This package provides statistical tests and algorithms for the detection of change points in time series and point processes - particularly for changes in the mean in time series and for changes in the rate and in the variance in point processes. References - Michael Messer, Marietta Kirchner, Julia Schiemann, Jochen Roeper, Ralph Neininger and Gaby Schneider (2014), A multiple filter test for the detection of rate changes in renewal processes with varying variance <doi:10.1214/14-AOAS782>. Stefan Albert, Michael Messer, Julia Schiemann, Jochen Roeper, Gaby Schneider (2017), Multi-scale detection of variance changes in renewal processes in the presence of rate change points <doi:10.1111/jtsa.12254>. Michael Messer, Kaue M. Costa, Jochen Roeper and Gaby Schneider (2017), Multi-scale detection of rate changes in spike trains with weak dependencies <doi:10.1007/s10827-016-0635-3>. Michael Messer, Stefan Albert and Gaby Schneider (2018), The multiple filter test for change point detection in time series <doi:10.1007/s00184-018-0672-1>. Michael Messer, Hendrik Backhaus, Albrecht Stroh and Gaby Schneider (2019+) Peak detection in time series.

Convenient wrapper functions for the analysis of matrix-assisted laser desorption/ionization-time-of-flight (MALDI-TOF) spectra data in order to select only representative spectra (also called cherry-pick). The package covers the preprocessing and dereplication steps (based on Strejcek, Smrhova, Junkova and Uhlik (2018) <doi:10.3389/fmicb.2018.01294>) needed to cluster MALDI-TOF spectra before the final cherry-picking step. It enables the easy exclusion of spectra and/or clusters to accommodate complex cherry-picking strategies. Alternatively, cherry-picking using taxonomic identification MALDI-TOF data is made easy with functions to import inconsistently formatted reports.

Implementation of commonly used p-value-based and parametric multiple testing procedures (computation of adjusted p-values and simultaneous confidence intervals) and parallel gatekeeping procedures based on the methodology presented in the book "Multiple Testing Problems in Pharmaceutical Statistics" (edited by Alex Dmitrienko, Ajit C. Tamhane and Frank Bretz) published by Chapman and Hall/CRC Press 2009.

This package provides a simulation modeling framework which significantly extends capabilities from the MGDrivE simulation package via a new mathematical and computational framework based on stochastic Petri nets. For more information about MGDrivE', see our publication: Sánchez et al. (2019) <doi:10.1111/2041-210X.13318> Some of the notable capabilities of MGDrivE2 include: incorporation of human populations, epidemiological dynamics, time-varying parameters, and a continuous-time simulation framework with various sampling algorithms for both deterministic and stochastic interpretations. MGDrivE2 relies on the genetic inheritance structures provided in package MGDrivE', so we suggest installing that package initially.

Applying the methodology from Manuel et al. to estimate parameters using a matched case control data with a mismeasured exposure variable that is accompanied by instrumental variables (Submitted).

Exploratory and predictive methods for the analysis of several blocks of variables measured on the same individuals.

This package provides functions and datasets from Hilbe, J.M., and Robinson, A.P. 2013. Methods of Statistical Model Estimation. Chapman & Hall / CRC.

This package provides a compilation of functions to create visually appealing and information-rich plots of meta-analytic data using ggplot2'. Currently allows to create forest plots, funnel plots, and many of their variants, such as rainforest plots, thick forest plots, additional evidence contour funnel plots, and sunset funnel plots. In addition, functionalities for visual inference with the funnel plot in the context of meta-analysis are provided.

This package provides functions for obtaining estimates of the parameter of the niche preemption model (also known as the geometric series), in particular a maximum likelihood estimator (Graffelman, 2021) <doi:10.1101/2021.01.27.428381>. The niche preemption model is a widely used model in ecology and biodiversity studies.

Multivariate Adaptive Regression Spline (MARS) based Artificial Neural Network (ANN) hybrid model is combined Machine learning hybrid approach which selects important variables using MARS and then fits ANN on the extracted important variables.

