Computes noncompartmental pharmacokinetic parameters for drug concentration profiles. For each profile, data imputations and adjustments are made as necessary and basic parameters are estimated. Supports single dose, multi-dose, and multi-subject data. Supports steady-state calculations and various routes of drug administration. See ?qpNCA and vignettes. Methodology follows Rowland and Tozer (2011, ISBN:978-0-683-07404-8), Gabrielsson and Weiner (1997, ISBN:978-91-9765-100-4), and Gibaldi and Perrier (1982, ISBN:978-0824710422).

This package provides tools for AI-assisted qualitative data coding using large language models ('LLMs') via the ellmer package, supporting providers including OpenAI', Anthropic', Google', Azure', and local models via Ollama'. Provides a codebook'-based workflow for defining coding instructions and applying them to texts, images, and other data. Includes built-in codebooks for common applications such as sentiment analysis and policy coding, and functions for creating custom codebooks for specific research questions. Supports systematic replication across models and settings, computing inter-coder reliability statistics including Krippendorff's alpha (Krippendorff 2019, <doi:10.4135/9781071878781>) and Fleiss kappa (Fleiss 1971, <doi:10.1037/h0031619>), as well as gold-standard validation metrics including accuracy, precision, recall, and F1 scores following Sokolova and Lapalme (2009, <doi:10.1016/j.ipm.2009.03.002>). Provides audit trail functionality for documenting coding workflows following Lincoln and Guba's (1985, ISBN:0803924313) framework for establishing trustworthiness in qualitative research.

This package provides methods for detecting structural breaks, determining the number of breaks, and estimating break locations in linear quantile regression, using one or multiple quantiles, based on Qu (2008) and Oka and Qu (2011). Applicable to both time series and repeated cross-sectional data. The main function is rq.break(). . References for detailed theoretical and empirical explanations: . (1) Qu, Z. (2008). "Testing for Structural Change in Regression Quantiles." Journal of Econometrics, 146(1), 170-184 <doi:10.1016/j.jeconom.2008.08.006> . (2) Oka, T., and Qu, Z. (2011). "Estimating Structural Changes in Regression Quantiles." Journal of Econometrics, 162(2), 248-267 <doi:10.1016/j.jeconom.2011.01.005>.

This package implements the Quantile-on-Quantile (QQ) regression methodology developed by Sim and Zhou (2015) <doi:10.1016/j.jbankfin.2015.01.013>. QQ regression estimates the effect that quantiles of one variable have on quantiles of another, capturing the dependence between distributions. The package provides functions for QQ regression estimation, 3D surface visualization with MATLAB'-style color schemes ('Jet', Viridis', Plasma'), heatmaps, contour plots, and quantile correlation analysis. Uses quantreg for quantile regression and plotly for interactive visualizations. Particularly useful for examining relationships between financial variables, oil prices, and stock returns under different market conditions.

This R package assists breeders in linking data systems with their analytic pipelines, a crucial step in digitizing breeding processes. It supports querying and retrieving phenotypic and genotypic data from systems like EBS <https://ebs.excellenceinbreeding.org/>, BMS <https://bmspro.io>, BreedBase <https://breedbase.org>, GIGWA <https://github.com/SouthGreenPlatform/Gigwa2> (using BrAPI <https://brapi.org> calls), , and Germinate <https://germinateplatform.github.io/get-germinate/>. Extra helper functions support environmental data sources, including TerraClimate <https://www.climatologylab.org/terraclimate.html> and FAO HWSDv2 <https://gaez.fao.org/pages/hwsd> soil database.

Create quantile binned and conditional plots for Exploratory Data Analysis. The package provides several plotting functions that are all based on quantile binning. The plots are created with ggplot2 and patchwork and can be further adjusted.

General purpose toolbox for simulating quantum versions of game theoretic models (Flitney and Abbott 2002) <arXiv:quant-ph/0208069>. Quantum (Nielsen and Chuang 2010, ISBN:978-1-107-00217-3) versions of models that have been handled are: Penny Flip Game (David A. Meyer 1998) <arXiv:quant-ph/9804010>, Prisoner's Dilemma (J. Orlin Grabbe 2005) <arXiv:quant-ph/0506219>, Two Person Duel (Flitney and Abbott 2004) <arXiv:quant-ph/0305058>, Battle of the Sexes (Nawaz and Toor 2004) <arXiv:quant-ph/0110096>, Hawk and Dove Game (Nawaz and Toor 2010) <arXiv:quant-ph/0108075>, Newcomb's Paradox (Piotrowski and Sladkowski 2002) <arXiv:quant-ph/0202074> and Monty Hall Problem (Flitney and Abbott 2002) <arXiv:quant-ph/0109035>.

