Sample size and effect size calculations for survival endpoints based on mixture survival-by-response model. The methods implemented can be found in Bofill, Shen & Gómez (2021) <arXiv:2008.12887>.

Handles both vector and matrices, using a flexible S4 class for automatic differentiation. The method used is forward automatic differentiation. Many functions and methods have been defined, so that in most cases, functions written without automatic differentiation in mind can be used without change.

This package provides a comprehensive Shiny application for analyzing Whole Genome Duplication ('WGD') events. This package provides a user-friendly Shiny web application for non-experienced researchers to prepare input data and execute command lines for several well-known WGD analysis tools, including wgd', ksrates', i-ADHoRe', OrthoFinder', and Whale'. This package also provides the source code for experienced researchers to adjust and install the package to their own server. Key Features 1) Input Data Preparation This package allows users to conveniently upload and format their data, making it compatible with various WGD analysis tools. 2) Command Line Generation This package automatically generates the necessary command lines for selected WGD analysis tools, reducing manual errors and saving time. 3) Visualization This package offers interactive visualizations to explore and interpret WGD results, facilitating in-depth WGD analysis. 4) Comparative Genomics Users can study and compare WGD events across different species, aiding in evolutionary and comparative genomics studies. 5) User-Friendly Interface This Shiny web application provides an intuitive and accessible interface, making WGD analysis accessible to researchers and bioinformaticians of all levels.

This package provides a simple method to display and characterise the multidimensional ecological niche of a species. The method also estimates the optimums and amplitudes along each niche dimension. Give also an estimation of the degree of niche overlapping between species. See Kleparski and Beaugrand (2022) <doi:10.1002/ece3.8830> for further details.

R Codes and Datasets for Stroup, W. W. (2012). Generalized Linear Mixed Models Modern Concepts, Methods and Applications, CRC Press.

This package provides functions for converting among CIE XYZ, xyY, Lab, and Luv. Calculate Correlated Color Temperature (CCT) and the Planckian and daylight loci. The XYZs of some standard illuminants and some standard linear chromatic adaptation transforms (CATs) are included. Three standard color difference metrics are included, plus the forward direction of the CIECAM02 color appearance model.

Estimate the receiver operating characteristic (ROC) curve, area under the curve (AUC) and optimal cut-off points for individual classification taking into account complex sampling designs when working with complex survey data. Methods implemented in this package are described in: A. Iparragirre, I. Barrio, I. Arostegui (2024) <doi:10.1002/sta4.635>; A. Iparragirre, I. Barrio, J. Aramendi, I. Arostegui (2022) <doi:10.2436/20.8080.02.121>; A. Iparragirre, I. Barrio (2024) <doi:10.1007/978-3-031-65723-8_7>.

Calculates enrolment, graduation, dropout, and programme-switch indicators from the Dutch higher education registration data (1CHO) supplied by DUO. Includes an interactive Shiny dashboard for exploring results.

This package provides the data sets used to exemplify specmine'. These data sets were formerly distributed with specmine', but they exceed current CRAN policy for package size.

Seven different methods for multiple testing problems. The SGoF-type methods (see for example, Carvajal Rodrà guez et al., 2009 <doi:10.1186/1471-2105-10-209>; de Uña à lvarez, 2012 <doi:10.1515/1544-6115.1812>; Castro Conde et al., 2015 <doi:10.1177/0962280215597580>) and the BH and BY false discovery rate controlling procedures.

Calculates parameters of the seawater carbonate system and assists in design of ocean acidification perturbation experiments.

Sample size estimation and blinded sample size reestimation in Adaptive Study Design.

Style sheets and JavaScript assets for shiny.semantic package.

Calculate the statistical power to detect clusters using kernel-based spatial relative risk functions that are estimated using the sparr package. Details about the sparr package methods can be found in the tutorial: Davies et al. (2018) <doi:10.1002/sim.7577>. Details about kernel density estimation can be found in J. F. Bithell (1990) <doi:10.1002/sim.4780090616>. More information about relative risk functions using kernel density estimation can be found in J. F. Bithell (1991) <doi:10.1002/sim.4780101112>.

Shiny wrappers for the RGL package. This package exposes RGL's ability to export WebGL visualization in a shiny-friendly format.

This package provides a tidy approach to spatial network analysis, in the form of classes and functions that enable a seamless interaction between the network analysis package tidygraph and the spatial analysis package sf'.

Similarity regression, evaluating the probability of association between sets of ontological terms and binary response vector. A no-association model is compared with one in which the log odds of a true response is linked to the semantic similarity between terms and a latent characteristic ontological profile - Phenotype Similarity Regression for Identifying the Genetic Determinants of Rare Diseases', Greene et al 2016 <doi:10.1016/j.ajhg.2016.01.008>.

Computes scores of outlyingness for data sets consisting of nominal variables and includes various evaluation metrics for assessing performance of outlier identification algorithms producing scores of outlyingness. The scores of nominal outlyingness are computed based on the framework of Costa and Papatsouma (2025) <doi:10.48550/arXiv.2408.07463>.

