Pharmacokinetics is the study of drug absorption, distribution, metabolism, and excretion. The pharmacokinetics model explains that how the drug concentration change as the drug moves through the different compartments of the body. For pharmacokinetic modeling and analysis, it is essential to understand the basic pharmacokinetic parameters. All parameters are considered, but only some of parameters are used in the model. Therefore, we need to convert the estimated parameters to the other parameters after fitting the specific pharmacokinetic model. This package is developed to help this converting work. For more detailed explanation of pharmacokinetic parameters, see "Gabrielsson and Weiner" (2007), "ISBN-10: 9197651001"; "Benet and Zia-Amirhosseini" (1995) <DOI: 10.1177/019262339502300203>; "Mould and Upton" (2012) <DOI: 10.1038/psp.2012.4>; "Mould and Upton" (2013) <DOI: 10.1038/psp.2013.14>.

Conduct dsep tests (piecewise SEM) of a directed, or mixed, acyclic graph without latent variables (but possibly with implicitly marginalized or conditioned latent variables that create dependent errors) based on linear, generalized linear, or additive modelswith or without a nesting structure for the data. Also included are functions to do desp tests step-by-step,exploratory path analysis, and Monte Carlo X2 probabilities. This package accompanies Shipley, B, (2026).Cause and Correlation in Biology: A User's Guide to Path Analysis, StructuralEquations and Causal Inference (3rd edition). Cambridge University Press.

Optogenetics is a new tool to study neuronal circuits that have been genetically modified to allow stimulation by flashes of light. This package implements the methodological framework, Point-process Response model for Optogenetics (PRO), for analyzing data from these experiments. This method provides explicit nonlinear transformations to link the flash point-process with the spiking point-process. Such response functions can be used to provide important and interpretable scientific insights into the properties of the biophysical process that governs neural spiking in response to optogenetic stimulation.

Calculate seat apportionment for legislative bodies with various methods. The algorithms include divisor or highest averages methods (e.g. Jefferson, Webster or Adams), largest remainder methods and biproportional apportionment. Gaffke, N. & Pukelsheim, F. (2008) <doi:10.1016/j.mathsocsci.2008.01.004> Oelbermann, K. F. (2016) <doi:10.1016/j.mathsocsci.2016.02.003>.

Use Prime Factorization for simplifying computations, for instance for ratios of large factorials.

Statistical power simulation for testing the Rasch Model based on a three-way analysis of variance design with mixed classification.

This package provides data set and function for exploration of Multiple Indicator Cluster Survey (MICS) 2017-18 Maternal Mortality questionnaire data for Punjab, Pakistan. The results of the present survey are critically important for the purposes of Sustainable Development Goals (SDGs) monitoring, as the survey produces information on 32 global Sustainable Development Goals (SDGs) indicators. The data was collected from 53,840 households selected at the second stage with systematic random sampling out of a sample of 2,692 clusters selected using probability proportional to size sampling. Six questionnaires were used in the survey: (1) a household questionnaire to collect basic demographic information on all de jure household members (usual residents), the household, and the dwelling; (2) a water quality testing questionnaire administered in three households in each cluster of the sample; (3) a questionnaire for individual women administered in each household to all women age 15-49 years; (4) a questionnaire for individual men administered in every second household to all men age 15-49 years; (5) an under-5 questionnaire, administered to mothers (or caretakers) of all children under 5 living in the household; and (6) a questionnaire for children age 5-17 years, administered to the mother (or caretaker) of one randomly selected child age 5-17 years living in the household (<http://www.mics.unicef.org/surveys>).

This package provides functions that facilitate the elaboration of population pyramids.

Build and manipulate partially ordered sets (posets), to perform some data analysis on them and to implement multi-criteria decision making procedures. Several efficient ways for generating linear extensions are implemented, together with functions for building mutual ranking probabilities, incomparability, dominance and separation scores (Fattore, M., De Capitani, L., Avellone, A., Suardi, A. (2024). A fuzzy posetic toolbox for multi-criteria evaluation on ordinal data systems. ANNALS OF OPERATIONS RESEARCH <doi:10.1007/s10479-024-06352-3>).

This package provides a low-level package for hosting persistence data. It is part of the TDAverse suite of packages, which is designed to provide a collection of packages for enabling machine learning and data science tasks using persistent homology. Implements a class for hosting persistence data, a number of coercers from and to already existing and used data structures from other packages and functions to compute distances between persistence diagrams. A formal definition and study of bottleneck and Wasserstein distances can be found in Bubenik, Scott and Stanley (2023) <doi:10.1007/s41468-022-00103-8>. Their implementation in phutil relies on the C++ Hera library developed by Kerber, Morozov and Nigmetov (2017) <doi:10.1145/3064175>.

