An educational package providing intuitive functions for calculating confidence intervals (CI) for various statistical parameters. Designed primarily for teaching and learning about statistical inference (particularly confidence intervals). Offers user-friendly wrappers around established methods for proportions, means, and bootstrap-based intervals. Integrates seamlessly with Tidyverse workflows, making it ideal for classroom demonstrations and student exercises.

This package provides a collection of data sets for teaching cluster analysis.

This package implements the Changepoints for a Range of Penalties (CROPS) algorithm of Haynes et al. (2017) <doi:10.1080/10618600.2015.1116445> for finding all of the optimal segmentations for multiple penalty values over a continuous range.

Biotechnology in spatial omics has advanced rapidly over the past few years, enhancing both throughput and resolution. However, existing annotation pipelines in spatial omics predominantly rely on clustering methods, lacking the flexibility to integrate extensive annotated information from single-cell RNA sequencing (scRNA-seq) due to discrepancies in spatial resolutions, species, or modalities. Here we introduce the CAESAR suite, an open-source software package that provides image-based spatial co-embedding of locations and genomic features. It uniquely transfers labels from scRNA-seq reference, enabling the annotation of spatial omics datasets across different technologies, resolutions, species, and modalities, based on the conserved relationship between signature genes and cells/locations at an appropriate level of granularity. Notably, CAESAR enriches location-level pathways, allowing for the detection of gradual biological pathway activation within spatially defined domain types. More details on the methods related to our paper currently under submission. A full reference to the paper will be provided in future versions once the paper is published.

This package provides a general-purpose toolkit for comparing any two data frames with optional CDISC (Clinical Data Interchange Standards Consortium) validation for clinical trial data. Core comparison functions work on arbitrary datasets: variable-level and observation-level comparison, data type checking, metadata attribute analysis (types, labels, lengths, formats), missing value handling, key-based row matching, tolerance-based numeric comparisons, and group-wise comparisons. Optional z-score outlier detection is available when enabled. When working with clinical data, the package additionally validates SDTM (Study Data Tabulation Model) and ADaM (Analysis Data Model) datasets against CDISC standards (SDTM IG 3.3/3.4, ADaM IG 1.1/1.2/1.3), automatically detecting domains and flagging non-conformant variables. Generates unified comparison reports in text or HTML format with interactive dashboards. For CDISC standards, see <https://www.cdisc.org/standards>.

This package provides a simple way to assess the stability of candidate housekeeping genes is implemented in this package.

Data stored in text file can be processed chunkwise using dplyr commands. These are recorded and executed per data chunk, so large files can be processed with limited memory using the LaF package.

Allows printing of character strings as messages/warnings/etc. with ASCII animals, including cats, cows, frogs, chickens, ghosts, and more.

Posterior inference under the convex mixture regression (CoMiRe) models introduced by Canale, Durante, and Dunson (2018) <doi:10.1111/biom.12917>.

This model fitting tool incorporates cyclic coordinate descent and majorization-minimization approaches to fit a variety of regression models found in large-scale observational healthcare data. Implementations focus on computational optimization and fine-scale parallelization to yield efficient inference in massive datasets. Please see: Suchard, Simpson, Zorych, Ryan and Madigan (2013) <doi:10.1145/2414416.2414791>.

Machine learning algorithms for predictor variables that are compositional data and the response variable is either continuous or categorical. Specifically, the Boruta variable selection algorithm, random forest, support vector machines and projection pursuit regression are included. Relevant papers include: Tsagris M.T., Preston S. and Wood A.T.A. (2011). "A data-based power transformation for compositional data". Fourth International International Workshop on Compositional Data Analysis. <doi:10.48550/arXiv.1106.1451> and Alenazi, A. (2023). "A review of compositional data analysis and recent advances". Communications in Statistics--Theory and Methods, 52(16): 5535--5567. <doi:10.1080/03610926.2021.2014890>.

Allows to generate colors from palettes defined in the colormap module of Node.js'. (see <https://github.com/bpostlethwaite/colormap> for more information). In total it provides 44 distinct palettes made from sequential and/or diverging colors. In addition to the pre defined palettes you can also specify your own set of colors. There are also scale functions that can be used with ggplot2'.

