General optimisation and specific tools for the parameter estimation (i.e. calibration) of complex models, including stochastic ones. It implements generic functions that can be used for fitting any type of models, especially those with non-differentiable objective functions, with the same syntax as base::optim. It supports multiple phases estimation (sequential parameter masking), constrained optimization (bounding box restrictions) and automatic parallel computation of numerical gradients. Some common maximum likelihood estimation methods and automated construction of the objective function from simulated model outputs is provided. See <https://roliveros-ramos.github.io/calibrar/> for more details.

Parameters of a user-specified probability distribution are modelled by a multi-layer perceptron artificial neural network. This framework can be used to implement probabilistic nonlinear models including mixture density networks, heteroscedastic regression models, zero-inflated models, etc. following Cannon (2012) <doi:10.1016/j.cageo.2011.08.023>.

This package provides a new method for identification of clusters of genomic regions within chromosomes. Primarily, it is used for calling clusters of cis-regulatory elements (COREs). CREAM uses genome-wide maps of genomic regions in the tissue or cell type of interest, such as those generated from chromatin-based assays including DNaseI, ATAC or ChIP-Seq. CREAM considers proximity of the elements within chromosomes of a given sample to identify COREs in the following steps: 1) It identifies window size or the maximum allowed distance between the elements within each CORE, 2) It identifies number of elements which should be clustered as a CORE, 3) It calls COREs, 4) It filters the COREs with lowest order which does not pass the threshold considered in the approach.

This package provides methods and data for color science - color conversions by observer, illuminant, and gamma. Color matching functions and chromaticity diagrams. Color indices, color differences, and spectral data conversion/analysis. This package is deprecated and will someday be removed; for reasons and details please see the README file.

Quickly estimate the net growth rate of a population or clone whose growth can be approximated by a birth-death branching process. Input should be phylogenetic tree(s) of clone(s) with edge lengths corresponding to either time or mutations. Based on coalescent results in Johnson et al. (2023) <doi:10.1093/bioinformatics/btad561>. Simulation techniques as well as growth rate methods build on prior work from Lambert A. (2018) <doi:10.1016/j.tpb.2018.04.005> and Stadler T. (2009) <doi:10.1016/j.jtbi.2009.07.018>.

It fits linear regression models for censored spatial data. It provides different estimation methods as the SAEM (Stochastic Approximation of Expectation Maximization) algorithm and seminaive that uses Kriging prediction to estimate the response at censored locations and predict new values at unknown locations. It also offers graphical tools for assessing the fitted model. More details can be found in Ordonez et al. (2018) <doi:10.1016/j.spasta.2017.12.001>.

Collects several different methods for analyzing and working with connectivity data in R. Though primarily oriented towards marine larval dispersal, many of the methods are general and useful for terrestrial systems as well.

Interacting with binary files can be difficult because R's types are a subset of what is generally supported by C'. This package provides a suite of functions for reading and writing binary data (with files, connections, and raw vectors) using C type descriptions. These functions convert data between C types and R types while checking for values outside the type limits, NA values, etc.

This package implements algorithms for analyzing Cayley graphs of permutation groups, with a focus on the TopSpin puzzle and similar permutation-based combinatorial puzzles. Provides methods for cycle detection, state space exploration, bidirectional BFS pathfinding, and finding optimal operation sequences in permutation groups generated by shift and reverse operations. Includes C++ implementations of core operations via Rcpp for performance. Optional GPU acceleration via ggmlR Vulkan backend for batch distance calculations and parallel state transformations.

This package provides a header-only C++20 API for manipulating R data structures from C++'. Provides C++20 concepts specific to R, custom scalar and vector classes with built-in NA handling, automatic object protection, SIMD (single-instruction-multiple-data), parallelisation, and a streamlined system for registering C++ functions, including templates, to R. Full API reference and documentation are available at <https://nicchr.github.io/cppally/>.

Colorful Data Frames in the terminal. The new class does change the behaviour of any of the objects, but adds a style definition and a print method. Using ANSI escape codes, it colors the terminal output of data frames. Some column types (such as p-values and identifiers) are automatically recognized.

This package implements coupling coordination degree (CCD) models and supports metacoupling analysis following Tang et al. (2021) <doi:10.1016/j.scs.2021.103405>.