Visualize the partitions of simple decision trees, involving one or two predictors, on the scale of the original data. Provides an intuitive alternative to traditional tree diagrams, by visualizing how a decision tree divides the predictor space in a simple 2D plot alongside the original data. The parttree package supports both classification and regression trees from rpart and partykit', as well as trees produced by popular frontend systems like tidymodels and mlr3'. Visualization methods are provided for both base R graphics and ggplot2'.

Generation of multiple count, binary, ordinal and normal variables simultaneously given the marginal characteristics and association structure. The details of the method are explained in Demirtas et al. (2012) <DOI:10.1002/sim.5362>.

Run population simulations using an Individual-Based Model (IBM) compiled in C.

To calculate the raw, central and standardized moments from distribution parameters. To solve the distribution parameters based on user-provided mean, standard deviation, skewness and kurtosis. Normal, skew-normal, skew-t and Tukey g-&-h distributions are supported, for now.

This package provides functions and data-sets that are helpful for teaching statistics and data analysis. It was originally designed for use when teaching students in the Psychology Department at Nottingham Trent University.

An implementation of the ternary plot for interpreting regression coefficients of trinomial regression models, as proposed in Santi, Dickson and Espa (2019) <doi:10.1080/00031305.2018.1442368>. Ternary plots can be drawn using either ggtern package (based on ggplot2') or Ternary package (based on standard graphics). The package and its features are illustrated in Santi, Dickson, Espa and Giuliani (2022) <doi:10.18637/jss.v103.c01>.

The merits of TIMESAT and phenopix are adopted. Besides, a simple and growing season dividing method and a practical snow elimination method based on Whittaker were proposed. 7 curve fitting methods and 4 phenology extraction methods were provided. Parameters boundary are considered for every curve fitting methods according to their ecological meaning. And optimx is used to select best optimization method for different curve fitting methods. Reference: Kong, D., (2020). R package: A state-of-the-art Vegetation Phenology extraction package, phenofit version 0.3.1, <doi:10.5281/zenodo.5150204>; Kong, D., Zhang, Y., Wang, D., Chen, J., & Gu, X. (2020). Photoperiod Explains the Asynchronization Between Vegetation Carbon Phenology and Vegetation Greenness Phenology. Journal of Geophysical Research: Biogeosciences, 125(8), e2020JG005636. <doi:10.1029/2020JG005636>; Kong, D., Zhang, Y., Gu, X., & Wang, D. (2019). A robust method for reconstructing global MODIS EVI time series on the Google Earth Engine. ISPRS Journal of Photogrammetry and Remote Sensing, 155, 13â 24; Zhang, Q., Kong, D., Shi, P., Singh, V.P., Sun, P., 2018. Vegetation phenology on the Qinghai-Tibetan Plateau and its response to climate change (1982â 2013). Agric. For. Meteorol. 248, 408â 417. <doi:10.1016/j.agrformet.2017.10.026>.

Bandwidth selector according to the Penalised Comparison to Overfitting (P.C.O.) criterion as described in Varet, S., Lacour, C., Massart, P., Rivoirard, V., (2019) <https://hal.archives-ouvertes.fr/hal-02002275>. It can be used with univariate and multivariate data.

Create a parallel coordinates plot, using `htmlwidgets` package and `d3.js`.

This package provides a simple way to add page numbers to base/ggplot/lattice graphics.

Conservation planning datasets for learning how to use the prioritizr package <https://CRAN.R-project.org/package=prioritizr>.

We implement two least-squares estimators under k-monotony constraint using a method based on the Support Reduction Algorithm from Groeneboom et al (2008) <DOI:10.1111/j.1467-9469.2007.00588.x>. The first one is a projection estimator on the set of k-monotone discrete functions. The second one is a projection on the set of k-monotone discrete probabilities. This package provides functions to generate samples from the spline basis from Lefevre and Loisel (2013) <DOI:10.1239/jap/1378401239>, and from mixtures of splines.

Annotate plots with legends for continuous variables and colour spectra using the base graphics plotting tools; and manipulate irregular polygons. Includes palettes for colour-blind viewers.

Village potential statistics (PODES) collects various information on village potential and challenges faced by villages in Indonesia. Information related to village potential includes economy, security, health, employment, communication and information, sports, entertainment, development, community empowerment, education, socio-culture, transportation in the village. Information related to challenges includes natural disasters, public health, environmental pollution, social problems and security disturbances that occur in the village.