This package provides functions that (1) fit multivariate discrete distributions, (2) generate random numbers from multivariate discrete distributions, and (3) run regression and penalized regression on the multivariate categorical response data. Implemented models include: multinomial logit model, Dirichlet multinomial model, generalized Dirichlet multinomial model, and negative multinomial model. Making the best of the minorization-maximization (MM) algorithm and Newton-Raphson method, we derive and implement stable and efficient algorithms to find the maximum likelihood estimates. On a multi-core machine, multi-threading is supported.

Estimates probit, logit, Poisson, negative binomial, and beta regression models, returning their marginal effects, odds ratios, or incidence rate ratios as an output. Greene (2008, pp. 780-7) provides a textbook introduction to this topic.

This package provides various functions for parameter estimation of one-dimensional stable distributions and their mixtures. It implements a diverse set of estimation methods, including quantile-based approaches, regression methods based on the empirical characteristic function (empirical, kernel, and recursive), and maximum likelihood estimation. For mixture models, it provides stochastic expectationâ maximization (SEM) algorithms and Bayesian estimation methods using sampling and importance sampling to overcome the long burn-in period of Markov Chain Monte Carlo (MCMC) strategies. The package also includes tools and statistical tests for analyzing whether a dataset follows a stable distribution. Some of the implemented methods are described in Hajjaji, O., Manou-Abi, S. M., and Slaoui, Y. (2024) <doi:10.1080/02664763.2024.2434627>.

Multiply robust estimation for population mean (Han and Wang 2013) <doi:10.1093/biomet/ass087>, regression analysis (Han 2014) <doi:10.1080/01621459.2014.880058> (Han 2016) <doi:10.1111/sjos.12177> and quantile regression (Han et al. 2019) <doi:10.1111/rssb.12309>.

Analyzes production and dispersal of seeds dispersed from trees and recovered in seed traps. Motivated by long-term inventory plots where seed collections are used to infer seed production by each individual plant.

This package implements likelihood inference based on higher order approximations for linear nonnormal regression models.

Uses dplyr and tidyeval to fit statistical models inside the database. It currently supports KMeans and linear regression models.

With foundations on the work by Goutali and Chebana (2024) <doi:10.1016/j.envsoft.2024.106090>, this package contains various univariate and multivariate trend tests. The main functions regard the Multivariate Dependence Trend and Multivariate Overall Trend tests as proposed by Goutali and Chebana (2024), as well as a plotting function that proves useful as a summary and complement of the tests. Although many packages and methods carry univariate tests, the Mann-Kendall and Spearman's rho test implementations are included in the package with an adapted version to hydrological formulation (e.g. as in Rao and Hamed 1998 <doi:10.1016/S0022-1694(97)00125-X> or Chebana 2022 <doi:10.1016/C2021-0-01317-1>). For better understanding of the example use of the functions, three datasets are included. These are synthetic data and shouldn't be used beyond that purpose.

Simulation-based sensitivity analysis for causal mediation studies. It numerically and graphically evaluates the sensitivity of causal mediation analysis results to the presence of unmeasured pretreatment confounding. The proposed method has primary advantages over existing methods. First, using an unmeasured pretreatment confounder conditional associations with the treatment, mediator, and outcome as sensitivity parameters, the method enables users to intuitively assess sensitivity in reference to prior knowledge about the strength of a potential unmeasured pretreatment confounder. Second, the method accurately reflects the influence of unmeasured pretreatment confounding on the efficiency of estimation of the causal effects. Third, the method can be implemented in different causal mediation analysis approaches, including regression-based, simulation-based, and propensity score-based methods. It is applicable to both randomized experiments and observational studies.

Convenience functions and datasets to be used with Practical Multilevel Modeling using R. The package includes functions for calculating group means, group mean centered variables, and displaying some basic missing data information. A function for computing robust standard errors for linear mixed models based on Liang and Zeger (1986) <doi:10.1093/biomet/73.1.13> and Bell and McCaffrey (2002) <https://www150.statcan.gc.ca/n1/en/pub/12-001-x/2002002/article/9058-eng.pdf?st=NxMjN1YZ> is included as well as a function for checking for level-one homoskedasticity (Raudenbush & Bryk, 2002, ISBN:076191904X).

Apply the marginal classification method to achieve the purpose of providing the point and interval estimates for the minimal clinically important difference based on the classical anchor-based method. For more details of the methodology, please see Zehua Zhou, Leslie J. Bisson and Jiwei Zhao (2021) <arXiv:2108.11589>.

Two method new of multigroup and simulation of data. The first technique called multigroup PCA (mgPCA) this multivariate exploration approach that has the idea of considering the structure of groups and / or different types of variables. On the other hand, the second multivariate technique called Multigroup Dimensionality Reduction (MDR) it is another multivariate exploration method that is based on projections. In addition, a method called Single Dimension Exploration (SDE) was incorporated for to analyze the exploration of the data. It could help us in a better way to observe the behavior of the multigroup data with certain variables of interest.

