Calculates two sets of post-hoc variable importance measures for multivariate random forests. The first set of variable importance measures are given by the sum of mean split improvements for splits defined by feature j measured on user-defined examples (i.e., training or testing samples). The second set of importance measures are calculated on a per-outcome variable basis as the sum of mean absolute difference of node values for each split defined by feature j measured on user-defined examples (i.e., training or testing samples). The user can optionally threshold both sets of importance measures to include only splits that are statistically significant as measured using an F-test.

This package provides a graphical user interface tool to estimate ploidy from DNA cells stained with fluorescent dyes and analyzed by flow cytometry, following the methodology of Gómez-Muñoz and Fischer (2024) <doi:10.1101/2024.01.24.577056>. Features include multiple file uploading and configuration, peak fluorescence intensity detection, histogram visualizations, peak error curation, ploidy and genome size calculations, and easy results export.

Advanced methods for a valuable quantitative environmental risk assessment using Bayesian inference of survival Data with toxicokinetics toxicodynamics (TKTD) models. Among others, it facilitates Bayesian inference of the general unified threshold model of survival (GUTS). See models description in Jager et al. (2011) <doi:10.1021/es103092a> and implementation using Bayesian inference in Baudrot and Charles (2019) <doi:10.1038/s41598-019-47698-0>.

Generate the monotonic binning and perform the woe (weight of evidence) transformation for the logistic regression used in the consumer credit scorecard development. The woe transformation is a piecewise transformation that is linear to the log odds. For a numeric variable, all of its monotonic functional transformations will converge to the same woe transformation.

This package implements methodologies for modelling interval data by Normal and Skew-Normal distributions, considering appropriate parameterizations of the variance-covariance matrix that takes into account the intrinsic nature of interval data, and lead to four different possible configuration structures. The Skew-Normal parameters can be estimated by maximum likelihood, while Normal parameters may be estimated by maximum likelihood or robust trimmed maximum likelihood methods.

This package provides a complete toolkit to process the Munich ChronoType Questionnaire (MCTQ) for its three versions (standard, micro, and shift). MCTQ is a quantitative and validated tool to assess chronotypes using peoples sleep behavior, originally presented by Till Roenneberg, Anna Wirz-Justice, and Martha Merrow (2003, <doi:10.1177/0748730402239679>).

This package provides exact and approximate algorithms for the horseshoe prior in linear regression models, which were proposed by Johndrow et al. (2020) <https://www.jmlr.org/papers/v21/19-536.html>.

Given an image of a formula (typeset or handwritten) this package provides calls to the Mathpix service to produce the LaTeX code which should generate that image, and pastes it into a (e.g. an rmarkdown') document. See <https://docs.mathpix.com/> for full details. Mathpix is an external service and use of the API is subject to their terms and conditions.

This package provides a suite of utility functions providing functionality commonly needed for production level projects such as logging, error handling, cache management and date-time parsing. Functions for date-time parsing and formatting require that time zones be specified explicitly, avoiding a common source of error when working with environmental time series.

This package provides a PC Algorithm with the Principle of Mendelian Randomization. This package implements the MRPC (PC with the principle of Mendelian randomization) algorithm to infer causal graphs. It also contains functions to simulate data under a certain topology, to visualize a graph in different ways, and to compare graphs and quantify the differences. See Badsha and Fu (2019) <doi:10.3389/fgene.2019.00460>, Badsha, Martin and Fu (2021) <doi:10.3389/fgene.2021.651812>, Kvamme and Badsha, et al. (2025) <doi:10.1093/genetics/iyaf064>.

Helping psychologists and other behavioural scientists to analyze mouse movement (and other 2-D trajectory) data. Bundles together several functions that compute spatial measures (e.g., maximum absolute deviation, area under the curve, sample entropy) or provide a shorthand for procedures that are frequently used (e.g., time normalization, linear interpolation, extracting initiation and movement times). For more information on these dependent measures, see Wirth et al. (2020) <doi:10.3758/s13428-020-01409-0>.

Core functions as well as diagnostic and calibration tools for combining matching and linear regression for causal inference in observational studies.

Framework for merging and disambiguating event data based on spatiotemporal co-occurrence and secondary event characteristics. It can account for intrinsic "fuzziness" in the coding of events, varying event taxonomies and different geo-precision codes.

Collect your data on digital marketing campaigns from Mailchimp using the Windsor.ai API <https://windsor.ai/api-fields/>.

This package contains functions for converting existing HTML/JavaScript source into equivalent shiny functions. Bootstraps the process of making new shiny functions by allowing us to turn HTML snippets directly into R functions.

