Prognostic Enrichment is a strategy of enriching a clinical trial for testing an intervention intended to prevent or delay an unwanted clinical event. A prognostically enriched trial enrolls only patients who are more likely to experience the unwanted clinical event than the broader patient population (R. Temple (2010) <doi:10.1038/clpt.2010.233>). By testing the intervention in an enriched study population, the trial may be adequately powered with a smaller sample size, which can have both practical and ethical advantages. This package provides tools to evaluate biomarkers for prognostic enrichment of clinical trials with survival/time-to-event outcomes.

This package provides methods and tools for estimating, simulating and forecasting of so-called BEKK-models (named after Baba, Engle, Kraft and Kroner) based on the fast Berndtâ Hallâ Hallâ Hausman (BHHH) algorithm described in Hafner and Herwartz (2008) <doi:10.1007/s00184-007-0130-y>. For an overview, we refer the reader to Fülle et al. (2024) <doi:10.18637/jss.v111.i04>.

Combine diverse evidence across multiple studies to test a high level scientific theory. The methods can also be used as an alternative to a standard meta-analysis.

Designed to simplify and streamline the process of reading and processing large volumes of data in R, this package offers a collection of functions tailored for bulk data operations. It enables users to efficiently read multiple sheets from Microsoft Excel and Google Sheets workbooks, as well as various CSV files from a directory. The data is returned as organized data frames, facilitating further analysis and manipulation. Ideal for handling extensive data sets or batch processing tasks, bulkreadr empowers users to manage data in bulk effortlessly, saving time and effort in data preparation workflows. Additionally, the package seamlessly works with labelled data from SPSS and Stata.

Subgroup analyses are routinely performed in clinical trial analyses. From a methodological perspective, two key issues of subgroup analyses are multiplicity (even if only predefined subgroups are investigated) and the low sample sizes of subgroups which lead to highly variable estimates, see e.g. Yusuf et al (1991) <doi:10.1001/jama.1991.03470010097038>. This package implements subgroup estimates based on Bayesian shrinkage priors, see Carvalho et al (2019) <https://proceedings.mlr.press/v5/carvalho09a.html>. In addition, estimates based on penalized likelihood inference are available, based on Simon et al (2011) <doi:10.18637/jss.v039.i05>. The corresponding shrinkage based forest plots address the aforementioned issues and can complement standard forest plots in practical clinical trial analyses.

Interactive box plot using plotly for clinical trial analysis.

This package performs logistic regression for binary longitudinal data, allowing for serial dependence among observations from a given individual and a random intercept term. Estimation is via maximization of the exact likelihood of a suitably defined model. Missing values and unbalanced data are allowed, with some restrictions. M. Helena Goncalves et al.(2007) <DOI: 10.18637/jss.v046.i09>.

It makes the creation of networks from sequences of RNA, with this is done the abstraction of characteristics of these networks with a methodology of maximum entropy for the purpose of making a classification between the classes of the sequences. There are two data present in the BASiNET package, "mRNA", and "ncRNA" with 10 sequences. These sequences were taken from the data set used in the article (LI, Aimin; ZHANG, Junying; ZHOU, Zhongyin, 2014) <doi:10.1186/1471-2105-15-311>, these sequences are used to run examples.

Producing probabilistic projections of net migration rate for all countries of the world or for subnational units using a Bayesian hierarchical model by Azose an Raftery (2015) <doi:10.1007/s13524-015-0415-0>.

Implementation of multisource exchangeability models for Bayesian analyses of prespecified subgroups arising in the context of basket trial design and monitoring. The R basket package facilitates implementation of the binary, symmetric multi-source exchangeability model (MEM) with posterior inference arising from both exact computation and Markov chain Monte Carlo sampling. Analysis output includes full posterior samples as well as posterior probabilities, highest posterior density (HPD) interval boundaries, effective sample sizes (ESS), mean and median estimations, posterior exchangeability probability matrices, and maximum a posteriori MEMs. In addition to providing "basketwise" analyses, the package includes similar calculations for "clusterwise" analyses for which subgroups are combined into meta-baskets, or clusters, using graphical clustering algorithms that treat the posterior exchangeability probabilities as edge weights. In addition plotting tools are provided to visualize basket and cluster densities as well as their exchangeability. References include Hyman, D.M., Puzanov, I., Subbiah, V., Faris, J.E., Chau, I., Blay, J.Y., Wolf, J., Raje, N.S., Diamond, E.L., Hollebecque, A. and Gervais, R (2015) <doi:10.1056/NEJMoa1502309>; Hobbs, B.P. and Landin, R. (2018) <doi:10.1002/sim.7893>; Hobbs, B.P., Kane, M.J., Hong, D.S. and Landin, R. (2018) <doi:10.1093/annonc/mdy457>; and Kaizer, A.M., Koopmeiners, J.S. and Hobbs, B.P. (2017) <doi:10.1093/biostatistics/kxx031>.

Generation of multiple binary and continuous non-normal variables simultaneously given the marginal characteristics and association structure based on the methodology proposed by Demirtas et al. (2012) <DOI:10.1002/sim.5362>.

