Calculate optimal Zhong's two-/three-stage Phase II designs (see Zhong (2012) <doi:10.1016/j.cct.2012.07.006>). Generate Target Toxicity decision table for Phase I dose-finding (two-/three-stage). This package also allows users to run dose-finding simulations based on customized decision table.

Token-Oriented Object Notation (TOON) is a compact, human-readable serialization format designed for passing structured data to Large Language Models with significantly reduced token usage. It's intended for LLM input as a lossless, drop-in representation of JSON data.

This package provides a collection of functions to deal with the truncated univariate and multivariate normal and Student distributions, described in Botev (2017) <doi:10.1111/rssb.12162> and Botev and L'Ecuyer (2015) <doi:10.1109/WSC.2015.7408180>.

Implementation of Testlet and Item Response Theory. A light-version yet comprehensive and streamlined framework for psychometric analysis using unidimensional Item Response Theory (IRT; Baker & Kim (2004) <doi:10.1201/9781482276725>) and Testlet Response Theory (TRT; Wainer et al., (2007) <doi:10.1017/CBO9780511618765>). Designed for researchers, this package supports the estimation of item and person parameters for a wide variety of models, including binary (i.e., Rasch, 2-Parameter Logistic, 3-Parameter Logistic) and polytomous (Partial Credit Model, Generalized Partial Credit Model, Graded Response Model) formats. It also supports the estimation of Testlet models (Rasch Testlet, 2-Parameter Logistic Testlet, 3-Parameter Logistic Testlet, Bifactor, Partial Credit Model Testlet, Graded Response), allowing users to account for local item dependence in bundled items. A key feature is the specialized support for combination use and joint estimation of item response model and testlet response model in one calibration. Beyond standard estimation via Marginal Maximum Likelihood with Expectation-Maximization (EM) or Joint Maximum Likelihood, the package also offers Bayesian estimation using priors with maximum a posteriori (MAP) method for item response theory models. It also provides functions for scale linking and equating (Mean-Mean, Mean-Sigma, Stocking-Lord) to ensure comparability across mixed-format test forms. It also facilitates fixed-parameter calibration, enabling users to estimate person abilities with known item parameters or vice versa, which is essential for pre-equating studies and item bank maintenance. Comprehensive data simulation functions are included to generate synthetic datasets with complex structures, including mixed-model blocks and specific testlet effects, aiding in methodological research and study design validation. Researchers can try multiple simulation situations.

This package provides tools for Topological Data Analysis. The package focuses on statistical analysis of persistent homology and density clustering. For that, this package provides an R interface for the efficient algorithms of the C++ libraries GUDHI <https://project.inria.fr/gudhi/software/>, Dionysus <https://www.mrzv.org/software/dionysus/>, and PHAT <https://bitbucket.org/phat-code/phat/>. This package also implements methods from Fasy et al. (2014) <doi:10.1214/14-AOS1252> and Chazal et al. (2015) <doi:10.20382/jocg.v6i2a8> for analyzing the statistical significance of persistent homology features.

This package provides an intuitive interface for working with the competing risk endpoints. The package wraps the cmprsk package, and exports functions for univariate cumulative incidence estimates and competing risk regression. Methods follow those introduced in Fine and Gray (1999) <doi:10.1002/sim.7501>.

For high-dimensional data whose main feature is a large number, p, of variables but a small sample size, the null hypothesis that the marginal distributions of p variables are the same for two groups is tested. We propose a test statistic motivated by the simple idea of comparing, for each of the p variables, the empirical characteristic functions computed from the two samples. If one rejects this global null hypothesis of no differences in distributions between the two groups, a set of permutation p-values is reported to identify which variables are not equally distributed in both groups.

Fit, compare, and visualize Bayesian graphical vector autoregressive (GVAR) network models using Stan'. These models are commonly used in psychology to represent temporal and contemporaneous relationships between multiple variables in intensive longitudinal data. Fitted models can be compared with a test based on matrix norm differences of posterior point estimates to quantify the differences between two estimated networks. See also Siepe, Kloft & Heck (2024) <doi:10.31234/osf.io/uwfjc>.

Measures the degree of balance for a given phylogenetic tree by calculating the Total Cophenetic Index. Reference: A. Mir, F. Rossello, L. A. Rotger (2013). A new balance index for phylogenetic trees. Math. Biosci. 241, 125-136 <doi:10.1016/j.mbs.2012.10.005>.

Innovative Trend Analysis is a graphical method to examine the trends in time series data. Sequential Mann-Kendall test uses the intersection of prograde and retrograde series to indicate the possible change point in time series data. Distribution free cumulative sum charts indicate location and significance of the change point in time series. Zekai, S. (2011). <doi:10.1061/(ASCE)HE.1943-5584.0000556>. Grayson, R. B. et al. (1996). Hydrological Recipes: Estimation Techniques in Australian Hydrology. Cooperative Research Centre for Catchment Hydrology, Australia, p. 125. Sneyers, S. (1990). On the statistical analysis of series of observations. Technical note no 5 143, WMO No 725 415. Secretariat of the World Meteorological Organization, Geneva, 192 pp.

Creates, manipulates, queries and repairs vectors of parameter terms. Parameter terms are the labels used to reference values in vectors, matrices and arrays. They represent the names in coefficient tables and the column names in mcmc and mcmc.list objects.

