Deals with Young tableaux (field of combinatorics). For standard Young tabeaux, performs enumeration, counting, random generation, the Robinson-Schensted correspondence, and conversion to and from paths on the Young lattice. Also performs enumeration and counting of semistandard Young tableaux, enumeration of skew semistandard Young tableaux, enumeration of Gelfand-Tsetlin patterns, and computation of Kostka numbers.

R version of scperturb tool for single-cell perturbation analysis. Contains wrappers for performing E-statistics for Seurat objects. More details on the method can be found in Peidli et al. (2023) <doi:10.1101/2022.08.20.504663> and in Székely and Rizzo (2004).

Computes Strongest Neighbor Coherence (SNC), a structural diagnostic that replaces Cronbach's alpha using top-k correlation structure. For methodology, see Wells (2025) <https://github.com/TheotherDrWells/snc>.

Efficient implementation of sparse group lasso with optional bound constraints on the coefficients; see <doi:10.18637/jss.v110.i06>. It supports the use of a sparse design matrix as well as returning coefficient estimates in a sparse matrix. Furthermore, it correctly calculates the degrees of freedom to allow for information criteria rather than cross-validation with very large data. Finally, the interface to compiled code avoids unnecessary copies and allows for the use of long integers.

Estimates split-half reliabilities for scoring algorithms of cognitive tasks and questionnaires. The splithalfr supports researcher-provided scoring algorithms, with six vignettes illustrating how on included datasets. The package provides four splitting methods (first-second, odd-even, permutated, Monte Carlo), the option to stratify splits by task design, a number of reliability coefficients, the option to sub-sample data, and bootstrapped confidence intervals.

Some M-estimators for 1-dimensional location (Bisquare, ML for the Cauchy distribution, and the estimators from application of the smoothing principle introduced in Hampel, Hennig and Ronchetti (2011) to the above, the Huber M-estimator, and the median, main function is smoothm), and Pitman estimator.

Calculates parameters of the seawater carbonate system and assists in design of ocean acidification perturbation experiments.

Authenticates against Community Solid Server identity providers using OAuth client credentials with DPoP proofs and performs authenticated requests against Solid resources.

This package produces various measures of expected treatment effect heterogeneity under an assumption of homogeneity across subgroups. Graphical presentations are created to compare these expected differences with the observed differences.

Provide a workflow to jointly embed chromatin accessibility peaks and expressed genes into a shared low-dimensional space using paired single-cell ATAC-seq (scATAC-seq) and single-cell RNA-seq (scRNA-seq) data. It integrates regulatory relationships among peak-peak interactions (via Cicero'), peak-gene interactions (via Lasso, random forest, and XGBoost), and gene-gene interactions (via principal component regression). With the input of paired scATAC-seq and scRNA-seq data matrices, it assigns a low-dimensional feature vector to each gene and peak. Additionally, it supports the reconstruction of gene-gene network with low-dimensional projections (via epsilon-NN) and then the comparison of the networks of two conditions through manifold alignment implemented in scTenifoldNet'. See <doi:10.1093/bioinformatics/btaf483> for more details.

Generates artificial point patterns marked by their spatial and temporal signatures. The resulting point cloud may exhibit inherent interactions between both signatures. The simulation integrates microsimulation (Holm, E., (2017)<doi:10.1002/9781118786352.wbieg0320>) and agent-based models (Bonabeau, E., (2002)<doi:10.1073/pnas.082080899>), beginning with the configuration of movement characteristics for the specified agents (referred to as walkers') and their interactions within the simulation environment. These interactions (Quaglietta, L. and Porto, M., (2019)<doi:10.1186/s40462-019-0154-8>) result in specific spatiotemporal patterns that can be visualized, analyzed, and used for various analytical purposes. Given the growing scarcity of detailed spatiotemporal data across many domains, this package provides an alternative data source for applications in social and life sciences.

Parametric survival regression models under the maximum likelihood approach via Stan'. Implemented regression models include accelerated failure time models, proportional hazards models, proportional odds models, accelerated hazard models, Yang and Prentice models, and extended hazard models. Available baseline survival distributions include exponential, Weibull, log-normal, log-logistic, gamma, generalized gamma, rayleigh, Gompertz and fatigue (Birnbaum-Saunders) distributions. References: Lawless (2002) <ISBN:9780471372158>; Bennett (1982) <doi:10.1002/sim.4780020223>; Chen and Wang(2000) <doi:10.1080/01621459.2000.10474236>; Demarqui and Mayrink (2021) <doi:10.1214/20-BJPS471>.

The saemix package implements the Stochastic Approximation EM algorithm for parameter estimation in (non)linear mixed effects models. It (i) computes the maximum likelihood estimator of the population parameters, without any approximation of the model (linearisation, quadrature approximation,...), using the Stochastic Approximation Expectation Maximization (SAEM) algorithm, (ii) provides standard errors for the maximum likelihood estimator (iii) estimates the conditional modes, the conditional means and the conditional standard deviations of the individual parameters, using the Hastings-Metropolis algorithm (see Comets et al. (2017) <doi:10.18637/jss.v080.i03>). Many applications of SAEM in agronomy, animal breeding and PKPD analysis have been published by members of the Monolix group. The full PDF documentation for the package including references about the algorithm and examples can be downloaded on the github of the IAME research institute for saemix': <https://github.com/iame-researchCenter/saemix/blob/7638e1b09ccb01cdff173068e01c266e906f76eb/docsaem.pdf>.

