Given a set of models for which a measure of model (mis)fit and model complexity is provided, CHull(), developed by Ceulemans and Kiers (2006) <doi:10.1348/000711005X64817>, determines the models that are located on the boundary of the convex hull and selects an optimal model by means of the scree test values.

This package contains a suite of functions for health economic evaluations with missing outcome data. The package can fit different types of statistical models under a fully Bayesian approach using the software JAGS (which should be installed locally and which is loaded in missingHE via the R package R2jags'). Three classes of models can be fitted under a variety of missing data assumptions: selection models, pattern mixture models and hurdle models. In addition to model fitting, missingHE provides a set of specialised functions to assess model convergence and fit, and to summarise the statistical and economic results using different types of measures and graphs. The methods implemented are described in Mason (2018) <doi:10.1002/hec.3793>, Molenberghs (2000) <doi:10.1007/978-1-4419-0300-6_18> and Gabrio (2019) <doi:10.1002/sim.8045>.

An implementation of Multi-Task Logistic Regression (MTLR) for R. This package is based on the method proposed by Yu et al. (2011) which utilized MTLR for generating individual survival curves by learning feature weights which vary across time. This model was further extended to account for left and interval censored data.

This package provides tools for cleaning, processing, and preparing microbiome sequencing data (e.g., 16S rRNA) for downstream analysis. Supports CSV, TXT, and Excel file formats. The main function, ezclean(), automates microbiome data transformation, including format validation, transposition, numeric conversion, and metadata integration. It also handles taxonomic levels efficiently, resolves duplicated taxa entries, and outputs a well-structured, analysis-ready dataset. The companion functions ezstat() run statistical tests and summarize results, while ezviz() produces publication-ready visualizations.

This package provides functions to run fixed effects or random effects multivariate meta-analysis.

Analyzes subject-level data in clinical trials using the metalite data structure. The package simplifies the workflow to create production-ready tables, listings, and figures discussed in the subject-level analysis chapters of "R for Clinical Study Reports and Submission" by Zhang et al. (2022) <https://r4csr.org/>.

Fits a geographically weighted regression model with different scales for each covariate. Uses the negative binomial distribution as default, but also accepts the normal, Poisson, or logistic distributions. Can fit the global versions of each regression and also the geographically weighted alternatives with only one scale, since they are all particular cases of the multiscale approach. Hanchen Yu (2024). "Exploring Multiscale Geographically Weighted Negative Binomial Regression", Annals of the American Association of Geographers <doi:10.1080/24694452.2023.2289986>. Fotheringham AS, Yang W, Kang W (2017). "Multiscale Geographically Weighted Regression (MGWR)", Annals of the American Association of Geographers <doi:10.1080/24694452.2017.1352480>. Da Silva AR, Rodrigues TCV (2014). "Geographically Weighted Negative Binomial Regression - incorporating overdispersion", Statistics and Computing <doi:10.1007/s11222-013-9401-9>.

User-friendly general package providing standard methods for meta-analysis and supporting Schwarzer, Carpenter, and Rücker <DOI:10.1007/978-3-319-21416-0>, "Meta-Analysis with R" (2015): - common effect and random effects meta-analysis; - several plots (forest, funnel, Galbraith / radial, L'Abbe, Baujat, bubble); - three-level meta-analysis model; - generalised linear mixed model; - logistic regression with penalised likelihood for rare events; - Hartung-Knapp method for random effects model; - Kenward-Roger method for random effects model; - prediction interval and density of the prediction distribution; - expected proportion of comparable studies with clinically important benefit or harm; - statistical tests for funnel plot asymmetry; - trim-and-fill method to evaluate bias in meta-analysis; - meta-regression; - cumulative meta-analysis and leave-one-out meta-analysis; - import data from RevMan 5'; - produce forest plot summarising several (subgroup) meta-analyses.

The mycobacrvR package contains utilities to provide detailed information for B cell and T cell epitopes for predicted adhesins from various servers such as ABCpred, Bcepred, Bimas, Propred, NetMHC and IEDB. Please refer the URL below to download data files (data_mycobacrvR.zip) used in functions of this package.

An R interface for the Java Machine Learning for Language Toolkit (mallet) <http://mallet.cs.umass.edu/> to estimate probabilistic topic models, such as Latent Dirichlet Allocation. We can use the R package to read textual data into mallet from R objects, run the Java implementation of mallet directly in R, and extract results as R objects. The Mallet toolkit has many functions, this wrapper focuses on the topic modeling sub-package written by David Mimno. The package uses the rJava package to connect to a JVM.

Fused lasso method to cluster and estimate regression coefficients of the same covariate across different data sets when a large number of independent data sets are combined. Package supports Gaussian, binomial, Poisson and Cox PH models.

Framework to facilitate patient subtyping with similarity network fusion and meta clustering. The similarity network fusion (SNF) algorithm was introduced by Wang et al. (2014) in <doi:10.1038/nmeth.2810>. SNF is a data integration approach that can transform high-dimensional and diverse data types into a single similarity network suitable for clustering with minimal loss of information from each initial data source. The meta clustering approach was introduced by Caruana et al. (2006) in <doi:10.1109/ICDM.2006.103>. Meta clustering involves generating a wide range of cluster solutions by adjusting clustering hyperparameters, then clustering the solutions themselves into a manageable number of qualitatively similar solutions, and finally characterizing representative solutions to find ones that are best for the user's specific context. This package provides a framework to easily transform multi-modal data into a wide range of similarity network fusion-derived cluster solutions as well as to visualize, characterize, and validate those solutions. Core package functionality includes easy customization of distance metrics, clustering algorithms, and SNF hyperparameters to generate diverse clustering solutions; calculation and plotting of associations between features, between patients, and between cluster solutions; and standard cluster validation approaches including resampled measures of cluster stability, standard metrics of cluster quality, and label propagation to evaluate generalizability in unseen data. Associated vignettes guide the user through using the package to identify patient subtypes while adhering to best practices for unsupervised learning.

