Implementation of the scregclust algorithm described in Larsson, Held, et al. (2024) <doi:10.1038/s41467-024-53954-3> which reconstructs regulatory programs of target genes in scRNA-seq data. Target genes are clustered into modules and each module is associated with a linear model describing the regulatory program.

Create short sprint acceleration-velocity (AVP) and force-velocity (FVP) profiles and predict kinematic and kinetic variables using the timing-gate split times, laser or radar gun data, tether devices data, as well as the data provided by the GPS and LPS monitoring systems. The modeling method utilized in this package is based on the works of Furusawa K, Hill AV, Parkinson JL (1927) <doi: 10.1098/rspb.1927.0035>, Greene PR. (1986) <doi: 10.1016/0025-5564(86)90063-5>, Chelly SM, Denis C. (2001) <doi: 10.1097/00005768-200102000-00024>, Clark KP, Rieger RH, Bruno RF, Stearne DJ. (2017) <doi: 10.1519/JSC.0000000000002081>, Samozino P. (2018) <doi: 10.1007/978-3-319-05633-3_11>, Samozino P. and Peyrot N., et al (2022) <doi: 10.1111/sms.14097>, Clavel, P., et al (2023) <doi: 10.1016/j.jbiomech.2023.111602>, Jovanovic M. (2023) <doi: 10.1080/10255842.2023.2170713>, and Jovanovic M., et al (2024) <doi: 10.3390/s24092894>.

R version of scperturb tool for single-cell perturbation analysis. Contains wrappers for performing E-statistics for Seurat objects. More details on the method can be found in Peidli et al. (2023) <doi:10.1101/2022.08.20.504663> and in Székely and Rizzo (2004).

Algorithms of nonparametric sequential test and online change-point detection for streams of univariate (sub-)Gaussian, binary, and bounded random variables, introduced in following publications - Shin et al. (2024) <doi:10.48550/arXiv.2203.03532>, Shin et al. (2021) <doi:10.48550/arXiv.2010.08082>.

This package provides tools for analyzing spatial cell-cell interactions based on ligand-receptor pairs, including functions for local, regional, and global analysis using spatial transcriptomics data. Integrates with databases like CellChat <https://github.com/jinworks/CellChat>, CellPhoneDB <https://www.cellphonedb.org/>, Cellinker <https://www.rna-society.org/cellinker/>, ICELLNET <https://github.com/soumelis-lab/ICELLNET>, and ConnectomeDB <https://humanconnectome.org/software/connectomedb/> to identify ligand-receptor pairs, visualize interactions through heatmaps, chord diagrams, and infer interactions on different spatial scales.

Routines for the seasonal analysis of health data, including regression models, time-stratified case-crossover, plotting functions and residual checks, see Barnett and Dobson (2010) ISBN 978-3-642-10748-1. Thanks to Yuming Guo for checking the case-crossover code.

Efficient framework to estimate high-dimensional generalized matrix factorization models using penalized maximum likelihood under a dispersion exponential family specification. Either deterministic and stochastic methods are implemented for the numerical maximization. In particular, the package implements the stochastic gradient descent algorithm with a block-wise mini-batch strategy to speed up the computations and an efficient adaptive learning rate schedule to stabilize the convergence. All the theoretical details can be found in Castiglione et al. (2024, <doi:10.48550/arXiv.2412.20509>). Other methods considered for the optimization are the alternated iterative re-weighted least squares and the quasi-Newton method with diagonal approximation of the Fisher information matrix discussed in Kidzinski et al. (2022, <http://jmlr.org/papers/v23/20-1104.html>).

Calculates graph theoretic scagnostics. Scagnostics describe various measures of interest for pairs of variables, based on their appearance on a scatterplot. They are useful tool for discovering interesting or unusual scatterplots from a scatterplot matrix, without having to look at every individual plot.

This package provides functions for the Skellam distribution, including: density (pmf), cdf, quantiles and regression.

Rapidly build accurate genetic prediction models for genome-wide association or whole-genome sequencing study data by smooth-threshold multivariate genetic prediction (STMGP) method. Variable selection is performed using marginal association test p-values with an optimal p-value cutoff selected by Cp-type criterion. Quantitative and binary traits are modeled respectively via linear and logistic regression models. A function that works through PLINK software (Purcell et al. 2007 <DOI:10.1086/519795>, Chang et al. 2015 <DOI:10.1186/s13742-015-0047-8>) <https://www.cog-genomics.org/plink2> is provided. Covariates can be included in regression model.

