The primary goal of phase I clinical trials is to find the maximum tolerated dose (MTD). To reach this objective, we introduce a new design for phase I clinical trials, the posterior predictive (PoP) design. The PoP design is an innovative model-assisted design that is as simply as the conventional algorithmic designs as its decision rules can be pre-tabulated prior to the onset of trial, but is of more flexibility of selecting diverse target toxicity rates and cohort sizes. The PoP design has desirable properties, such as coherence and consistency. Moreover, the PoP design provides better empirical performance than the BOIN and Keyboard design with respect to high average probabilities of choosing the MTD and slightly lower risk of treating patients at subtherapeutic or overly toxic doses.

Population dynamic models underpin a range of analyses and applications in ecology and epidemiology. The various approaches for analysing population dynamics models (MPMs, IPMs, ODEs, POMPs, PVA) each require the model to be defined in a different way. This makes it difficult to combine different modelling approaches and data types to solve a given problem. pop aims to provide a flexible and easy to use common interface for constructing population dynamic models and enabling to them to be fitted and analysed in lots of different ways.

Simulate the dynamic of lion populations using a specific Individual-Based Model (IBM) compiled in C.

Set of tools for reading, writing and transforming spatial and seasonal data, model selection and specific statistical tests for ecologists. It includes functions to interpolate regular positions of points between landmarks, to discretize polylines into regular point positions, link distant observations to points and convert a bounding box in a spatial object. It also provides miscellaneous functions for field ecologists such as spatial statistics and inference on diversity indexes, writing data.frame with Chinese characters.

Preparing a scanner data set for price dynamics calculations (data selecting, data classification, data matching, data filtering). Computing bilateral and multilateral indexes. For details on these methods see: Diewert and Fox (2020) <doi:10.1080/07350015.2020.1816176>, BiaÅ ek (2019) <doi:10.2478/jos-2019-0014> or BiaÅ ek (2020) <doi:10.2478/jos-2020-0037>.

Computes the minimum sample size required for the development of a new multivariable prediction model using the criteria proposed by Riley et al. (2018) <doi: 10.1002/sim.7992>. pmsampsize can be used to calculate the minimum sample size for the development of models with continuous, binary or survival (time-to-event) outcomes. Riley et al. (2018) <doi: 10.1002/sim.7992> lay out a series of criteria the sample size should meet. These aim to minimise the overfitting and to ensure precise estimation of key parameters in the prediction model.

Implementation of Probabilistic Regression Trees (PRTree), providing functions for model fitting and prediction, with specific adaptations to handle missing values. The main computations are implemented in Fortran for high efficiency. The package is based on the PRTree methodology described in Alkhoury et al. (2020), "Smooth and Consistent Probabilistic Regression Trees" <https://proceedings.neurips.cc/paper_files/paper/2020/file/8289889263db4a40463e3f358bb7c7a1-Paper.pdf>. Details on the treatment of missing data and implementation aspects are presented in Prass, T.S.; Neimaier, A.S.; Pumi, G. (2025), "Handling Missing Data in Probabilistic Regression Trees: Methods and Implementation in R" <doi:10.48550/arXiv.2510.03634>.

Use Pokemon(R) inspired palettes with additional ggplot2 scales. Palettes are the colours in each Pokemon's sprite, ordered by how common they are in the image. The first 386 Pokemon are currently provided.

This package provides a suite of likelihood ratio test based methods to use in pharmacovigilance. Contains various testing and post-processing functions.

Miscellaneous small utilities are provided to mitigate issues with messy, inconsistent or high dimensional data and help for preprocessing and preparing analyses.

Inspired by Moreira and Gamerman (2022) <doi:10.1214/21-AOAS1569>, this methodology expands the idea by including Marks in the point process. Using efficient C++ code, the estimation is possible and made faster with OpenMP <https://www.openmp.org/> enabled computers. This package was developed under the project PTDC/MAT-STA/28243/2017, supported by Portuguese funds through the Portuguese Foundation for Science and Technology (FCT).

Automate the detection of gaps and elevations in mapped sequencing read coverage using a 2D pattern-matching algorithm. ProActive detects, characterizes and visualizes read coverage patterns in both genomes and metagenomes. Optionally, users may provide gene annotations associated with their genome or metagenome in the form of a .gff file. In this case, ProActive will generate an additional output table containing the gene annotations found within the detected regions of gapped and elevated read coverage. Additionally, users can search for gene annotations of interest in the output read coverage plots.

