Dictionary-like reference for computing scoring rules in a wide range of situations. Covers both parametric forecast distributions (such as mixtures of Gaussians) and distributions generated via simulation. Further details can be found in the package vignettes <doi:10.18637/jss.v090.i12>, <doi:10.18637/jss.v110.i08>.

Sequential triangular test for the arithmetic mean in one- and two- samples, proportions in one- and two-samples, and the Pearson's correlation coefficient.

It is a single cell active pathway analysis tool based on the graph neural network (F. Scarselli (2009) <doi:10.1109/TNN.2008.2005605>; Thomas N. Kipf (2017) <arXiv:1609.02907v4>) to construct the gene-cell association network, infer pathway activity scores from different single cell modalities data, integrate multiple modality data on the same cells into one pathway activity score matrix, identify cell phenotype activated gene modules and parse association networks of gene modules under multiple cell phenotype. In addition, abundant visualization programs are provided to display the results.

This package provides functionality to fit a zero-inflated estimator for small area estimation. This estimator is a combines a linear mixed effects regression model and a logistic mixed effects regression model via a two-stage modeling approach. The estimator's mean squared error is estimated via a parametric bootstrap method. Chandra and others (2012, <doi:10.1080/03610918.2011.598991>) introduce and describe this estimator and mean squared error estimator. White and others (2024+, <doi:10.48550/arXiv.2402.03263>) describe the applicability of this estimator to estimation of forest attributes and further assess the estimator's properties.

Collection of stepwise procedures to conduct multiple hypotheses testing. The details of the stepwise algorithm can be found in Romano and Wolf (2007) <DOI:10.1214/009053606000001622> and Hsu, Kuan, and Yen (2014) <DOI:10.1093/jjfinec/nbu014>.

We provide functionality to implement penalized PCA with an option to smooth the objective function using Nesterov smoothing. Two functions are available to compute a user-specified number of eigenvectors. The function unsmoothed_penalized_EV() computes a penalized PCA without smoothing and has three parameters (the input matrix, the Lasso penalty, and the number of desired eigenvectors). The function smoothed_penalized_EV() computes a smoothed penalized PCA using the same parameters and additionally requires the specification of a smoothing parameter. Both functions return a matrix having the desired eigenvectors as columns.

This package provides a flexible framework combining variable screening and random projection techniques for fitting ensembles of predictive generalized linear models to high-dimensional data. Designed for extensibility, the package implements key techniques as S3 classes with user-friendly constructors, enabling easy integration and development of new procedures for high-dimensional applications.

This package provides simulation-based power, type I error, and operating- characteristic evaluation for stepped-wedge cluster randomized trials. General binary-outcome designs support arbitrary crossover schedules, unequal clusters per sequence, secular trends, flexible cluster-period sizes, reproducible parallel execution, sensitivity grids, and mixed-model diagnostics. A component-based engine supports the four treatment states Control, A, B, and A+B under arbitrary asynchronous schedules, including structurally unobserved cluster-periods, withdrawal, reintroduction, wash-in delays, user-defined carryover decay, component main effects, an A-by-B interaction, estimability audits, multiplicity adjustment, conditional and failure-aware power, and explicit classification of hard model errors, nonconvergence, non-finite contrasts, singular fits, and successful fits. A batch-aware interface represents classic and batched stepped-wedge designs with delayed cluster initiation, structurally unobserved cluster-periods, and calendar-time, time-on-trial, or separate batch-specific time effects, following Kasza, Bowden, Hooper and Forbes (2022) <doi:10.1002/sim.9438>. The cumulative Control-to-A-to-A+B interface from earlier versions remains available. The design and mixed-effects analysis follow Hussey and Hughes (2007) <doi:10.1016/j.cct.2006.05.007>. Intraclass correlations for binary outcomes are converted to random-intercept standard deviations on the latent scale of the logistic-normal model, as reviewed by Eldridge, Ukoumunne and Carlin (2009) <doi:10.1111/j.1751-5823.2009.00092.x>. Monte Carlo uncertainty is reported using exact intervals from Clopper and Pearson (1934) <doi:10.1093/biomet/26.4.404>.

