This package implements the Maki (2012) <doi:10.1016/j.econmod.2012.05.006> cointegration test that allows for an unknown number of structural breaks. The test detects cointegration relationships in the presence of up to five structural breaks in the intercept and/or slope coefficients. Four different model specifications are supported: level shifts, level shifts with trend, regime shifts, and trend with regime shifts. The method is described in Maki (2012) "Tests for cointegration allowing for an unknown number of breaks" <doi:10.1016/j.econmod.2012.05.006>.

Generate central composite designs (CCD)with full as well as fractional factorial points (half replicate) and Box Behnken designs (BBD) with minimally changed run sequence.

This package implements the methods described in Bond S, Farewell V, 2006, Exact Likelihood Estimation for a Negative Binomial Regression Model with Missing Outcomes, Biometrics.

This package provides a number of functions to facilitate the handling and production of reports using time series data. The package was developed to be understandable for beginners, so some functions aim to transform processes that would be complex into functions with a few lines. The main advantage of using the metools package is the ease of producing reports and working with time series using a few lines of code, so the code is clean and easy to understand/maintain. Learn more about the metools at <https://metoolsr.wordpress.com>.

Allows the user to generate a friendly user interface for emails sending. The user can choose from the most popular free email services ('Gmail', Outlook', Yahoo') and his default email application. The package is a wrapper for the Mailtoui JavaScript library. See <https://mailtoui.com/#menu> for more information.

Conducts moderated nonlinear factor analysis (e.g., Curran et al., 2014, <doi:10.1080/00273171.2014.889594>). Regularization methods are implemented for assessing non-invariant items. Currently, the package includes dichotomous items and unidimensional item response models. Extensions will be included in future package versions.

Nonparametric estimation and inference for natural direct and indirect effects by Chan, Imai, Yam and Zhang (2016) <arXiv:1601.03501>.

Compute effect sizes and their sampling variances from factorial experimental designs. The package supports calculation of simple effects, overall effects, and interaction effects for use in factorial meta-analyses. See Gurevitch et al. (2000) <doi:10.1086/303337>, Morris et al. (2007) <doi:10.1890/06-0442>, Lajeunesse (2011) <doi:10.1890/11-0423.1> and Macartney et al. (2022) <doi:10.1016/j.neubiorev.2022.104554>.

Advanced methods for a valuable quantitative environmental risk assessment using Bayesian inference of survival Data with toxicokinetics toxicodynamics (TKTD) models. Among others, it facilitates Bayesian inference of the general unified threshold model of survival (GUTS). See models description in Jager et al. (2011) <doi:10.1021/es103092a> and implementation using Bayesian inference in Baudrot and Charles (2019) <doi:10.1038/s41598-019-47698-0>.

This package provides tools for estimating, measuring, and analyzing migration data. Designed to assist researchers and analysts in working effectively with migration data.

The ultimate goal is to support 2-2-1, 2-1-1, and 1-1-1 models for multilevel mediation, the option of a moderating variable for either the a, b, or both paths, and covariates. Currently the 1-1-1 model is supported and several options of random effects; the initial code for bootstrapping was evaluated in simulations by Falk, Vogel, Hammami, and MioÄ eviÄ (2024) <doi:10.3758/s13428-023-02079-4>. Support for Bayesian estimation using brms comprises ongoing work. Currently only continuous mediators and outcomes are supported. Factors for any predictors must be numerically represented.

The iterative procedure estimates structural changes in the success probability of Bernoulli variables. It estimates the number and location of the breakpoints as well as the success probability of the different sequences between the breakpoints. In addition, it provides a graphical illustration of the result.

Allows users familiar with MATLAB to use MATLAB-named functions in R. Several basic MATLAB functions are written in this package to mimic the behavior of their original counterparts, with more to come as this package grows.

Estimation of multivariate differences between two groups (e.g., multivariate sex differences) with regularized regression methods and predictive approach. See Ilmarinen et al. (2023) <doi:10.1177/08902070221088155>. Deconstructing difference score correlations (e.g., gender-equality paradox), see Ilmarinen & Lönnqvist (2024) <doi:10.1037/pspp0000508>. Includes also tools that help in understanding difference score reliability, conditional intra-class correlations, tail-dependency, and heterogeneity of variance estimates. Package development was supported by the Academy of Finland research grant 338891.

Compute the multiple Grubbs-Beck low-outlier test on positively distributed data and utilities for noninterpretive U.S. Geological Survey annual peak-streamflow data processing discussed in Cohn et al. (2013) <doi:10.1002/wrcr.20392> and England et al. (2017) <doi:10.3133/tm4B5>.

This package provides methods for analyzing DNA methylation data via Most Recurrent Methylation Patterns (MRMPs). Supports cell-type annotation, spatial deconvolution, unsupervised clustering, and cancer cell-of-origin inference. Includes C-backed summaries for YAME â .cg/.cmâ files (overlap counts, log2 odds ratios, beta/depth aggregation), an XGBoost classifier, NNLS deconvolution, and plotting utilities. Scales to large spatial and single-cell methylomes and is robust to extreme sparsity.