This is an interface for the Python package StepMix'. It is a Python package following the scikit-learn API for model-based clustering and generalized mixture modeling (latent class/profile analysis) of continuous and categorical data. StepMix handles missing values through Full Information Maximum Likelihood (FIML) and provides multiple stepwise Expectation-Maximization (EM) estimation methods based on pseudolikelihood theory. Additional features include support for covariates and distal outcomes, various simulation utilities, and non-parametric bootstrapping, which allows inference in semi-supervised and unsupervised settings. Software paper available at <doi:10.18637/jss.v113.i08>.

This package performs structured OLS (sOLS) and structured SIR (sSIR).

Bayesian variable selection, model choice, and regularized estimation for (spatial) generalized additive mixed regression models via stochastic search variable selection with spike-and-slab priors.

This package provides a non convex optimization package that optimizes any function under the criterion, combination of variables are on the surface of a unit sphere, as described in the paper : Das et al. (2019) <arXiv:1909.04024> .

Allows users to easily build custom docker images <https://docs.docker.com/> from Amazon Web Service Sagemaker <https://aws.amazon.com/sagemaker/> using Amazon Web Service CodeBuild <https://aws.amazon.com/codebuild/>.

Forms likelihood-based confidence intervals (LBCIs) for parameters in structural equation modeling, introduced in Cheung and Pesigan (2023) <doi:10.1080/10705511.2023.2183860>. Currently implements the algorithm illustrated by Pek and Wu (2018) <doi:10.1037/met0000163>, and supports the robust LBCI proposed by Falk (2018) <doi:10.1080/10705511.2017.1367254>.

Application of theoretical results which ensure that the summation of an infinite discrete series is within an arbitrary margin of error of its true value. The C code under the hood is shared through header files to allow users to sum their own low level functions as well. Based on the paper by Braden (1992) <doi: 10.2307/2324995>.

Fast single trait Genome Wide Association Studies (GWAS) following the method described in Kang et al. (2010), <doi:10.1038/ng.548>. One of a series of statistical genetic packages for streamlining the analysis of typical plant breeding experiments developed by Biometris.

Maximum likelihood estimation for stochastic frontier analysis (SFA) of production (profit) and cost functions. The package includes the basic stochastic frontier for cross-sectional or pooled data with several distributions for the one-sided error term (i.e., Rayleigh, gamma, Weibull, lognormal, uniform, generalized exponential and truncated skewed Laplace), the latent class stochastic frontier model (LCM) as described in Dakpo et al. (2021) <doi:10.1111/1477-9552.12422>, for cross-sectional and pooled data, and the sample selection model as described in Greene (2010) <doi:10.1007/s11123-009-0159-1>, and applied in Dakpo et al. (2021) <doi:10.1111/agec.12683>. Several possibilities in terms of optimization algorithms are proposed.

Simulation methods for the Fisher Bingham distribution on the unit sphere, the matrix Bingham distribution on a Grassmann manifold, the matrix Fisher distribution on SO(3), and the bivariate von Mises sine model on the torus. The methods use an acceptance/rejection simulation algorithm for the Bingham distribution and are described fully by Kent, Ganeiber and Mardia (2018) <doi:10.1080/10618600.2017.1390468>. These methods supersede earlier MCMC simulation methods and are more general than earlier simulation methods. The methods can be slower in specific situations where there are existing non-MCMC simulation methods (see Section 8 of Kent, Ganeiber and Mardia (2018) <doi:10.1080/10618600.2017.1390468> for further details).

Seamlessly create interactive online catalogues for geospatial data. Items can be mapped as points or areas and retrieved using either a map or a dynamic table with search form and optional column filters.

Data sets from Ramsey, F.L. and Schafer, D.W. (2002), "The Statistical Sleuth: A Course in Methods of Data Analysis (2nd ed)", Duxbury.

This package implements different kinds of bootstraps to estimate sampling variation from survey data with complex designs. Includes the rescaled bootstrap described in Rust and Rao (1996) <doi:10.1177/096228029600500305> and Rao and Wu (1988) <doi:10.1080/01621459.1988.10478591>.

This package performs simulations of binary spatial raster data using the Ising model (Ising (1925) <doi:10.1007/BF02980577>; Onsager (1944) <doi:10.1103/PhysRev.65.117>). It allows to set a few parameters that represent internal and external pressures, and the number of simulations (Stepinski and Nowosad (2023) <doi:10.1098/rsos.231005>).