Calculates irrigation water quality ratios and has functions that could be used to plot several popular diagrams for irrigation water quality classification.

We provide the collection of data-sets used in the book An Introduction to Statistical Learning with Applications in R, Second Edition'. These include many data-sets that we used in the first edition (some with minor changes), and some new datasets.

This package provides functions to compute a continuum of information-based measures for quantifying the temporal stability of populations, communities, and ecosystems, as well as their associated synchrony, based on species (or species assemblage) biomass, or other key variables. When biodiversity data are available, the package also enables the assessment of the corresponding diversityâ stability and diversityâ synchrony relationships. All measures are applicable in both temporal and spatial contexts. The theoretical and methodological background is detailed in Chao et al. (2025) <doi:10.1101/2025.08.20.671203>.

This package provides a pipeline application programming interface (API) for Monte Carlo simulation-based sample-size planning in item response theory (IRT). Implements the 10-decision framework from Schroeders and Gnambs (2025) <doi:10.1177/25152459251314798> as a three-step workflow: specify the data-generating model with irt_design(), add study conditions with irt_study(), and run simulations with irt_simulate(). Supports one-parameter logistic (1PL), two-parameter logistic (2PL), three-parameter logistic (3PL), graded response (GRM), partial credit (PCM), and generalized partial credit (GPCM) models with missing-completely-at-random (MCAR), missing-at-random (MAR), booklet, and linking missingness mechanisms. Results include mean squared error (MSE), bias, root mean squared error (RMSE), standard error (SE), and coverage criteria with summary and plot methods.

This package provides a joint mixture model has been developed by Majumdar et al. (2025) <doi:10.48550/arXiv.2412.17511> that integrates information from gene expression data and methylation data at the modelling stage to capture their inherent dependency structure, enabling simultaneous identification of differentially methylated cytosine-guanine dinucleotide (CpG) sites and differentially expressed genes. The model leverages a joint likelihood function that accounts for the nested structure in the data, with parameter estimation performed using an expectation-maximisation algorithm.

Categorization and scoring of injury severity typically involves trained personnel with access to injured persons or their medical records. icdpicr contains a function that provides automated calculation of Abbreviated Injury Scale ('AIS') and Injury Severity Score ('ISS') from International Classification of Diseases ('ICD') codes and may be a useful substitute to manual injury severity scoring. ICDPIC was originally developed in Stata', and icdpicr is an open-access update that accepts both ICD-9 and ICD-10 codes.

Easily implement the checking of WHOIS information for a particular domain. IP2WHOIS supports the query for 1113 Top-level Domains(TLDs) and 634 Country Code Top-level Domains(ccTLDs). To get started with a free API key, you may sign up at here <https://www.ip2whois.com/register>.

Computes and tests individual (species, phylogenetic and functional) diversity-area relationships, i.e., how species-, phylogenetic- and functional-diversity varies with spatial scale around the individuals of some species in a community. See applications of these methods in Wiegand et al. (2007) <doi:10.1073/pnas.0705621104> or Chacon-Labella et al. (2016) <doi:10.1007/s00442-016-3547-z>.

Calculates calorific values (gross and net), density, relative density, and Wobbe indices together with their standard uncertainties from natural gas composition, implementing the method of ISO 6976:2016 "Natural Gas â Calculation of calorific values, density, relative density and Wobbe indices from composition". Uncertainty propagation follows Annex B of that standard. Reference: International Organization for Standardization (2016) <https://www.iso.org/standard/55842.html>.

Select set of parametric and non-parametric statistical tests. inferr builds upon the solid set of statistical tests provided in stats package by including additional data types as inputs, expanding and restructuring the test results. The tests included are t tests, variance tests, proportion tests, chi square tests, Levene's test, McNemar Test, Cochran's Q test and Runs test.

This package implements likelihood based methods for mediation analysis.

Runs classical item analysis for multiple-choice test items and polytomous items (e.g., rating scales). The statistics reported in this package can be found in any measurement textbook such as Crocker and Algina (2006, ISBN:9780495395911).

Multiple Imputation for Informative Censoring. This package implements two methods. Gamma Imputation described in <DOI:10.1002/sim.6274> and Risk Score Imputation described in <DOI:10.1002/sim.3480>.

