For high-dimensional correlated observations, this package carries out the L_1 penalized maximum likelihood estimation of the precision matrix (network) and the correlation parameters. The correlated data can be longitudinal data (may be irregularly spaced) with dampening correlation or clustered data with uniform correlation. For the details of the algorithms, please see the paper Jie Zhou et al. Identifying Microbial Interaction Networks Based on Irregularly Spaced Longitudinal 16S rRNA sequence data <doi:10.1101/2021.11.26.470159>.

Estimation of the local false discovery rate using the method of moments.

This package provides a wrapper around the LIBLINEAR C/C++ library for machine learning (available at <https://www.csie.ntu.edu.tw/~cjlin/liblinear/>). LIBLINEAR is a simple library for solving large-scale regularized linear classification and regression. It currently supports L2-regularized classification (such as logistic regression, L2-loss linear SVM and L1-loss linear SVM) as well as L1-regularized classification (such as L2-loss linear SVM and logistic regression) and L2-regularized support vector regression (with L1- or L2-loss). The main features of LiblineaR include multi-class classification (one-vs-the rest, and Crammer & Singer method), cross validation for model selection, probability estimates (logistic regression only) or weights for unbalanced data. The estimation of the models is particularly fast as compared to other libraries.

This package performs approximate GP regression for large computer experiments and spatial datasets. The approximation is based on finding small local designs for prediction (independently) at particular inputs. OpenMP and SNOW parallelization are supported for prediction over a vast out-of-sample testing set; GPU acceleration is also supported for an important subroutine. OpenMP and GPU features may require special compilation. An interface to lower-level (full) GP inference and prediction is provided. Wrapper routines for blackbox optimization under mixed equality and inequality constraints via an augmented Lagrangian scheme, and for large scale computer model calibration, are also provided. For details and tutorial, see Gramacy (2016 <doi:10.18637/jss.v072.i01>.

Computes comorbidity indices and combined frailty scores for multiple ICD coding systems, including ICD-10-CA, ICD-10-CM, and ICD-11. The package provides tools to preprocess episode data, map diagnosis codes to chronic categories, propagate conditions across episodes, and generate comorbidity and frailty measures. The methodology is described in Nikiema, Bayani, and Bally (2026), "A Semantic-Based Carry-Forward Approach: Uncovering Chronic Disease Burden in Real-World Data Analysis", International Journal of Medical Informatics, article 106709 <doi:10.1016/j.ijmedinf.2026.106709>.

Simple functions to lookup items in key-value pairs. See Mehta (2021) <doi:10.1007/978-1-4842-6613-7_6>.

This package provides functions and tools for using open GIS and remote sensing command-line interfaces in a reproducible environment.

An adaption of the consensus clustering approach from ConsensusClusterPlus for longitudinal data. The longitudinal data is clustered with flexible mixture models from flexmix', while the consensus matrices are hierarchically clustered as in ConsensusClusterPlus'. By using the flexibility from flexmix and FactoMineR', one can use mixed data types for the clustering.

The landmark approach allows survival predictions to be updated dynamically as new measurements from an individual are recorded. The idea is to set predefined time points, known as "landmark times", and form a model at each landmark time using only the individuals in the risk set. This package allows the longitudinal data to be modelled either using the last observation carried forward or linear mixed effects modelling. There is also the option to model competing risks, either through cause-specific Cox regression or Fine-Gray regression. To find out more about the methods in this package, please see <https://isobelbarrott.github.io/Landmarking/articles/Landmarking>.

Inference for the Lorenz and penalized Lorenz regressions. More broadly, the package proposes functions to assess inequality and graphically represent it. The Lorenz Regression procedure is introduced in Heuchenne and Jacquemain (2022) <doi:10.1016/j.csda.2021.107347> and in Jacquemain, A., C. Heuchenne, and E. Pircalabelu (2024) <doi:10.1214/23-EJS2200>.

Due to lack of proper inference procedure and software, the ordinary linear regression model is seldom used in practice for the analysis of right censored data. This paper presents an S-Plus/R program that implements a recently developed inference procedure (Jin, Lin and Ying, 2006) <doi:10.1093/biomet/93.1.147> for the accelerated failure time model based on the least-squares principle.

This package implements Latent Unknown Clusters By Integrating Multi-omics Data (LUCID; Peng (2019) <doi:10.1093/bioinformatics/btz667>) for integrative clustering with exposures, multi-omics data, and health outcomes. Supports three integration strategies: early, parallel, and serial. Provides model fitting and tuning, lasso-type regularization for exposure and omics feature selection, handling of missing data, including both sporadic and complete-case patterns, prediction, and g-computation for estimating causal effects of exposures, bootstrap inference for uncertainty estimation, and S3 summary and plot methods. For the multi-omics integration framework, see Jia (2024) <https://journal.r-project.org/articles/RJ-2024-012/RJ-2024-012.pdf>. For the missing-data imputation mechanism, see Jia (2024) <doi:10.1093/bioadv/vbae123>.

Change-point detection algorithm with label constraints and a penalty for each change outside of labels. Read TD Hocking, A Srivastava (2023) <doi:10.1007/s00180-022-01238-z> for details.