Fits Bayesian hierarchical piecewise regression models with multiple logistic-smoothed change-points. Non-linear parameters (change-point locations and transition sharpness) and linear parameters can each be conditioned on covariates and factors via flexible design matrices. A random-intercept structure is supported for any parameter. Spike-and-slab regularization is supported for selecting the number of breakpoints. Posterior inference uses a Metropolis-within-Gibbs sampler implemented in Rust for speed. Methods are based on the smooth transition piecewise regression model of Bacon and Watts (1971) <doi:10.2307/2334389> and variable selection spike-and-slab priors of Kuo and Mallick (1998) <https://www.jstor.org/stable/25053023>. Methods are described in Bindoff (2026) <doi:10.48550/arXiv.2606.19044>.

This package provides model-aware behavioral validation and audit certificates for statistical analyses. Controlled transformations and model-specific diagnostic checks are organized across five domains: computational integrity, numerical stability, design adequacy, assumption screening, and influence stability. Supported workflows include linear models, generalized linear models, classical and repeated-measures analyses of variance, mixed-effects models fitted using lme4 or glmmTMB', and survival models fitted using survival'. Checks are selected according to registered applicability conditions for each model class. The resulting certificates describe computational behavior and selected diagnostic findings; they do not establish causal validity, model correctness, or scientific appropriateness.

Support for reading/writing simple feature ('sf') spatial objects from/to Parquet files. Parquet files are an open-source, column-oriented data storage format from Apache (<https://parquet.apache.org/>), now popular across programming languages. This implementation converts simple feature list geometries into well-known binary format for use by arrow', and coordinate reference system information is maintained in a standard metadata format.

Generate continuous (normal, non-normal, or mixture distributions), binary, ordinal, and count (regular or zero-inflated, Poisson or Negative Binomial) variables with a specified correlation matrix, or one continuous variable with a mixture distribution. This package can be used to simulate data sets that mimic real-world clinical or genetic data sets (i.e., plasmodes, as in Vaughan et al., 2009 <DOI:10.1016/j.csda.2008.02.032>). The methods extend those found in the SimMultiCorrData R package. Standard normal variables with an imposed intermediate correlation matrix are transformed to generate the desired distributions. Continuous variables are simulated using either Fleishman (1978)'s third order <DOI:10.1007/BF02293811> or Headrick (2002)'s fifth order <DOI:10.1016/S0167-9473(02)00072-5> polynomial transformation method (the power method transformation, PMT). Non-mixture distributions require the user to specify mean, variance, skewness, standardized kurtosis, and standardized fifth and sixth cumulants. Mixture distributions require these inputs for the component distributions plus the mixing probabilities. Simulation occurs at the component level for continuous mixture distributions. The target correlation matrix is specified in terms of correlations with components of continuous mixture variables. These components are transformed into the desired mixture variables using random multinomial variables based on the mixing probabilities. However, the package provides functions to approximate expected correlations with continuous mixture variables given target correlations with the components. Binary and ordinal variables are simulated using a modification of ordsample() in package GenOrd'. Count variables are simulated using the inverse CDF method. There are two simulation pathways which calculate intermediate correlations involving count variables differently. Correlation Method 1 adapts Yahav and Shmueli's 2012 method <DOI:10.1002/asmb.901> and performs best with large count variable means and positive correlations or small means and negative correlations. Correlation Method 2 adapts Barbiero and Ferrari's 2015 modification of the GenOrd package <DOI:10.1002/asmb.2072> and performs best under the opposite scenarios. The optional error loop may be used to improve the accuracy of the final correlation matrix. The package also contains functions to calculate the standardized cumulants of continuous mixture distributions, check parameter inputs, calculate feasible correlation boundaries, and summarize and plot simulated variables.

This package implements a parametric decision-theoretic framework for optimal diagnostic cutoff selection under the family of scale mixtures of skew-normal (SMSN) distributions, including the skew-normal (SN) and skew-t (ST) models as special cases. The optimal cutoff is defined by minimising a weighted misclassification risk that incorporates disease prevalence and asymmetric costs, leading to a likelihood-ratio equation that generalises the Youden criterion. Under a monotone likelihood ratio condition, existence, uniqueness, and global optimality of the cutoff are established. Asymptotic normality and a closed-form plug-in variance estimator are provided via the implicit function theorem and the multivariate delta method. Tools for model fitting, cutoff estimation, confidence intervals, the local identifiability diagnostic, and Monte Carlo simulation are included. The methodology is described in de Paula, Mouriño, and Dias Domingues (2026) <doi:10.48550/arXiv.2605.07829>.

This package provides tools for simulation of plant breeding programs as described, for example, by Melchinger and Frisch (2023) <doi:10.1007/s00122-023-04446-3>, prediction of segregation variance (Osthushenrich, Frisch and Herzog (2017) <doi:10.1371/journal.pone.0188839>), genomic prediction (Hofheinz and Frisch (2014) <doi:10.1534/g3.113.010025>), linkage disequilibrium based haplotype construction, and planning of marker assisted back crossing programs. It provides an integrated framework for simulation and analysis of plant breeding programs.