Monitoring reporting rates of subject-level clinical events (e.g. adverse events, protocol deviations) reported by clinical trial sites is an important aspect of risk-based quality monitoring strategy. Sites that are under-reporting or over-reporting events can be detected using bootstrap simulations during which patients are redistributed between sites. Site-specific distributions of event reporting rates are generated that are used to assign probabilities to the observed reporting rates. (Koneswarakantha 2024 <doi:10.1007/s43441-024-00631-8>).

This package provides historical datasets related to John Snow's 1854 cholera outbreak study in London. Includes data on cholera cases, water pump locations, and the street layout, enabling analysis and visualisation of the outbreak.

This package provides a revised framework for statistical matching of categorical data based on latent class models, including multiple imputation, predictive modeling, nearest-neighbour hot-deck matching, and probabilistic assignment of categorical target variables. It allows researchers to perform data integration when no unique identifiers are available by modeling the joint distribution of variables through latent categorical structures. The package supports estimation of latent class models, probabilistic matching between donor and recipient data sets, and generation of synthetic linked data under uncertainty. It is particularly useful in survey research and data fusion applications where combining information from multiple sources is required while preserving statistical properties and accounting for measurement error and missing data mechanisms. The latent class matching methods are described by Lewaa, Hafez and Ismail (2023) <doi:10.18576/jsap/120123>. (2.0->2.1): in smc2_step2() Gower distance is replaced by Euclidean distance in hot deck method.

Carries out a two-level sample selection where the possibility of an initially selected site not wanting to participate is anticipated, and the site is optimally replaced. The procedure aims to reduce bias (and/or loss of external validity) with respect to the target population. In selecting units and sub-units, sitepickR uses the cube method developed by Deville & Tillé', (2004) <http://www.math.helsinki.fi/msm/banocoss/Deville_Tille_2004.pdf> and described in Tillé (2011) <https://www150.statcan.gc.ca/n1/en/pub/12-001-x/2011002/article/11609-eng.pdf?st=5-sx8Q8n>. The cube method is a probability sampling method that is designed to satisfy criteria for balance between the sample and the population. Recent research has shown that this method performs well in simulations for studies of educational programs (see Fay & Olsen (2021, under review). To implement the cube method, sitepickR uses the sampling R package <https://cran.r-project.org/package=sampling>. To implement statistical matching, sitepickR uses the MatchIt R package <https://cran.r-project.org/package=MatchIt>.

The function generates and plots random snowflakes. Each snowflake is defined by a given diameter, width of the crystal, color, and random seed. Snowflakes are plotted in such way that they always remain round, no matter what the aspect ratio of the plot is. Snowflakes can be created using transparent colors, which creates a more interesting, somewhat realistic, image. Images of the snowflakes can be separately saved as svg files and used in websites as static or animated images.

Processes amino acid alignments produced by the IPD-IMGT/HLA (Immuno Polymorphism-ImMunoGeneTics/Human Leukocyte Antigen) Database to identify user-defined amino acid residue motifs shared across HLA alleles, HLA alleles, or HLA haplotypes, and calculates frequencies based on HLA allele frequency data. SSHAARP (Searching Shared HLA Amino Acid Residue Prevalence) uses Generic Mapping Tools (GMT) software and the GMT R package to generate global frequency heat maps that illustrate the distribution of each user-defined map around the globe. SSHAARP analyzes the allele frequency data described by Solberg et al. (2008) <doi:10.1016/j.humimm.2008.05.001>, a global set of 497 population samples from 185 published datasets, representing 66,800 individuals total. Users may also specify their own datasets, but file conventions must follow the prebundled Solberg dataset, or the mock haplotype dataset.

