Solves quadratic programming problems where the Hessian is represented as the product of two matrices. Thanks to Greg Hunt for helping getting this version back on CRAN. The methods in this package are described in: Ormerod, Wand and Koch (2008) "Penalised spline support vector classifiers: computational issues" <doi:10.1007/s00180-007-0102-8>.

Navigating the shift of clinical laboratory data from primary everyday clinical use to secondary research purposes presents a significant challenge. Given the substantial time and expertise required for lab data pre-processing and cleaning and the lack of all-in-one tools tailored for this need, we developed our algorithm lab2clean as an open-source R-package. lab2clean package is set to automate and standardize the intricate process of cleaning clinical laboratory results. With a keen focus on improving the data quality of laboratory result values and units, our goal is to equip researchers with a straightforward, plug-and-play tool, making it smoother for them to unlock the true potential of clinical laboratory data in clinical research and clinical machine learning (ML) model development. Functions to clean & validate result values (Version 1.0) are described in detail in Zayed et al. (2024) <doi:10.1186/s12911-024-02652-7>. Functions to standardize & harmonize result units (added in Version 2.0) are described in detail in Zayed et al. (2025) <doi:10.1016/j.ijmedinf.2025.106131>.

The aim of the package is to create data objects which allow for accesses like x["test"] and x["test","test"].

Latent Markov models for longitudinal continuous and categorical data. See Bartolucci, Pandolfi, Pennoni (2017)<doi:10.18637/jss.v081.i04>.

This package provides a suite of tools for estimating, assessing model fit, simulating from, and visualizing location dependent marked point processes characterized by regularity in the pattern. You provide a reference marked point process, a set of raster images containing location specific covariates, and select the estimation algorithm and type of mark model. ldmppr estimates the process and mark models and allows you to check the appropriateness of the model using a variety of diagnostic tools. Once a satisfactory model fit is obtained, you can simulate from the model and visualize the results. Documentation for the package ldmppr is available in the form of a vignette.

Constructs tree for continuous longitudinal data and survival data using baseline covariates as partitioning variables according to the LongCART and SurvCART algorithm, respectively. Later also included functions to calculate conditional power and predictive power of success based on interim results and probability of success for a prospective trial.

This package creates plots of peptides from shotgun proteomics analysis of secretome and lysate samples. These plots contain associated protein features and scores for potential secretion and truncation.

This is for code management functions, NLP tools, a Monty Hall simulator, and for implementing my own variable reduction technique called Feed Reduction. The Feed Reduction technique is not yet published, but is merely a tool for implementing a series of binary neural networks meant for reducing data into N dimensions, where N is the number of possible values of the response variable.

Label-free bottom-up proteomics expression data is often affected by data heterogeneity and missing values. Normalization and missing value imputation are commonly used techniques to address these issues and make the dataset suitable for further downstream analysis. This package provides an optimal combination of normalization and imputation methods for the dataset. The package utilizes three normalization methods and three imputation methods.The statistical evaluation measures named pooled co-efficient of variance, pooled estimate of variance and pooled median absolute deviation are used for selecting the best combination of normalization and imputation method for the given dataset. The user can also visualize the results by using various plots available in this package. The user can also perform the differential expression analysis between two sample groups with the function included in this package. The chosen three normalization methods, three imputation methods and three evaluation measures were chosen for this study based on the research papers published by Välikangas et al. (2016) <doi:10.1093/bib/bbw095>, Jin et al. (2021) <doi:10.1038/s41598-021-81279-4> and Srivastava et al. (2023) <doi:10.2174/1574893618666230223150253>.This work has published by Sakthivel et al. (2025) <doi:10.1021/acs.jproteome.4c00552>.

Linear ridge regression coefficient's estimation and testing with different ridge related measures such as MSE, R-squared etc. REFERENCES i. Hoerl and Kennard (1970) <doi:10.1080/00401706.1970.10488634>, ii. Halawa and El-Bassiouni (2000) <doi:10.1080/00949650008812006>, iii. Imdadullah, Aslam, and Saima (2017), iv. Marquardt (1970) <doi:10.2307/1267205>.

R interface for working with nanometer scale secondary ion mass spectrometry (NanoSIMS) data exported from Look at NanoSIMS.

Probabilistic record linkage without direct identifiers using only diagnosis codes. Method is detailed in: Hejblum, Weber, Liao, Palmer, Churchill, Szolovits, Murphy, Kohane & Cai (2019) <doi: 10.1038/sdata.2018.298> ; Zhang, Hejblum, Weber, Palmer, Churchill, Szolovits, Murphy, Liao, Kohane & Cai (2021) <doi: 10.1093/jamia/ocab187>.

Import, processing, validation, and visualization of personal light exposure measurement data from wearable devices. The package implements features such as the import of data and metadata files, conversion of common file formats, validation of light logging data, verification of crucial metadata, calculation of common parameters, and semi-automated analysis and visualization.

