Wrapper around the Open Source Routing Machine (OSRM) API <http://project-osrm.org/>. osrmr works with API versions 4 and 5 and can handle servers that run locally as well as the OSRM webserver.

Allows you to easily execute expensive compute operations only once, and save the resulting object to disk.

Anomaly detection in dynamic, temporal networks. The package oddnet uses a feature-based method to identify anomalies. First, it computes many features for each network. Then it models the features using time series methods. Using time series residuals it detects anomalies. This way, the temporal dependencies are accounted for when identifying anomalies (Kandanaarachchi, Hyndman 2022) <arXiv:2210.07407>.

This package provides functions to estimate the optimal threshold of diagnostic markers or treatment selection markers. The optimal threshold is the marker value that maximizes the utility of the marker based-strategy (for diagnostic or treatment selection) in a given population. The utility function depends on the type of marker (diagnostic or treatment selection), but always takes into account the preferences of the patients or the physician in the decision process. For estimating the optimal threshold, ones must specify the distributions of the marker in different groups (defined according to the type of marker, diagnostic or treatment selection) and provides data to estimate the parameters of these distributions. Ones must also provide some features of the target populations (disease prevalence or treatment efficacies) as well as the preferences of patients or physicians. The functions rely on Bayesian inference which helps producing several indicators derived from the optimal threshold. See Blangero, Y, Rabilloud, M, Ecochard, R, and Subtil, F (2019) <doi:10.1177/0962280218821394> for the original article that describes the estimation method for treatment selection markers and Subtil, F, and Rabilloud, M (2019) <doi:10.1002/bimj.200900242> for diagnostic markers.

This is a tool to find the optimal rerandomization threshold in non-sequential experiments. We offer three procedures based on assumptions made on the residuals distribution: (1) normality assumed (2) excess kurtosis assumed (3) entire distribution assumed. Illustrations are included. Also included is a routine to unbiasedly estimate Frobenius norms of variance-covariance matrices. Details of the method can be found in "Optimal Rerandomization via a Criterion that Provides Insurance Against Failed Experiments" Adam Kapelner, Abba M. Krieger, Michael Sklar and David Azriel (2020) <arXiv:1905.03337>.

This package provides functions to retrieve public data from ORCID (Open Researcher and Contributor ID) records via the ORCID public API. Fetches employment history, education, works (publications, datasets, preprints), funding, peer review activities, and other public information. Returns data as structured data.table objects for easy analysis and manipulation. Replaces the discontinued rorcid package with a modern, CRAN-compliant implementation.

Apply unsupervised segmentation algorithms included in Orfeo ToolBox software (<https://www.orfeo-toolbox.org/>), such as mean shift or watershed segmentation.

Data input/output functions for data that conform to the Digital Imaging and Communications in Medicine (DICOM) standard, part of the Rigorous Analytics bundle.

Interface to OpenStreetMap API for fetching and saving data from/to the OpenStreetMap database (<https://wiki.openstreetmap.org/wiki/API_v0.6>).

Visualise results obtained from analysing data mapped to the Observational Medical Outcomes Partnership (OMOP) common data model using shiny applications.

Flexible optimizer with numerous input specifications for detailed parameterisation. Designed for complex loss functions with state and parameter space constraints. Visualization tools for validation and analysis of the convergence are included.

Implementation of optimistic optimization methods for global optimization of deterministic or stochastic functions. The algorithms feature guarantees of the convergence to a global optimum. They require minimal assumptions on the (only local) smoothness, where the smoothness parameter does not need to be known. They are expected to be useful for the most difficult functions when we have no information on smoothness and the gradients are unknown or do not exist. Due to the weak assumptions, however, they can be mostly effective only in small dimensions, for example, for hyperparameter tuning.

The identity provider ['OneLogin']<http://onelogin.com> is used for authentication via Single Sign On (SSO). This package provides an R interface to their API.

Match, download, convert and import Open Street Map data extracts obtained from several providers.

This package provides an R interface to the OMOPHub API for accessing OHDSI ATHENA standardized medical vocabularies. Supports concept search, vocabulary exploration, hierarchy navigation, relationship queries, and concept mappings with automatic pagination and rate limiting.

Offers a gene-based meta-analysis test with filtering to detect gene-environment interactions (GxE) with association data, proposed by Wang et al. (2018) <doi:10.1002/gepi.22115>. It first conducts a meta-filtering test to filter out unpromising SNPs by combining all samples in the consortia data. It then runs a test of omnibus-filtering-based GxE meta-analysis (ofGEM) that combines the strengths of the fixed- and random-effects meta-analysis with meta-filtering. It can also analyze data from multiple ethnic groups.