This package provides functions of marginal mean and quantile regression models are used to analyze environmental exposure and biomonitoring data with repeated measurements and non-detects (i.e., values below the limit of detection (LOD)), as well as longitudinal exposure data that include non-detects and time-dependent covariates. For more details see Chen IC, Bertke SJ, Curwin BD (2021) <doi:10.1038/s41370-021-00345-1>, Chen IC, Bertke SJ, Estill CF (2024) <doi:10.1038/s41370-024-00640-7>, Chen IC, Bertke SJ, Dahm MM (2024) <doi:10.1093/annweh/wxae068>, and Chen IC (2025) <doi:10.1038/s41370-025-00752-8>.

Data sets related to the Islas Malvinas /// Sets de datos relacionados a las Islas Malvinas - La Nación Argentina ratifica su legà tima e imprescriptible soberanà a sobre las islas Malvinas, Georgias del Sur y Sándwich del Sur y los espacios marà timos e insulares correspondientes, por ser parte integrante del territorio nacional. La recuperación de dichos territorios y el ejercicio pleno de la soberanà a, respetando el modo de vida de sus habitantes y conforme a los principios del Derecho Internacional, constituyen un objetivo permanente e irrenunciable del pueblo argentino.

Utility functions for mutational signature analysis as described in Alexandrov, L. B. (2020) <doi:10.1038/s41586-020-1943-3>. This package provides two groups of functions. One is for dealing with mutational signature "exposures" (i.e. the counts of mutations in a sample that are due to each mutational signature). The other group of functions is for matching or comparing sets of mutational signatures. mSigTools stands for mutational Signature analysis Tools.

This package provides a collection of functions to download and process weather data from the Oklahoma Mesonet <https://mesonet.org>. Functions are available for downloading station metadata, downloading Mesonet time series (MTS) files, importing MTS files into R, and converting soil temperature change measurements into soil matric potential and volumetric soil moisture.

Permutation tests for variance components for 2-level, 3-level and 4-level data with univariate or multivariate responses.

This package provides a disciplined, lazy subset of dplyr semantics for MongoDB aggregation pipelines. Queries remain lazy until collect() and compile into MongoDB-native aggregation stages.

If results from a meta-GWAS are used for validation in one of the cohorts that was included in the meta-analysis, this will yield biased (i.e. too optimistic) results. The validation cohort needs to be independent from the meta-Genome-Wide-Association-Study (meta-GWAS) results. MetaSubtract will subtract the results of the respective cohort from the meta-GWAS results analytically without having to redo the meta-GWAS analysis using the leave-one-out methodology. It can handle different meta-analyses methods and takes into account if single or double genomic control correction was applied to the original meta-analysis. It can also handle different meta-analysis methods. It can be used for whole GWAS, but also for a limited set of genetic markers. See for application: Nolte I.M. et al. (2017); <doi: 10.1038/ejhg.2017.50>.

The Mutual Information Index (M) introduced to social science literature by Theil and Finizza (1971) <doi:10.1080/0022250X.1971.9989795> is a multigroup segregation measure that is highly decomposable and that according to Frankel and Volij (2011) <doi:10.1016/j.jet.2010.10.008> and Mora and Ruiz-Castillo (2011) <doi:10.1111/j.1467-9531.2011.01237.x> satisfies the Strong Unit Decomposability and Strong Group Decomposability properties. This package allows computing and decomposing the total index value into its "between" and "within" terms. These last terms can also be decomposed into their contributions, either by group or unit characteristics. The factors that produce each "within" term can also be displayed at the user's request. The results can be computed considering a variable or sets of variables that define separate clusters.

Model time series using mixture autoregressive (MAR) models. Implemented are frequentist (EM) and Bayesian methods for estimation, prediction and model evaluation. See Wong and Li (2002) <doi:10.1111/1467-9868.00222>, Boshnakov (2009) <doi:10.1016/j.spl.2009.04.009>), and the extensive references in the documentation.

This package provides methods and functions to analyze the quantitative or qualitative performance for diagnostic assays, and outliers detection, reader precision and reference range are discussed. Most of the methods and algorithms refer to CLSI (Clinical & Laboratory Standards Institute) recommendations and NMPA (National Medical Products Administration) guidelines. In additional, relevant plots are constructed by ggplot2'.

Fit (by Maximum Likelihood or MCMC/Bayesian), simulate, and forecast various Markov-Switching GARCH models as described in Ardia et al. (2019) <doi:10.18637/jss.v091.i04>.

This package performs the multiple testing procedures of Cox (2011) <doi:10.5170/CERN-2011-006> and Wong and Cox (2007) <doi:10.1080/02664760701240014>.