Estimation and comparison of the performances of diagnostic tests in multi-reader multi-case studies where true case statuses (or ground truths) are known and one or more readers provide test ratings for multiple cases. Reader performance metrics are provided for area under and expected utility of ROC curves, likelihood ratio of positive or negative tests, and sensitivity and specificity. ROC curves can be estimated empirically or with binormal or binormal likelihood-ratio models. Statistical comparisons of diagnostic tests are based on the ANOVA model of Obuchowski-Rockette and the unified framework of Hillis (2005) <doi:10.1002/sim.2024>. The ANOVA can be conducted with data from a full factorial, nested, or partially paired study design; with random or fixed readers or cases; and covariances estimated with the DeLong method, jackknifing, or an unbiased method. Smith and Hillis (2020) <doi:10.1117/12.2549075>.

Fit flexible (excess) hazard regression models with the possibility of including non-proportional effects of covariables and of adding a random effect at the cluster level (corresponding to a shared frailty). A detailed description of the package functionalities is provided in Charvat and Belot (2021) <doi: 10.18637/jss.v098.i14>.

Identifies the optimal number of clusters by calculating the similarity between two clustering methods at the same number of clusters using the corrected indices of Rand and Jaccard as described in Albatineh and Niewiadomska-Bugaj (2011). The number of clusters at which the index attain its maximum more frequently is a candidate for being the optimal number of clusters.

Finds the Maximum Likelihood (ML) Estimate of the mean vector and variance-covariance matrix for multivariate normal data with missing values.

This package provides a set of functions, classes and methods for performing ABC and ABC/XYZ analyses, identifying overperforming, underperforming and constantly performing items, and plotting, analyzing as well as predicting the temporal development of items.

Statistical methods to match feature vectors between multiple datasets in a one-to-one fashion. Given a fixed number of classes/distributions, for each unit, exactly one vector of each class is observed without label. The goal is to label the feature vectors using each label exactly once so to produce the best match across datasets, e.g. by minimizing the variability within classes. Statistical solutions based on empirical loss functions and probabilistic modeling are provided. The Gurobi software and its R interface package are required for one of the package functions (match.2x()) and can be obtained at <https://www.gurobi.com/> (free academic license). For more details, refer to Degras (2022) <doi:10.1080/10618600.2022.2074429> "Scalable feature matching for large data collections" and Bandelt, Maas, and Spieksma (2004) <doi:10.1057/palgrave.jors.2601723> "Local search heuristics for multi-index assignment problems with decomposable costs".

This package provides a single function plotting Marradi's trees: a graphical representation of a numerical variable for comparing the variable mean and standard deviation across subgroups. See A. Marradi "L'analisi monovariata" (1993, ISBN: 9788820496876).

Micro simulation model to reproduce natural history of cervical cancer and cost-effectiveness evaluation of prevention strategies. See Georgalis L, de Sanjose S, Esnaola M, Bosch F X, Diaz M (2016) <doi:10.1097/CEJ.0000000000000202> for more details.

Solve scalar-on-function linear models, including generalized linear mixed effect model and quantile linear regression model, and bias correction estimation methods due to measurement error. Details about the measurement error bias correction methods, see Luan et al. (2023) <doi:10.48550/arXiv.2305.12624>, Tekwe et al. (2022) <doi:10.1093/biostatistics/kxac017>, Zhang et al. (2023) <doi:10.5705/ss.202021.0246>, Tekwe et al. (2019) <doi:10.1002/sim.8179>.

Multi-Fidelity emulator for data from computer simulations of the same underlying system but at different input locations and fidelity level, where both the input locations and fidelity level can be continuous. Active Learning can be performed with an implementation of the Integrated Mean Square Prediction Error (IMSPE) criterion developed by Boutelet and Sung (2025, <doi:10.48550/arXiv.2503.23158>).

Calculation routines based on the FOCUS Kinetics Report (2006, 2014). Includes a function for conveniently defining differential equation models, model solution based on eigenvalues if possible or using numerical solvers. If a C compiler (on windows: Rtools') is installed, differential equation models are solved using automatically generated C functions. Non-constant errors can be taken into account using variance by variable or two-component error models <doi:10.3390/environments6120124>. Hierarchical degradation models can be fitted using nonlinear mixed-effects model packages as a back end <doi:10.3390/environments8080071>. Please note that no warranty is implied for correctness of results or fitness for a particular purpose.

This package implements the three parallel forecast combinations of Markov Switching GARCH and extreme learning machine model along with the selection of appropriate model for volatility forecasting. For method details see Hsiao C, Wan SK (2014). <doi:10.1016/j.jeconom.2013.11.003>, Hansen BE (2007). <doi:10.1111/j.1468-0262.2007.00785.x>, Elliott G, Gargano A, Timmermann A (2013). <doi:10.1016/j.jeconom.2013.04.017>.

Calculates multi-scale geomorphometric terrain attributes from regularly gridded digital terrain models using a variable focal windows size (Ilich et al. (2023) <doi:10.1111/tgis.13067>).

