This package creates sophisticated models of training data and validates the models with an independent test set, cross validation, or Out Of Bag (OOB) predictions on the training data. Create graphs and tables of the model validation results. Applies these models to GIS .img files of predictors to create detailed prediction surfaces. Handles large predictor files for map making, by reading in the .img files in chunks, and output to the .txt file the prediction for each data chunk, before reading the next chunk of data.

Cancer cells accumulate DNA mutations as result of DNA damage and DNA repair processes. This computational framework is aimed at deciphering DNA mutational signatures operating in cancer. The framework includes modules that support raw data import and processing, mutational signature extraction, and results interpretation and visualization. The framework accepts widely used file formats storing information about DNA variants, such as Variant Call Format files. The framework performs Non-Negative Matrix Factorization to extract mutational signatures explaining the observed set of DNA mutations. Bootstrapping is performed as part of the analysis. The framework supports parallelization and is optimized for use on multi-core systems. The software was described by Fantini D et al (2020) <doi:10.1038/s41598-020-75062-0> and is based on a custom R-based implementation of the original MATLAB WTSI framework by Alexandrov LB et al (2013) <doi:10.1016/j.celrep.2012.12.008>.

Plug-in and difference-based long-run covariance matrix estimation for time series regression. Two applications of hypothesis testing are also provided. The first one is for testing for structural stability in coefficient functions. The second one is aimed at detecting long memory in time series regression. Lujia Bai and Weichi Wu (2024)<doi:10.3150/23-BEJ1680> Zhou Zhou and Wei Biao Wu(2010)<doi:10.1111/j.1467-9868.2010.00743.x> Jianqing Fan and Wenyang Zhang<doi:10.1214/aos/1017939139> Lujia Bai and Weichi Wu(2024)<doi:10.1093/biomet/asae013> Dimitris N. Politis, Joseph P. Romano, Michael Wolf(1999)<doi:10.1007/978-1-4612-1554-7> Weichi Wu and Zhou Zhou(2018)<doi:10.1214/17-AOS1582>.

Implementation of the mid-n algorithms presented in Wellek S (2015) <DOI:10.1111/stan.12063> Statistica Neerlandica 69, 358-373 for exact sample size calculation for superiority trials with binary outcome.

This package performs the execution of the main procedures of multiple comparisons in the literature, Scott-Knott (1974) <http://www.jstor.org/stable/2529204>, Batista (2016) <http://repositorio.ufla.br/jspui/handle/1/11466>, including graphic representations and export to different extensions of its results. An additional part of the package is the presence of the performance evaluation of the tests (Type I error per experiment and the power). This will assist the user in making the decision for the chosen test.

Conveniently log everything you type into the R console. Logs are are stored as tidy data frames which can then be analyzed using tidyverse style tools.

Fits and tests meta regression models and generates a number of useful test statistics: next to t- and z-tests, the likelihood ratio, bartlett corrected likelihood ratio and permutation tests are performed on the model coefficients.

This package produces clean and neat Markdown log file and also provide an argument to include the function call inside the Markdown log.

Projects mean squared out-of-sample error for a linear regression based upon the methodology developed in Rohlfs (2022) <doi:10.48550/arXiv.2209.01493>. It consumes as inputs the lm object from an estimated OLS regression (based on the "training sample") and a data.frame of out-of-sample cases (the "test sample") that have non-missing values for the same predictors. The test sample may or may not include data on the outcome variable; if it does, that variable is not used. The aim of the exercise is to project what what mean squared out-of-sample error can be expected given the predictor values supplied in the test sample. Output consists of a list of three elements: the projected mean squared out-of-sample error, the projected out-of-sample R-squared, and a vector of out-of-sample "hat" or "leverage" values, as defined in the paper.

This package provides tools for high-dimensional peaks-over-threshold inference and simulation of Brown-Resnick and extremal Student spatial extremal processes. These include optimization routines based on censored likelihood and gradient scoring, and exact simulation algorithms for max-stable and multivariate Pareto distributions based on rejection sampling. Fast multivariate Gaussian and Student distribution functions using separation-of-variable algorithm with quasi Monte Carlo integration are also provided. Key references include de Fondeville and Davison (2018) <doi:10.1093/biomet/asy026>, Thibaud and Opitz (2015) <doi:10.1093/biomet/asv045>, Wadsworth and Tawn (2014) <doi:10.1093/biomet/ast042> and Genz and Bretz (2009) <doi:10.1007/978-3-642-01689-9>.

The Iterative Proportional Fitting (IPF) algorithm operates on count data. This package offers implementations for several algorithms that extend this to nested structures: parent and child items for both of which constraints can be provided. The fitting algorithms include Iterative Proportional Updating <https://trid.trb.org/view/881554>, Hierarchical IPF <doi:10.3929/ethz-a-006620748>, Entropy Optimization <https://trid.trb.org/view/881144>, and Generalized Raking <doi:10.2307/2290793>. Additionally, a number of replication methods is also provided such as Truncate, replicate, sample <doi:10.1016/j.compenvurbsys.2013.03.004>.

This package provides basic tools and wrapper functions for computing clusters of instances described by multiple time-to-event censored endpoints. From long-format datasets, where one instance is described by one or more dated records, the main function, `make_state_matrices()`, creates state matrices. Based on these matrices, optimised procedures using the Jaccard distance between instances enable the construction of longitudinal typologies. The package is under active development, with additional tools for graphical representation of typologies planned. For methodological details, see our accompanying paper: `Delord M, Douiri A (2025) <doi:10.1186/s12874-025-02476-7>`.