Provide principally an eponymic function that numerically computes the Le Cam's one-step estimator for an independent and identically distributed sample. One-step estimation is asymptotically efficient (see L. Le Cam (1956) <https://projecteuclid.org/euclid.bsmsp/1200501652>) and can be computed faster than the maximum likelihood estimator for large observation samples, see e.g. Brouste et al. (2021) <doi:10.32614/RJ-2021-044>.

Creativity research involves the need to score open-ended problems. Usually done by humans, automatic scoring using AI becomes more and more accurate. This package provides a simple interface to the Open Scoring API <https://openscoring.du.edu/docs>, leading creativity scoring technology by Organiscak et al. (2023) <doi:10.1016/j.tsc.2023.101356>. With it, you can score your own data directly from an R script.

Clinical reports generated by Oncomine Reporter software contain critical data in unstructured PDF format, making manual extraction time-consuming and error-prone. ORscraper provides a coherent suite of functions to automate this process, allowing researchers to parse reports, identify key biomarkers, extract genetic variant tables, and filter results. It also integrates with the NCBI ClinVar API <https://www.ncbi.nlm.nih.gov/clinvar/> to enrich extracted data.

Two-part system for first collecting then managing direct observation data, as described by Hibbing PR, Ellingson LD, Dixon PM, & Welk GJ (2018) <doi:10.1249/MSS.0000000000001486>.

This package provides a tool for visualizing numerical data (e.g., gene expression, protein abundance) on predefined anatomical maps of human/mouse organs and subcellular organelles. It supports customization of color schemes, filtering by organ systems (for organisms) or organelle types, and generation of optional bar charts for quantitative comparison. The package integrates coordinate data for organs and organelles to plot anatomical/subcellular contours, mapping data values to specific structures for intuitive visualization of biological data distribution.The underlying method was described in the preprint by Zhou et al. (2022) <doi:10.1101/2022.09.07.506938>.

Developed to help researchers who need to model the kinetics of carbon dioxide (CO2) production in alcoholic fermentation of wines, beers and other fermented products. The following models are available for modeling the carbon dioxide production curve as a function of time: 5PL, Gompertz and 4PL. This package has different functions, which applied can: perform the modeling of the data obtained in the fermentation and return the coefficients, analyze the model fit and return different statistical metrics, and calculate the kinetic parameters: Maximum production of carbon dioxide; Maximum rate of production of carbon dioxide; Moment in which maximum fermentation rate occurs; Duration of the latency phase for carbon dioxide production; Carbon dioxide produced until maximum fermentation rate occurs. In addition, a function that generates graphs with the observed and predicted data from the models, isolated and combined, is available. Gava, A., Borsato, D., & Ficagna, E. (2020)."Effect of mixture of fining agents on the fermentation kinetics of base wine for sparkling wine production: Use of methodology for modeling". <doi:10.1016/j.lwt.2020.109660>.

Set of tools to generate samples of k-th order statistics and others quantities of interest from new families of distributions. The main references for this package are: C. Kleiber and S. Kotz (2003) Statistical size distributions in economics and actuarial sciences; Gentle, J. (2009), Computational Statistics, Springer-Verlag; Naradajah, S. and Rocha, R. (2016), <DOI:10.18637/jss.v069.i10> and Stasinopoulos, M. and Rigby, R. (2015), <DOI:10.1111/j.1467-9876.2005.00510.x>. The families of distributions are: Benini distributions, Burr distributions, Dagum distributions, Feller-Pareto distributions, Generalized Pareto distributions, Inverse Pareto distributions, The Inverse Paralogistic distributions, Marshall-Olkin G distributions, exponentiated G distributions, beta G distributions, gamma G distributions, Kumaraswamy G distributions, generalized beta G distributions, beta extended G distributions, gamma G distributions, gamma uniform G distributions, beta exponential G distributions, Weibull G distributions, log gamma G I distributions, log gamma G II distributions, exponentiated generalized G distributions, exponentiated Kumaraswamy G distributions, geometric exponential Poisson G distributions, truncated-exponential skew-symmetric G distributions, modified beta G distributions, exponentiated exponential Poisson G distributions, Poisson-inverse gaussian distributions, Skew normal type 1 distributions, Skew student t distributions, Singh-Maddala distributions, Sinh-Arcsinh distributions, Sichel distributions, Zero inflated Poisson distributions.

Makes it easy to display descriptive information on a data set. Getting an easy overview of a data set by displaying and visualizing sample information in different tables (e.g., time and scope conditions). The package also provides publishable LaTeX code to present the sample information.