This package provides pipe-style interface for data.table'. Package preserves all data.table features without significant impact on performance. let and take functions are simplified interfaces for most common data manipulation tasks. For example, you can write take(mtcars, mean(mpg), by = am) for aggregation or let(mtcars, hp_wt = hp/wt, hp_wt_mpg = hp_wt/mpg) for modification. Use take_if/let_if for conditional aggregation/modification. Additionally there are some conveniences such as automatic data.frame conversion to data.table'.

This package implements a general interface for model-based estimations for a wide variety of models, used in the computation of marginal means, contrast analysis and predictions. For a list of supported models, see insight::supported_models()'.

Matrix eQTL is designed for fast eQTL analysis on large datasets. Matrix eQTL can test for association between genotype and gene expression using linear regression with either additive or ANOVA genotype effects. The models can include covariates to account for factors as population stratification, gender, and clinical variables. It also supports models with heteroscedastic and/or correlated errors, false discovery rate estimation and separate treatment of local (cis) and distant (trans) eQTLs. For more details see Shabalin (2012) <doi:10.1093/bioinformatics/bts163>.

This package provides a set of functions for some multivariate analyses utilizing a structural equation modeling (SEM) approach through the OpenMx package. These analyses include canonical correlation analysis (CANCORR), redundancy analysis (RDA), and multivariate principal component regression (MPCR). It implements procedures discussed in Gu and Cheung (2023) <doi:10.1111/bmsp.12301>, Gu, Yung, and Cheung (2019) <doi:10.1080/00273171.2018.1512847>, and Gu et al. (2023) <doi:10.1080/00273171.2022.2141675>.

This package implements a generalization of the Cochran-Armitage trend test to multinomial data. In addition to an overall test, multiple testing adjusted p-values for trend in individual outcomes and power calculation is available.

This function allows to generate two biological conditions synthetic microarray dataset which has similar behavior to those currently observed with common platforms. User provides a subset of parameters. Available default parameters settings can be modified.

Machine learning algorithms have been used for performing single missing data imputation and most recently, multiple imputations. However, this is the first attempt for using automated machine learning algorithms for performing both single and multiple imputation. Automated machine learning is a procedure for fine-tuning the model automatic, performing a random search for a model that results in less error, without overfitting the data. The main idea is to allow the model to set its own parameters for imputing each variable separately instead of setting fixed predefined parameters to impute all variables of the dataset. Using automated machine learning, the package fine-tunes an Elastic Net (default) or Gradient Boosting, Random Forest, Deep Learning, Extreme Gradient Boosting, or Stacked Ensemble machine learning model (from one or a combination of other supported algorithms) for imputing the missing observations. This procedure has been implemented for the first time by this package and is expected to outperform other packages for imputing missing data that do not fine-tune their models. The multiple imputation is implemented via bootstrapping without letting the duplicated observations to harm the cross-validation procedure, which is the way imputed variables are evaluated. Most notably, the package implements automated procedure for handling imputing imbalanced data (class rarity problem), which happens when a factor variable has a level that is far more prevalent than the other(s). This is known to result in biased predictions, hence, biased imputation of missing data. However, the autobalancing procedure ensures that instead of focusing on maximizing accuracy (classification error) in imputing factor variables, a fairer procedure and imputation method is practiced.

Comprehensive analytical tools are provided to characterize infectious disease superspreading from contact tracing surveillance data. The underlying theoretical frameworks of this toolkit include branching process with transmission heterogeneity (Lloyd-Smith et al. (2005) <doi:10.1038/nature04153>), case cluster size distribution (Nishiura et al. (2012) <doi:10.1016/j.jtbi.2011.10.039>, Blumberg et al. (2014) <doi:10.1371/journal.ppat.1004452>, and Kucharski and Althaus (2015) <doi:10.2807/1560-7917.ES2015.20.25.21167>), and decomposition of reproduction number (Zhao et al. (2022) <doi:10.1371/journal.pcbi.1010281>).

R Client for the Microsoft Cognitive Services Text-to-Speech REST API, including voice synthesis. A valid account must be registered at the Microsoft Cognitive Services website <https://azure.microsoft.com/en-us/products/ai-services/> in order to obtain a (free) API key. Without an API key, this package will not work properly.

This package provides functions are provided for calculating efficiency using multiplier DEA (Data Envelopment Analysis): Measuring the efficiency of decision making units (Charnes et al., 1978 <doi:10.1016/0377-2217(78)90138-8>) and cross efficiency using single and two-phase approach. In addition, it includes some datasets for calculating efficiency and cross efficiency.

This package provides tools to quantify ecological memory in long time-series with Random Forest models (Breiman 2001 <doi:10.1023/A:1010933404324>) fitted with the ranger library (Wright and Ziegler 2017 <doi:10.18637/jss.v077.i01>). Particularly oriented to palaeoecological datasets and simulated pollen curves produced by the virtualPollen package, but also applicable to other long time-series involving a set of environmental drivers and a biotic response.

