Density, distribution function, quantile function, and random generation function, maximum likelihood estimation (MLE), penalized maximum likelihood estimation (PMLE), the quartiles method estimation (QM), and median rank estimation (MEDRANK) for the two-parameter exponential distribution. MLE and PMLE are based on Mengjie Zheng (2013)<https://scse.d.umn.edu/sites/scse.d.umn.edu/files/mengjie-thesis_masters-1.pdf>. QM is based on Entisar Elgmati and Nadia Gregni (2016)<doi:10.5539/ijsp.v5n5p12>. MEDRANK is based on Matthew Reid (2022)<doi:10.5281/ZENODO.3938000>.

The Cancer Genome Atlas (TCGA) is a program aimed at improving our understanding of Cancer Biology. Several TCGA Datasets are available online. TCGAretriever helps accessing and downloading TCGA data hosted on cBioPortal via its Web Interface (see <https://www.cbioportal.org/> for more information).

This package provides a lightweight toolkit that provides functions for printing tables from input data in the R console or terminal with customizable formatting. Supported outputs include American Psychological Association (APA)-style tables (American Psychological Association, 2020, ISBN:9781433832178), correlation matrices, contingency tables, and two-column summary tables.

Defines the classes used to identify outliers (threshing) and compute the number of significant principal components and number of clusters (reaping) in a joint application of PCA and hierarchical clustering. See Wang et al., 2018, <doi:10.1186/s12859-017-1998-9>.

This package implements the TabNet model by Sercan O. Arik et al. (2019) <doi:10.48550/arXiv.1908.07442> with Coherent Hierarchical Multi-label Classification Networks by Giunchiglia et al. <doi:10.48550/arXiv.2010.10151> and provides a consistent interface for fitting and creating predictions. It's also fully compatible with the tidymodels ecosystem.

This package creates a framework to store and apply display metadata to Analysis Results Datasets (ARDs). The use of tfrmt allows users to define table format and styling without the data, and later apply the format to the data.

The ToxCast Data Analysis Pipeline ('tcpl') is an R package that manages, curve-fits, plots, and stores ToxCast data to populate its linked MySQL database, invitrodb'. The package was developed for the chemical screening data curated by the US EPA's Toxicity Forecaster (ToxCast) program, but tcpl can be used to support diverse chemical screening efforts.

Estimates heterogeneous treatment effects using tidy semantics on experimental or observational data. Methods are based on the doubly-robust learner of Kennedy (2023) <doi:10.1214/23-EJS2157>. You provide a simple recipe for what machine learning algorithms to use in estimating the nuisance functions and tidyhte will take care of cross-validation, estimation, model selection, diagnostics and construction of relevant quantities of interest about the variability of treatment effects.

Download and compile any version of the IANA Time Zone Database (also known as Olson database) and make it current in your R session. Beware: on Windows Cygwin is required!

This package provides a user-friendly R data package that is intended to make Turkish higher education statistics more accessible.

This package provides a two-stage regression method that can be used when various input data types are correlated, for example gene expression and methylation in drug response prediction. In the first stage it uses the upstream features (such as methylation) to predict the response variable (such as drug response), and in the second stage it uses the downstream features (such as gene expression) to predict the residuals of the first stage. In our manuscript (Aben et al., 2016, <doi:10.1093/bioinformatics/btw449>), we show that using TANDEM prevents the model from being dominated by gene expression and that the features selected by TANDEM are more interpretable.

Custom template and output formats for use with rmarkdown. Produce Edward Tufte-style handouts in html formats with full support for rmarkdown features.

This package provides functions to produce, fit and predict from bipartite networks with abundance, trait and phylogenetic information. Its methods are described in detail in Benadi, G., Dormann, C.F., Fruend, J., Stephan, R. & Vazquez, D.P. (2021) Quantitative prediction of interactions in bipartite networks based on traits, abundances, and phylogeny. The American Naturalist, in press.

This package provides functions and example files to calculate the tRNA adaptation index, a measure of the level of co-adaptation between the set of tRNA genes and the codon usage bias of protein-coding genes in a given genome. The methodology is described in dos Reis, Wernisch and Savva (2003) <doi:10.1093/nar/gkg897>, and dos Reis, Savva and Wernisch (2004) <doi:10.1093/nar/gkh834>.