This package provides a set of all-cause and cause-specific life expectancy sensitivity and decomposition methods, including Arriaga (1984) <doi:10.2307/2061029>, others documented by Ponnapalli (2005) <doi:10.4054/DemRes.2005.12.7>, lifetable, numerical, and other algorithmic approaches such as Horiuchi et al (2008) <doi:10.1353/dem.0.0033>, or Andreev et al (2002) <doi:10.4054/DemRes.2002.7.14>.

Fit and simulate latent position and cluster models for statistical networks. See Krivitsky and Handcock (2008) <doi:10.18637/jss.v024.i05> and Krivitsky, Handcock, Raftery, and Hoff (2009) <doi:10.1016/j.socnet.2009.04.001>.

Bayesian population size estimation using non parametric latent-class models.

Brings together a comprehensive collection of R packages providing access to API functions and curated datasets from Argentina, Brazil, Chile, Colombia, and Peru. Includes real-time and historical data through public RESTful APIs ('Nager.Date', World Bank API, REST Countries API, and country-specific APIs) and extensive curated collections of open datasets covering economics, demographics, public health, environmental data, political indicators, social metrics, and cultural information. Designed to provide researchers, analysts, educators, and data scientists with centralized access to Latin American data sources, facilitating reproducible research, comparative analysis, and teaching applications focused on these five major Latin American countries. Included packages: - ArgentinAPI': API functions and curated datasets for Argentina covering exchange rates, inflation, political figures, national holidays and more. - BrazilDataAPI': API functions and curated datasets for Brazil covering postal codes, banks, economic indicators, holidays, company registrations and more. - ChileDataAPI': API functions and curated datasets for Chile covering financial indicators ('UF', UTM, Dollar, Euro, Yen, Copper, Bitcoin, IPSA index), holidays and more. - ColombiAPI': API functions and curated datasets for Colombia covering geographic locations, cultural attractions, economic indicators, demographic data, national holidays and more. - PeruAPIs': API functions and curated datasets for Peru covering economic indicators, demographics, national holidays, administrative divisions, electoral data, biodiversity and more. For more information on the APIs, see: Nager.Date <https://date.nager.at/Api>, World Bank API <https://datahelpdesk.worldbank.org/knowledgebase/articles/889392>, REST Countries API <https://restcountries.com/>, ArgentinaDatos API <https://argentinadatos.com/>, BrasilAPI <https://brasilapi.com.br/>, FINDIC <https://findic.cl/>, and API-Colombia <https://api-colombia.com/>.

Fit response surfaces for datasets with latent-variable Gaussian process modeling, predict responses for new inputs, and plot latent variables locations in the latent space (only 1D or 2D). The input variables of the datasets can be quantitative, qualitative/categorical or mixed. The output variable of the datasets is a scalar (quantitative). The optimization of the likelihood function is done using a successive approximation/relaxation algorithm similar to another GP modeling package "GPM". The modeling method is published in "A Latent Variable Approach to Gaussian Process Modeling with Qualitative and Quantitative Factors" by Yichi Zhang, Siyu Tao, Wei Chen, and Daniel W. Apley (2018) <arXiv:1806.07504>. The package is developed in IDEAL of Northwestern University.

Facilitates building likelihood models in the Fisherian tradition following Richard Royall (1997, ISBN:978-0412044113) "Statistical Evidence: A Likelihood Paradigm". Defines generic methods for working with likelihoods (loglik(), score(), hess_loglik(), fim()) and provides functions for pure likelihood-based inference (support(), relative_likelihood(), likelihood_interval(), profile_loglik()). Includes a likelihood contributions model for heterogeneous observation types (exact, censored, etc.) assuming i.i.d. data.

This package provides instrumental variable estimation of treatment effects when both the endogenous treatment and its instrument are binary. Applicable to both binary and continuous outcomes.

We present a method based on filtering algorithms to estimate the parameters of linear, i.e. the coefficients and the variance of the error term. The proposed algorithms make use of Particle Filters following Ristic, B., Arulampalam, S., Gordon, N. (2004, ISBN: 158053631X) resampling methods. Parameters of logistic regression models are also estimated using an evolutionary particle filter method.

Short for linear binning', the linbin package provides functions for manipulating, binning, and plotting linearly referenced data. Although developed for data collected on river networks, it can be used with any interval or point data referenced to a 1-dimensional coordinate system. Flexible bin generation and batch processing makes it easy to compute and visualize variables at multiple scales, useful for identifying patterns within and between variables and investigating the influence of scale of observation on data interpretation.

Common coordinate-based workflows involving processed chromatin loop and genomic element data are considered and packaged into appropriate customizable functions. Includes methods for linking element sets via chromatin loops and creating consensus loop datasets.

Summarizes characteristics of linear mixed effects models without data or a fitted model by converting code for fitting lmer() from lme4 and lme() from nlme into tables, equations, and visuals. Outputs can be used to learn how to fit linear mixed effects models in R and to communicate about these models in presentations, manuscripts, and analysis plans.