This package contains functions performing Bayesian inference for meta-analytic and network meta-analytic models through Markov chain Monte Carlo algorithm. Currently, the package implements Hui Yao, Sungduk Kim, Ming-Hui Chen, Joseph G. Ibrahim, Arvind K. Shah, and Jianxin Lin (2015) <doi:10.1080/01621459.2015.1006065> and Hao Li, Daeyoung Lim, Ming-Hui Chen, Joseph G. Ibrahim, Sungduk Kim, Arvind K. Shah, Jianxin Lin (2021) <doi:10.1002/sim.8983>. For maximal computational efficiency, the Markov chain Monte Carlo samplers for each model, written in C++, are fine-tuned. This software has been developed under the auspices of the National Institutes of Health and Merck & Co., Inc., Kenilworth, NJ, USA.

Defines the classes used to explore, cluster and visualize distance matrices, especially those arising from binary data. See Abrams and colleagues, 2021, <doi:10.1093/bioinformatics/btab037>.

This package performs maximum likelihood estimation for finite mixture models for families including Normal, Weibull, Gamma and Lognormal by using EM algorithm, together with Newton-Raphson algorithm or bisection method when necessary. It also conducts mixture model selection by using information criteria or bootstrap likelihood ratio test. The data used for mixture model fitting can be raw data or binned data. The model fitting process is accelerated by using R package Rcpp'.

Bayesian estimation of inverse variance weighted (IVW), Burgess et al. (2013) <doi:10.1002/gepi.21758>, and MR-Egger, Bowden et al. (2015) <doi:10.1093/ije/dyv080>, summary data models for Mendelian randomization analyses.

An implementation of popular screening methods that are commonly employed in ultra-high and high dimensional data. Through this publicly available package, we provide a unified framework to carry out model-free screening procedures including SIS (Fan and Lv (2008) <doi:10.1111/j.1467-9868.2008.00674.x>), SIRS (Zhu et al. (2011)<doi:10.1198/jasa.2011.tm10563>), DC-SIS (Li et al. (2012) <doi:10.1080/01621459.2012.695654>), MDC-SIS (Shao and Zhang (2014) <doi:10.1080/01621459.2014.887012>), Bcor-SIS (Pan et al. (2019) <doi:10.1080/01621459.2018.1462709>), PC-Screen (Liu et al. (2020) <doi:10.1080/01621459.2020.1783274>), WLS (Zhong et al.(2021) <doi:10.1080/01621459.2021.1918554>), Kfilter (Mai and Zou (2015) <doi:10.1214/14-AOS1303>), MVSIS (Cui et al. (2015) <doi:10.1080/01621459.2014.920256>), PSIS (Pan et al. (2016) <doi:10.1080/01621459.2014.998760>), CAS (Xie et al. (2020) <doi:10.1080/01621459.2019.1573734>), CI-SIS (Cheng and Wang. (2023) <doi:10.1016/j.cmpb.2022.107269>) and CSIS (Cheng et al. (2023) <doi:10.1007/s00180-023-01399-5>).

Conjoint measurement is a psychophysical procedure in which stimulus pairs are presented that vary along 2 or more dimensions and the observer is required to compare the stimuli along one of them. This package contains functions to estimate the contribution of the n scales to the judgment by a maximum likelihood method under several hypotheses of how the perceptual dimensions interact. Reference: Knoblauch & Maloney (2012) "Modeling Psychophysical Data in R". <doi:10.1007/978-1-4614-4475-6>.

Exploratory and predictive methods for the analysis of several blocks of variables measured on the same individuals.

This package provides a novel framework to estimate mixed models via gradient boosting. The implemented functions are based on the mboost and lme4 packages, and the family range is therefore determined by lme4'. A correction mechanism for cluster-constant covariates is implemented, as well as estimation of the covariance of random effects. These methods are described in the accompanying publication; see <doi:10.1007/s11222-025-10612-y> for details.

This package creates an object that stores a matrix ensemble, matrices that share the same common properties, where rows and columns can be annotated. Matrices must have the same dimension and dimnames. Operators to manipulate these objects are provided as well as mechanisms to apply functions to these objects.

To assess a summary survival curve from survival probabilities and number of at-risk patients collected at various points in time in various studies, and to test the between-strata heterogeneity.

Run the same analysis over a range of arbitrary data processing decisions. multitool provides an interface for creating alternative analysis pipelines and turning them into a grid of all possible pipelines. Using this grid as a blueprint, you can model your data across all possible pipelines and summarize the results.

The Iterative Proportional Fitting (IPF) algorithm operates on count data. This package offers implementations for several algorithms that extend this to nested structures: parent and child items for both of which constraints can be provided. The fitting algorithms include Iterative Proportional Updating <https://trid.trb.org/view/881554>, Hierarchical IPF <doi:10.3929/ethz-a-006620748>, Entropy Optimization <https://trid.trb.org/view/881144>, and Generalized Raking <doi:10.2307/2290793>. Additionally, a number of replication methods is also provided such as Truncate, replicate, sample <doi:10.1016/j.compenvurbsys.2013.03.004>.

This package provides functions for reading (tab, csv, Bruker fid, Ciphergen XML, mzXML, mzML, imzML, Analyze 7.5, CDF, mMass MSD) and writing (tab, csv, mMass MSD, mzML, imzML) different file formats of mass spectrometry data into/from MALDIquant objects.