Maximum likelihood estimation of log-binomial regression with special functionality when the MLE is on the boundary of the parameter space.

Given independent and identically distributed observations X(1), ..., X(n), allows to compute the maximum likelihood estimator (MLE) of probability mass function (pmf) under the assumption that it is log-concave, see Weyermann (2007) and Balabdaoui, Jankowski, Rufibach, and Pavlides (2012). The main functions of the package are logConDiscrMLE that allows computation of the log-concave MLE, logConDiscrCI that computes pointwise confidence bands for the MLE, and kInflatedLogConDiscr that computes a mixture of a log-concave PMF and a point mass at k.

Functionalities for calculating the local score and calculating statistical relevance (p-value) to find a local Score in a sequence of given distribution (S. Mercier and J.-J. Daudin (2001) <https://hal.science/hal-00714174/>) ; S. Karlin and S. Altschul (1990) <https://pmc.ncbi.nlm.nih.gov/articles/PMC53667/> ; S. Mercier, D. Cellier and F. Charlot (2003) <https://hal.science/hal-00937529v1/> ; A. Lagnoux, S. Mercier and P. Valois (2017) <doi:10.1093/bioinformatics/btw699> ).

We provide a solution for performing permutation tests on linear and mixed linear regression models. It allows users to obtain accurate p-values without making distributional assumptions about the data. By generating a null distribution of the test statistics through repeated permutations of the response variable, permutation tests provide a powerful alternative to traditional parameter tests (Holt et al. (2023) <doi:10.1007/s10683-023-09799-6>). In this early version, we focus on the permutation tests over observed t values of beta coefficients, i.e.original t values generated by parameter tests. After generating a null distribution of the test statistic through repeated permutations of the response variable, each observed t values would be compared to the null distribution to generate a p-value. To improve the efficiency,a stop criterion (Anscombe (1953) <doi:10.1111/j.2517-6161.1953.tb00121.x>) is adopted to force permutation to stop if the estimated standard deviation of the value falls below a fraction of the estimated p-value. By doing so, we avoid the need for massive calculations in exact permutation methods while still generating stable and accurate p-values.

The main function of the package is to perform backward selection of fixed effects, forward fitting of the random effects, and post-hoc analysis using parallel capabilities. Other functionality includes the computation of ANOVAs with upper- or lower-bound p-values and R-squared values for each model term, model criticism plots, data trimming on model residuals, and data visualization. The data to run examples is contained in package LCF_data.

Lights Out is a puzzle game consisting of a grid of lights that are either on or off. Pressing any light will toggle it and its adjacent lights. The goal of the game is to switch all the lights off. This package provides an interface to play the game on different board sizes, both through the command line or with a visual application. Puzzles can also be solved using the automatic solver included. View a demo online at <https://daattali.com/shiny/lightsout/>.

R interface for working with nanometer scale secondary ion mass spectrometry (NanoSIMS) data exported from Look at NanoSIMS.

Inference for the Lorenz and penalized Lorenz regressions. More broadly, the package proposes functions to assess inequality and graphically represent it. The Lorenz Regression procedure is introduced in Heuchenne and Jacquemain (2022) <doi:10.1016/j.csda.2021.107347> and in Jacquemain, A., C. Heuchenne, and E. Pircalabelu (2024) <doi:10.1214/23-EJS2200>.

This package implements an interface to the legacy Fortran code from O'Connell and Dobson (1984) <DOI:10.2307/2531148>. Implements Fortran 77 code for the methods developed by Schouten (1982) <DOI:10.1111/j.1467-9574.1982.tb00774.x>. Includes estimates of average agreement for each observer and average agreement for each subject.

Additional documentation, a package vignette and regression tests for package mlt.

The unique function of this package allows representing in a single graph the relative occurrence and co-occurrence of events measured in a sample. As examples, the package was applied to describe the occurrence and co-occurrence of different species of bacterial or viral symbionts infecting arthropods at the individual level. The graphics allows determining the prevalence of each symbiont and the patterns of multiple infections (i.e. how different symbionts share or not the same individual hosts). We named the package after the famous painter as the graphical output recalls Mondrianâ s paintings.

Bayesian estimation of inverse variance weighted (IVW), Burgess et al. (2013) <doi:10.1002/gepi.21758>, and MR-Egger, Bowden et al. (2015) <doi:10.1093/ije/dyv080>, summary data models for Mendelian randomization analyses.

Multivariate distribution derived from a Bernoulli mixed model under a marginal approach, incorporating a non-normal random intercept whose distribution is assumed to follow a generalized log-gamma (GLG) specification under a particular parameter setting. Estimation is performed by maximizing the log-likelihood using numerical optimization techniques (Lizandra C. Fabio, Vanessa Barros, Cristian Lobos, Jalmar M. F. Carrasco, Marginal multivariate approach: A novel strategy for handling correlated binary outcomes, 2025, under submission).