Defines functions to describe regression models using only pre-computed summary statistics (i.e. means, variances, and covariances) in place of individual participant data. Possible models include linear models for linear combinations, products, and logical combinations of phenotypes. Implements methods presented in Wolf et al. (2021) <doi:10.3389/fgene.2021.745901> Wolf et al. (2020) <doi:10.1142/9789811215636_0063> and Gasdaska et al. (2019) <doi:10.1142/9789813279827_0036>.

Normalizes city names for EEA countries and matches them to NUTS 3 regions using provided crosswalks. Features include comprehensive normalization rules, cascading matching logic (Exact NUTS -> Exact LAU -> Fuzzy), and single-source data synthesis. The package implements the NUTS classification as described in the NUTS methodology (Eurostat (2021) <https://ec.europa.eu/eurostat/web/nuts>).

Producing the time-dependent receiver operating characteristic (ROC) curve through parametric approaches. Tools for generating random data, fitting, predicting and check goodness of fit are prepared. The methods are developed from the theoretical framework of proportional hazard model and copula functions. Using this package, users can now simulate parametric time-dependent ROC and run experiment to understand the behavior of the curve under different scenario.

This package provides beginner friendly framework to analyse population genetic data. Based on adegenet objects it uses knitr to create comprehensive reports on spatial genetic data. For detailed information how to use the package refer to the comprehensive tutorials or visit <http://www.popgenreport.org/>.

This package provides tools for Bayesian power analysis and assurance calculations using the statistical frameworks of brms and INLA'. Includes simulation-based approaches, support for multiple decision rules (direction, threshold, ROPE), sequential designs, and visualisation helpers. Methods are based on Kruschke (2014, ISBN:9780124058880) "Doing Bayesian Data Analysis: A Tutorial with R, JAGS, and Stan", O'Hagan & Stevens (2001) <doi:10.1177/0272989X0102100307> "Bayesian Assessment of Sample Size for Clinical Trials of Cost-Effectiveness", Kruschke (2018) <doi:10.1177/2515245918771304> "Rejecting or Accepting Parameter Values in Bayesian Estimation", Rue et al. (2009) <doi:10.1111/j.1467-9868.2008.00700.x> "Approximate Bayesian inference for latent Gaussian models by using integrated nested Laplace approximations", and Bürkner (2017) <doi:10.18637/jss.v080.i01> "brms: An R Package for Bayesian Multilevel Models using Stan".

This package provides a framework for defining pipelines of functions for applying data transformations, model estimation and inverse-transformations, resulting in predicted value generation (or model-scoring) functions that automatically apply the entire pipeline of functions required to go from input to predicted output.

The pharmaverse is a set of packages that compose multiple pathways through clinical data generation and reporting in the pharmaceutical industry. This package is designed to guide users to our work-spaces on GitHub', Slack and LinkedIn as well as our website and examples. Learn more about the pharmaverse at <https://pharmaverse.org>.

R Interface to Pullword Service for natural language processing in Chinese. It enables users to extract valuable words from text by deep learning models. For more details please visit the official site (in Chinese) <http://www.pullword.com/>.

This package provides functions for conventionally formatting descriptive stats, reshaping data frames and formatting R output as HTML.

Pivotal Tracker <https://www.pivotaltracker.com> is a project management software-as-a-service that provides a REST API. This package provides an R interface to that API, allowing you to query it and work with its responses.

Power and sample size calculations for a variety of study designs and outcomes. Methods include t tests, ANOVA (including tests for interactions, simple effects and contrasts), proportions, categorical data (chi-square tests and proportional odds), linear, logistic and Poisson regression, alternative and coprimary endpoints, power for confidence intervals, correlation coefficient tests, cluster randomized trials, individually randomized group treatment trials, multisite trials, treatment-by-covariate interaction effects and nonparametric tests of location. Utilities are provided for computing various effect sizes. Companion package to the book "Power and Sample Size in R", Crespi (2025, ISBN:9781138591622). Further resources available at <https://powerandsamplesize.org/>.

When using pooled p-values to adjust for multiple testing, there is an inherent balance that must be struck between rejection based on weak evidence spread among many tests and strong evidence in a few, explored in Salahub and Olford (2023) <arXiv:2310.16600>. This package provides functionality to compute marginal and central rejection levels and the centrality quotient for p-value pooling functions and provides implementations of the chi-squared quantile pooled p-value (described in Salahub and Oldford (2023)) and a proposal from Heard and Rubin-Delanchy (2018) <doi:10.1093/biomet/asx076> to control the quotient's value.