This package provides a tool for registering (aligning) gene expression profiles between reference and query data.

This package provides functions to develop simulated continuous data (e.g., gene expression) from a sigma covariance matrix derived from a graph structure in igraph objects. Intended to extend mvtnorm to take igraph structures rather than sigma matrices as input. This allows the use of simulated data that correctly accounts for pathway relationships and correlations. This allows the use of simulated data that correctly accounts for pathway relationships and correlations. Here we present a versatile statistical framework to simulate correlated gene expression data from biological pathways, by sampling from a multivariate normal distribution derived from a graph structure. This package allows the simulation of biological pathways from a graph structure based on a statistical model of gene expression. For example methods to infer biological pathways and gene regulatory networks from gene expression data can be tested on simulated datasets using this framework. This also allows for pathway structures to be considered as a confounding variable when simulating gene expression data to test the performance of genomic analyses.

Create R functions that interact with OAuth2 Google APIs <https://developers.google.com/apis-explorer/> easily, with auto-refresh and Shiny compatibility.

Testing, Implementation and Forecasting of Grey Model (GM(1, 1)). For method details see Hsu, L. and Wang, C. (2007). <doi:10.1016/j.techfore.2006.02.005>.

Inference, goodness-of-fit tests, and predictions for continuous and discrete univariate Hidden Markov Models (HMM), including zero-inflated distributions. The goodness-of-fit test is based on a Cramer-von Mises statistic and uses parametric bootstrap to estimate the p-value. The description of the methodology is taken from Nasri et al (2020) <doi:10.1029/2019WR025122>.

This package provides a collection of different indices and visualization techniques for evaluate the seed germination process in ecophysiological studies (Lozano-Isla et al. 2019) <doi:10.1111/1440-1703.1275>.

This package provides functions to analyze data exported from Google Takeout'. The package supports unzipping archives and extracting user review data from Google Business Profile exports into tidy data frames for further analysis.

GEE estimation of the parameters in mean structures with possible correlation between the outcomes. User-specified mean link and variance functions are allowed, along with observation weighting. The M in the name geeM is meant to emphasize the use of the Matrix package, which allows for an implementation based fully in R.

Implementation of several goodness-of-fit tests for functional data. Currently, mostly related with the functional linear model with functional/scalar response and functional/scalar predictor. The package allows for the replication of the data applications considered in Garcà a-Portugués, à lvarez-Liébana, à lvarez-Pérez and González-Manteiga (2021) <doi:10.1111/sjos.12486>.

Discrete scales for the colorblind-friendly Okabe-Ito palette, including color', fill', and edge_colour'. ggokabeito provides ggplot2 and ggraph scales to easily use the Okabe-Ito palette in your data visualizations.

When evaluating the results of a genome-wide association study (GWAS), it is important to perform a quality control to ensure that the results are valid, complete, correctly formatted, and, in case of meta-analysis, consistent with other studies that have applied the same analysis. This package was developed to facilitate and streamline this process and provide the user with a comprehensive report.

Density, distribution function, quantile function and random generation for the Generalized Binomial Distribution. Functions to compute the Clopper-Pearson Confidence Interval and the required sample size. Enhanced model for burn-in studies, where failures are tackled by countermeasures.

This package provides a framework to assist creation of marine ecosystem models, generating either R or C++ code which can then be optimised using the TMB package and standard R tools. Principally designed to reproduce gadget2 models in TMB', but can be extended beyond gadget2's capabilities. Kasper Kristensen, Anders Nielsen, Casper W. Berg, Hans Skaug, Bradley M. Bell (2016) <doi:10.18637/jss.v070.i05> "TMB: Automatic Differentiation and Laplace Approximation.". Begley, J., & Howell, D. (2004) <https://files01.core.ac.uk/download/pdf/225936648.pdf> "An overview of Gadget, the globally applicable area-disaggregated general ecosystem toolbox. ICES.".

Identifying spatially variable genes is critical in linking molecular cell functions with tissue phenotypes. This package implemented a granularity-based dimension-agnostic tool for the identification of spatially variable genes. The detailed description of this method is available at Wang, J. and Li, J. et al. 2023 (Wang, J. and Li, J. (2023), <doi:10.1038/s41467-023-43256-5>).