This package provides a collection of machine learning helper functions, particularly assisting in the Exploratory Data Analysis phase. Makes heavy use of the data.table package for optimal speed and memory efficiency. Highlights include a versatile bin_data() function, sparsify() for converting a data.table to sparse matrix format with one-hot encoding, fast evaluation metrics, and empirical_cdf() for calculating empirical Multivariate Cumulative Distribution Functions.

Distance between multivariate Cauchy distributions, as presented by N. Bouhlel and D. Rousseau (2022) <doi:10.3390/e24060838>. Manipulation of multivariate Cauchy distributions.

This package provides tools for phase-type distributions including the following variants: continuous, discrete, multivariate, in-homogeneous, right-censored, and regression. Methods for functional evaluation, simulation and estimation using the expectation-maximization (EM) algorithm are provided for all models. The methods of this package are based on the following references. Asmussen, S., Nerman, O., & Olsson, M. (1996). Fitting phase-type distributions via the EM algorithm, Olsson, M. (1996). Estimation of phase-type distributions from censored data, Albrecher, H., & Bladt, M. (2019) <doi:10.1017/jpr.2019.60>, Albrecher, H., Bladt, M., & Yslas, J. (2022) <doi:10.1111/sjos.12505>, Albrecher, H., Bladt, M., Bladt, M., & Yslas, J. (2022) <doi:10.1016/j.insmatheco.2022.08.001>, Bladt, M., & Yslas, J. (2022) <doi:10.1080/03461238.2022.2097019>, Bladt, M. (2022) <doi:10.1017/asb.2021.40>, Bladt, M. (2023) <doi:10.1080/10920277.2023.2167833>, Albrecher, H., Bladt, M., & Mueller, A. (2023) <doi:10.1515/demo-2022-0153>, Bladt, M. & Yslas, J. (2023) <doi:10.1016/j.insmatheco.2023.02.008>.

Data sets from a variety of biological sample matrices, analysed using a number of mass spectrometry based metabolomic analytical techniques. The example data sets are stored remotely using GitHub releases <https://github.com/aberHRML/metaboData/releases> which can be accessed from R using the package. The package also includes the abr1 FIE-MS data set from the FIEmspro package <https://users.aber.ac.uk/jhd/> <doi:10.1038/nprot.2007.511>.

Computational tools to represent phylogenetic signals using adapted eigenvector maps.

Computing metabolite set enrichment analysis (MSEA) (Yamamoto, H. et al. (2014) <doi:10.1186/1471-2105-15-51>), single sample enrichment analysis (SSEA) (Yamamoto, H. (2023) <doi:10.51094/jxiv.262>) and over-representation analysis (ORA) that accounts for undetected metabolites (Yamamoto, H. (2024) <doi:10.51094/jxiv.954>).

Mixture model with overlapping clusters for binary actor-event data. Parameters are estimated in a Bayesian framework. Model and inference are described in Ranciati, Vinciotti, Wit (2017) Modelling actor-event network data via a mixture model under overlapping clusters. Submitted.

Miscellaneous functions and wrappers for development in other packages created, maintained by Jordan Mark Barbone.

An interactive presentation on the topic of Multinomial Logistic Regression. It is helpful to those who want to learn Multinomial Logistic Regression quickly and get a hands on experience. The presentation has a template for solving problems on Multinomial Logistic Regression. Runtime examples are provided in the package function as well as at <https://jarvisatharva.shinyapps.io/MultinomPresentation>.

This package provides a framework that boosts the imputation of missForest by Stekhoven, D.J. and Bühlmann, P. (2012) <doi:10.1093/bioinformatics/btr597> by harnessing parallel processing and through the fast Gradient Boosted Decision Trees (GBDT) implementation LightGBM by Ke, Guolin et al.(2017) <https://papers.nips.cc/paper/6907-lightgbm-a-highly-efficient-gradient-boosting-decision>. misspi has the following main advantages: 1. Allows embrassingly parallel imputation on large scale data. 2. Accepts a variety of machine learning models as methods with friendly user portal. 3. Supports multiple initializations methods. 4. Supports early stopping that prohibits unnecessary iterations.

Approximate node interaction parameters of Markov Random Fields graphical networks. Models can incorporate additional covariates, allowing users to estimate how interactions between nodes in the graph are predicted to change across covariate gradients. The general methods implemented in this package are described in Clark et al. (2018) <doi:10.1002/ecy.2221>.