Data from the United States Center for Medicare and Medicaid Services (CMS) is included in this package. There are ICD-9 and ICD-10 diagnostic and procedure codes, and lists of the chapter and sub-chapter headings and the ranges of ICD codes they encompass. There are also two sample datasets. These data are used by the icd package for finding comorbidities.

Simulation of the random evolution of heterogeneous populations using stochastic Individual-Based Models (IBMs) <doi:10.48550/arXiv.2303.06183>. The package enables users to simulate population evolution, in which individuals are characterized by their age and some characteristics, and the population is modified by different types of events, including births/arrivals, death/exit events, or changes of characteristics. The frequency at which an event can occur to an individual can depend on their age and characteristics, but also on the characteristics of other individuals (interactions). Such models have a wide range of applications. For instance, IBMs can be used for simulating the evolution of a heterogeneous insurance portfolio with selection or for validating mortality forecasts. This package overcomes the limitations of time-consuming IBMs simulations by implementing new efficient algorithms based on thinning methods, which are compiled using the Rcpp package while providing a user-friendly interface.

This package produces a publication-ready table that includes all effect estimates necessary for full reporting effect modification and interaction analysis as recommended by Knol and Vanderweele (2012) [<doi:10.1093/ije/dyr218>]. It also estimates confidence interval for the trio of additive interaction measures using the delta method (see Hosmer and Lemeshow (1992), [<doi:10.1097/00001648-199209000-00012>]), variance recovery method (see Zou (2008), [<doi:10.1093/aje/kwn104>]), or percentile bootstrapping (see Assmann et al. (1996), [<doi:10.1097/00001648-199605000-00012>]).

Allows for the non-parametric estimation of transition intensities in interval-censored multi-state models using the approach of Gomon and Putter (2024) <doi:10.48550/arXiv.2409.07176> or Gu et al. (2023) <doi:10.1093/biomet/asad073>.

Pre-processing and basic analytical tasks for working with Eurostat's symmetric inputâ output tables, and basic inputâ output economics calculations. Part of rOpenGov <https://ropengov.github.io/> for open source open government initiatives.

Compute missing values on a training data set and impute them on a new data set. Current available options are median/mode and random forest.

Generalized Odds Rate Hazards (GORH) model is a flexible model of fitting survival data, including the Proportional Hazards (PH) model and the Proportional Odds (PO) Model as special cases. This package fit the GORH model with interval censored data.

ISO 3166-1 country codes and ISO 4217 currency codes provided by the International Organization for Standardization.

This package provides datasets and functions for the class "Modelling and Data Analysis for Pharmaceutical Sciences". The datasets can be used to present various methods of data analysis and statistical modeling. Functions for data visualization are also implemented.

Interface to the OpenGWAS database API <https://api.opengwas.io/api/>. Includes a wrapper to make generic calls to the API, plus convenience functions for specific queries.

This package provides functions to analyse missing value mechanisms and to impute data sets in the context of bottom-up MS-based proteomics.

This package provides datasets and supporting functions for the book Introduction to Biostatistics with R by Schifano and Yan (2026+), published by Taylor & Francis. The package is intended for teaching introductory biostatistics and for reproducing examples in the text.

Implementation of Tyler, Critchley, Duembgen and Oja's (JRSS B, 2009, <doi:10.1111/j.1467-9868.2009.00706.x>) and Oja, Sirkia and Eriksson's (AJS, 2006, <https://www.ajs.or.at/index.php/ajs/article/view/vol35,%20no2%263%20-%207>) method of two different scatter matrices to obtain an invariant coordinate system or independent components, depending on the underlying assumptions.

This package provides a monthly summary of Iowa liquor (class E) sales from January 2015 to October 2020. See the package website for more information, documentation and examples. Data source: Iowa Data portal <https://data.iowa.gov/resource/m3tr-qhgy.csv>.

Compute distributional quantities for an Integrated Gamma (IG) or Integrated Gamma Limit (IGL) copula, such as a cdf and density. Compute corresponding conditional quantities such as the cdf and quantiles. Generate data from an IG or IGL copula. See the vignette for formulas, or for a derivation, see Coia, V (2017) "Forecasting of Nonlinear Extreme Quantiles Using Copula Models." PhD Dissertation, The University of British Columbia.

The Inductive Subgroup Comparison Approach ('ISCA') offers a way to compare groups that are internally differentiated and heterogeneous. It starts by identifying the social structure of a reference group against which a minority or another group is to be compared, yielding empirical subgroups to which minority members are then matched based on how similar they are. The modelling of specific outcomes then occurs within specific subgroups in which majority and minority members are matched. ISCA is characterized by its data-driven, probabilistic, and iterative approach and combines fuzzy clustering, Monte Carlo simulation, and regression analysis. ISCA_random_assignments() assigns subjects probabilistically to subgroups. ISCA_clustertable() provides summary statistics of each cluster across iterations. ISCA_modeling() provides Ordinary Least Squares regression results for each cluster across iterations. For further details please see Drouhot (2021) <doi:10.1086/712804>.

Generalised linear models via the iteratively reweighted least squares algorithm. The functions perform logistic, Poisson and Gamma regression (ISBN:9780412317606), either for a single model or many regression models in a column-wise fashion.

This package implements the Information Combination (IComb) approach proposed by Nguyen, Vahid and Wickramasuriya (2025)<https://www.monash.edu/business/ebs/research/publications/ebs/2025/wp11-2025.pdf> for hierarchical forecast reconciliation. The method combines information from base forecasts constructed using different information sets while ensuring coherence. It is implemented using a penalized regression-based framework.

Implementations of the weighted Kozachenko-Leonenko entropy estimator and independence tests based on this estimator, (Kozachenko and Leonenko (1987) <http://mi.mathnet.ru/eng/ppi797>). Also includes a goodness-of-fit test for a linear model which is an independence test between covariates and errors.

Manipulate integer-bounded intervals including finding overlaps, piling and merging.

Performing Item Response Theory analysis such as parameter estimation, ability estimation, data generation, item and model fit analyse, local independence assumption, dimensionality assumption, wright map, characteristic and information curves under various models with a user-friendly Graphic User Interface.

Non-parametric resampling-based inference tests for ExPosition.

Based on large margin principle, this package performs feature selection methods: "IM4E"(Iterative Margin-Maximization under Max-Min Entropy Algorithm); "Immigrate"(Iterative Max-Min Entropy Margin-Maximization with Interaction Terms Algorithm); "BIM"(Boosted version of IMMIGRATE algorithm); "Simba"(Iterative Search Margin Based Algorithm); "LFE"(Local Feature Extraction Algorithm). This package also performs prediction for the above feature selection methods.

This package provides a set of tools for processing and analyzing in vitro toxicokinetic measurements in a standardized and reproducible pipeline. The package was developed to perform frequentist and Bayesian estimation on a variety of in vitro toxicokinetic measurements including -- but not limited to -- chemical fraction unbound in the presence of plasma (f_up), intrinsic hepatic clearance (Clint, uL/min/million hepatocytes), and membrane permeability for oral absorption (Caco2). The methods provided by the package were described in Wambaugh et al. (2019) <doi:10.1093/toxsci/kfz205>.