The inference in multi-state models is traditionally performed under a Markov assumption that claims that past and future of the process are independent given the present state. In this package, we consider tests of the Markov assumption that are applicable to general multi-state models. Three approaches using existing methodology are considered: a simple method based on including covariates depending on the history in Cox models for the transition intensities; methods based on measuring the discrepancy of the non-Markov estimators of the transition probabilities to the Markov Aalen-Johansen estimators; and, finally, methods that were developed by considering summaries from families of log-rank statistics where patients are grouped by the state occupied of the process at a particular time point (see Soutinho G, Meira-Machado L (2021) <doi:10.1007/s00180-021-01139-7> and Titman AC, Putter H (2020) <doi:10.1093/biostatistics/kxaa030>).

Causal moderated mediation analysis using the methods proposed by Qin and Wang (2023) <doi:10.3758/s13428-023-02095-4>. Causal moderated mediation analysis is crucial for investigating how, for whom, and where a treatment is effective by assessing the heterogeneity of mediation mechanism across individuals and contexts. This package enables researchers to estimate and test the conditional and moderated mediation effects, assess their sensitivity to unmeasured pre-treatment confounding, and visualize the results. The package is built based on the quasi-Bayesian Monte Carlo method, because it has relatively better performance at small sample sizes, and its running speed is the fastest. The package is applicable to a treatment of any scale, a binary or continuous mediator, a binary or continuous outcome, and one or more moderators of any scale.

Gibbs sampler for fitting multivariate Bayesian linear regression with shrinkage priors (MBSP), using the three parameter beta normal family. The method is described in Bai and Ghosh (2018) <doi:10.1016/j.jmva.2018.04.010>.

Generate a monochrome palette from a starting colour for a specified number of colours. The package can also be used to display colour palettes in the plot window, with or without hex codes and colour labels.

Estimates key quantities in causal mediation analysis - including average causal mediation effects (indirect effects), average direct effects, total effects, and proportions mediated - in the presence of multiple uncausally related mediators. Methods are described by Jérolon et al., (2021) <doi:10.1515/ijb-2019-0088> and extended to accommodate survival outcomes as described by Domingo-Relloso et al., (2024) <doi:10.1101/2024.02.16.24302923>.

This package provides tools for data analysis with multivariate Bayesian structural time series (MBSTS) models. Specifically, the package provides facilities for implementing general structural time series models, flexibly adding on different time series components (trend, season, cycle, and regression), simulating them, fitting them to multivariate correlated time series data, conducting feature selection on the regression component.

When choosing proper variable selection methods, it is important to consider the uncertainty of a certain method. The model confidence bound for variable selection identifies two nested models (upper and lower confidence bound models) containing the true model at a given confidence level. A good variable selection method is the one of which the model confidence bound under a certain confidence level has the shortest width. When visualizing the variability of model selection and comparing different model selection procedures, model uncertainty curve is a good graphical tool. A good variable selection method is the one of whose model uncertainty curve will tend to arch towards the upper left corner. This function aims to obtain the model confidence bound and draw the model uncertainty curve of certain single model selection method under a coverage rate equal or little higher than user-given confidential level. About what model confidence bound is and how it work please see Li,Y., Luo,Y., Ferrari,D., Hu,X. and Qin,Y. (2019) Model Confidence Bounds for Variable Selection. Biometrics, 75:392-403. <DOI:10.1111/biom.13024>. Besides, flare is needed only you apply the SQRT or LAD method ('mcb totally has 8 methods). Although flare has been archived by CRAN, you can still get it in <https://CRAN.R-project.org/package=flare> and the latest version is useful for mcb'.

This package provides the mean to parse and render markdown text with grid along with facilities to define the styling of the text.

Implementation of the Monothetic Clustering algorithm (Chavent, 1998 <doi:10.1016/S0167-8655(98)00087-7>) on continuous data sets. A lot of extensions are included in the package, including applying Monothetic clustering on data sets with circular variables, visualizations with the results, and permutation and cross-validation based tests to support the decision on the number of clusters.

Framework for the Item Response Theory analysis of dichotomous and ordinal polytomous outcomes under the assumption of multidimensionality and discreteness of the latent traits. The fitting algorithms allow for missing responses and for different item parameterizations and are based on the Expectation-Maximization paradigm. Individual covariates affecting the class weights may be included in the new version (since 2.1).

In the context of multistate models, which are popular in sociology, demography, and epidemiology, Markov chain with rewards calculations can help to refine transition timings and so obtain more accurate estimates. The package code accommodates up to nine transient states and irregular age (time) intervals. Traditional demographic life tables result as a special case. Formulas and methods involved are explained in detail in the accompanying article: Schneider / Myrskyla / van Raalte (2021): Flexible Transition Timing in Discrete-Time Multistate Life Tables Using Markov Chains with Rewards, MPIDR Working Paper WP-2021-002.

Regression models can be fitted for multiple outcomes simultaneously. This package computes estimates of parameters across fitted models and returns the matrix of asymptotic covariance. Various applications of this package, including CUPED (Controlled Experiments Utilizing Pre-Experiment Data), multiple comparison adjustment, are illustrated.