Simulate genotypes for case-parent triads, case-control, and quantitative trait samples with realistic linkage diequilibrium structure and allele frequency distribution. For studies of epistasis one can simulate models that involve specific SNPs at specific sets of loci, which we will refer to as "pathways". TriadSim generates genotype data by resampling triad genotypes from existing data. The details of the method is described in the manuscript under preparation "Simulating Autosomal Genotypes with Realistic Linkage Disequilibrium and a Spiked in Genetic Effect" Shi, M., Umbach, D.M., Wise A.S., Weinberg, C.R.

Ports the Stata ado package tost which provides a suite of commands to perform two one-sided tests for equivalence following the approach by Schuirman (1987) <doi:10.1007/BF01068419>. Commands are provided for t tests on means, z tests on proportions, McNemar's test (1947) <doi:10.1007/BF02295996> on proportions and related tests, tests on the regression coefficients from OLS linear regression (not yet implementing all of the current regression options from the Stata tostregress command, e.g., survey regression options, estimation options, etc.), Wilcoxon's (1945) <doi:10.2307/3001968> signed rank tests, Wilcoxon-Mann-Whitney (1947) <doi:10.1214/aoms/1177730491> rank sum tests, supporting inference about equivalence for a number of paired and unpaired, parametric and nonparametric study designs and data types. Each command tests a null hypothesis that samples were drawn from populations different by at least plus or minus some researcher-defined level of tolerance, which can be defined in terms of units of the data or rank units (Delta), or in units of the test statistic's distribution (epsilon) except for tost.rrp() and tost.rrpi(). Enough evidence rejects this null hypothesis in favor of equivalence within the tolerance. Equivalence intervals for all tests may be defined symmetrically or asymmetrically.

This package provides multiple water chemistry-based models and published empirical models in one standard format. As many models have been included as possible, however, users should be aware that models have varying degrees of accuracy and applicability. To learn more, read the references provided below for the models implemented. Functions can be chained together to model a complete treatment process and are designed to work in a tidyverse workflow. Models are primarily based on these sources: Benjamin, M. M. (2002, ISBN:147862308X), Crittenden, J. C., Trussell, R., Hand, D., Howe, J. K., & Tchobanoglous, G., Borchardt, J. H. (2012, ISBN:9781118131473), USEPA. (2001) <https://www.epa.gov/sites/default/files/2017-03/documents/wtp_model_v._2.0_manual_508.pdf>.

Extensions to lattice', providing new high-level functions, methods for existing functions, panel functions, and a theme.

The tabularmap is one of the visualization methods for efficiently displaying data consisting of multiple elements by tiling them. When dealing with geospatial, it corrects for differences in visibility between areas.

Utilities for rapidly loading specified rows and/or columns of data from large tab-separated value (tsv) files (large: e.g. 1 GB file of 10000 x 10000 matrix). tsvio is an R wrapper to C code that creates an index file for the rows of the tsv file, and uses that index file to collect rows and/or columns from the tsv file without reading the whole file into memory.

This package provides a step-up test for genetic rare variants in a gene or in a pathway. The method determines an optimal grouping of rare variants analytically. The method has been described in Hoffmann TJ, Marini NJ, and Witte JS (2010) <doi:10.1371/journal.pone.0013584>.

Most estimators implemented by the video game industry cannot obtain reliable initial estimates nor guarantee comparability between distant estimates. TrueSkill Through Time solves all these problems by modeling the entire history of activities using a single Bayesian network allowing the information to propagate correctly throughout the system. This algorithm requires only a few iterations to converge, allowing millions of observations to be analyzed using any low-end computer. Landfried G, Mocskos E (2025). "TrueSkill Through Time: Reliable Initial Skill Estimates and Historical Comparability with Julia, Python, and R." <doi:10.18637/jss.v112.i06>. The core ideas implemented in this project were developed by Dangauthier P, Herbrich R, Minka T, Graepel T (2007). "Trueskill through time: Revisiting the history of chess.".

Streamlines the analysis of clinical data by automatically selecting appropriate statistical descriptions and inference methods based on variable types. For method details see Motulsky H J (2016) <https://www.graphpad.com/guides/prism/10/statistics/index.htm> and d'Agostino R B (1971) <doi:10.1093/biomet/58.2.341>.

