An S3 class groupedHyperframe that inherits from hyper data frame. Batch processes and aggregation of hyper column(s) over a nested grouping structure.

Factor analysis implementation for multiple data sources, i.e., for groups of variables. The whole data analysis pipeline is provided, including functions and recommendations for data normalization and model definition, as well as missing value prediction and model visualization. The model group factor analysis (GFA) is inferred with Gibbs sampling, and it has been presented originally by Virtanen et al. (2012), and extended in Klami et al. (2015) <DOI:10.1109/TNNLS.2014.2376974> and Bunte et al. (2016) <DOI:10.1093/bioinformatics/btw207>; for details, see the citation info.

Defines window or bin boundaries for the analysis of genomic data. Boundaries are based on the inflection points of a cubic smoothing spline fitted to the raw data. Along with defining boundaries, a technique to evaluate results obtained from unequally-sized windows is provided. Applications are particularly pertinent for, though not limited to, genome scans for selection based on variability between populations (e.g. using Wright's fixations index, Fst, which measures variability in subpopulations relative to the total population).

This package provides a ggplot2 based implementation of biplots, giving a representation of a dataset in a two dimensional space accounting for the greatest variance, together with variable vectors showing how the data variables relate to this space. It provides a replacement for stats::biplot(), but with many enhancements to control the analysis and graphical display. It implements biplot and scree plot methods which can be used with the results of prcomp(), princomp(), FactoMineR::PCA(), ade4::dudi.pca() or MASS::lda() and can be customized using ggplot2 techniques.

Quantifying systematic heterogeneity in meta-analysis using R. The M statistic aggregates heterogeneity information across multiple variants to, identify systematic heterogeneity patterns and their direction of effect in meta-analysis. It's primary use is to identify outlier studies, which either show "null" effects or consistently show stronger or weaker genetic effects than average across, the panel of variants examined in a GWAS meta-analysis. In contrast to conventional heterogeneity metrics (Q-statistic, I-squared and tau-squared) which measure random heterogeneity at individual variants, M measures systematic (non-random) heterogeneity across multiple independently associated variants. Systematic heterogeneity can arise in a meta-analysis due to differences in the study characteristics of participating studies. Some of the differences may include: ancestry, allele frequencies, phenotype definition, age-of-disease onset, family-history, gender, linkage disequilibrium and quality control thresholds. See <https://magosil86.github.io/getmstatistic/> for statistical statistical theory, documentation and examples.

Create plots that combine a phylogeny and frequency dynamics. Phylogenetic input can be a generic adjacency matrix or a tree of class "phylo". Inspired by similar plots in publications of the labs of RE Lenski and JE Barrick. Named for HJ Muller (who popularised such plots) and H Wickham (whose code this package exploits).

This package provides a GraphQL client, with an R6 interface for initializing a connection to a GraphQL instance, and methods for constructing queries, including fragments and parameterized queries. Queries are checked with the libgraphqlparser C++ parser via the graphql package.

This package provides tools for solving common geocaching puzzle types, and other Geocaching-related tasks.

Features the marginal parametric and semi-parametric proportional hazards mixture cure models for analyzing clustered survival data with a possible cure fraction. A reference is Yi Niu and Yingwei Peng (2014) <doi:10.1016/j.jmva.2013.09.003>.

The American Community Survey (ACS) <https://www.census.gov/programs-surveys/acs> offers geodatabases with geographic information and associated data of interest to researchers in the area. The goal of this package is to generate objects that allow us to access and consult the information available in various formats, such as in GeoPackage format or in multidimensional ROLAP (Relational On-Line Analytical Processing) star format.

Encode and decode the Google Encoded Polyline Algorithm Format. See <https://developers.google.com/maps/documentation/utilities/polylinealgorithm> for more information.

This package provides a function to retrieve the system timezone on Unix systems which has been found to find an answer when Sys.timezone() has failed. It is based on an answer by Duane McCully posted on StackOverflow', and adapted to be callable from R. The package also builds on Windows, but just returns NULL.

Fits a multivariate linear mixed effects model that uses a polygenic term, after Zhou & Stephens (2014) (<https://www.nature.com/articles/nmeth.2848>). Of particular interest is the estimation of variance components with restricted maximum likelihood (REML) methods. Genome-wide efficient mixed-model association (GEMMA), as implemented in the package gemma2', uses an expectation-maximization algorithm for variance components inference for use in quantitative trait locus studies.