We develop a novel matrix factorization tool named scINSIGHT to jointly analyze multiple single-cell gene expression samples from biologically heterogeneous sources, such as different disease phases, treatment groups, or developmental stages. Given multiple gene expression samples from different biological conditions, scINSIGHT simultaneously identifies common and condition-specific gene modules and quantify their expression levels in each sample in a lower-dimensional space. With the factorized results, the inferred expression levels and memberships of common gene modules can be used to cluster cells and detect cell identities, and the condition-specific gene modules can help compare functional differences in transcriptomes from distinct conditions. Please also see Qian K, Fu SW, Li HW, Li WV (2022) <doi:10.1186/s13059-022-02649-3>.

This package provides tools to simulate and analyze survival data with interval-, left-, right-, and uncensored observations under common parametric distributions, including "Weibull", "Exponential", "Log-Normal", "Log-Logistic", "Gamma", "Gompertz", "Normal", "Logistic", and "EMV". The package supports both direct maximum likelihood estimation and imputation-based methods, making it suitable for methodological research, simulation benchmarking, and teaching. A web-based companion app is also available for demonstration purposes.

This package provides a comprehensive framework for quantifying the fundamental thermodynamic parameters of adsorption reactionsâ changes in the standard Gibbs free energy (delta G), enthalpy (delta H), and entropy (delta S)â is essential for understanding the spontaneity, heat effects, and molecular ordering associated with sorption processes. By analysing temperature-dependent equilibrium data, thermodynamic interpretation expands adsorption studies beyond conventional isotherm fitting, offering deeper insight into underlying mechanisms and surfaceâ solute interactions. Such an approach typically involves evaluating equilibrium coefficients across multiple temperatures and non-temperature treatments, deriving thermodynamic parameters using established thermodynamic relationships, and determining delta G as a temperature-specific indicator of adsorption favourability. This analytical pathway is widely applicable across environmental science, soil science, chemistry, materials science, and engineering, where reliable assessment of sorption behaviour is critical for examining contaminant retention, nutrient dynamics, and the behaviour of natural and engineered surfaces. By focusing specifically on thermodynamic inference, this framework complements existing adsorption isotherm-fitting packages such as âAdIsMFâ <https://CRAN.R-project.org/package=AdIsMF> <doi:10.32614/CRAN.package.AdIsMF>, and strengthens the scientific basis for interpreting adsorption energetics in both research and applied contexts. Details can be found in Roy et al. (2025) <doi:10.1007/s11270-025-07963-7>.

This package provides functions to model and forecast crop yields using a spatial temporal conditional copula approach. The package incorporates extreme weather covariates and Bayesian Structural Time Series models to analyze crop yield dependencies across multiple regions. Includes tools for fitting, simulating, and visualizing results. This method build upon established R packages, including Hofert et al'. (2025) <doi:10.32614/CRAN.package.copula>, Scott (2024) <doi:10.32614/CRAN.package.bsts>, and Stephenson et al'. (2024) <doi:10.32614/CRAN.package.evd>.

This package provides a simple interface to recursively list files from a directory, filter them using a regular expression, read their contents, and extract lines that match a user-defined pattern. The package returns a dataframe containing the matched lines, their line numbers, file paths, and the corresponding matched substrings. Designed for quick code base exploration, log inspection, or any use case involving pattern-based file and line filtering.

This package implements a custom matrix input field.

This package provides functions for fitting multi-state semi-Markov models to longitudinal data. A parametric maximum likelihood estimation method adapted to deal with Exponential, Weibull and Exponentiated Weibull distributions is considered. Right-censoring can be taken into account and both constant and time-varying covariates can be included using a Cox proportional model. Reference: A. Krol and P. Saint-Pierre (2015) <doi:10.18637/jss.v066.i06>.

This package provides a function that behaves nearly as base::source() but implements a caching mechanism on disk, project based. It allows to quasi source() R scripts that gather data but can fail or consume to much time to respond even if nothing new is expected. It comes with tools to check and execute on demand or when cache is invalid the script.

Computes the optimal alignment of two character sequences. Visualizes the result of the alignment in a matrix plot. Needleman, Saul B.; Wunsch, Christian D. (1970) "A general method applicable to the search for similarities in the amino acid sequence of two proteins" <doi:10.1016/0022-2836(70)90057-4>.

Variable and interaction selection are essential to classification in high-dimensional setting. In this package, we provide the implementation of SODA procedure, which is a forward-backward algorithm that selects both main and interaction effects under logistic regression and quadratic discriminant analysis. We also provide an extension, S-SODA, for dealing with the variable selection problem for semi-parametric models with continuous responses.

Streamline searching, downloading and formatting of nature media files (e.g. audios, photos) from online repositories. The package offers functions for obtaining media metadata from online repositories, downloading associated media files and updating data sets with new records.