This package provides a minimal set of routines to calculate the Grantham distance <doi:10.1126/science.185.4154.862>. The Grantham distance attempts to provide a proxy for the evolutionary distance between two amino acids based on three key chemical properties: composition, polarity and molecular volume. In turn, evolutionary distance is used as a proxy for the impact of missense mutations. The higher the distance, the more deleterious the substitution is expected to be.

This package provides functions for Gaussian and Non Gaussian (bivariate) spatial and spatio-temporal data analysis are provided for a) (fast) simulation of random fields, b) inference for random fields using standard likelihood and a likelihood approximation method called weighted composite likelihood based on pairs and b) prediction using (local) best linear unbiased prediction. Weighted composite likelihood can be very efficient for estimating massive datasets. Both regression and spatial (temporal) dependence analysis can be jointly performed. Flexible covariance models for spatial and spatial-temporal data on Euclidean domains and spheres are provided. There are also many useful functions for plotting and performing diagnostic analysis. Different non Gaussian random fields can be considered in the analysis. Among them, random fields with marginal distributions such as Skew-Gaussian, Student-t, Tukey-h, Sin-Arcsin, Two-piece, Weibull, Gamma, Log-Gaussian, Binomial, Negative Binomial and Poisson. See the URL for the papers associated with this package, as for instance, Bevilacqua and Gaetan (2015) <doi:10.1007/s11222-014-9460-6>, Bevilacqua et al. (2016) <doi:10.1007/s13253-016-0256-3>, Vallejos et al. (2020) <doi:10.1007/978-3-030-56681-4>, Bevilacqua et. al (2020) <doi:10.1002/env.2632>, Bevilacqua et. al (2021) <doi:10.1111/sjos.12447>, Bevilacqua et al. (2022) <doi:10.1016/j.jmva.2022.104949>, Morales-Navarrete et al. (2023) <doi:10.1080/01621459.2022.2140053>, and a large class of examples and tutorials.

Robust Estimation of Multivariate Location and Scatter in the Presence of Cellwise and Casewise Contamination and Missing Data.

This package provides tools for the generalized logistic distribution (Type I, also known as skew-logistic distribution), encompassing basic distribution functions (p, q, d, r, score), maximum likelihood estimation, and structural change methods.

Interface for extra high-dimensional smooth functions for Generalized Additive Models for Location Scale and Shape (GAMLSS) including (adaptive) lasso, ridge, elastic net and least angle regression.

Design and analysis of group sequential designs for negative binomial outcomes, as described by T Mütze, E Glimm, H Schmidli, T Friede (2018) <doi:10.1177/0962280218773115>.

This package provides classes and methods for handling networks or graphs whose nodes are geographical (i.e. locations in the globe). The functionality includes the creation of objects of class geonetwork as a graph with node coordinates, the computation of network measures, the support of spatial operations (projection to different Coordinate Reference Systems, handling of bounding boxes, etc.) and the plotting of the geonetwork object combined with supplementary cartography for spatial representation.

Stores small spatial datasets used to teach basic spatial analysis concepts. Datasets are based off of the GeoDa software workbook and data site <https://geodacenter.github.io/data-and-lab/> developed by Luc Anselin and team at the University of Chicago. Datasets are stored as sf objects.

Analyze small-sample clustered or longitudinal data with binary outcome using modified generalized estimating equations (GEE) with bias-adjusted covariance estimator. The package provides any combination of three GEE methods and 12 covariance estimators.

This package implements the Generalized Method of Wavelet Moments with Exogenous Inputs estimator (GMWMX) presented in Voirol, L., Xu, H., Zhang, Y., Insolia, L., Molinari, R. and Guerrier, S. (2024) <doi:10.48550/arXiv.2409.05160>. The GMWMX estimator allows to estimate functional and stochastic parameters of linear models with correlated residuals in presence of missing data. The gmwmx2 package provides functions to load and plot Global Navigation Satellite System (GNSS) data from the Nevada Geodetic Laboratory and functions to estimate linear model model with correlated residuals in presence of missing data.