This package provides a novel feature-wise normalization method based on a zero-inflated negative binomial model. This method assumes that the effects of sequencing depth vary for each taxon on their mean and also incorporates a rational link of zero probability and taxon dispersion as a function of sequencing depth. Ziyue Wang, Dillon Lloyd, Shanshan Zhao, Alison Motsinger-Reif (2023) <doi:10.1101/2023.10.31.563648>.

This package provides methods for low-rank tensor regression with tensor-valued predictors and scalar covariates. Model estimation is performed using stochastic optimization with random-walk updates for low-rank factor matrices. Computationally intensive components for coefficient estimation and prediction are implemented in C++ via Rcpp'. The package also includes tools for cross-validation and prediction error assessment.

Easily construct prompts and associated logic for interacting with large language models (LLMs). tidyprompt introduces the concept of prompt wraps, which are building blocks that you can use to quickly turn a simple prompt into a complex one. Prompt wraps do not just modify the prompt text, but also add extraction and validation functions that will be applied to the response of the LLM. This ensures that the user gets the desired output. tidyprompt can add various features to prompts and their evaluation by LLMs, such as structured output, automatic feedback, retries, reasoning modes, autonomous R function calling, and R code generation and evaluation. It is designed to be compatible with any LLM provider that offers chat completion.

When plotting treated-minus-control differences, after-minus-before changes, or difference-in-differences, the ttrans() function symmetrically transforms the positive and negative tails to aid plotting. The package includes an observational study with three control groups and an unaffected outcome; see Rosenbaum (2022) <doi:10.1080/00031305.2022.2063944>.

This package provides a terribly-simple data base for numeric time series, written purely in R, so no external database-software is needed. Series are stored in plain-text files (the most-portable and enduring file type) in CSV format. Timestamps are encoded using R's native numeric representation for Date'/'POSIXct', which makes them fast to parse, but keeps them accessible with other software. The package provides tools for saving and updating series in this standardised format, for retrieving and joining data, for summarising files and directories, and for coercing series from and to other data types (such as zoo series).

How can we measure how the usage or frequency of some feature, such as words, differs across some group or set, such as documents? One option is to use the log odds ratio, but the log odds ratio alone does not account for sampling variability; we haven't counted every feature the same number of times so how do we know which differences are meaningful? Enter the weighted log odds, which tidylo provides an implementation for, using tidy data principles. In particular, here we use the method outlined in Monroe, Colaresi, and Quinn (2008) <doi:10.1093/pan/mpn018> to weight the log odds ratio by a prior. By default, the prior is estimated from the data itself, an empirical Bayes approach, but an uninformative prior is also available.

Compute age-adjusted rates by direct and indirect methods and other epidemiological indicators in a tidy way, wrapping functions from the epitools package.

This package provides an extensible formula system to quickly and easily create production quality tables. The processing steps are a formula parser, statistical content generation from data as defined by formula, followed by rendering into a table. Each step of the processing is separate and user definable thus creating a set of composable building blocks for highly customizable table generation. A user is not limited by any of the choices of the package creator other than the formula grammar. For example, one could chose to add a different S3 rendering function and output a format not provided in the default package, or possibly one would rather have Gini coefficients for their statistical content in a resulting table. Routines to achieve New England Journal of Medicine style, Lancet style and Hmisc::summaryM() statistics are provided. The package contains rendering for HTML5, Rmarkdown and an indexing format for use in tracing and tracking are provided.

This package provides a new measure of similarity between a pair of mass spectrometry (MS) experiments, called truncated rank correlation (TRC). To provide a robust metric of similarity in noisy high-dimensional data, TRC uses truncated top ranks (or top m-ranks) for calculating correlation. Truncated rank correlation as a robust measure of test-retest reliability in mass spectrometry data. For more details see Lim et al. (2019) <doi:10.1515/sagmb-2018-0056>.

Computing diversity measures on tripartite graphs. This package first implements a parametrized family of such diversity measures which apply on probability distributions. Sometimes called "True Diversity", this family contains famous measures such as the richness, the Shannon entropy, the Herfindahl-Hirschman index, and the Berger-Parker index. Second, the package allows to apply these measures on probability distributions resulting from random walks between the levels of tripartite graphs. By defining an initial distribution at a given level of the graph and a path to follow between the three levels, the probability of the walker's position within the final level is then computed, thus providing a particular instance of diversity to measure.

Improves the predictive performance of ridge and lasso regression exploiting one or more sources of prior information on the importance and direction of effects (Rauschenberger and others 2023, <doi:10.1093/bioinformatics/btad680>). For running the vignette (optional), install fwelnet and ecpc from <https://github.com/kjytay/fwelnet> and <https://github.com/Mirrelijn/ecpc>, respectively.

