We provide a collection of various classical tests and latest normal-reference tests for comparing high-dimensional mean vectors including two-sample and general linear hypothesis testing (GLHT) problem. Some existing tests for two-sample problem [see Bai, Zhidong, and Hewa Saranadasa.(1996) <https://www.jstor.org/stable/24306018>; Chen, Song Xi, and Ying-Li Qin.(2010) <doi:10.1214/09-aos716>; Srivastava, Muni S., and Meng Du.(2008) <doi:10.1016/j.jmva.2006.11.002>; Srivastava, Muni S., Shota Katayama, and Yutaka Kano.(2013)<doi:10.1016/j.jmva.2012.08.014>]. Normal-reference tests for two-sample problem [see Zhang, Jin-Ting, Jia Guo, Bu Zhou, and Ming-Yen Cheng.(2020) <doi:10.1080/01621459.2019.1604366>; Zhang, Jin-Ting, Bu Zhou, Jia Guo, and Tianming Zhu.(2021) <doi:10.1016/j.jspi.2020.11.008>; Zhang, Liang, Tianming Zhu, and Jin-Ting Zhang.(2020) <doi:10.1016/j.ecosta.2019.12.002>; Zhang, Liang, Tianming Zhu, and Jin-Ting Zhang.(2023) <doi:10.1080/02664763.2020.1834516>; Zhang, Jin-Ting, and Tianming Zhu.(2022) <doi:10.1080/10485252.2021.2015768>; Zhang, Jin-Ting, and Tianming Zhu.(2022) <doi:10.1007/s42519-021-00232-w>; Zhu, Tianming, Pengfei Wang, and Jin-Ting Zhang.(2023) <doi:10.1007/s00180-023-01433-6>]. Some existing tests for GLHT problem [see Fujikoshi, Yasunori, Tetsuto Himeno, and Hirofumi Wakaki.(2004) <doi:10.14490/jjss.34.19>; Srivastava, Muni S., and Yasunori Fujikoshi.(2006) <doi:10.1016/j.jmva.2005.08.010>; Yamada, Takayuki, and Muni S. Srivastava.(2012) <doi:10.1080/03610926.2011.581786>; Schott, James R.(2007) <doi:10.1016/j.jmva.2006.11.007>; Zhou, Bu, Jia Guo, and Jin-Ting Zhang.(2017) <doi:10.1016/j.jspi.2017.03.005>]. Normal-reference tests for GLHT problem [see Zhang, Jin-Ting, Jia Guo, and Bu Zhou.(2017) <doi:10.1016/j.jmva.2017.01.002>; Zhang, Jin-Ting, Bu Zhou, and Jia Guo.(2022) <doi:10.1016/j.jmva.2021.104816>; Zhu, Tianming, Liang Zhang, and Jin-Ting Zhang.(2022) <doi:10.5705/ss.202020.0362>; Zhu, Tianming, and Jin-Ting Zhang.(2022) <doi:10.1007/s00180-021-01110-6>; Zhang, Jin-Ting, and Tianming Zhu.(2022) <doi:10.1016/j.csda.2021.107385>].

Computes the ACMIF test and Bonferroni-adjusted p-value of interaction in two-factor studies. Produces corresponding interaction plot and analysis of variance tables and p-values from several other tests of non-additivity.

This package provides a set of routines to quickly download and import the HUGO Gene Nomenclature Committee (HGNC) data set on mapping of gene symbols to gene entries in other genomic databases or resources.

Pfafstetter Hydrological Codes as cited in Verdin and Verdin (1999) <doi: 10.1016/S0022-1694(99)00011-6> are decoded for upstream or downstream queries.

This package provides a scalable implementation of the highly adaptive lasso algorithm, including routines for constructing sparse matrices of basis functions of the observed data, as well as a custom implementation of Lasso regression tailored to enhance efficiency when the matrix of predictors is composed exclusively of indicator functions. For ease of use and increased flexibility, the Lasso fitting routines invoke code from the glmnet package by default. The highly adaptive lasso was first formulated and described by MJ van der Laan (2017) <doi:10.1515/ijb-2015-0097>, with practical demonstrations of its performance given by Benkeser and van der Laan (2016) <doi:10.1109/DSAA.2016.93>. This implementation of the highly adaptive lasso algorithm was described by Hejazi, Coyle, and van der Laan (2020) <doi:10.21105/joss.02526>.