This package implements methods for selecting the number of factors in Poisson factor models, with a primary focus on Thinning Cross-Validation (TCV). The TCV method is based on the data thinning technique, which probabilistically partitions each count observation into training and test sets while preserving the underlying factor structure. The Poisson factor model is then fit on the training set, and model selection is performed by comparing predictive performance on the test set. This toolkit is designed for researchers working with high-dimensional count data in fields such as genomics, text mining, and social sciences. The data thinning methodology is detailed in Dharamshi et al. (2025) <doi:10.1080/01621459.2024.2353948> and Wang et al. (2025) <doi:10.1080/01621459.2025.2546577>.

Create structured, formatted HTML tables of in a flexible and convenient way.

Infer constant and stochastic, time-dependent parameters to consider intrinsic stochasticity of a dynamic model and/or to analyze model structure modifications that could reduce model deficits. The concept is based on inferring time-dependent parameters as stochastic processes in the form of Ornstein-Uhlenbeck processes jointly with inferring constant model parameters and parameters of the Ornstein-Uhlenbeck processes. The package also contains functions to sample from and calculate densities of Ornstein-Uhlenbeck processes. References: Tomassini, L., Reichert, P., Kuensch, H.-R. Buser, C., Knutti, R. and Borsuk, M.E. (2009), A smoothing algorithm for estimating stochastic, continuous-time model parameters and its application to a simple climate model, Journal of the Royal Statistical Society: Series C (Applied Statistics) 58, 679-704, <doi:10.1111/j.1467-9876.2009.00678.x> Reichert, P., and Mieleitner, J. (2009), Analyzing input and structural uncertainty of nonlinear dynamic models with stochastic, time-dependent parameters. Water Resources Research, 45, W10402, <doi:10.1029/2009WR007814> Reichert, P., Ammann, L. and Fenicia, F. (2021), Potential and challenges of investigating intrinsic uncertainty of hydrological models with time-dependent, stochastic parameters. Water Resources Research 57(8), e2020WR028311, <doi:10.1029/2020WR028311> Reichert, P. (2022), timedeppar: An R package for inferring stochastic, time-dependent model parameters, in preparation.

Mixed models for repeated measures (MMRM) are a popular choice for analyzing longitudinal continuous outcomes in randomized clinical trials and beyond; see for example Cnaan, Laird and Slasor (1997) <doi:10.1002/(SICI)1097-0258(19971030)16:20%3C2349::AID-SIM667%3E3.0.CO;2-E>. This package provides an interface for fitting MMRM within the tern <https://cran.r-project.org/package=tern> framework by Zhu et al. (2023) and tabulate results easily using rtables <https://cran.r-project.org/package=rtables> by Becker et al. (2023). It builds on mmrm <https://cran.r-project.org/package=mmrm> by Sabanés Bové et al. (2023) for the actual MMRM computations.

When plotting treated-minus-control differences, after-minus-before changes, or difference-in-differences, the ttrans() function symmetrically transforms the positive and negative tails to aid plotting. The package includes an observational study with three control groups and an unaffected outcome; see Rosenbaum (2022) <doi:10.1080/00031305.2022.2063944>.

Draws tornado plots for model sensitivity to univariate changes. Implements methods for many modeling methods including linear models, generalized linear models, survival regression models, and arbitrary machine learning models in the caret package. Also draws variable importance plots.

Comprehensive functions to calculate sample size and power for clinical trials with two co-primary endpoints. The package supports five endpoint combinations: two continuous endpoints (Sozu et al. 2011 <doi:10.1080/10543406.2011.551329>), two binary endpoints using asymptotic methods (Sozu et al. 2010 <doi:10.1002/sim.3972>) and exact methods (Homma and Yoshida 2025 <doi:10.1177/09622802251368697>), mixed continuous and binary endpoints (Sozu et al. 2012 <doi:10.1002/bimj.201100221>), and mixed count and continuous endpoints (Homma and Yoshida 2024 <doi:10.1002/pst.2337>). All methods appropriately account for correlation between endpoints and provide both sample size and power calculation capabilities.

To handle higher-order tensor data. See Kolda and Bader (2009) <doi:10.1137/07070111X> for details on tensor. While existing packages on tensor data extend the base array class to some data classes, this package serves as an alternative resort to handle tensor only as array class. Some functionalities related to missingness are also supported.

This package provides a tm Source to create corpora from articles exported from the LexisNexis content provider as HTML files. It is able to read both text content and meta-data information (including source, date, title, author and pages). Note that the file format is highly unstable: there is no warranty that this package will work for your corpus, and you may have to adjust the code to adapt it to your particular format.

Component analysis for three-way data arrays by means of Candecomp/Parafac, Tucker3, Tucker2 and Tucker1 models.

This package provides a slightly-opinionated R interface for the Tremendous API (<https://www.tremendous.com/>). In addition to supporting GET and POST requests, tremendousr has, dare I say, tremendously intuitive functions for sending digital rewards and incentives directly from R.

This package provides functionalities based on the paper "Time Varying Dictionary and the Predictive Power of FED Minutes" (Lima, 2018) <doi:10.2139/ssrn.3312483>. It selects the most predictive terms, that we call time-varying dictionary using supervised machine learning techniques as lasso and elastic net.

Statistics students often have problems understanding the relation between a random variable's true scale and its z-values. To allow instructors to better better visualize histograms for these students, the package provides histograms with two horizontal axis containing z-values and the true scale of the variable. The function TeachHistDens() provides a density histogram with two axis. TeachHistCounts() and TeachHistRelFreq() are variations for count and relative frequency histograms, respectively. TeachConfInterv() and TeachHypTest() help instructors to visualize confidence levels and the results of hypothesis tests.