This package implements the Model Context Protocol (MCP). Users can start R'-based servers, serving functions as tools for large language models to call before responding to the user in MCP-compatible apps like Claude Desktop and Claude Code', with options to run those tools inside of interactive R sessions. On the other end, when R is the client via the ellmer package, users can register tools from third-party MCP servers to integrate additional context into chats.

This will allow easier management of a CRAN-style repository on local networks (i.e. not on CRAN). This might be necessary where hosted packages contain intellectual property owned by a corporation.

This package performs treatment assignment for (field) experiments considering available, possibly multivariate and continuous, information (covariates, observable characteristics), that is: forms balanced treatment groups, according to the minMSE-method as proposed by Schneider and Schlather (2017) <DOI:10419/161931>.

To assess a summary survival curve from survival probabilities and number of at-risk patients collected at various points in time in various studies, and to test the between-strata heterogeneity.

This package provides a unified workflow for probing, plotting, and assessing the robustness of cross-level interaction effects in two-level mixed-effects models fitted with lme4 (Bates et al., 2015) <doi:10.18637/jss.v067.i01>. Implements simple slopes analysis following Aiken and West (1991, ISBN:9780761907121), Johnson-Neyman intervals following Johnson and Fay (1950) <doi:10.1007/BF02288864> and Bauer and Curran (2005) <doi:10.1207/s15327906mbr4003_5>, and grand- or group-mean centering as described in Enders and Tofighi (2007) <doi:10.1037/1082-989X.12.2.121>. Includes a slope variance decomposition that separates fixed-effect uncertainty from random-slope variance (tau11), a contour surface plot of predicted outcomes over the full predictor-by-moderator space, and robustness diagnostics comprising intraclass correlation coefficient shift analysis and leave-one-cluster-out (LOCO) stability checks. Designed for researchers in education, psychology, biostatistics, epidemiology, organizational science, and other fields where outcomes are clustered within higher-level units.

Fits multiple variable mixtures of various parametric proportional hazard models using the EM-Algorithm. Proportionality restrictions can be imposed on the latent groups and/or on the variables. Several survival distributions can be specified. Missing values and censored values are allowed. Independence is assumed over the single variables.

Identifying comorbidities, frailty, and multimorbidity in claims and administrative data is often a duplicative process. The functions contained in this package are meant to first prepare the data to a format acceptable by all other packages, then provide a uniform and simple approach to generate comorbidity and multimorbidity metrics based on these claims data. The package is ever evolving to include new metrics, and is always looking for new measures to include. The citations used in this package include the following publications: Anne Elixhauser, Claudia Steiner, D. Robert Harris, Rosanna M. Coffey (1998) <doi:10.1097/00005650-199801000-00004>, Brian J Moore, Susan White, Raynard Washington, et al. (2017) <doi:10.1097/MLR.0000000000000735>, Mary E. Charlson, Peter Pompei, Kathy L. Ales, C. Ronald MacKenzie (1987) <doi:10.1016/0021-9681(87)90171-8>, Richard A. Deyo, Daniel C. Cherkin, Marcia A. Ciol (1992) <doi:10.1016/0895-4356(92)90133-8>, Hude Quan, Vijaya Sundararajan, Patricia Halfon, et al. (2005) <doi:10.1097/01.mlr.0000182534.19832.83>, Dae Hyun Kim, Sebastian Schneeweiss, Robert J Glynn, et al. (2018) <doi:10.1093/gerona/glx229>, Melissa Y Wei, David Ratz, Kenneth J Mukamal (2020) <doi:10.1111/jgs.16310>, Kathryn Nicholson, Amanda L. Terry, Martin Fortin, et al. (2015) <doi:10.15256/joc.2015.5.61>, Martin Fortin, José Almirall, and Kathryn Nicholson (2017)<doi:10.15256/joc.2017.7.122>.

To determine the number of quantitative assays needed for a sample of data using pooled testing methods, which include mini-pooling (MP), MP with algorithm (MPA), and marker-assisted MPA (mMPA). To estimate the number of assays needed, the package also provides a tool to conduct Monte Carlo (MC) to simulate different orders in which the sample would be collected to form pools. Using MC avoids the dependence of the estimated number of assays on any specific ordering of the samples to form pools.

This package provides modules as an organizational unit for source code. Modules enforce to be more rigorous when defining dependencies and have a local search path. They can be used as a sub unit within packages or in scripts.

This package implements likelihood-based estimation and diagnostics for multi-type recurrent event data with dynamic risk that depends on prior events and accommodates terminating events. Methods are described in Ghosh, Chan, Younes and Davis (2023) "A Dynamic Risk Model for Multitype Recurrent Events" <doi:10.1093/aje/kwac213>.

Extract, transform and load MITRE standards. This package gives you an approach to cybersecurity data sets. All data sets are build on runtime downloading raw data from MITRE public services. MITRE <https://www.mitre.org/> is a government-funded research organization based in Bedford and McLean. Current version includes most used standards as data frames. It also provide a list of nodes and edges with all relationships.