This package provides a unified framework for detecting spatially variable genes (SVGs) in spatial transcriptomics data. This package integrates multiple state-of-the-art SVG detection methods including MERINGUE (Moran's I based spatial autocorrelation), Giotto binSpect (binary spatial enrichment test), SPARK-X (non-parametric kernel-based test), and nnSVG (nearest-neighbor Gaussian processes). Each method is implemented with optimized performance through vectorization, parallelization, and C++ acceleration where applicable. Methods are described in Miller et al. (2021) <doi:10.1101/gr.271288.120>, Dries et al. (2021) <doi:10.1186/s13059-021-02286-2>, Zhu et al. (2021) <doi:10.1186/s13059-021-02404-0>, and Weber et al. (2023) <doi:10.1038/s41467-023-39748-z>.

This is an all-encompassing suite to facilitate the simulation of so-called quantities of interest by way of a multivariate normal distribution of the regression model's coefficients and variance-covariance matrix.

Penalized and non-penalized maximum likelihood estimation of smooth transition vector autoregressive models with various types of transition weight functions, conditional distributions, and identification methods. Constrained estimation with various types of constraints is available. Residual based model diagnostics, forecasting, simulations, counterfactual analysis, and computation of impulse response functions, generalized impulse response functions, generalized forecast error variance decompositions, as well as historical decompositions. See Heather Anderson, Farshid Vahid (1998) <doi:10.1016/S0304-4076(97)00076-6>, Helmut Lütkepohl, Aleksei NetÅ¡unajev (2017) <doi:10.1016/j.jedc.2017.09.001>, Markku Lanne, Savi Virolainen (2025) <doi:10.1016/j.jedc.2025.105162>, Savi Virolainen (2025) <doi:10.48550/arXiv.2404.19707>.

The Brazilian system for diploma registration and validation on technical and superior courses are managing by Sistec platform, see <https://sistec.mec.gov.br/>. This package provides tools for Brazilian institutions to update the student's registration and make data analysis about their situation, retention and drop out.

Offers a suite of functions for converting to and from (atomic) vectors, matrices, data.frames, and (3D+) arrays as well as lists of these objects. It is an alternative to the base R as.<str>.<method>() functions (e.g., as.data.frame.array()) that provides more useful and/or flexible restructuring of R objects. To do so, it only works with common structuring of R objects (e.g., data.frames with only atomic vector columns).

Generate programmable surveys using markdown and R code chunks. Surveys are composed of two files: a survey.qmd Quarto file defining the survey content (pages, questions, etc), and an app.R file defining a shiny app with global settings (libraries, database configuration, etc.) and server configuration options (e.g., conditional skipping / display, etc.). Survey data collected from respondents is stored in a PostgreSQL database. Features include controls for conditional skip logic (skip to a page based on an answer to a question), conditional display logic (display a question based on an answer to a question), a customizable progress bar, and a wide variety of question types, including multiple choice (single choice and multiple choices), select, text, numeric, multiple choice buttons, text area, and dates. Because the surveys render into a shiny app, designers can also leverage the reactive capabilities of shiny to create dynamic and interactive surveys.

Statistical models for specific coronavirus disease 2019 use cases at German local health authorities. All models of Statistical modelling for infectious disease management smidm are part of the decision support toolkit in the EsteR project. More information is published in Sonja Jäckle, Rieke Alpers, Lisa Kühne, Jakob Schumacher, Benjamin Geisler, Max Westphal "'EsteR â A Digital Toolkit for COVID-19 Decision Support in Local Health Authorities" (2022) <doi:10.3233/SHTI220799> and Sonja Jäckle, Elias Röger, Volker Dicken, Benjamin Geisler, Jakob Schumacher, Max Westphal "A Statistical Model to Assess Risk for Supporting COVID-19 Quarantine Decisions" (2021) <doi:10.3390/ijerph18179166>.

Enables drag-and-drop behaviour in Shiny apps, by exposing the functionality of the SortableJS <https://sortablejs.github.io/Sortable/> JavaScript library as an htmlwidget'. You can use this in Shiny apps and widgets, learnr tutorials as well as R Markdown. In addition, provides a custom learnr question type - question_rank() - that allows ranking questions with drag-and-drop.