This package provides tools that facilitate ordinary differential equation (ODE) modeling in R'. This package allows one to perform simulations for ODE models that are encoded in the GNU MCSim model specification language (Bois, 2009) <doi:10.1093/bioinformatics/btp162> using ODE solvers from the R package deSolve (Soetaert et al., 2010) <doi:10.18637/jss.v033.i09>.

The 1001 time series from the M-competition (Makridakis et al. 1982) <DOI:10.1002/for.3980010202> and the 3003 time series from the IJF-M3 competition (Makridakis and Hibon, 2000) <DOI:10.1016/S0169-2070(00)00057-1>.

This package implements a model-based clustering method for categorical life-course sequences relying on mixtures of exponential-distance models introduced by Murphy et al. (2021) <doi:10.1111/rssa.12712>. A range of flexible precision parameter settings corresponding to weighted generalisations of the Hamming distance metric are considered, along with the potential inclusion of a noise component. Gating covariates can be supplied in order to relate sequences to baseline characteristics and sampling weights are also accommodated. The models are fitted using the EM algorithm and tools for visualising the results are also provided.

Quickly and conveniently create interactive visualisations of spatial data with or without background maps. Attributes of displayed features are fully queryable via pop-up windows. Additional functionality includes methods to visualise true- and false-color raster images and bounding boxes.

Multivariate Information-based Inductive Causation, better known by its acronym MIIC, is a causal discovery method, based on information theory principles, which learns a large class of causal or non-causal graphical models from purely observational data, while including the effects of unobserved latent variables. Starting from a complete graph, the method iteratively removes dispensable edges, by uncovering significant information contributions from indirect paths, and assesses edge-specific confidences from randomization of available data. The remaining edges are then oriented based on the signature of causality in observational data. The recent more interpretable MIIC extension (iMIIC) further distinguishes genuine causes from putative and latent causal effects, while scaling to very large datasets (hundreds of thousands of samples). Since the version 2.0, MIIC also includes a temporal mode (tMIIC) to learn temporal causal graphs from stationary time series data. MIIC has been applied to a wide range of biological and biomedical data, such as single cell gene expression data, genomic alterations in tumors, live-cell time-lapse imaging data (CausalXtract), as well as medical records of patients. MIIC brings unique insights based on causal interpretation and could be used in a broad range of other data science domains (technology, climatology, economy, ...). For more information, you can refer to: Simon et al., eLife 2024, <doi:10.1101/2024.02.06.579177>, Ribeiro-Dantas et al., iScience 2024, <doi:10.1016/j.isci.2024.109736>, Cabeli et al., NeurIPS 2021, <https://why21.causalai.net/papers/WHY21_24.pdf>, Cabeli et al., Comput. Biol. 2020, <doi:10.1371/journal.pcbi.1007866>, Li et al., NeurIPS 2019, <https://papers.nips.cc/paper/9573-constraint-based-causal-structure-learning-with-consistent-separating-sets>, Verny et al., PLoS Comput. Biol. 2017, <doi:10.1371/journal.pcbi.1005662>, Affeldt et al., UAI 2015, <https://auai.org/uai2015/proceedings/papers/293.pdf>. Changes from the previous 1.5.3 release on CRAN are available at <https://github.com/miicTeam/miic_R_package/blob/master/NEWS.md>.

Given independent and identically distributed observations X(1), ..., X(n) from a density f, provides five methods to perform a multiscale analysis about f as well as the necessary critical values. The first method, introduced in Duembgen and Walther (2008), provides simultaneous confidence statements for the existence and location of local increases (or decreases) of f, based on all intervals I(all) spanned by any two observations X(j), X(k). The second method approximates the latter approach by using only a subset of I(all) and is therefore computationally much more efficient, but asymptotically equivalent. Omitting the additive correction term Gamma in either method offers another two approaches which are more powerful on small scales and less powerful on large scales, however, not asymptotically minimax optimal anymore. Finally, the block procedure is a compromise between adding Gamma or not, having intermediate power properties. The latter is again asymptotically equivalent to the first and was introduced in Rufibach and Walther (2010).

