An interactive shiny application for sample size and power calculation under general conditions for clinical trials with survival endpoints. Implements the weighted log-rank method of Lu (2021) <doi:10.1002/pst.2069> via the lrstat package, supporting non-proportional hazards, delayed treatment effects, unequal allocation and dropout, as well as the classic method of Freedman (1982) <doi:10.1002/sim.4780010204> via the powerSurvEpi package. Results are presented interactively with survival curves and event-prediction timelines.

This package provides a mechanism for easily generating and organizing a collection of seeds from a single seed, which may be subsequently used to ensure reproducibility in processes/pipelines that utilize multiple random components (e.g., trial simulation).

Analysis tools to investigate changes in intercellular communication from scRNA-seq data. Using a Seurat object as input, the package infers which cell-cell interactions are present in the dataset and how these interactions change between two conditions of interest (e.g. young vs old). It relies on an internal database of ligand-receptor interactions (available for human, mouse and rat) that have been gathered from several published studies. Detection and differential analyses rely on permutation tests. The package also contains several tools to perform over-representation analysis and visualize the results. See Lagger, C. et al. (2023) <doi:10.1038/s43587-023-00514-x> for a full description of the methodology.

Enables drag-and-drop behaviour in Shiny apps, by exposing the functionality of the SortableJS <https://sortablejs.github.io/Sortable/> JavaScript library as an htmlwidget'. You can use this in Shiny apps and widgets, learnr tutorials as well as R Markdown. In addition, provides a custom learnr question type - question_rank() - that allows ranking questions with drag-and-drop.

Allows to connect selectizeInputs widgets as filters to a reactable table. As known from spreadsheet applications, column filters are interdependent, so each filter only shows the values that are really available at the moment based on the current selection in other filters. Filter values currently not available (and also those being available) can be shown via popovers or tooltips.

When comparing single cases to control populations and no parameters are known researchers and clinicians must estimate these with a control sample. This is often done when testing a case's abnormality on some variable or testing abnormality of the discrepancy between two variables. Appropriate frequentist and Bayesian methods for doing this are here implemented, including tests allowing for the inclusion of covariates. These have been developed first and foremost by John Crawford and Paul Garthwaite, e.g. in Crawford and Howell (1998) <doi:10.1076/clin.12.4.482.7241>, Crawford and Garthwaite (2005) <doi:10.1037/0894-4105.19.3.318>, Crawford and Garthwaite (2007) <doi:10.1080/02643290701290146> and Crawford, Garthwaite and Ryan (2011) <doi:10.1016/j.cortex.2011.02.017>. The package is also equipped with power calculators for each method.

It allows to rapidly compute, bootstrap and plot up to fourth-order Sobol'-based sensitivity indices using several state-of-the-art first and total-order estimators. Sobol indices can be computed either for models that yield a scalar as a model output or for systems of differential equations. The package also provides a suit of benchmark tests functions and several options to obtain publication-ready figures of the model output uncertainty and sensitivity-related analysis. An overview of the package can be found in Puy et al. (2022) <doi:10.18637/jss.v102.i05>.

Fits a semiparametric spatiotemporal model for data with mixed frequencies, specifically where the response variable is observed at a lower frequency than some covariates. The estimation uses an iterative backfitting algorithm that combines a non-parametric smoothing spline for high-frequency data, parametric estimation for low-frequency and spatial neighborhood effects, and an autoregressive error structure. Methodology based on Malabanan, Lansangan, and Barrios (2022) <https://scienggj.org/2022/SciEnggJ%202022-vol15-no02-p90-107-Malabanan%20et%20al.pdf>.

The aim of this package is to offer new methodology for unit-level small area models under transformations and limited population auxiliary information. In addition to this new methodology, the widely used nested error regression model without transformations (see "An Error-Components Model for Prediction of County Crop Areas Using Survey and Satellite Data" by Battese, Harter and Fuller (1988) <doi:10.1080/01621459.1988.10478561>) and its well-known uncertainty estimate (see "The estimation of the mean squared error of small-area estimators" by Prasad and Rao (1990) <doi:10.1080/01621459.1995.10476570>) are provided. In this package, the log transformation and the data-driven log-shift transformation are provided. If a transformation is selected, an appropriate method is chosen depending on the respective input of the population data: Individual population data (see "Empirical best prediction under a nested error model with log transformation" by Molina and Martà n (2018) <doi:10.1214/17-aos1608>) but also aggregated population data (see "Estimating regional income indicators under transformations and access to limited population auxiliary information" by Würz, Schmid and Tzavidis <unpublished>) can be entered. Especially under limited data access, new methodologies are provided in saeTrafo. Several options are available to assess the used model and to judge, present and export its results. For a detailed description of the package and the methods used see the corresponding vignette.

Test and estimates of location, tests of independence, tests of sphericity and several estimates of shape all based on spatial signs, symmetrized signs, ranks and signed ranks. For details, see Oja and Randles (2004) <doi:10.1214/088342304000000558> and Oja (2010) <doi:10.1007/978-1-4419-0468-3>.

An implementation of sparse Gaussian Markov random field mixtures presented by Ide et al. (2016) <doi:10.1109/ICDM.2016.0119>. It provides a novel anomaly detection method for multivariate noisy sensor data. It can automatically handle multiple operational modes. And it can also compute variable-wise anomaly scores.

This package implements the revised Synthetic Matching Algorithm of Kreitmeir, Lane, and Raschky (2025) <doi:10.2139/ssrn.3751162>, building on the original approach of Acemoglu, Johnson, Kermani, Kwak, and Mitton (2016) <doi:10.1016/j.jfineco.2015.10.001>, to estimate the cumulative treatment effect of an event on treated firmsâ stock returns.

