelated. The large sample approximation test generally controls type I error when the sample size is large (>200).

This package performs statistical tests to compare coefficients and residual variance across models. Also provides graphical methods for assessing heterogeneity in coefficients and residuals. Currently supports linear and generalized linear models.

Generation of multiple count, binary, ordinal and normal variables simultaneously given the marginal characteristics and association structure. The details of the method are explained in Demirtas et al. (2012) <DOI:10.1002/sim.5362>.

Data sets for statistical inference modeling related to People Analytics. Contains various data sets from the book Handbook of Regression Modeling in People Analytics by Keith McNulty (2020).

This package implements projected sparse Gaussian process Kriging ('Ingram et. al.', 2008, <doi:10.1007/s00477-007-0163-9>) as an additional method for the intamap package. More details on implementation ('Barillec et. al.', 2010, <doi:10.1016/j.cageo.2010.05.008>).

This package contains utilities for the analysis of post-translational modifications (PTMs) in proteins, with particular emphasis on the sulfoxidation of methionine residues. Features include the ability to download, filter and analyze data from the sulfoxidation database MetOSite'. Utilities to search and characterize S-aromatic motifs in proteins are also provided. In addition, functions to analyze sequence environments around modifiable residues in proteins can be found. For instance, ptm allows to search for amino acids either overrepresented or avoided around the modifiable residues from the proteins of interest. Functions tailored to test statistical hypothesis related to these differential sequence environments are also implemented. Further and detailed information regarding the methods in this package can be found in (Aledo (2020) <https://metositeptm.com>).

It allows the user to determine sample sizes, select probabilistic samples, make estimates of different parameters for the total finite population and in studio domains, using the main design drawings.

Simulating and conducting four phase 12 clinical trials with correlated binary bivariate outcomes described. Uses the Efftox (efficacy and toxicity tradeoff, <https://biostatistics.mdanderson.org/SoftwareDownload/SingleSoftware/Index/2>) and SPSO (Semi-Parametric Stochastic Ordering) models with Utility and Desirability based objective functions for dose finding.

Hidden Markov Models are useful for modeling sequential data. This package provides several functions implemented in C++ for explaining the algorithms used for Hidden Markov Models (forward, backward, decoding, learning).

Conduct power analyses and inference of marginal effects. Uses plug-in estimation and influence functions to perform robust inference, optionally leveraging historical data to increase precision with prognostic covariate adjustment. The methods are described in Højbjerre-Frandsen et al. (2025) <doi:10.48550/arXiv.2503.22284>.

The semiparametric accelerated failure time (AFT) model is an attractive alternative to the Cox proportional hazards model. This package provides a suite of functions for fitting one popular rank-based estimator of the semiparametric AFT model, the regularized Gehan estimator. Specifically, we provide functions for cross-validation, prediction, coefficient extraction, and visualizing both trace plots and cross-validation curves. For further details, please see Suder, P. M. and Molstad, A. J., (2022) Scalable algorithms for semiparametric accelerated failure time models in high dimensions, Statistics in Medicine <doi:10.1002/sim.9264>.

Defines aesthetically pleasing colour palettes.

Generation of multiple count, binary and continuous variables simultaneously given the marginal characteristics and association structure. Throughout the package, the word Poisson is used to imply count data under the assumption of Poisson distribution. The details of the method are explained in Amatya et al. (2015) <DOI:10.1080/00949655.2014.953534>.

Tailoring the optimal biomarker(s) for disease screening or diagnosis based on subjects individual characteristics.

Bivariate additive categorical regression via penalized maximum likelihood. Under a multinomial framework, the method fits bivariate models where both responses are nominal, ordinal, or a mix of the two. Partial proportional odds models are supported, with flexible (non-)uniform association structures. Various logit types and parametrizations can be specified for both marginals and the association, including Daleâ s model. The association structure can be regularized using polynomial-type penalty terms. Additive effects are modeled using P-splines. Standard methods such as summary(), residuals(), and predict() are available.

Dynamize headers or R code within Rmd files to prevent proliferation of Rmd files for similar reports. Add in external HTML document within rmarkdown rendered HTML doc.

Color palettes generated from paintings.

This provides utilities for creating classed error and warning conditions based on where the error originated.

This package implements L1 and L2 penalized conditional logistic regression with penalty factors allowing for integration of multiple data sources. Implements stability selection for variable selection.

Text mining of PubMed Abstracts (text and XML) from <https://pubmed.ncbi.nlm.nih.gov/>.

Automatically create a web server from annotated R files or by building it up programmatically. Provides automatic OpenAPI documentation, input handling, asynchronous evaluation, and plugin support.

This package provides a function to estimate panel-corrected standard errors. Data may contain balanced or unbalanced panels.

Investigate (analytically or visually) the inputs and outputs of probabilistic analyses of health economic models using standard health economic visualisation and metamodelling methods.