Joint models have been widely used to study the associations between longitudinal biomarkers and a survival outcome. However, existing joint models only consider one or a few longitudinal biomarkers and cannot deal with high-dimensional longitudinal biomarkers. This package can be used to fit our recently developed penalized joint model that can handle high-dimensional longitudinal biomarkers. Specifically, an adaptive lasso penalty is imposed on the parameters for the effects of the longitudinal biomarkers on the survival outcome, which allows for variable selection. Also, our algorithm is computationally efficient, which is based on the Gaussian variational approximation method.

This package performs Gaussian process regression with heteroskedastic noise following the model by Binois, M., Gramacy, R., Ludkovski, M. (2016) <doi:10.48550/arXiv.1611.05902>, with implementation details in Binois, M. & Gramacy, R. B. (2021) <doi:10.18637/jss.v098.i13>. The input dependent noise is modeled as another Gaussian process. Replicated observations are encouraged as they yield computational savings. Sequential design procedures based on the integrated mean square prediction error and lookahead heuristics are provided, and notably fast update functions when adding new observations.

Apply an adaptation of the SuperFastHash algorithm to any R object. Hash whole R objects or, for vectors or lists, hash R objects to obtain a set of hash values that is stored in a structure equivalent to the input. See <http://www.azillionmonkeys.com/qed/hash.html> for a description of the hash algorithm.

Work with model files (setup, input, output) from the hydrological catchment model HYPE: Streamlined file import and export, standard evaluation plot routines, diverse post-processing and aggregation routines for hydrological model analysis. The HYPEtools package is also archived at <doi:10.5281/zenodo.7627955> and can be cited in publications with Brendel et al. (2024) <doi:10.1016/j.envsoft.2024.106094>.

Various functions and algorithms are provided here for solving optimal matching tasks in the context of preclinical cancer studies. Further, various helper and plotting functions are provided for unsupervised and supervised machine learning as well as longitudinal mixed-effects modeling of tumor growth response patterns.

This package contains ten datasets used in the chapters and exercises of Paul, Alice (2023) "Health Data Science in R" <https://alicepaul.github.io/health-data-science-using-r/>.

Spatial heterogeneity can be specified in various ways. hspm is an ambitious project that aims at implementing various methodologies to control for heterogeneity in spatial models. The current version of hspm deals with spatial and (non-spatial) regimes models. In particular, the package allows to estimate a general spatial regimes model with additional endogenous variables, specified in terms of a spatial lag of the dependent variable, the spatially lagged regressors, and, potentially, a spatially autocorrelated error term. Spatial regime models are estimated by instrumental variables and generalized methods of moments (see Arraiz et al., (2010) <doi:10.1111/j.1467-9787.2009.00618.x>, Bivand and Piras, (2015) <doi:10.18637/jss.v063.i18>, Drukker et al., (2013) <doi:10.1080/07474938.2013.741020>, Kelejian and Prucha, (2010) <doi:10.1016/j.jeconom.2009.10.025>).

This package provides a set of tools supporting more flexible heatmaps. The graphics is grid-like using the old graphics system. The main function is heatmap.n2(), which is a wrapper around the various functions constructing individual parts of the heatmap, like sidebars, picket plots, legends etc. The function supports zooming and splitting, i.e., having (unlimited) small heatmaps underneath each other in one plot deriving from the same data set, e.g., clustered and ordered by a supervised clustering method.

We provide extensions to the classical dataset "Example 4: Death by the kick of a horse in the Prussian Army" first used by Ladislaus von Bortkeiwicz in his treatise on the Poisson distribution "Das Gesetz der kleinen Zahlen", <DOI:10.1017/S0370164600019453>. As well as an extended time series for the horse-kick death data, we also provide, in parallel, deaths by falling from a horse and by drowning.