This package provides a collection of functions for reading soil data from U.S. Department of Agriculture Natural Resources Conservation Service (USDA-NRCS) and National Cooperative Soil Survey (NCSS) databases.

This package performs inference of several model-free group contrast measures, which include difference/ratio of cumulative incidence rates at given time points, quantiles, and restricted mean survival times (RMST). Two kinds of covariate adjustment procedures (i.e., regression and augmentation) for inference of the metrics based on RMST are also included.

Fits complex parametric models using the method proposed by Cox and Kartsonaki (2012) without likelihoods.

Enables instrumentation of Shiny apps for tracking user session events such as input changes, browser type, and session duration. These events can be sent to any of the available storage backends and analyzed using the included Shiny app to gain insights about app usage and adoption.

This package provides a unifying framework for managing and deploying shiny applications that consist of modules, where an "app" is a tab-based workflow that guides a user step-by-step through an analysis. The shinymgr app builder "stitches" shiny modules together so that outputs from one module serve as inputs to the next, creating an analysis pipeline that is easy to implement and maintain. Users of shinymgr apps can save analyses as an RDS file that fully reproduces the analytic steps and can be ingested into an R Markdown report for rapid reporting. In short, developers use the shinymgr framework to write modules and seamlessly combine them into shiny apps, and users of these apps can execute reproducible analyses that can be incorporated into reports for rapid dissemination.

Automatic generation and selection of spatial predictors for Random Forest models fitted to spatially structured data. Spatial predictors are constructed from a distance matrix among training samples using Moran's Eigenvector Maps (MEMs; Dray, Legendre, and Peres-Neto 2006 <DOI:10.1016/j.ecolmodel.2006.02.015>) or the RFsp approach (Hengl et al. <DOI:10.7717/peerj.5518>). These predictors are used alongside user-supplied explanatory variables in Random Forest models. The package provides functions for model fitting, multicollinearity reduction, interaction identification, hyperparameter tuning, evaluation via spatial cross-validation, and result visualization using partial dependence and interaction plots. Model fitting relies on the ranger package (Wright and Ziegler 2017 <DOI:10.18637/jss.v077.i01>).

This package provides a set of functions to support experimentation in the utility of partially synthetic data sets. All functions compare an observed data set to one or a set of partially synthetic data sets derived from the observed data to (1) check that data sets have identical attributes, (2) calculate overall and specific variable perturbation rates, (3) check for potential logical inconsistencies, and (4) calculate confidence intervals and standard errors of desired variables in multiple imputed data sets. Confidence interval and standard error formulas have options for either synthetic data sets or multiple imputed data sets. For more information on the formulas and methods used, see Reiter & Raghunathan (2007) <doi:10.1198/016214507000000932>.

Parametric source-filter synthesis of harmonic-noise signals, such as animal vocalizations and human voice, with control over pitch, formants, noise, amplitude modulation, nonlinear phenomena, and morphing. General signal processing tools for audio analysis and manipulation: pitch tracking, formant and vocal tract length estimation, reassigned and auditory spectrograms, modulation spectra and psychoacoustic roughness, self-similarity and surprisal, audio segmentation, pitch and formant shifting, etc. Includes four interactive web apps for audio synthesis, annotation, formant analysis, and manually correcting pitch contours. Reference: Anikin (2019) <doi:10.3758/s13428-018-1095-7>.

This package implements a general algorithm for estimating Sparse Multiple Index (SMI) models for nonparametric forecasting and prediction. Estimation of SMI models requires the Gurobi mixed integer programming (MIP) solver via the gurobi R package. To use this functionality, the Gurobi Optimizer must be installed, and a valid license obtained and activated from <https://www.gurobi.com>. The gurobi R package must then be installed and configured following the instructions at <https://support.gurobi.com/hc/en-us/articles/14462206790033-How-do-I-install-Gurobi-for-R>. The package also includes functions for fitting nonparametric additive models with backward elimination, group-wise additive index models, and projection pursuit regression models as benchmark comparison methods. In addition, it provides tools for generating prediction intervals to quantify uncertainty in point forecasts produced by the SMI model and benchmark models, using the classical block bootstrap and a new method called conformal bootstrap, which integrates block bootstrap with split conformal prediction.

Hail is an open-source, general-purpose, python based data analysis tool with additional data types and methods for working with genomic data, see <https://hail.is/>. Hail is built to scale and has first-class support for multi-dimensional structured data, like the genomic data in a genome-wide association study (GWAS). Hail is exposed as a python library, using primitives for distributed queries and linear algebra implemented in scala', spark', and increasingly C++'. The sparkhail is an R extension using sparklyr package. The idea is to help R users to use hail functionalities with the well-know tidyverse syntax, see <https://www.tidyverse.org/>.

It visualizes data along an Archimedean spiral <https://en.wikipedia.org/wiki/Archimedean_spiral>, makes so-called spiral graph or spiral chart. It has two major advantages for visualization: 1. It is able to visualize data with very long axis with high resolution. 2. It is efficient for time series data to reveal periodic patterns.

Simulate complex traits given a SNP genotype matrix and model parameters (the desired heritability, number of causal loci, and either the true ancestral allele frequencies used to generate the genotypes or the mean kinship for a real dataset). Emphasis on avoiding common biases due to the use of estimated allele frequencies. The code selects random loci to be causal, constructs coefficients for these loci and random independent non-genetic effects, and can optionally generate random group effects. Traits can follow three models: random coefficients, fixed effect sizes, and infinitesimal (multivariate normal). GWAS method benchmarking functions are also provided. Described in Yao and Ochoa (2022) <doi:10.1101/2022.03.25.485885>.