Help to the occasional R user for synthesis and enhanced graphical visualization of redundancy analysis (RDA) and principal component analysis (PCA) methods and objects. Inputs are : data frame, RDA (package vegan') and PCA (package FactoMineR') objects. Outputs are : synthesized results of RDA, displayed in console and saved in tables ; displayed and saved objects of PCA graphic visualization of individuals and variables projections with multiple graphic parameters.

Estimation of the variogram through trimmed mean, radial basis functions (optimization, prediction and cross-validation), summary statistics from cross-validation, pocket plot, and design of optimal sampling networks through sequential and simultaneous points methods.

Population-averaged models have been increasingly used in the design and analysis of cluster randomized trials (CRTs). To facilitate the applications of population-averaged models in CRTs, the package implements the generalized estimating equations (GEE) and matrix-adjusted estimating equations (MAEE) approaches to jointly estimate the marginal mean models correlation models both for general CRTs and stepped wedge CRTs. Despite the general GEE/MAEE approach, the package also implements a fast cluster-period GEE method by Li et al. (2022) <doi:10.1093/biostatistics/kxaa056> specifically for stepped wedge CRTs with large and variable cluster-period sizes and gives a simple and efficient estimating equations approach based on the cluster-period means to estimate the intervention effects as well as correlation parameters. In addition, the package also provides functions for generating correlated binary data with specific mean vector and correlation matrix based on the multivariate probit method in Emrich and Piedmonte (1991) <doi:10.1080/00031305.1991.10475828> or the conditional linear family method in Qaqish (2003) <doi:10.1093/biomet/90.2.455>.

Data sets and scripts used in the book Generalized Additive Models: An Introduction with R', Wood (2006,2017) CRC.

Recursive partitioning based on (generalized) linear mixed models (GLMMs) combining lmer()/glmer() from lme4 and lmtree()/glmtree() from partykit'. The fitting algorithm is described in more detail in Fokkema, Smits, Zeileis, Hothorn & Kelderman (2018; <DOI:10.3758/s13428-017-0971-x>). For detecting and modeling subgroups in growth curves with GLMM trees see Fokkema & Zeileis (2024; <DOI:10.3758/s13428-024-02389-1>).

This package performs genetic algorithm (Scrucca, L (2013) <doi:10.18637/jss.v053.i04>) assisted genomic best liner unbiased prediction for genomic selection. It also provides a binning method in natural population for genomic selection under the principle of linkage disequilibrium for dimensional reduction.

Connects to the Google Charts geographic data resources described in <https://developers.google.com/chart/interactive/docs/gallery/geochart>, allowing the user to download contents to use as a reference for related services like Google Trends'.

This package provides ggplot2 extensions for creating dice-based visualizations where each dot position represents a specific categorical variable. The package includes geom_dice() for displaying presence/absence of categorical variables using traditional dice patterns. Each dice position (1-6) represents a different category, with dots shown only when that category is present. This allows intuitive visualization of up to 6 categorical variables simultaneously.

Two-step modeling with separation of sources of variation through analysis of variance and subsequent multivariate modeling through a range of unsupervised and supervised statistical methods. Separation can focus on removal of interfering effects or isolation of effects of interest. EF Mosleth et al. (2021) <doi:10.1038/s41598-021-82388-w> and EF Mosleth et al. (2020) <doi:10.1016/B978-0-12-409547-2.14882-6>.

Gene-Ranking Analysis of Pathway Expression (GRAPE) is a tool for summarizing the consensus behavior of biological pathways in the form of a template, and for quantifying the extent to which individual samples deviate from the template. GRAPE templates are based only on the relative rankings of the genes within the pathway and can be used for classification of tissue types or disease subtypes. GRAPE can be used to represent gene-expression samples as vectors of pathway scores, where each pathway score indicates the departure from a given collection of reference samples. The resulting pathway- space representation can be used as the feature set for various applications, including survival analysis and drug-response prediction. Users of GRAPE should use the following citation: Klein MI, Stern DF, and Zhao H. GRAPE: A pathway template method to characterize tissue-specific functionality from gene expression profiles. BMC Bioinformatics, 18:317 (June 2017).

The social network literature features numerous methods for assigning value to paths as a function of their ties. gretel systemizes these approaches, casting them as instances of a generalized path value function indexed by a penalty parameter. The package also calculates probabilistic path value and identifies optimal paths in either value framework. Finally, proximity matrices can be generated in these frameworks that capture high-order connections overlooked in primitive adjacency sociomatrices. Novel methods are described in Buch (2019) <https://davidbuch.github.io/analyzing-networks-with-gretel.html>. More traditional methods are also implemented, as described in Yang, Knoke (2001) <doi:10.1016/S0378-8733(01)00043-0>.