Split a dataframe, tibble, or data.table into training and test sets. Return either a list, an index, or directly assign training and test sets into memory.

This package provides bindings to a C grammar for Tree-sitter, to be used alongside the treesitter package. Tree-sitter builds concrete syntax trees for source files and can efficiently update them or generate code like producing R C API wrappers from C functions, structs and global definitions from header files.

Trust region algorithm for nonlinear optimization. Efficient when the Hessian of the objective function is sparse (i.e., relatively few nonzero cross-partial derivatives). See Braun, M. (2014) <doi:10.18637/jss.v060.i04>.

First - Generates (potentially high-dimensional) high-frequency and low-frequency series for simulation studies in temporal disaggregation; Second - a toolkit utilizing temporal disaggregation and benchmarking techniques with a low-dimensional matrix of indicator series previously proposed in Dagum and Cholette (2006, ISBN:978-0-387-35439-2) ; and Third - novel techniques proposed by Mosley, Gibberd and Eckley (2021) <arXiv:2108.05783> for disaggregating low-frequency series in the presence of high-dimensional indicator matrices.

Simulation, estimation and inference for univariate and multivariate TV(s)-GARCH(p,q,r)-X models, where s indicates the number and shape of the transition functions, p is the ARCH order, q is the GARCH order, r is the asymmetry order, and X indicates that covariates can be included; see Campos-Martins and Sucarrat (2024) <doi:10.18637/jss.v108.i09>. In the multivariate case, variances are estimated equation by equation and dynamic conditional correlations are allowed. The TV long-term component of the variance as in the multiplicative TV-GARCH model of Amado and Terasvirta (2013) <doi:10.1016/j.jeconom.2013.03.006> introduces non-stationarity whereas the GARCH-X short-term component describes conditional heteroscedasticity. Maximisation by parts leads to consistent and asymptotically normal estimates.

This package provides a general regression neural network (GRNN) is a variant of a Radial Basis Function Network characterized by a fast single-pass learning. tsfgrnn allows you to forecast time series using a GRNN model Francisco Martinez et al. (2019) <doi:10.1007/978-3-030-20521-8_17> and Francisco Martinez et al. (2022) <doi:10.1016/j.neucom.2021.12.028>. When the forecasting horizon is higher than 1, two multi-step ahead forecasting strategies can be used. The model built is autoregressive, that is, it is only based on the observations of the time series. You can consult and plot how the prediction was done. It is also possible to assess the forecasting accuracy of the model using rolling origin evaluation.

Estimation of models for truncated Gaussian variables by maximum likelihood.

This package provides a constrained two-dimensional Delaunay triangulation package providing both triangulation and generation of voronoi mosaics of irregular spaced data. Please note that most of the functions are now also covered in package interp, which is a re-implementation from scratch under a free license based on a different triangulation algorithm.

This package contains summary data on gene expression in normal human tissues from the Human Protein Atlas for use with the Tissue-Adjusted Pathway Analysis of cancer (TPAC) method. Frost, H. Robert (2023) "Tissue-adjusted pathway analysis of cancer (TPAC)" <doi:10.1101/2022.03.17.484779>.

Provide the core functionality to transform longitudinal data to complex-time (kime) data using analytic and numerical techniques, visualize the original time-series and reconstructed kime-surfaces, perform model based (e.g., tensor-linear regression) and model-free classification and clustering methods in the book Dinov, ID and Velev, MV. (2021) "Data Science: Time Complexity, Inferential Uncertainty, and Spacekime Analytics", De Gruyter STEM Series, ISBN 978-3-11-069780-3. <https://www.degruyter.com/view/title/576646>. The package includes 18 core functions which can be separated into three groups. 1) draw longitudinal data, such as Functional magnetic resonance imaging(fMRI) time-series, and forecast or transform the time-series data. 2) simulate real-valued time-series data, e.g., fMRI time-courses, detect the activated areas, report the corresponding p-values, and visualize the p-values in the 3D brain space. 3) Laplace transform and kimesurface reconstructions of the fMRI data.