Multivariate Surrogate Synchrony ('mvSUSY') estimates the synchrony within datasets that contain more than two time series. mvSUSY was developed from Surrogate Synchrony ('SUSY') with respect to implementing surrogate controls, and extends synchrony estimation to multivariate data. mvSUSY works as described in Meier & Tschacher (2021).

Agricultural data for 1888-2021 from the Morrow Plots at the University of Illinois. The world's second oldest ongoing agricultural experiment, the Morrow Plots measure the impact of crop rotation and fertility treatments on corn yields. The data includes planting information and annual yield measures for corn grown continuously and in rotation with other crops, in treated and untreated soil.

Use the open source MDB Tools utilities <https://github.com/mdbtools/mdbtools/>. Primarily used for converting proprietary Microsoft Access files to simple text files and then reading those as data frames.

This package provides functions to calculate Unique Trait Combinations (UTC) and scaled Unique Trait Combinations (sUTC) as measures of multivariate richness. The package can also calculate beta-diversity for trait richness and can partition this into nestedness-related and turnover components. The code will also calculate several measures of overlap. See Keyel and Wiegand (2016) <doi:10.1111/2041-210X.12558> for more details.

This package provides functions and S4 methods to create and manage discrete time Markov chains more easily. In addition functions to perform statistical (fitting and drawing random variates) and probabilistic (analysis of their structural proprieties) analysis are provided. See Spedicato (2017) <doi:10.32614/RJ-2017-036>. Some functions for continuous times Markov chains depend on the suggested ctmcd package.

Estimation of interaction (i.e., moderation) effects between latent variables in structural equation models (SEM). The supported methods are: The constrained approach (Algina & Moulder, 2001). The unconstrained approach (Marsh et al., 2004). The residual centering approach (Little et al., 2006). The double centering approach (Lin et al., 2010). The latent moderated structural equations (LMS) approach (Klein & Moosbrugger, 2000). The quasi-maximum likelihood (QML) approach (Klein & Muthén, 2007) The constrained- unconstrained, residual- and double centering- approaches are estimated via lavaan (Rosseel, 2012), whilst the LMS- and QML- approaches are estimated via modsem it self. Alternatively model can be estimated via Mplus (Muthén & Muthén, 1998-2017). References: Algina, J., & Moulder, B. C. (2001). <doi:10.1207/S15328007SEM0801_3>. "A note on estimating the Jöreskog-Yang model for latent variable interaction using LISREL 8.3." Klein, A., & Moosbrugger, H. (2000). <doi:10.1007/BF02296338>. "Maximum likelihood estimation of latent interaction effects with the LMS method." Klein, A. G., & Muthén, B. O. (2007). <doi:10.1080/00273170701710205>. "Quasi-maximum likelihood estimation of structural equation models with multiple interaction and quadratic effects." Lin, G. C., Wen, Z., Marsh, H. W., & Lin, H. S. (2010). <doi:10.1080/10705511.2010.488999>. "Structural equation models of latent interactions: Clarification of orthogonalizing and double-mean-centering strategies." Little, T. D., Bovaird, J. A., & Widaman, K. F. (2006). <doi:10.1207/s15328007sem1304_1>. "On the merits of orthogonalizing powered and product terms: Implications for modeling interactions among latent variables." Marsh, H. W., Wen, Z., & Hau, K. T. (2004). <doi:10.1037/1082-989X.9.3.275>. "Structural equation models of latent interactions: evaluation of alternative estimation strategies and indicator construction." Muthén, L.K. and Muthén, B.O. (1998-2017). "'Mplus Userâ s Guide. Eighth Edition." <https://www.statmodel.com/>. Rosseel Y (2012). <doi:10.18637/jss.v048.i02>. "'lavaan': An R Package for Structural Equation Modeling.".

This package provides methods for high-dimensional multi-view learning based on the multi-view stacking (MVS) framework. For technical details on the MVS and stacked penalized logistic regression (StaPLR) methods see Van Loon, Fokkema, Szabo, & De Rooij (2020) <doi:10.1016/j.inffus.2020.03.007> and Van Loon et al. (2022) <doi:10.3389/fnins.2022.830630>.

This package provides methods for calculating and testing the significance of pairwise monotonic association from and based on the work of Pimentel (2009) <doi:10.4135/9781412985291.n2>. Computation of association of vectors from one or multiple sets can be performed in parallel thanks to the packages foreach and doMC'.

This package provides tools to generate random landscape graphs, evaluate species occurrence in dynamic landscapes, simulate future landscape occupation and evaluate range expansion when new empty patches are available (e.g. as a result of climate change). References: Mestre, F., Canovas, F., Pita, R., Mira, A., Beja, P. (2016) <doi:10.1016/j.envsoft.2016.03.007>; Mestre, F., Risk, B., Mira, A., Beja, P., Pita, R. (2017) <doi:10.1016/j.ecolmodel.2017.06.013>; Mestre, F., Pita, R., Mira, A., Beja, P. (2020) <doi:10.1186/s12898-019-0273-5>.

First- and higher-order likelihood inference in meta-analysis and meta-regression models.

Curve Fitting of monotonic(sigmoidal) & non-monotonic(J-shaped) dose-response data. Predicting mixture toxicity based on reference models such as concentration addition', independent action', and generalized concentration addition'.

An easy-to-use workflow that provides tools to create, update and fill literature matrices commonly used in research, specifically epidemiology and health sciences research. The project is born out of need as an easyâ toâ use tool for my research methods classes.