Cure dependent censoring regression models for long-term survival multivariate data. These models are based on extensions of the frailty models, capable to accommodating the cure fraction and the dependence between failure and censoring times, with Weibull and piecewise exponential marginal distributions. Theoretical details regarding the models implemented in the package can be found in Schneider et al. (2022) <doi:10.1007/s10651-022-00549-0>.

This package provides a uniform statistical inferential tool in making individualized treatment decisions, which implements the methods of Ma et al. (2017)<DOI:10.1177/0962280214541724> and Guo et al. (2021)<DOI:10.1080/01621459.2020.1865167>. It uses a flexible semiparametric modeling strategy for heterogeneous treatment effect estimation in high-dimensional settings and can gave valid confidence bands. Based on it, one can find the subgroups of patients that benefit from each treatment, thereby making individualized treatment selection.

Competence-based knowledge space theory (CbKST) is an extension of knowledge space theory (KST) modeling the latent skills and competencies underlying the observable response behaviour as described by Heller & Stefanutti (2024) <doi:10.1142/9789811280481_0001>. The package focuses on the mappings between competence and performance level (skill (multi) map, problem function etc.).

Compute expected shortfall (ES) and Value at Risk (VaR) from a quantile function, distribution function, random number generator, probability density function, or data. ES is also known as Conditional Value at Risk (CVaR). Virtually any continuous distribution can be specified. The functions are vectorized over the arguments. The computations are done directly from the definitions, see e.g. Acerbi and Tasche (2002) <doi:10.1111/1468-0300.00091>. Some support for GARCH models is provided, as well.

This package provides a collection of functions to calculate Composite Indicators methods, focusing, in particular, on the normalisation and weighting-aggregation steps, as described in OECD Handbook on constructing composite indicators: methodology and user guide, 2008, Vidoli and Fusco and Mazziotta <doi:10.1007/s11205-014-0710-y>, Mazziotta and Pareto (2016) <doi:10.1007/s11205-015-0998-2>, Van Puyenbroeck and Rogge <doi:10.1016/j.ejor.2016.07.038> and other authors.

It is an open source insurance claim simulation engine sponsored by the Casualty Actuarial Society. It generates individual insurance claims including open claims, reopened claims, incurred but not reported claims and future claims. It also includes claim data fitting functions to help set simulation assumptions. It is useful for claim level reserving analysis. Parodi (2013) <https://www.actuaries.org.uk/documents/triangle-free-reserving-non-traditional-framework-estimating-reserves-and-reserve-uncertainty>.

This package provides tools for interacting with the Circle CI API (<https://circleci.com/docs/api/v2/>). Besides executing common tasks such as querying build logs and restarting builds, this package also helps setting up permissions to deploy from builds.

This package contains a time series classification method that obtains a set of filters that maximize the between-class and minimize the within-class distances.

Example data sets to run the example problems from causal inference textbooks. Currently, contains data sets for Huntington-Klein, Nick (2021 and 2025) "The Effect" <https://theeffectbook.net>, first and second edition, Cunningham, Scott (2021 and 2025, ISBN-13: 978-0-300-25168-5) "Causal Inference: The Mixtape", and Hernán, Miguel and James Robins (2020) "Causal Inference: What If" <https://www.hsph.harvard.edu/miguel-hernan/causal-inference-book/>.

This package provides tools for advanced analysis of continuous glucose monitoring (CGM) time-series, implementing GRID (Glucose Rate Increase Detector) and GRID-based algorithms for postprandial peak detection, and detection of hypoglycemic and hyperglycemic episodes (Levels 1/2/Extended) aligned with international consensus CGM metrics. Core algorithms are implemented in optimized C++ using Rcpp to provide accurate and fast analysis on large datasets.

Estimation and inference methods for the continuous threshold expectile regression. It can fit the continuous threshold expectile regression and test the existence of change point, for the paper, "Feipeng Zhang and Qunhua Li (2016). A continuous threshold expectile regression, submitted.".

Several functions are available for calculating the most widely used effect sizes (ES), along with their variances, confidence intervals and p-values. The output includes ES's of d (mean difference), g (unbiased estimate of d), r (correlation coefficient), z (Fisher's z), and OR (odds ratio and log odds ratio). In addition, NNT (number needed to treat), U3, CLES (Common Language Effect Size) and Cliff's Delta are computed. This package uses recommended formulas as described in The Handbook of Research Synthesis and Meta-Analysis (Cooper, Hedges, & Valentine, 2009). A free web application is available at <https://acdelre.github.io/apps/compute_es/>.

This package implements the covariate balancing propensity score (CBPS) proposed by Imai and Ratkovic (2014) <DOI:10.1111/rssb.12027>. The propensity score is estimated such that it maximizes the resulting covariate balance as well as the prediction of treatment assignment. The method, therefore, avoids an iteration between model fitting and balance checking. The package also implements optimal CBPS from Fan et al. (in-press) <DOI:10.1080/07350015.2021.2002159>, several extensions of the CBPS beyond the cross-sectional, binary treatment setting. They include the CBPS for longitudinal settings so that it can be used in conjunction with marginal structural models from Imai and Ratkovic (2015) <DOI:10.1080/01621459.2014.956872>, treatments with three- and four-valued treatment variables, continuous-valued treatments from Fong, Hazlett, and Imai (2018) <DOI:10.1214/17-AOAS1101>, propensity score estimation with a large number of covariates from Ning, Peng, and Imai (2020) <DOI:10.1093/biomet/asaa020>, and the situation with multiple distinct binary treatments administered simultaneously. In the future it will be extended to other settings including the generalization of experimental and instrumental variable estimates.