This package provides a wrapper to a set of algorithms designed to recognise positional cues present in hierarchical for-human Tables (which would normally be interpreted visually by the human brain) to decompose, then reconstruct the data into machine-readable LongForm Dataframes.

This package provides a crawler for programmatically navigating THREDDS Data Server (<https://www.unidata.ucar.edu/software/tds/>) catalogs, and access dataset metadata and resources.

This package provides a shared tsibble data easily communicates between htmlwidgets on both client and server sides, powered by crosstalk'. A shiny module is provided to visually explore periodic/aperiodic temporal patterns.

This package implements the Topic Testlet Model (TTM) as described by Xiong et al. (2025) <doi:10.1111/jedm.70001>. The package integrates Latent Dirichlet Allocation (LDA) with the Partial Credit Model to account for local item dependence in testlets using latent topics from student textual responses.

Generalization of the classification and regression tree (CART) model that partitions subjects into terminal nodes and tailors machine learning model to each terminal node.

Download geographic shapes from the United States Census Bureau TIGER/Line Shapefiles <https://www.census.gov/geographies/mapping-files/time-series/geo/tiger-line-file.html>. Functions support downloading and reading in geographic boundary data. All downloads can be set up with a cache to avoid multiple downloads. Data is available back to 2000 for most geographies.

This application provides exploratory and confirmatory factor analysis, classical test theory, unidimensional and multidimensional item response theory, and continuous item response model analysis, through the shiny interactive interface. In addition, it offers rich functionalities for visualizing and downloading results. Users can download figures, tables, and analysis reports via the interactive interface.

Instance feature calculation and evolutionary instance generation for the traveling salesman problem. Also contains code to "morph" two TSP instances into each other. And the possibility to conveniently run a couple of solvers on TSP instances.

Estimate the transition diagnostic classification model (TDCM) described in Madison & Bradshaw (2018) <doi:10.1007/s11336-018-9638-5>, a longitudinal extension of the log-linear cognitive diagnosis model (LCDM) in Henson, Templin & Willse (2009) <doi:10.1007/s11336-008-9089-5>. As the LCDM subsumes many other diagnostic classification models (DCMs), many other DCMs can be estimated longitudinally via the TDCM. The TDCM package includes functions to estimate the single-group and multigroup TDCM, summarize results of interest including item parameters, growth proportions, transition probabilities, transitional reliability, attribute correlations, model fit, and growth plots.

Two-stage procedure compares hazard rate functions, which may or may not cross each other.

This package provides a method for comparing the results of two binary diagnostic tests using paired data. Users can rapidly perform descriptive and inferential statistics in a single function call. Options permit users to select which parameters they are interested in comparing and methods for correction for multiple comparisons. Confidence intervals are calculated using the methods with the best coverage. Hypothesis tests use the methods with the best asymptotic performance. A summary of the methods is available in Roldán-Nofuentes (2020) <doi:10.1186/s12874-020-00988-y>. This package is targeted at clinical researchers who want to rapidly and effectively compare results from binary diagnostic tests.

This package provides a kernel of functions for programming time series methods in a way that is relatively independently of the representation of time. Also provides plotting, time windowing, and some other utility functions which are specifically intended for time series. See the Guide distributed as a vignette, or ?tframe.Intro for more details. (User utilities are in package tfplot.).

The tinytest package offers a light-weight zero-dependency unit-testing framework to which this package adds support via the diffobj package for diff'-style textual comparison of R objects, as well as via tinysnapshot package for visual differences in plots.

This package implements a likelihood ratio test and two pairwise standardized mean difference tests for testing equality of means against tree ordered alternatives in one-way ANOVA. The null hypothesis assumes all group means are equal, while the alternative assumes the control mean is less than or equal to each treatment mean with at least one strict inequality. Inputs are a list of numeric vectors (groups) and a significance level; outputs include the test statistic, critical value, and decision. Methods described in "Testing Against Tree Ordered Alternatives in One-way ANOVA" <doi:10.48550/arXiv.2507.17229>.

This package provides functions that can be used to calculate time-dependent state and parameter sensitivities for both continuous- and discrete-time deterministic models. See Ng et al. (2023) <doi:10.1086/726143> for more information about time-dependent sensitivity analysis.