This package provides a collection of multivariate nonparametric methods, selected in part to support an MS level course in nonparametric statistical methods. Methods include adjustments for multiple comparisons, implementation of multivariate Mann-Whitney-Wilcoxon testing, inversion of these tests to produce a confidence region, some permutation tests for linear models, and some algorithms for calculating exact probabilities associated with one- and two- stage testing involving Mann-Whitney-Wilcoxon statistics. Supported by grant NSF DMS 1712839. See Kolassa and Seifu (2013) <doi:10.1016/j.acra.2013.03.006>.

Three main functions about analyzing massive data (missing observations are allowed) considered from multiple layers of categories are demonstrated. Flexible and diverse applications of the function parameters make the data analyses powerful.

This package performs the multiple testing procedures of Cox (2011) <doi:10.5170/CERN-2011-006> and Wong and Cox (2007) <doi:10.1080/02664760701240014>.

Calculates the expected/observed Fisher information and the bias-corrected maximum likelihood estimate(s) via Cox-Snell Methodology.

Calculates mean cumulative count (MCC) to estimate the expected cumulative number of recurrent events per person over time in the presence of competing risks and censoring. Implements both the Dong-Yasui equation method and sum of cumulative incidence method described in Dong, et al. (2015) <doi:10.1093/aje/kwu289>. Supports inverse probability weighting for causal inference as outlined in Gaber, et al. (2023) <doi:10.1093/aje/kwad031>. Provides S3 methods for printing, summarizing, plotting, and extracting results. Handles grouped analyses and integrates with ggplot2 <https://ggplot2.tidyverse.org/> for visualization.

This package provides a variety of association tests for microbiome data analysis including Quasi-Conditional Association Tests (QCAT) described in Tang Z.-Z. et al.(2017) <doi:10.1093/bioinformatics/btw804> and Zero-Inflated Generalized Dirichlet Multinomial (ZIGDM) tests described in Tang Z.-Z. & Chen G. (2017, submitted).

Takes a .state file generated by IQ-TREE as an input and, for each ancestral node present in the file, generates a FASTA-formatted maximum likelihood (ML) sequence as well as an âAltAllâ sequence in which uncertain sites, determined by the two parameters thres_1 and thres_2, have the maximum likelihood state swapped with the next most likely state as described in Geeta N. Eick, Jamie T. Bridgham, Douglas P. Anderson, Michael J. Harms, and Joseph W. Thornton (2017), "Robustness of Reconstructed Ancestral Protein Functions to Statistical Uncertainty" <doi:10.1093/molbev/msw223>.

This package implements the Maki (2012) <doi:10.1016/j.econmod.2012.05.006> cointegration test that allows for an unknown number of structural breaks. The test detects cointegration relationships in the presence of up to five structural breaks in the intercept and/or slope coefficients. Four different model specifications are supported: level shifts, level shifts with trend, regime shifts, and trend with regime shifts. The method is described in Maki (2012) "Tests for cointegration allowing for an unknown number of breaks" <doi:10.1016/j.econmod.2012.05.006>.

Administrative Boundaries of Spain at several levels (Autonomous Communities, Provinces, Municipalities) based on the GISCO Eurostat database <https://ec.europa.eu/eurostat/web/gisco> and CartoBase SIANE from Instituto Geografico Nacional <https://www.ign.es/>. It also provides a leaflet plugin and the ability of downloading and processing static tiles.

Multimodal mediation analysis is an emerging problem in microbiome data analysis. Multimedia make advanced mediation analysis techniques easy to use, ensuring that all statistical components are transparent and adaptable to specific problem contexts. The package provides a uniform interface to direct and indirect effect estimation, synthetic null hypothesis testing, bootstrap confidence interval construction, and sensitivity analysis. More details are available in Jiang et al. (2024) "multimedia: Multimodal Mediation Analysis of Microbiome Data" <doi:10.1101/2024.03.27.587024>.

Translate R code into MongoDB aggregation pipelines.

This package provides a Comprehensive tool for almost all existing multiple testing methods for multiple families. The package summarizes the existing methods for multiple families multiple testing procedures (MTPs) such as double FDR, group Benjamini-Hochberg (GBH) procedure and average FDR controlling procedure. The package also provides some novel multiple testing procedures using selective inference idea.

The need for anonymization of individual survey responses often leads to many suppressed grid cells in a regular grid. Here we provide functionality for creating multi-resolution gridded data, respecting the confidentiality rules, such as a minimum number of units and dominance by one or more units for each grid cell. The functions also include the possibility for contextual suppression of data. For more details see Skoien et al. (2025) <doi:10.48550/arXiv.2410.17601>.

Transferring over a code base from Matlab to R is often a repetitive and inefficient use of time. This package provides a translator for Matlab / Octave code into R code. It does some syntax changes, but most of the heavy lifting is in the function changes since the languages are so similar. Options for different data structures and the functions that can be changed are given. The Matlab code should be mostly in adherence to the standard style guide but some effort has been made to accommodate different number of spaces and other small syntax issues. This will not make the code more R friendly and may not even run afterwards. However, the rudimentary syntax, base function and data structure conversion is done quickly so that the maintainer can focus on changes to the design structure.

Friendly implementation of the Mann-Whitney-Wilcoxon test for competitive gene set enrichment analysis.