Generalized additive models under shape constraints on the component functions of the linear predictor. Models can include multiple shape-constrained (univariate and bivariate) and unconstrained terms. Routines of the package mgcv are used to set up the model matrix, print, and plot the results. Multiple smoothing parameter estimation by the Generalized Cross Validation or similar. See Pya and Wood (2015) <doi:10.1007/s11222-013-9448-7> for an overview. A broad selection of shape-constrained smoothers, linear functionals of smooths with shape constraints, and Gaussian models with AR1 residuals.

Uses parametric and nonparametric methods to quantify the proportion of the estimated selection bias (SB) explained by each observed confounder when estimating propensity score weighted treatment effects. Parast, L and Griffin, BA (2020). "Quantifying the Bias due to Observed Individual Confounders in Causal Treatment Effect Estimates". Statistics in Medicine, 39(18): 2447- 2476 <doi: 10.1002/sim.8549>.

This package provides tools for the simultaneous improvement of multiple traits in plant breeding. Building upon the classical selection index (Smith 1937 <doi:10.1111/j.1469-1809.1936.tb02143.x>) and modern quantitative genetics (Kang 2020 <doi:10.1007/978-3-319-91223-3>), this package calculates classical phenotypic, genomic, marker-assisted, restricted/constrained, and eigen selection indices. It also incorporates multi-stage selection evaluation and stochastic simulations to estimate genetic advance based on economic weights, heritability, and genetic correlations.

An R data package containing setlists from all Bruce Springsteen concerts over 1973-2021. Also includes all his song details such as lyrics and albums. Data extracted from: <http://brucebase.wikidot.com/>.

This package contains more modern tools for causal inference using regression standardization. Four general classes of models are implemented; generalized linear models, conditional generalized estimating equation models, Cox proportional hazards models, and shared frailty gamma-Weibull models. Methodological details are described in Sjölander, A. (2016) <doi:10.1007/s10654-016-0157-3>. Also includes functionality for doubly robust estimation for generalized linear models in some special cases, and the ability to implement custom models.

Estimating the force of infection from time varying, age varying, or constant serocatalytic models from population based seroprevalence studies using a Bayesian framework, including data simulation functions enabling the generation of serological surveys based on this models. This tool also provides a flexible prior specification syntax for the force of infection and the seroreversion rate, as well as methods to assess model convergence and comparison criteria along with useful visualisation functions.

Computes the effective range of a smoothing matrix, which is a measure of the distance to which smoothing occurs. This is motivated by the application of spatial splines for adjusting for unmeasured spatial confounding in regression models, but the calculation of effective range can be applied to smoothing matrices in other contexts. For algorithmic details, see Rainey and Keller (2024) "spconfShiny: an R Shiny application..." <doi:10.1371/journal.pone.0311440> and Keller and Szpiro (2020) "Selecting a Scale for Spatial Confounding Adjustment" <doi:10.1111/rssa.12556>.

This package provides a rendering tool for parameterized SQL that also translates into different SQL dialects. These dialects include Microsoft SQL Server', Oracle', PostgreSql', Amazon RedShift', Apache Impala', IBM Netezza', Google BigQuery', Microsoft PDW', Snowflake', Azure Synapse Analytics Dedicated', Apache Spark', SQLite', and InterSystems IRIS'.

For making Trellis-type conditioning plots without strip labels. This is useful for displaying the structure of results from factorial designs and other studies when many conditioning variables would clutter the display with layers of redundant strip labels. Settings of the variables are encoded by layout and spacing in the trellis array and decoded by a separate legend. The functionality is implemented by a single S3 generic strucplot() function that is a wrapper for the Lattice package's xyplot() function. This allows access to all Lattice graphics capabilities in the usual way.

Allows fitting of step-functions to univariate serial data where neither the number of jumps nor their positions is known by implementing the multiscale regression estimators SMUCE, simulataneous multiscale changepoint estimator, (K. Frick, A. Munk and H. Sieling, 2014) <doi:10.1111/rssb.12047> and HSMUCE, heterogeneous SMUCE, (F. Pein, H. Sieling and A. Munk, 2017) <doi:10.1111/rssb.12202>. In addition, confidence intervals for the change-point locations and bands for the unknown signal can be obtained.