Analysis of plant pathogen pathotype survey data. Functions provided calculate distribution of susceptibilities, distribution of complexities with statistics, pathotype frequency distribution, as well as diversity indices for pathotypes. This package is meant to be a direct replacement for Herrmann, Löwer and Schachtel's (1999) <doi:10.1046/j.1365-3059.1999.00325.x> Habgood-Gilmour Spreadsheet, HaGiS', previously used for pathotype analysis.

Add, share and manage annotations for Shiny applications and R Markdown documents via hypothes.is'.

Generates Hadamard matrices using different construction methods. For those who want to generate Hadamard matrix, a generic function, Hadamard_matrix() is provided. For those who want to generate Hadamard matrix using a particular method, separate functions are available. See Horadam (2007, ISBN:9780691119212) Hadamard Matrices and their applications, Princeton University Press for more information on Hadamard Matrices.

This package provides a Haar-Fisz algorithm for Poisson intensity estimation. Will denoise Poisson distributed sequences where underlying intensity is not constant. Uses the multiscale variance-stabilization method called the Haar-Fisz transform. Contains functions to carry out the forward and inverse Haar-Fisz transform and denoising on near-Gaussian sequences. Can also carry out cycle-spinning. Main reference: Fryzlewicz, P. and Nason, G.P. (2004) "A Haar-Fisz algorithm for Poisson intensity estimation." Journal of Computational and Graphical Statistics, 13, 621-638. <doi:10.1198/106186004X2697>.

This package implements Heckman selection models using a Bayesian approach via Stan and compares the performance of normal, Studentâ s t, and contaminated normal distributions in addressing complexities and selection bias (Heeju Lim, Victor E. Lachos, and Victor H. Lachos, Bayesian analysis of flexible Heckman selection models using Hamiltonian Monte Carlo, 2025, under submission).

This package provides tools to estimate, compare, and visualize healthcare resource utilization using data derived from electronic health records or real-world evidence sources. The package supports pre index and post index analysis, patient cohort comparison, and customizable summaries and visualizations for clinical and health economics research. Methods implemented are based on Scott et al. (2022) <doi:10.1080/13696998.2022.2037917> and Xia et al. (2024) <doi:10.14309/ajg.0000000000002901>.

This package provides a modern idiomatic header-only C++ interface for libhdf5'. Original software can be found at <https://github.com/highfive-devs/highfive/>.

Automatically displays the order and spatial weighting matrix of the distance between locations. This concept was derived from the research of Mubarak, Aslanargun, and Siklar (2021) <doi:10.52403/ijrr.20211150> and Mubarak, Aslanargun, and Siklar (2022) <doi:10.17654/0972361722052>. Distance data between locations can be imported from Ms. Excel', maps package or created in R programming directly. This package also provides 5 simulations of distances between locations derived from fictitious data, the maps package, and from research by Mubarak, Aslanargun, and Siklar (2022) <doi:10.29244/ijsa.v6i1p90-100>.

This package provides a collection of reweighted marginal hypothesis tests for clustered data, based on reweighting methods of Williamson, J., Datta, S., and Satten, G. (2003) <doi:10.1111/1541-0420.00005>. The tests in this collection are clustered analogs to well-known hypothesis tests in the classical setting, and are appropriate for data with cluster- and/or group-size informativeness. The syntax and output of functions are modeled after common, recognizable functions native to R. Methods used in the package refer to Gregg, M., Datta, S., and Lorenz, D. (2020) <doi:10.1177/0962280220928572>, Nevalainen, J., Oja, H., and Datta, S. (2017) <doi:10.1002/sim.7288> Dutta, S. and Datta, S. (2015) <doi:10.1111/biom.12447>, Lorenz, D., Datta, S., and Harkema, S. (2011) <doi:10.1002/sim.4368>, Datta, S. and Satten, G. (2008) <doi:10.1111/j.1541-0420.2007.00923.x>, Datta, S. and Satten, G. (2005) <doi:10.1198/016214504000001583>.

Discriminant analysis and data clustering methods for high dimensional data, based on the assumption that high-dimensional data live in different subspaces with low dimensionality proposing a new parametrization of the Gaussian mixture model which combines the ideas of dimension reduction and constraints on the model.