Transforms away factors with many levels prior to doing an OLS. Useful for estimating linear models with multiple group fixed effects, and for estimating linear models which uses factors with many levels as pure control variables. See Gaure (2013) <doi:10.1016/j.csda.2013.03.024> Includes support for instrumental variables, conditional F statistics for weak instruments, robust and multi-way clustered standard errors, as well as limited mobility bias correction (Gaure 2014 <doi:10.1002/sta4.68>). Since version 3.0, it provides dedicated functions to estimate Poisson models.

This package provides in built datasets and three functions. These functions are mobility_index, nonStanTest and linkedLives. The mobility_index function facilitates the calculation of lifecourse fluidity, whilst the nonStanTest and the linkedLives functions allow the user to determine the probability that the observed sequence data was due to chance. The linkedLives function acknowledges the fact that some individuals may have identical sequences. The datasets available provide sequence data on marital status(maritalData) and mobility (mydata) for a selected group of individuals from the British Household Panel Study (BHPS). In addition, personal and house ID's for 100 individuals are provided in a third dataset (myHouseID) from the BHPS.

This package provides functions for genome-wide association studies (GWAS)/gene-environment-wide interaction studies (GEWIS) with longitudinal outcomes and exposures. He et al. (2017) "Set-Based Tests for Gene-Environment Interaction in Longitudinal Studies" and He et al. (2017) "Rare-variant association tests in longitudinal studies, with an application to the Multi-Ethnic Study of Atherosclerosis (MESA)".

Fits structural equation modeling via penalized likelihood.

This package provides functions to automatically retrieve and deduplicate reference metadata based on saved search strings. Access to Web of Science and Scopus requires personal API keys, while PubMed can be queried without one. The optional deduplication functionality requires the package ASySD available from <https://github.com/camaradesuk/ASySD>.

This package contains functions for a flexible varying-coefficient landmark model by incorporating multiple short-term events into the prediction of long-term survival probability. For more information about landmark prediction please see Li, W., Ning, J., Zhang, J., Li, Z., Savitz, S.I., Tahanan, A., Rahbar.M.H., (2023+). "Enhancing Long-term Survival Prediction with Multiple Short-term Events: Landmarking with A Flexible Varying Coefficient Model".

Lattice-based space-filling designs with fill or separation distance properties including interleaved lattice-based minimax distance designs proposed in Xu He (2017) <doi:10.1093/biomet/asx036>, interleaved lattice-based maximin distance designs proposed in Xu He (2018) <doi:10.1093/biomet/asy069>, interleaved lattice-based designs with low fill and high separation distance properties proposed in Xu He (2024) <doi:10.1137/23M156940X>, (sliced) rotated sphere packing designs proposed in Xu He (2017) <doi:10.1080/01621459.2016.1222289> and Xu He (2019) <doi:10.1080/00401706.2018.1458655>, densest packing-based maximum projections designs proposed in Xu He (2020) <doi:10.1093/biomet/asaa057> and Xu He (2018) <doi:10.48550/arXiv.1709.02062>, maximin distance designs for mixed continuous, ordinal, and binary variables proposed in Hui Lan and Xu He (2025) <doi:10.48550/arXiv.2507.23405>, and optimized and regularly repeated lattice-based Latin hypercube designs for large-scale computer experiments proposed in Xu He, Junpeng Gong, and Zhaohui Li (2025) <doi:10.48550/arXiv.2506.04582>.

Create lipidome-wide heatmaps of statistics with the lipidomeR'. The lipidomeR provides a streamlined pipeline for the systematic interpretation of the lipidome through publication-ready visualizations of regression models fitted on lipidomics data. With lipidomeR', associations between covariates and the lipidome can be interpreted systematically and intuitively through heatmaps, where lipids are categorized by the lipid class and are presented on two-dimensional maps organized by the lipid size and level of saturation. This way, the lipidomeR helps you gain an immediate understanding of the multivariate patterns in the lipidome already at first glance. You can create lipidome-wide heatmaps of statistical associations, changes, differences, variation, or other lipid-specific values. The heatmaps are provided with publication-ready quality and the results behind the visualizations are based on rigorous statistical models.

This package provides functions implementing multivariate state space models for purposes of time series analysis and forecasting. The focus of the package is on multivariate models, such as Vector Exponential Smoothing, Vector ETS (Error-Trend-Seasonal model) etc. It currently includes Vector Exponential Smoothing (VES, de Silva et al., 2010, <doi:10.1177/1471082X0901000401>), Vector ETS (Svetunkov et al., 2023, <doi:10.1016/j.ejor.2022.04.040>) and simulation function for VES.

Maximum likelihood estimation of log-binomial regression with special functionality when the MLE is on the boundary of the parameter space.

This package performs likelihood-based inference for stationary time series extremes. The general approach follows Fawcett and Walshaw (2012) <doi:10.1002/env.2133>. Marginal extreme value inferences are adjusted for cluster dependence in the data using the methodology in Chandler and Bate (2007) <doi:10.1093/biomet/asm015>, producing an adjusted log-likelihood for the model parameters. A log-likelihood for the extremal index is produced using the K-gaps model of Suveges and Davison (2010) <doi:10.1214/09-AOAS292>. These log-likelihoods are combined to make inferences about extreme values. Both maximum likelihood and Bayesian approaches are available.