We perform linear, logistic, and cox regression using the base functions lm(), glm(), and coxph() in the R software and the survival package. Likewise, we can use ols(), lrm() and cph() from the rms package for the same functionality. Each of these two sets of commands has a different focus. In many cases, we need to use both sets of commands in the same situation, e.g. we need to filter the full subset model using AIC, and we need to build a visualization graph for the final model. base.rms package can help you to switch between the two sets of commands easily.

BAYesian inference for MEDical designs in R. Functions for the computation of Bayes factors for common biomedical research designs. Implemented are functions to test the equivalence (equiv_bf), non-inferiority (infer_bf), and superiority (super_bf) of an experimental group compared to a control group on a continuous outcome measure, as well as functions for simulating survival data and calculating a Bayes factor for Cox proportional hazards models. Bayes factors for these tests can be computed based on raw data or summary statistics.

Simultaneously clusters the Periodontal diseases (PD) patients and their tooth sites after taking the patient- and site-level covariates into consideration. BAREB uses the determinantal point process (DPP) prior to induce diversity among different biclusters to facilitate parsimony and interpretability. Essentially, BAREB is a cluster-wise linear model based on Yuliang (2020) <doi:10.1002/sim.8536>.

Various layers of B.C., including administrative boundaries, natural resource management boundaries, census boundaries etc. All layers are available in BC Albers (<https://spatialreference.org/ref/epsg/3005/>) equal-area projection, which is the B.C. government standard. The layers are sourced from the British Columbia and Canadian government under open licenses, including B.C. Data Catalogue (<https://data.gov.bc.ca>), the Government of Canada Open Data Portal (<https://open.canada.ca/en/using-open-data>), and Statistics Canada (<https://www.statcan.gc.ca/en/terms-conditions/open-licence>).

Efficient Markov Chain Monte Carlo (MCMC) algorithms for the fully Bayesian estimation of vectorautoregressions (VARs) featuring stochastic volatility (SV). Implements state-of-the-art shrinkage priors following Gruber & Kastner (2025) <doi:10.1016/j.ijforecast.2025.02.001>. Efficient equation-per-equation estimation following Kastner & Huber (2020) <doi:10.1002/for.2680> and Carrerio et al. (2021) <doi:10.1016/j.jeconom.2021.11.010>.

Enables a user to consume the BambooHR API endpoints using R. The actual URL of the API will depend on your company domain, and will be handled by the package automatically once you setup the config file. The API documentation can be found here <https://documentation.bamboohr.com/docs>.

This package contains several Bayesian models for data analysis of psychological tests. A user friendly interface for these models should enable students and researchers to perform professional level Bayesian data analysis without advanced knowledge in programming and Bayesian statistics. This package is based on the Stan platform (Carpenter et el. 2017 <doi:10.18637/jss.v076.i01>).

This package performs Bayesian posterior inference for heteroskedastic Gaussian processes. Models are trained through MCMC including elliptical slice sampling (ESS) of latent noise processes and Metropolis-Hastings sampling of kernel hyperparameters. Replicates are handled efficientyly through a Woodbury formulation of the joint likelihood for the mean and noise process (Binois, M., Gramacy, R., Ludkovski, M. (2018) <doi:10.1080/10618600.2018.1458625>) For large data, Vecchia-approximation for faster computation is leveraged (Sauer, A., Cooper, A., and Gramacy, R., (2023), <doi:10.1080/10618600.2022.2129662>). Incorporates OpenMP and SNOW parallelization and utilizes C'/'C++ under the hood.

Simulating synthetic clumped isotope dataset, fitting linear regression models under Bayesian and non-Bayesian frameworks, and generating temperature reconstructions for the same two approaches. Please note that models implemented in this package are described in Roman-Palacios et al. (2021) <doi:10.1002/essoar.10507995.1>.

An umbrella package providing a phenotype/genotype data structure and scalable and efficient computational methods for large genomic datasets in combination with several other packages: BEDMatrix', LinkedMatrix', and symDMatrix'.

Stock, Options and Futures Trading Strategies for Traders and Investors with Bearish Outlook. The indicators, strategies, calculations, functions and all other discussions are for academic, research, and educational purposes only and should not be construed as investment advice and come with absolutely no Liability. Guy Cohen (â The Bible of Options Strategies (2nd ed.)â , 2015, ISBN: 9780133964028). Juan A. Serur, Juan A. Serur (â 151 Trading Strategiesâ , 2018, ISBN: 9783030027919). Chartered Financial Analyst Institute ("Chartered Financial Analyst Program Curriculum 2020 Level I Volumes 1-6. (Vol. 5, pp. 385-453)", 2019, ISBN: 9781119593577). John C. Hull (â Options, Futures, and Other Derivatives (11th ed.)â , 2022, ISBN: 9780136939979).

This package implements three test procedures using bootstrap resampling techniques for assessing treatment effects in one-way ANOVA models with unequal variances (heteroscedasticity). It includes a parametric bootstrap likelihood ratio test (PB_LRT()), a pairwise parametric bootstrap mean test (PPBMT()), and a Rademacher wild pairwise non-parametric bootstrap test (RWPNPBT()). These methods provide robust alternatives to classical ANOVA and standard pairwise comparisons when the assumption of homogeneity of variances is violated.

Generalization of the Bayesian classification and regression tree (CART) model that partitions subjects into terminal nodes and tailors regression model to each terminal node.