Hierarchical workspace tree, code editing and backup, easy package prep, editing of packages while loaded, per-object lazy-loading, easy documentation, macro functions, and miscellaneous utilities. Needed by debug package.

This package implements a regularized Bayesian estimator that optimizes the estimation of between-group coefficients for multilevel latent variable models by minimizing mean squared error (MSE) and balancing variance and bias. The package provides more reliable estimates in scenarios with limited data, offering a robust solution for accurate parameter estimation in two-level latent variable models. It is designed for researchers in psychology, education, and related fields who face challenges in estimating between-group effects under small sample sizes and low intraclass correlation coefficients. The package includes comprehensive S3 methods for result objects: print(), summary(), coef(), se(), vcov(), confint(), as.data.frame(), dim(), length(), names(), and update() for enhanced usability and integration with standard R workflows. Dashuk et al. (2025a) <doi:10.1017/psy.2025.10045> derived the optimal regularized Bayesian estimator; Dashuk et al. (2025b) <doi:10.1007/s41237-025-00264-7> extended it to the multivariate case; and Luedtke et al. (2008) <doi:10.1037/a0012869> formalized the two-level latent variable framework.

Metadynamics is a state of the art biomolecular simulation technique. Plumed Tribello, G.A. et al. (2014) <doi:10.1016/j.cpc.2013.09.018> program makes it possible to perform metadynamics using various simulation codes. The results of metadynamics done in Plumed can be analyzed by metadynminer'. The package metadynminer reads 1D and 2D metadynamics hills files from Plumed package. As an addendum, metadynaminer3d is used to visualize 3D hills. It uses a fast algorithm by Hosek, P. and Spiwok, V. (2016) <doi:10.1016/j.cpc.2015.08.037> to calculate a free energy surface from hills. Minima can be located and plotted on the free energy surface. Free energy surfaces and minima can be plotted to produce publication quality images.

It contains the function to apply MARMoT balancing technique discussed in: Silan, Boccuzzo, Arpino (2021) <DOI:10.1002/sim.9192>, Silan, Belloni, Boccuzzo, (2023) <DOI:10.1007/s10260-023-00695-0>; furthermore it contains a function for computing the Deloof's approximation of the average rank (and also a parallelized version) and a function to compute the Absolute Standardized Bias.

Computes efficient data distributions from highly inconsistent datasets with many missing values using multi-set intersections. Based upon hash functions, mulset can quickly identify intersections from very large matrices of input vectors across columns and rows and thus provides scalable solution for dealing with missing values. Tomic et al. (2019) <doi:10.1101/545186>.

Epistasis, commonly defined as the interaction between genetic loci, is known to play an important role in the phenotypic variation of complex traits. As a result, many statistical methods have been developed to identify genetic variants that are involved in epistasis, and nearly all of these approaches carry out this task by focusing on analyzing one trait at a time. Previous studies have shown that jointly modeling multiple phenotypes can often dramatically increase statistical power for association mapping. In this package, we present the multivariate MArginal ePIstasis Test ('mvMAPIT') â a multi-outcome generalization of a recently proposed epistatic detection method which seeks to detect marginal epistasis or the combined pairwise interaction effects between a given variant and all other variants. By searching for marginal epistatic effects, one can identify genetic variants that are involved in epistasis without the need to identify the exact partners with which the variants interact â thus, potentially alleviating much of the statistical and computational burden associated with conventional explicit search based methods. Our proposed mvMAPIT builds upon this strategy by taking advantage of correlation structure between traits to improve the identification of variants involved in epistasis. We formulate mvMAPIT as a multivariate linear mixed model and develop a multi-trait variance component estimation algorithm for efficient parameter inference and P-value computation. Together with reasonable model approximations, our proposed approach is scalable to moderately sized genome-wide association studies. Crawford et al. (2017) <doi:10.1371/journal.pgen.1006869>. Stamp et al. (2023) <doi:10.1093/g3journal/jkad118>.

This package provides tools to analysis of experiments having two or more quantitative explanatory variables and one quantitative dependent variable. Experiments can be without repetitions or with a statistical design (Hair JF, 2016) <ISBN: 13: 978-0138132637>. Pacote para uma analise de experimentos havendo duas ou mais variaveis explicativas quantitativas e uma variavel dependente quantitativa. Os experimentos podem ser sem repeticoes ou com delineamento estatistico (Hair JF, 2016) <ISBN: 13: 978-0138132637>.

This package provides functions to access drug regulatory data from public RESTful APIs including the FDA Open API and the Health Canada Drug Product Database API', retrieving real-time or historical information on drug approvals, adverse events, recalls, and product details. Additionally, the package includes a curated collection of open datasets focused on drugs, pharmaceuticals, treatments, and clinical studies. These datasets cover diverse topics such as treatment dosages, pharmacological studies, placebo effects, drug reactions, misuses of pain relievers, and vaccine effectiveness. The package supports reproducible research and teaching in pharmacology, medicine, and healthcare by integrating reliable international APIs and structured datasets from public, academic, and government sources. For more information on the APIs, see: FDA API <https://open.fda.gov/apis/> and Health Canada API <https://health-products.canada.ca/api/documentation/dpd-documentation-en.html>.

This package implements the computation of discrepancy statistics summarizing differences between the density of imputed and observed values and the construction of weights to balance covariates that are part of the missing data mechanism as described in Marbach (2021) <arXiv:2107.05427>.