This package provides tools for cleaning, processing, and preparing microbiome sequencing data (e.g., 16S rRNA) for downstream analysis. Supports CSV, TXT, and Excel file formats. The main function, ezclean(), automates microbiome data transformation, including format validation, transposition, numeric conversion, and metadata integration. It also handles taxonomic levels efficiently, resolves duplicated taxa entries, and outputs a well-structured, analysis-ready dataset. The companion functions ezstat() run statistical tests and summarize results, while ezviz() produces publication-ready visualizations.

An approach to identify microbiome biomarker for time to event data by discovering microbiome for predicting survival and classifying subjects into risk groups. Classifiers are constructed as a linear combination of important microbiome and treatment effects if necessary. Several methods were implemented to estimate the microbiome risk score such as the LASSO method by Robert Tibshirani (1998) <doi:10.1002/(SICI)1097-0258(19970228)16:4%3C385::AID-SIM380%3E3.0.CO;2-3>, Elastic net approach by Hui Zou and Trevor Hastie (2005) <doi:10.1111/j.1467-9868.2005.00503.x>, supervised principle component analysis of Wold Svante et al. (1987) <doi:10.1016/0169-7439(87)80084-9>, and supervised partial least squares analysis by Inge S. Helland <https://www.jstor.org/stable/4616159>. Sensitivity analysis on the quantile used for the classification can also be accessed to check the deviation of the classification group based on the quantile specified. Large scale cross validation can be performed in order to investigate the mostly selected microbiome and for internal validation. During the evaluation process, validation is accessed using the hazard ratios (HR) distribution of the test set and inference is mainly based on resampling and permutations technique.

This package provides tools to simulate morphological traits along phylogenetic trees with branch lengths representing evolutionary distance or time. Includes functions for visualizing evolutionary processes along trees and within morphological character matrices.

This package provides methods for quantifying the information gain contributed by individual modalities in multimodal regression models. Information gain is measured using Expected Relative Entropy (ERE) or pseudo-R² metrics, with corresponding p-values and confidence intervals. Currently supports linear and logistic regression models with plans for extension to additional Generalized Linear Models and Cox proportional hazard model.

Generates multivariate imputations using sequential regression with L2 penalty. For more details see Zahid and Heumann (2018) <doi:10.1177/0962280218755574>.

Computes the degrees of freedom of the lasso, elastic net, generalized elastic net and adaptive lasso based on the generalized path seeking algorithm. The optimal model can be selected by model selection criteria including Mallows Cp, bias-corrected AIC (AICc), generalized cross validation (GCV) and BIC.

Package for estimating, analyzing, and forecasting multi-country macro-finance affine term structure models (ATSMs). All setups build on the single-country unspanned macroeconomic risk framework from Joslin, Priebsch, and Singleton (2014, JF) <doi:10.1111/jofi.12131>. Multicountry extensions by Jotikasthira, Le, and Lundblad (2015, JFE) <doi:10.1016/j.jfineco.2014.09.004>, Candelon and Moura (2023, EM) <doi:10.1016/j.econmod.2023.106453>, and Candelon and Moura (2024, JFEC) <doi:10.1093/jjfinec/nbae008> are also available. The package also provides tools for bias correction as in Bauer Rudebusch and Wu (2012, JBES) <doi:10.1080/07350015.2012.693855>, bootstrap analysis, and several graphical/numerical outputs.

Estimates multivariate subgaussian stable densities and probabilities as well as generates random variates using product distribution theory. A function for estimating the parameters from data to fit a distribution to data is also provided, using the method from Nolan (2013) <doi:10.1007/s00180-013-0396-7>.