Multi modality data matrices are factorized conjointly into the multiplication of a shared sub-matrix and multiple modality specific sub-matrices, group sparse constraint is applied to the shared sub-matrix to capture the homogeneous and heterogeneous information, respectively. Then the samples are classified by clustering the shared sub-matrix with kmeanspp(), a new version of kmeans() developed here to obtain concordant results. The package also provides the cluster number estimation by rotation cost. Moreover, cluster specific features could be retrieved using hypergeometric tests.

Multidimensional projection techniques are used to create two dimensional representations of multidimensional data sets.

Sometimes data for analysis are obtained using more convenient or less expensive means yielding "surrogate" variables for what could be obtained more accurately, albeit with less convenience; or less conveniently or at more expense yielding "reference" variables, thought of as being measured without error. Analysis of the surrogate variables measured with error generally yields biased estimates when the objective is to make inference about the reference variables. Often it is thought that ignoring the measurement error in surrogate variables only biases effects toward the null hypothesis, but this need not be the case. Measurement errors may bias parameter estimates either toward or away from the null hypothesis. If one has a data set with surrogate variable data from the full sample, and also reference variable data from a randomly selected subsample, then one can assess the bias introduced by measurement error in parameter estimation, and use this information to derive improved estimates based upon all available data. Formulaically these estimates based upon the reference variables from the validation subsample combined with the surrogate variables from the whole sample can be interpreted as starting with the estimate from reference variables in the validation subsample, and "augmenting" this with additional information from the surrogate variables. This suggests the term "augmented" estimate. The meerva package calculates these augmented estimates in the regression setting when there is a randomly selected subsample with both surrogate and reference variables. Measurement errors may be differential or non-differential, in any or all predictors (simultaneously) as well as outcome. The augmented estimates derive, in part, from the multivariate correlation between regression model parameter estimates from the reference variables and the surrogate variables, both from the validation subset. Because the validation subsample is chosen at random any biases imposed by measurement error, whether non-differential or differential, are reflected in this correlation and these correlations can be used to derive estimates for the reference variables using data from the whole sample. The main functions in the package are meerva.fit which calculates estimates for a dataset, and meerva.sim.block which simulates multiple datasets as described by the user, and analyzes these datasets, storing the regression coefficient estimates for inspection. The augmented estimates, as well as how measurement error may arise in practice, is described in more detail by Kremers WK (2021) <arXiv:2106.14063> and is an extension of the works by Chen Y-H, Chen H. (2000) <doi:10.1111/1467-9868.00243>, Chen Y-H. (2002) <doi:10.1111/1467-9868.00324>, Wang X, Wang Q (2015) <doi:10.1016/j.jmva.2015.05.017> and Tong J, Huang J, Chubak J, et al. (2020) <doi:10.1093/jamia/ocz180>.

It computes arbitrary products moments (mean vector and variance-covariance matrix), for some double truncated (and folded) multivariate distributions. These distributions belong to the family of selection elliptical distributions, which includes well known skewed distributions as the unified skew-t distribution (SUT) and its particular cases as the extended skew-t (EST), skew-t (ST) and the symmetric student-t (T) distribution. Analogous normal cases unified skew-normal (SUN), extended skew-normal (ESN), skew-normal (SN), and symmetric normal (N) are also included. Density, probabilities and random deviates are also offered for these members.

Computes mutual information matrices from continuous, categorical and survival variables, as well as feature selection with minimum redundancy, maximum relevance (mRMR) and a new ensemble mRMR technique. Published in De Jay et al. (2013) <doi:10.1093/bioinformatics/btt383>.

This package provides a new pipeline to explore chemical structural similarity across metabolites. It allows the metabolite classification in structurally-related modules and identifies common shared functional groups. The KODAMA algorithm is used to highlight structural similarity between metabolites. See Cacciatore S, Tenori L, Luchinat C, Bennett PR, MacIntyre DA. (2017) Bioinformatics <doi:10.1093/bioinformatics/btw705>, Cacciatore S, Luchinat C, Tenori L. (2014) Proc Natl Acad Sci USA <doi:10.1073/pnas.1220873111>, and Abdel-Shafy EA, Melak T, MacIntyre DA, Zadra G, Zerbini LF, Piazza S, Cacciatore S. (2023) Bioinformatics Advances <doi:10.1093/bioadv/vbad053>.

This package implements two versions of the algorithm namely: stochastic and batch. The package determines also the best number of clusters and offers to the user the best clustering scheme from different results.

Randomization schedules are generated in the schemes with k (k>=2) treatment groups and any allocation ratios by minimization algorithms.

Multivariate tests, estimates and methods based on the identity score, spatial sign score and spatial rank score are provided. The methods include one and c-sample problems, shape estimation and testing, linear regression and principal components. The methodology is described in Oja (2010) <doi:10.1007/978-1-4419-0468-3> and Nordhausen and Oja (2011) <doi:10.18637/jss.v043.i05>.