This package implements a suite of semiparametric and nonparametric kernel-smoothed estimation and testing procedures for continuous mark-specific stratified hazard ratio (treatment/placebo) models in a randomized treatment efficacy trial with a time-to-event endpoint. Semiparametric methods, allowing multivariate marks, are described in Juraska M and Gilbert PB (2013), Mark-specific hazard ratio model with multivariate continuous marks: an application to vaccine efficacy. Biometrics 69(2):328-337 <doi:10.1111/biom.12016>, and in Juraska M and Gilbert PB (2016), Mark-specific hazard ratio model with missing multivariate marks. Lifetime Data Analysis 22(4):606-25 <doi:10.1007/s10985-015-9353-9>. Nonparametric kernel-smoothed methods, allowing univariate marks only, are described in Sun Y and Gilbert PB (2012), Estimation of stratified markâ specific proportional hazards models with missing marks. Scandinavian Journal of Statistics

The purpose of this package is to manipulate SVG files that are templates of charts the user wants to produce. In vector graphics one copes with x-/y-coordinates of elements (e.g. lines, rectangles, text). Their scale is often dependent on the program that is used to produce the graphics. In applied statistics one usually has numeric values on a fixed scale (e.g. percentage values between 0 and 100) to show in a chart. Basically, svgtools transforms the statistical values into coordinates and widths/heights of the vector graphics. This is done by stackedBar() for bar charts, by linesSymbols() for charts with lines and/or symbols (dot markers) and scatterSymbols() for scatterplots.

Model age schedules of mortality, nqx, suitable for a life table. This package implements the SVD-Comp mortality model indexed by either child or child/adult mortality. Given input value(s) of either 5q0 or (5q0, 45q15), the qx() function generates single-year 1qx or 5-year 5qx conditional age-specific probabilities of dying. See Clark (2016) <doi:10.48550/arXiv.1612.01408> and Clark (2019) <doi:10.1007/s13524-019-00785-3>.

Package including functions and interactive shiny application for the psychometric analysis of educational tests, psychological assessments, health-related and other types of multi-item measurements, or ratings from multiple raters.

This package provides several functions and datasets for area level of Small Area Estimation under Spatial Model using Hierarchical Bayesian (HB) Method. Model-based estimators include the HB estimators based on a Spatial Fay-Herriot model with univariate normal distribution for variable of interest.The rjags package is employed to obtain parameter estimates. For the reference, see Rao and Molina (2015) <doi:10.1002/9781118735855>.

Computationally efficient tools for high dimensional predictive modeling (regression and classification). SAM is short for sparse additive modeling, and adopts the computationally efficient basis spline technique. We solve the optimization problems by various computational algorithms including the block coordinate descent algorithm, fast iterative soft-thresholding algorithm, and newton method. The computation is further accelerated by warm-start and active-set tricks.

Graphical and computational methods that can be used to assess the stability of results from supervised statistical learning.

This package provides a set of user interface components to create outstanding shiny apps <https://shiny.posit.co/>, with the power of React JavaScript <https://react.dev/>. Seamlessly support dark and light themes, customize CSS with tailwind <https://tailwindcss.com/>.

Evaluating probabilistic forecasts via proper scoring rules. scoring implements the beta, power, and pseudospherical families of proper scoring rules, along with ordered versions of the latter two families. Included among these families are popular rules like the Brier (quadratic) score, logarithmic score, and spherical score. For two-alternative forecasts, also includes functionality for plotting scores that one would obtain under specific scoring rules.

Simulate a virtual population of subjects that has demographic distributions (height, weight, and BMI) and correlations (height and weight), by sex and age, which mimic those reported in real-world anthropometric growth charts (CDC, WHO, or Fenton).

Some M-estimators for 1-dimensional location (Bisquare, ML for the Cauchy distribution, and the estimators from application of the smoothing principle introduced in Hampel, Hennig and Ronchetti (2011) to the above, the Huber M-estimator, and the median, main function is smoothm), and Pitman estimator.

Includes general data manipulation functions, algorithms for statistical disclosure control (Langsrud, 2024) <doi:10.1007/978-3-031-69651-0_6> and functions for hierarchical computations by sparse model matrices (Langsrud, 2023) <doi:10.32614/RJ-2023-088>.

This package provides utilities for conducting specification curve analyses (Simonsohn, Simmons & Nelson (2020, <doi: 10.1038/s41562-020-0912-z>) or multiverse analyses (Steegen, Tuerlinckx, Gelman & Vanpaemel, 2016, <doi: 10.1177/1745691616658637>) including functions to setup, run, evaluate, and plot all specifications.

This package performs sensitivity analysis for Structural Equation Modeling (SEM). It determines which sample points need to be removed for the sign of a specific path in the SEM model to change, thus assessing the robustness of the model. Methodological manuscript in preparation.

This package provides functions to run and assist four different similarity measures. The similarity measures included are: longest common subsequence (LCSS), Frechet distance, edit distance and dynamic time warping (DTW). Each of these similarity measures can be calculated from two n-dimensional trajectories, both in matrix form.

An R data package containing setlists from all Bruce Springsteen concerts over 1973-2021. Also includes all his song details such as lyrics and albums. Data extracted from: <http://brucebase.wikidot.com/>.