This package provides a quantum computer simulator framework with up to 24 qubits. It allows to define general single qubit gates and general controlled single qubit gates. For convenience, it currently provides the most common gates (X, Y, Z, H, Z, S, T, Rx, Ry, Rz, CNOT, SWAP, Toffoli or CCNOT, Fredkin or CSWAP). qsimulatR also implements noise models. qsimulatR supports plotting of circuits and is able to export circuits to Qiskit <https://qiskit.org/>, a python package which can be used to run on IBM's hardware <https://quantum-computing.ibm.com/>.

The Ensemble Quadratic and Affine Invariant Markov chain Monte Carlo algorithms provide an efficient way to perform Bayesian inference in difficult parameter space geometries. The Ensemble Quadratic Monte Carlo algorithm was developed by Militzer (2023) <doi:10.3847/1538-4357/ace1f1>. The Ensemble Affine Invariant algorithm was developed by Goodman and Weare (2010) <doi:10.2140/camcos.2010.5.65> and it was implemented in Python by Foreman-Mackey et al (2013) <doi:10.48550/arXiv.1202.3665>. The Quadratic Monte Carlo method was shown to perform better than the Affine Invariant method in the paper by Militzer (2023) <doi:10.3847/1538-4357/ace1f1> and the Quadratic Monte Carlo method is the default method used. The Chen-Shao Highest Posterior Density Estimation algorithm is used for obtaining credible intervals and the potential scale reduction factor diagnostic is used for checking the convergence of the chains.

Molecular descriptors and outcomes for several public domain data sets.

These functions use data augmentation and Bayesian techniques for the assessment of single-member and incomplete ensembles of climate projections. It provides unbiased estimates of climate change responses of all simulation chains and of all uncertainty variables. It additionally propagates uncertainty due to missing information in the estimates. - Evin, G., B. Hingray, J. Blanchet, N. Eckert, S. Morin, and D. Verfaillie. (2019) <doi:10.1175/JCLI-D-18-0606.1>.

High-throughput analysis of growth curves and fluorescence data using three methods: linear regression, growth model fitting, and smooth spline fit. Analysis of dose-response relationships via smoothing splines or dose-response models. Complete data analysis workflows can be executed in a single step via user-friendly wrapper functions. The results of these workflows are summarized in detailed reports as well as intuitively navigable R data containers. A shiny application provides access to all features without requiring any programming knowledge. The package is described in further detail in Wirth et al. (2023) <doi:10.1038/s41596-023-00850-7>.

This package provides a tool that can be customized to aid in the clean up of ecological data collected using quadrats and can crop quadrats to ensure comparability between quadrats collected under different methodologies.

This package provides methods for statistical analysis of count data and quantal data. For the analysis of count data an implementation of the Closure Principle Computational Approach Test ("CPCAT") is provided (Lehmann, R et al. (2016) <doi:10.1007/s00477-015-1079-4>), as well as an implementation of a "Dunnett GLM" approach using a Quasi-Poisson regression (Hothorn, L, Kluxen, F (2020) <doi:10.1101/2020.01.15.907881>). For the analysis of quantal data an implementation of the Closure Principle Fisherâ Freemanâ Halton test ("CPFISH") is provided (Lehmann, R et al. (2018) <doi:10.1007/s00477-017-1392-1>). P-values and no/lowest observed (adverse) effect concentration values are calculated. All implemented methods include further functions to evaluate the power and the minimum detectable difference using a bootstrapping approach.

Dynamically generate tabset panels <https://quarto.org/docs/output-formats/html-basics.html#tabsets> in Quarto HTML documents using a data frame as input.

This package provides functions and tools for creating, visualizing, and investigating properties of continuous-time quantum walks, including efficient calculation of matrices such as the mixing matrix, average mixing matrix, and spectral decomposition of the Hamiltonian. E. Farhi (1997): <arXiv:quant-ph/9706062v2>; C. Godsil (2011) <arXiv:1103.2578v3>.