This package provides probability mass, distribution, quantile, random variate generation, and method-of-moments parameter fitting for the MBBEFD family of distributions used in insurance modeling as described in Bernegger (1997) <doi:10.2143/AST.27.1.563208> without any external dependencies.

Distance multivariance is a measure of dependence which can be used to detect and quantify dependence of arbitrarily many random vectors. The necessary functions are implemented in this packages and examples are given. It includes: distance multivariance, distance multicorrelation, dependence structure detection, tests of independence and copula versions of distance multivariance based on the Monte Carlo empirical transform. Detailed references are given in the package description, as starting point for the theoretic background we refer to: B. Böttcher, Dependence and Dependence Structures: Estimation and Visualization Using the Unifying Concept of Distance Multivariance. Open Statistics, Vol. 1, No. 1 (2020), <doi:10.1515/stat-2020-0001>.

Make all elements of a character vector unique. Differs from make.unique by starting at 1 and allowing users to customise suffix format.

Efficiently estimates single- and multilevel latent class models with covariates, allowing for output visualization in all specifications. For more technical details, see Lyrvall et al. (2025) <doi:10.1080/00273171.2025.2473935>.

This package provides functions for reading (tab, csv, Bruker fid, Ciphergen XML, mzXML, mzML, imzML, Analyze 7.5, CDF, mMass MSD) and writing (tab, csv, mMass MSD, mzML, imzML) different file formats of mass spectrometry data into/from MALDIquant objects.

Create and integrate thematic maps in your workflow. This package helps to design various cartographic representations such as proportional symbols, choropleth or typology maps. It also offers several functions to display layout elements that improve the graphic presentation of maps (e.g. scale bar, north arrow, title, labels). mapsf maps sf objects on base graphics.

This package provides a comprehensive framework for analyzing agricultural nutrient balances across multiple spatial scales (county, HUC8', HUC2') with integration of wastewater treatment plant ('WWTP') effluent loads for both nitrogen and phosphorus. Supports classification of spatial units as nutrient sources, sinks, or balanced areas based on agricultural surplus and deficit calculations. Includes visualization tools, spatial transition probability analysis, and nutrient flow network mapping. Built-in datasets include agricultural nutrient balance data from the Nutrient Use Geographic Information System ('NuGIS'; The Fertilizer Institute and Plant Nutrition Canada, 1987-2016) <https://nugis.tfi.org/tabular_data/> and U.S. Environmental Protection Agency ('EPA') wastewater discharge data from the ECHO Discharge Monitoring Report ('DMR') Loading Tool (2007-2016) <https://echo.epa.gov/trends/loading-tool/water-pollution-search>. Data are downloaded on demand from the Open Science Framework ('OSF') repository to minimize package size while maintaining full functionality. The integrated manureshed framework methodology is described in Akanbi et al. (2025) <doi:10.1016/j.resconrec.2025.108697>. Designed for nutrient management planning, environmental analysis, and circular economy research at watershed/administrative to national scales. This material is based upon financial support by the National Science Foundation, EEC Division of Engineering Education and Centers, NSF Engineering Research Center for Advancing Sustainable and Distributed Fertilizer Production (CASFER), NSF 20-553 Gen-4 Engineering Research Centers award 2133576. We thank Dr. Robert D. Sabo (U.S. Environmental Protection Agency) for his valuable contributions to the conceptual development and review of this work.

Covariate measurement error correction is implemented by means of regression calibration by Carroll RJ, Ruppert D, Stefanski LA & Crainiceanu CM (2006, ISBN:1584886331), efficient regression calibration by Spiegelman D, Carroll RJ & Kipnis V (2001) <doi:10.1002/1097-0258(20010115)20:1%3C139::AID-SIM644%3E3.0.CO;2-K> and maximum likelihood estimation by Bartlett JW, Stavola DBL & Frost C (2009) <doi:10.1002/sim.3713>. Outcome measurement error correction is implemented by means of the method of moments by Buonaccorsi JP (2010, ISBN:1420066560) and efficient method of moments by Keogh RH, Carroll RJ, Tooze JA, Kirkpatrick SI & Freedman LS (2014) <doi:10.1002/sim.7011>. Standard error estimation of the corrected estimators is implemented by means of the Delta method by Rosner B, Spiegelman D & Willett WC (1990) <doi:10.1093/oxfordjournals.aje.a115715> and Rosner B, Spiegelman D & Willett WC (1992) <doi:10.1093/oxfordjournals.aje.a116453>, the Fieller method described by Buonaccorsi JP (2010, ISBN:1420066560), and the Bootstrap by Carroll RJ, Ruppert D, Stefanski LA & Crainiceanu CM (2006, ISBN:1584886331).