Optimizers for torch deep learning library. These functions include recent results published in the literature and are not part of the optimizers offered in torch'. Prospective users should test these optimizers with their data, since performance depends on the specific problem being solved. The packages includes the following optimizers: (a) adabelief by Zhuang et al (2020), <arXiv:2010.07468>; (b) adabound by Luo et al.(2019), <arXiv:1902.09843>; (c) adahessian by Yao et al.(2021) <arXiv:2006.00719>; (d) adamw by Loshchilov & Hutter (2019), <arXiv:1711.05101>; (e) madgrad by Defazio and Jelassi (2021), <arXiv:2101.11075>; (f) nadam by Dozat (2019), <https://openreview.net/pdf/OM0jvwB8jIp57ZJjtNEZ.pdf>; (g) qhadam by Ma and Yarats(2019), <arXiv:1810.06801>; (h) radam by Liu et al. (2019), <arXiv:1908.03265>; (i) swats by Shekar and Sochee (2018), <arXiv:1712.07628>; (j) yogi by Zaheer et al.(2019), <https://papers.nips.cc/paper/8186-adaptive-methods-for-nonconvex-optimization>.

Transmission Ratio Distortion (TRD) is a genetic phenomenon where the two alleles from either parent are not transmitted to the offspring at the expected 1:1 ratio under Mendelian inheritance, leading to spurious signals in genetic association studies. Functions in this package are developed to account for this phenomenon using loglinear model and Transmission Disequilibrium Test (TDT). Some population information can also be calculated.

Thematic maps are geographical maps in which spatial data distributions are visualized. This package offers a flexible, layer-based, and easy to use approach to create thematic maps, such as choropleths and bubble maps.

Data analysis package for estimating potential biological effects from chemical concentrations in environmental samples. Included are a set of functions to analyze, visualize, and organize measured concentration data as it relates to user-selected chemical-biological interaction benchmark data such as water quality criteria. The intent of these analyses is to develop a better understanding of the potential biological relevance of environmental chemistry data. Results can be used to prioritize which chemicals at which sites may be of greatest concern. These methods are meant to be used as a screening technique to predict potential for biological influence from chemicals that ultimately need to be validated with direct biological assays. A description of the analysis can be found in Blackwell (2017) <doi:10.1021/acs.est.7b01613>.

Helper functions for processing REDCap data in R. REDCap is a web-enabled application for building and managing surveys and databases developed at Vanderbilt University.

Pure R implementation of Apache Thrift. This library doesn't require any code generation. To learn more about Thrift go to <https://thrift.apache.org>.

This package provides data frames for forest or tree data structures. You can create forest data structures from data frames and process them based on their hierarchies.

Topological data analysis studies structure and shape of the data using topological features. We provide a variety of algorithms to learn with persistent homology of the data based on functional summaries for clustering, hypothesis testing, visualization, and others. We refer to Wasserman (2018) <doi:10.1146/annurev-statistics-031017-100045> for a statistical perspective on the topic.

To facilitate the analysis of positron emission tomography (PET) time activity curve (TAC) data, and to encourage open science and replicability, this package supports data loading and analysis of multiple TAC file formats. Functions are available to analyze loaded TAC data for individual participants or in batches. Major functionality includes weighted TAC merging by region of interest (ROI), calculating models including standardized uptake value ratio (SUVR) and distribution volume ratio (DVR, Logan et al. 1996 <doi:10.1097/00004647-199609000-00008>), basic plotting functions and calculation of cut-off values (Aizenstein et al. 2008 <doi:10.1001/archneur.65.11.1509>). Please see the walkthrough vignette for a detailed overview of tacmagic functions.

This package provides a calculator for the two-dimensional clinical Disease Activity index for Psoriatic Arthritis (TwoDcDAPSA), a principal component-derived measure that complements the conventional clinical DAPSA score. The TwoDcDAPSA captures residual variation in patient-reported outcomes (pain and patient global assessment) and joint counts (swollen and tender) after adjusting for standardized cDAPSA using natural spline coefficients derived from published models. Residuals are standardized and combined with fixed principal component loadings to yield a continuous PROs-Joint Contrast (PJC) score and quartile groupings. The package applies pre-specified coefficients and loadings to new datasets but does not estimate spline models or principal components itself.

This package provides tools for translating environmental change into organismal response. Microclimate models to vertically scale weather station data to organismal heights. The biophysical modeling tools include both general models for heat flows and specific models to predict body temperatures for a variety of ectothermic taxa. Additional functions model and temporally partition air and soil temperatures and solar radiation. Utility functions estimate the organismal and environmental parameters needed for biophysical ecology. TrenchR focuses on relatively simple and modular functions so users can create transparent and flexible biophysical models. Many functions are derived from Gates (1980) <doi:10.1007/978-1-4612-6024-0> and Campbell and Norman (1988) <isbn:9780387949376>.

Implement text and sentiment analysis with texter'. Generate sentiment scores on text data and also visualize sentiments. texter allows you to quickly generate insights on your data. It includes support for lexicons such as NRC and Bing'.

This package provides functions to get personal Google Scholar profile data from web API and show it in table or figure format.