G-computation for a set of time-fixed exposures with quantile-based basis functions, possibly under linearity and homogeneity assumptions. Effect measure modification in this method is a way to assess how the effect of the mixture varies by a binary, categorical or continuous variable. Reference: Alexander P. Keil, Jessie P. Buckley, Katie M. OBrien, Kelly K. Ferguson, Shanshan Zhao, and Alexandra J. White (2019) A quantile-based g-computation approach to addressing the effects of exposure mixtures; <doi:10.1289/EHP5838>.

This package provides a set of functions for taking qualitative GIS data, hand drawn on a map, and converting it to a simple features object. These tools are focused on data that are drawn on a map that contains some type of polygon features. For each area identified on the map, the id numbers of these polygons can be entered as vectors and transformed using qualmap.

This software provides tools for quantitative trait mapping in populations such as advanced intercross lines where relatedness among individuals should not be ignored. It can estimate background genetic variance components, impute missing genotypes, simulate genotypes, perform a genome scan for putative quantitative trait loci (QTL), and plot mapping results. It also has functions to calculate identity coefficients from pedigrees, especially suitable for pedigrees that consist of a large number of generations, or estimate identity coefficients from genotypic data in certain circumstances.

The main goal is to make descriptive evaluations easier to create bigger and more complex outputs in less time with less code. Introducing format containers with multilabels <https://documentation.sas.com/doc/en/pgmsascdc/v_067/proc/p06ciqes4eaqo6n0zyqtz9p21nfb.htm>, a more powerful summarise which is capable to output every possible combination of the provided grouping variables in one go <https://documentation.sas.com/doc/en/pgmsascdc/v_067/proc/p0jvbbqkt0gs2cn1lo4zndbqs1pe.htm>, tabulation functions which can create any table in different styles <https://documentation.sas.com/doc/en/pgmsascdc/v_067/proc/n1ql5xnu0k3kdtn11gwa5hc7u435.htm> and other more readable functions. The code is optimized to work fast even with datasets of over a million observations.

Fits quadratic generalized autoregressive conditional heteroskedasticity-in-mean (QGARCH-M) models motivated by Campbell and Hentschel (1992). The package supports models with lambda fixed at zero, lambda restricted to a function of the remaining parameters, lambda estimated freely, and a threshold extension with state-dependent lambda. It also provides tools for starting values, estimation, forecasting, likelihood-ratio testing, moment diagnostics, and replication with the included monthly U.S. stock market dataset.

R implementation of Quantile Data Envelopment Analysis. The package qDEA allows a user specified proportion of observations to lie external to a given Decision Making Units's (DMU's)reference hyperplane. qDEA can be used to detect and address influential outliers or to implement quantile benchmarking, as discussed in Atwood and Shaik (2020). Quantile benchmarking is accomplished by using heuristic procedures to find a DMU's closest input-output projection point in a specified direction while allowing a specified proportion of observations to lie external to the projected point's hyperplane. The qDEA package accommodates standard (DEA) and quantile DEA estimation, returns to scale CRS(constant),VRS(variable),DRS(decreasing) or IRS(increasing), the use of directional vectors, bias correction through subsample bootstrapping and subsample size selection procedures. The user can also recover each DMU's reference DMUs and external DMUs if desired. The implemented procedures are based on discussions in: Atwood and Shaik (2020) <doi:10.1016/j.ejor.2020.03.054> Atwood and Shaik (2018) <doi:10.1007/978-3-319-68678-3_4> Walden and Atwood (2023) <doi:10.1086/724932> Walden and Atwood (2025) <doi:10.1086/736554>.

Conduct multiple quantitative trait loci (QTL) mapping under the framework of random-QTL-effect linear mixed model. First, each position on the genome is detected in order to obtain a negative logarithm P-value curve against genome position. Then, all the peaks on each effect (additive or dominant) curve are viewed as potential QTL, all the effects of the potential QTL are included in a multi-QTL model, their effects are estimated by empirical Bayes in doubled haploid population or by adaptive lasso in F2 population, and true QTL are identified by likelihood radio test. See Wen et al. (2018) <doi:10.1093/bib/bby058>.

This package provides functions to Simultaneously Infer Causal Graphs and Genetic Architecture. Includes acyclic and cyclic graphs for data from an experimental cross with a modest number (<10) of phenotypes driven by a few genetic loci (QTL). Chaibub Neto E, Keller MP, Attie AD, Yandell BS (2010) Causal Graphical Models in Systems Genetics: a unified framework for joint inference of causal network and genetic architecture for correlated phenotypes. Annals of Applied Statistics 4: 320-339. <doi:10.1214/09-AOAS288>.