Constrained randomization by Raab and Butcher (2001) <doi:10.1002/1097-0258(20010215)20:3%3C351::AID-SIM797%3E3.0.CO;2-C> is suitable for cluster randomized trials (CRTs) with a small number of clusters (e.g., 20 or fewer). The procedure of constrained randomization is based on the baseline values of some cluster-level covariates specified. The intervention effect on the individual outcome can then be analyzed through clustered permutation test introduced by Gail, et al. (1996) <doi:10.1002/(SICI)1097-0258(19960615)15:11%3C1069::AID-SIM220%3E3.0.CO;2-Q>. Motivated from Li, et al. (2016) <doi:10.1002/sim.7410>, the package performs constrained randomization on the baseline values of cluster-level covariates and clustered permutation test on the individual-level outcomes for cluster randomized trials.

This package infers the causal effect of an intervention on a multivariate response through the use of Multivariate Bayesian Structural Time Series models (MBSTS) as described in Menchetti & Bojinov (2020) <arXiv:2006.12269>. The package also includes functions for model building and forecasting.

This package provides tools for creating and visualizing statistical process control charts. Control charts are used for monitoring measurement processes, such as those occurring in manufacturing. The objective is to monitor the history of such processes and flag outlying measurements: out-of-control signals. Montgomery, D. (2009, ISBN:978-0-470-16992-6) contains an extensive discussion of the methodology.

This package provides a method for modeling genetic data as a combination of discrete layers, within each of which relatedness may decay continuously with geographic distance. This package contains code for running analyses (which are implemented in the modeling language rstan') and visualizing and interpreting output. See the paper for more details on the model and its utility.

This package provides tools for interacting with the Circle CI API (<https://circleci.com/docs/api/v2/>). Besides executing common tasks such as querying build logs and restarting builds, this package also helps setting up permissions to deploy from builds.

This package provides a helpful R6 class and methods for interacting with the Posit Connect Server API along with some meaningful utility functions for regular tasks. API documentation varies by Posit Connect installation and version, but the latest documentation is also hosted publicly at <https://docs.posit.co/connect/api/>.

This package provides a chess program which allows the user to create a game, add moves, check for legal moves and game result, plot the board, take back, read and write FEN (Forsythâ Edwards Notation). A basic chess engine based on minimax is implemented.

Psychometrically analyze latent individual differences related to tasks, interventions, or maturational/aging effects in the context of experimental or longitudinal cognitive research using methods first described by Thomas et al. (2020) <doi:10.1177/0013164420919898>.

DNA methylation signatures are usually based on multivariate approaches that require hundreds of sites for predictions. CimpleG is a method for the detection of small CpG methylation signatures used for cell-type classification and deconvolution. CimpleG is time efficient and performs as well as top performing methods for cell-type classification of blood cells and other somatic cells, while basing its prediction on a single DNA methylation site per cell type (but users can also select more sites if they so wish). Users can train cell type classifiers ('CimpleG based, and others) and directly apply these in a deconvolution of cell mixes context. Altogether, CimpleG provides a complete computational framework for the delineation of DNAm signatures and cellular deconvolution. For more details see Maié et al. (2023) <doi:10.1186/s13059-023-03000-0>.

This package provides a toolkit for making use of credentials mediated by Posit Connect'. It handles the details of communicating with the Connect API correctly, OAuth token caching, and refresh behaviour.

This package provides a header only, C++ interface to R with enhancements over cpp11'. Enforces copy-on-write semantics consistent with R behavior. Offers native support for ALTREP objects, UTF-8 string handling, modern C++11 features and idioms, and reduced memory requirements. Allows for vendoring, making it useful for restricted environments. Compared to cpp11', it adds support for converting C++ maps to R lists, Roxygen documentation directly in C++ code, proper handling of matrix attributes, support for nullable external pointers, bidirectional copy of complex number types, flexibility in type conversions, use of nullable pointers, and various performance optimizations.

Implement an interval censor method to break ties when using data with ties to fitting a bivariate copula.