This package provides a fast way to loop a character vector or file names as a menu in the console for the user to choose an option.

An implementation of efficiency first conformal prediction (EFCP) and validity first conformal prediction (VFCP) that demonstrates both validity (coverage guarantee) and efficiency (width guarantee). To learn how to use it, check the vignettes for a quick tutorial. The package is based on the work by Yang Y., Kuchibhotla A.,(2021) <arxiv:2104.13871>.

Clean, decompose and aggregate univariate time series following the procedure "Cyclic/trend decomposition using bin interpolation" and the Logbox method for flagging outliers, both detailed in Ritter, F.: Technical note: A procedure to clean, decompose, and aggregate time series, Hydrol. Earth Syst. Sci., 27, 349â 361, <doi:10.5194/hess-27-349-2023>, 2023.

An agent runtime that gives Large Language Models (LLMs) from Anthropic <https://www.anthropic.com/>, OpenAI <https://openai.com/>, Moonshot <https://www.moonshot.ai/>, and Ollama <https://ollama.com/> direct access to a live R session with managed workspace state. Tools execute as R function calls with provenance tracking, and a deterministic retrieval system keeps relevant objects in context across turns. Three entry points: a shell command-line interface (CLI), a console read-eval-print-loop via chat(), and a Model Context Protocol (MCP) server via serve() for external clients.

This package provides a large number of measurements generate count data. This is a statistical data type that only assumes non-negative integer values and is generated by counting. Typically, counting data can be found in biomedical applications, such as the analysis of DNA double-strand breaks. The number of DNA double-strand breaks can be counted in individual cells using various bioanalytical methods. For diagnostic applications, it is relevant to record the distribution of the number data in order to determine their biomedical significance (Roediger, S. et al., 2018. Journal of Laboratory and Precision Medicine. <doi:10.21037/jlpm.2018.04.10>). The software offers functions for a comprehensive automated evaluation of distribution models of count data. In addition to programmatic interaction, a graphical user interface (web server) is included, which enables fast and interactive data-scientific analyses. The user is supported in selecting the most suitable counting distribution for his own data set.

Clusters longitudinal trajectories over time (can be unequally spaced, unequal length time series and/or partially overlapping series) on a common time axis. Performs k-means clustering on a single continuous variable measured over time, where each mean is defined by a thin plate spline fit to all points in a cluster. Distance is MSE across trajectory points to cluster spline. Provides graphs of derived cluster splines, silhouette plots, and Adjusted Rand Index evaluations of the number of clusters. Scales well to large data with multicore parallelism available to speed computation.

This package provides a Shiny application to conduct comprehensive analysis of latent means including the examination of group equivalency, propensity score analysis, measurement invariance analysis, and assessment of latent mean differences of equivalent groups with invariant data. Group equivalency and propensity score analyses are implemented using the MatchIt package [Ho et al. (2011) <doi:10.18637/jss.v042.i08>], ensuring robust control for covariates. Structural equation modeling and invariance testing rely heavily on the lavaan package [Rosseel (2012) <doi:10.18637/jss.v048.i02>], providing a flexible and powerful modeling framework. The application also integrates modified functions from Hammack-Brown et al. (2021) <doi:10.1002/hrdq.21452> to support factor ratio testing and the list-and-delete procedure.

Immune related gene sets provided along with the cinaR package.

Assess the calibration of an existing (i.e. previously developed) multistate model through calibration plots. Calibration is assessed using one of three methods. 1) Calibration methods for binary logistic regression models applied at a fixed time point in conjunction with inverse probability of censoring weights. 2) Calibration methods for multinomial logistic regression models applied at a fixed time point in conjunction with inverse probability of censoring weights. 3) Pseudo-values estimated using the Aalen-Johansen estimator of observed risk. All methods are applied in conjunction with landmarking when required. These calibration plots evaluate the calibration (in a validation cohort of interest) of the transition probabilities estimated from an existing multistate model. While package development has focused on multistate models, calibration plots can be produced for any model which utilises information post baseline to update predictions (e.g. dynamic models); competing risks models; or standard single outcome survival models, where predictions can be made at any landmark time. Please see Pate et al. (2024) <doi:10.1002/sim.10094> and Pate et al. (2024) <https://alexpate30.github.io/calibmsm/articles/Overview.html>.

Maximum likelihood estimation of the Cauchy-Cacoullos (discrete Cauchy) distribution. Probability mass, distribution and quantile function are also included. The reference paper is: Papadatos N. (2022). "The Characteristic Function of the Discrete Cauchy Distribution in Memory of T. Cacoullos". Journal of Statistical Theory Practice, 16(3): 47. <doi:10.1007/s42519-022-00268-6>.

Generate random numbers from the Cryptographically Secure Pseudorandom Number Generator (CSPRNG) provided by the underlying operating system. System CSPRNGs are seeded internally by the OS with entropy it gathers from the system hardware. The following system functions are used: arc4random_buf() on macOS and BSD; BCryptgenRandom() on Windows; Sys_getrandom() on Linux.