This package provides a number of functions to facilitate the handling and production of reports using time series data. The package was developed to be understandable for beginners, so some functions aim to transform processes that would be complex into functions with a few lines. The main advantage of using the metools package is the ease of producing reports and working with time series using a few lines of code, so the code is clean and easy to understand/maintain. Learn more about the metools at <https://metoolsr.wordpress.com>.

Incorporates Approximate Bayesian Computation to get a posterior distribution and to select a model optimal parameter for an observation point. Additionally, the meta-sampling heuristic algorithm is realized for parameter estimation, which requires no model runs and is dimension-independent. A sampling scheme is also presented that allows model runs and uses the meta-sampling for point generation. A predictor is realized as the meta-sampling for the model output. All the algorithms leverage a machine learning method utilizing the maxima weighted Isolation Kernel approach, or MaxWiK'. The method involves transforming raw data to a Hilbert space (mapping) and measuring the similarity between simulated points and the maxima weighted Isolation Kernel mapping corresponding to the observation point. Comprehensive details of the methodology can be found in the papers Iurii Nagornov (2024) <doi:10.1007/978-3-031-66431-1_16> and Iurii Nagornov (2023) <doi:10.1007/978-3-031-29168-5_18>.

This package contains a dataset of morphological and structural features of Medicinal LEAves (MedLEA)'. The features of each species is recorded by manually viewing the medicinal plant repository available at (<http://www.instituteofayurveda.org/plants/>). You can also download repository of leaf images of 1099 medicinal plants in Sri Lanka.

Interactions between different biological entities are crucial for the function of biological systems. In such networks, nodes represent biological elements, such as genes, proteins and microbes, and their interactions can be defined by edges, which can be either binary or weighted. The dysregulation of these networks can be associated with different clinical conditions such as diseases and response to treatments. However, such variations often occur locally and do not concern the whole network. To capture local variations of such networks, we propose multiplex network differential analysis (MNDA). MNDA allows to quantify the variations in the local neighborhood of each node (e.g. gene) between the two given clinical states, and to test for statistical significance of such variation. Yousefi et al. (2023) <doi:10.1101/2023.01.22.525058>.

Several functions can be used to analyze neuroimaging data using multivariate methods based on the msma package. The functions used in the book entitled "Multivariate Analysis for Neuroimaging Data" (2021, ISBN-13: 978-0367255329) are contained.

This package provides functions for calculating metrics for the measurement biodiversity and its changes across scales, treatments, and gradients. The methods implemented in this package are described in: Chase, J.M., et al. (2018) <doi:10.1111/ele.13151>, McGlinn, D.J., et al. (2019) <doi:10.1111/2041-210X.13102>, McGlinn, D.J., et al. (2020) <doi:10.1101/851717>, and McGlinn, D.J., et al. (2023) <doi:10.1101/2023.09.19.558467>.

Estimate Multidimensional Poverty Indices disaggregated by population subgroups based on the Alkire and Foster method (2011) <doi:10.1016/j.jpubeco.2010.11.006>. This includes the calculation of standard errors and confidence intervals. Other partial indices such as incidence, intensity and indicator-specific measures as well as intertemporal changes analysis can also be estimated. The standard errors and confidence intervals are calculated considering the complex survey design.

This package provides a collection of function to solve multiple criteria optimization problems using genetic algorithms (NSGA-II). Also included is a collection of test functions.

This package contains model-based treatment of missing data for regression models with missing values in covariates or the dependent variable using maximum likelihood or Bayesian estimation (Ibrahim et al., 2005; <doi:10.1198/016214504000001844>; Luedtke, Robitzsch, & West, 2020a, 2020b; <doi:10.1080/00273171.2019.1640104><doi:10.1037/met0000233>). The regression model can be nonlinear (e.g., interaction effects, quadratic effects or B-spline functions). Multilevel models with missing data in predictors are available for Bayesian estimation. Substantive-model compatible multiple imputation can be also conducted.

Extends the base classes and methods of caret package for integration of base learners. The user can input the number of different base learners, and specify the final learner, along with the train-validation-test data partition split ratio. The predictions on the unseen new data is the resultant of the ensemble meta-learning <https://machinelearningmastery.com/stacking-ensemble-machine-learning-with-python/> of the heterogeneous learners aimed to reduce the generalization error in the predictive models. It significantly lowers the barrier for the practitioners to apply heterogeneous ensemble learning techniques in an amateur fashion to their everyday predictive problems.

The midasml package implements estimation and prediction methods for high-dimensional mixed-frequency (MIDAS) time-series and panel data regression models. The regularized MIDAS models are estimated using orthogonal (e.g. Legendre) polynomials and sparse-group LASSO (sg-LASSO) estimator. For more information on the midasml approach see Babii, Ghysels, and Striaukas (2021, JBES forthcoming) <doi:10.1080/07350015.2021.1899933>. The package is equipped with the fast implementation of the sg-LASSO estimator by means of proximal block coordinate descent. High-dimensional mixed frequency time-series data can also be easily manipulated with functions provided in the package.

Density, distribution function, ... hazard function, cumulative hazard function, survival function for survival distributions with piece-wise constant hazards and multiple states and methods to plot and summarise those distributions. A derivation of the used algorithms can be found in my masters thesis <doi:10.25365/thesis.76098>.