Clean, decompose and aggregate univariate time series following the procedure "Cyclic/trend decomposition using bin interpolation" and the Logbox method for flagging outliers, both detailed in Ritter, F.: Technical note: A procedure to clean, decompose, and aggregate time series, Hydrol. Earth Syst. Sci., 27, 349â 361, <doi:10.5194/hess-27-349-2023>, 2023.

This package provides tools for analyzing performances of cricketers based on stats in ESPN Cricinfo Statsguru. The toolset can be used for analysis of Tests,ODIs and Twenty20 matches of both batsmen and bowlers. The package can also be used to analyze team performances.

The Core Microbiome refers to the group of microorganisms that are consistently present in a particular environment, habitat, or host species. These microorganisms play a crucial role in the functioning and stability of that ecosystem. Identifying these microorganisms can contribute to the emerging field of personalized medicine. The CoreMicrobiomeR is designed to facilitate the identification, statistical testing, and visualization of this group of microorganisms.This package offers three key functions to analyze and visualize microbial community data. This package has been developed based on the research papers published by Pereira et al.(2018) <doi:10.1186/s12864-018-4637-6> and Beule L, Karlovsky P. (2020) <doi:10.7717/peerj.9593>.

Utilize the shiny interface for visualizing results from a pyDarwin (<https://certara.github.io/pyDarwin/>) machine learning pharmacometric model search. It generates Goodness-of-Fit plots and summary tables for selected models, allowing users to customize diagnostic outputs within the interface. The underlying R code for generating plots and tables can be extracted for use outside the interactive session. Model diagnostics can also be incorporated into an R Markdown document and rendered in various output formats.

Predicts anticancer peptides using random forests trained on the n-gram encoded peptides. The implemented algorithm can be accessed from both the command line and shiny-based GUI. The CancerGram model is too large for CRAN and it has to be downloaded separately from the repository: <https://github.com/BioGenies/CancerGramModel>. For more information see: Burdukiewicz et al. (2020) <doi:10.3390/pharmaceutics12111045>.

This package performs a series of offline and/or online change-point detection algorithms for 1) univariate mean: <doi:10.1214/20-EJS1710>, <arXiv:2006.03283>; 2) univariate polynomials: <doi:10.1214/21-EJS1963>; 3) univariate and multivariate nonparametric settings: <doi:10.1214/21-EJS1809>, <doi:10.1109/TIT.2021.3130330>; 4) high-dimensional covariances: <doi:10.3150/20-BEJ1249>; 5) high-dimensional networks with and without missing values: <doi:10.1214/20-AOS1953>, <arXiv:2101.05477>, <arXiv:2110.06450>; 6) high-dimensional linear regression models: <arXiv:2010.10410>, <arXiv:2207.12453>; 7) high-dimensional vector autoregressive models: <arXiv:1909.06359>; 8) high-dimensional self exciting point processes: <arXiv:2006.03572>; 9) dependent dynamic nonparametric random dot product graphs: <arXiv:1911.07494>; 10) univariate mean against adversarial attacks: <arXiv:2105.10417>.

This is a function for validating microarray clusters via reproducibility, based on the paper referenced below.

This package provides a candidate correspondence table between two classifications can be created when there are correspondence tables leading from the first classification to the second one via intermediate pivot classifications. The correspondence table between two statistical classifications can be updated when one of the classifications gets updated to a new version.

Parameter estimation, one-step ahead forecast and new location prediction methods for spatio-temporal data.

Modular and unified R6-based interface for counterfactual explanation methods. The following methods are currently implemented: Burghmans et al. (2022) <doi:10.48550/arXiv.2104.07411>, Dandl et al. (2020) <doi:10.1007/978-3-030-58112-1_31> and Wexler et al. (2019) <doi:10.1109/TVCG.2019.2934619>. Optional extensions allow these methods to be applied to a variety of models and use cases. Once generated, the counterfactuals can be analyzed and visualized by provided functionalities. The package is described in detail in Dandl et al. (2025) <doi:10.18637/jss.v115.i09>.

Copula-based imputation methods: parametric and nonparametric algorithms for missing multivariate data through conditional copulas.

Adjusts the loglikelihood of common econometric models for clustered data based on the estimation process suggested in Chandler and Bate (2007) <doi:10.1093/biomet/asm015>, using the chandwich package <https://cran.r-project.org/package=chandwich>, and provides convenience functions for inference on the adjusted models.