This package provides tools for phase-type distributions including the following variants: continuous, discrete, multivariate, in-homogeneous, right-censored, and regression. Methods for functional evaluation, simulation and estimation using the expectation-maximization (EM) algorithm are provided for all models. The methods of this package are based on the following references. Asmussen, S., Nerman, O., & Olsson, M. (1996). Fitting phase-type distributions via the EM algorithm, Olsson, M. (1996). Estimation of phase-type distributions from censored data, Albrecher, H., & Bladt, M. (2019) <doi:10.1017/jpr.2019.60>, Albrecher, H., Bladt, M., & Yslas, J. (2022) <doi:10.1111/sjos.12505>, Albrecher, H., Bladt, M., Bladt, M., & Yslas, J. (2022) <doi:10.1016/j.insmatheco.2022.08.001>, Bladt, M., & Yslas, J. (2022) <doi:10.1080/03461238.2022.2097019>, Bladt, M. (2022) <doi:10.1017/asb.2021.40>, Bladt, M. (2023) <doi:10.1080/10920277.2023.2167833>, Albrecher, H., Bladt, M., & Mueller, A. (2023) <doi:10.1515/demo-2022-0153>, Bladt, M. & Yslas, J. (2023) <doi:10.1016/j.insmatheco.2023.02.008>.

This package provides functionality for estimating cross-sectional network structures representing partial correlations while accounting for missing data. Networks are estimated via neighborhood selection or regularization, with model selection guided by information criteria. Missing data can be handled primarily via multiple imputation or a maximum likelihood-based approach, as demonstrated by Nehler and Schultze (2025a) <doi:10.31234/osf.io/qpj35> and Nehler and Schultze (2025b) <doi:10.1080/00273171.2025.2503833>. Deletion-based approaches are also available but play a secondary role.

These guidelines are meant to provide a pragmatic, yet rigorous, help to drug developers and decision makers, since they are shaped by three fundamental ingredients: the clinically determined margin of detriment on OS that is unacceptably high (delta null); the benefit on OS that is plausible given the mechanism of action of the novel intervention (delta alt); and the quantity of information (i.e. survival events) it is feasible to accrue given the clinical and drug development setting. The proposed guidelines facilitate transparent discussions between stakeholders focusing on the risks of erroneous decisions and what might be an acceptable trade-off between power and the false positive error rate.

Modelling Multivariate Binary Data with Blocks of Specific One-Factor Distribution. Variables are grouped into independent blocks. Each variable is described by two continuous parameters (its marginal probability and its dependency strength with the other block variables), and one binary parameter (positive or negative dependency). Model selection consists in the estimation of the repartition of the variables into blocks. It is carried out by the maximization of the BIC criterion by a deterministic (faster) algorithm or by a stochastic (more time consuming but optimal) algorithm. Tool functions facilitate the model interpretation.

This package provides a simple and the early stage package for matrix profile based on the paper of Chin-Chia Michael Yeh, Yan Zhu, Liudmila Ulanova, Nurjahan Begum, Yifei Ding, Hoang Anh Dau, Diego Furtado Silva, Abdullah Mueen, and Eamonn Keogh (2016) <DOI:10.1109/ICDM.2016.0179>. This package calculates all-pairs-similarity for a given window size for time series data.

This function allows to generate two biological conditions synthetic microarray dataset which has similar behavior to those currently observed with common platforms. User provides a subset of parameters. Available default parameters settings can be modified.

Gene selection based on variance using the marginal distributions of gene profiles that characterized by a mixture of three-component multivariate distributions. Please see the reference: Li X, Fu Y, Wang X, DeMeo DL, Tantisira K, Weiss ST, Qiu W. (2018) <doi:10.1155/2018/6591634>.

This package provides a simple function, mwsApp(), that runs a shiny app spanning multiple, connected windows. This uses all standard shiny conventions, and depends only on the shiny package.

This package provides a method for the multiresolution analysis of spatial fields and images to capture scale-dependent features. mrbsizeR is based on scale space smoothing and uses differences of smooths at neighbouring scales for finding features on different scales. To infer which of the captured features are credible, Bayesian analysis is used. The scale space multiresolution analysis has three steps: (1) Bayesian signal reconstruction. (2) Using differences of smooths, scale-dependent features of the reconstructed signal can be found. (3) Posterior credibility analysis of the differences of smooths created. The method has first been proposed by Holmstrom, Pasanen, Furrer, Sain (2011) <DOI:10.1016/j.csda.2011.04.011> and extended in Flury, Gerber, Schmid and Furrer (2021) <DOI:10.1016/j.spasta.2020.100483>.

This package performs Multiple Factor Analysis method for quantitative, categorical, frequency and mixed data, in addition to generating a lot of graphics, also has other useful functions.

We introduce a high-dimensional multi-study robust factor model, which learns latent features and accounts for the heterogeneity among source. It could be used for analyzing heterogeneous RNA sequencing data. More details can be referred to Jiang et al. (2025) <doi:10.48550/arXiv.2506.18478>.

An R interface for the Java Machine Learning for Language Toolkit (mallet) <http://mallet.cs.umass.edu/> to estimate probabilistic topic models, such as Latent Dirichlet Allocation. We can use the R package to read textual data into mallet from R objects, run the Java implementation of mallet directly in R, and extract results as R objects. The Mallet toolkit has many functions, this wrapper focuses on the topic modeling sub-package written by David Mimno. The package uses the rJava package to connect to a JVM.