This package provides a suite of functions for conducting and interpreting analysis of statistical interaction in regression models that was formerly part of the jtools package. Functionality includes visualization of two- and three-way interactions among continuous and/or categorical variables as well as calculation of "simple slopes" and Johnson-Neyman intervals (see e.g., Bauer & Curran, 2005 <doi:10.1207/s15327906mbr4003_5>). These capabilities are implemented for generalized linear models in addition to the standard linear regression context.

An interval-valued extension of ordinary and simple kriging. Optimization of the function is based on a generalized interval distance. This creates a non-differentiable cost function that requires a differentiable approximation to the absolute value function. This differentiable approximation is optimized using a Newton-Raphson algorithm with a penalty function to impose the constraints. Analyses in the package are driven by the intsp and intgrd classes, which are interval-valued extensions of SpatialPointsDataFrame and SpatialPixelsDataFrame respectively. The package includes several wrappers to functions in the gstat and sp packages.

This package provides a comprehensive analytics framework for building reproducible pipelines on T-cell and B-cell immune receptor repertoire data. Delivers multi-modal immune profiling (bulk, single-cell, CITE-seq/AbSeq, spatial, immunogenicity data), feature engineering (ML-ready feature tables and matrices), and biomarker discovery workflows (cohort comparisons, longitudinal tracking, repertoire similarity, enrichment). Provides a user-friendly interface to widely used AIRR methods â clonality/diversity, V(D)J usage, similarity, annotation, tracking, and many more. Think Scanpy or Seurat, but for AIRR data, a.k.a. Adaptive Immune Receptor Repertoire, VDJ-seq, RepSeq, or VDJ sequencing data. A successor to our previously published "tcR" R package (Nazarov 2015).

Survival analysis of interval-censored data with proportional hazards, and an explicit smooth estimate of the baseline log-hazard with P-splines.

This package performs hypothesis testing using the interval estimates (e.g., confidence intervals). The non-overlapping interval estimates indicates the statistical significance. References to these procedures can be found at Noguchi and Marmolejo-Ramos (2016) <doi:10.1080/00031305.2016.1200487>, Bonett and Seier (2003) <doi:10.1198/0003130032323>, and Lemm (2006) <doi:10.1300/J082v51n02_05>.

This package provides a collection of datasets containing a variety of in vitro toxicokinetic measurements including -- but not limited to -- chemical fraction unbound in the presence of plasma (f_up), intrinsic hepatic clearance (Clint, uL/min/million hepatocytes), and membrane permeability for oral absorption (Caco2). The datasets provided by the package were processed and analyzed with the companion invitroTKstats package.

Let us consider a sample of patients who can suffer from several diseases simultaneously, in a given set of diseases. The goal of the implemented algorithm is to estimate the individual average cost of each disease, starting from the global health costs available for each patient.

It provides in-place operators for R that are equivalent to +=', -=', *=', /= in C++. Those can be applied on integer|double vectors|matrices. You have also access to sweep operations (in-place).

Immunotherapy has revolutionized cancer treatment, but predicting patient response remains challenging. Here, we presented Intelligent Predicting Response to cancer Immunotherapy through Systematic Modeling (iPRISM), a novel network-based model that integrates multiple data types to predict immunotherapy outcomes. It incorporates gene expression, biological functional network, tumor microenvironment characteristics, immune-related pathways, and clinical data to provide a comprehensive view of factors influencing immunotherapy efficacy. By identifying key genetic and immunological factors, it provides an insight for more personalized treatment strategies and combination therapies to overcome resistance mechanisms.

Expands iNEXT to include the estimation of sample completeness and evenness. The package provides simple functions to perform the following four-step biodiversity analysis: STEP 1: Assessment of sample completeness profiles. STEP 2a: Analysis of size-based rarefaction and extrapolation sampling curves to determine whether the asymptotic diversity can be accurately estimated. STEP 2b: Comparison of the observed and the estimated asymptotic diversity profiles. STEP 3: Analysis of non-asymptotic coverage-based rarefaction and extrapolation sampling curves. STEP 4: Assessment of evenness profiles. The analyses in STEPs 2a, 2b and STEP 3 are mainly based on the previous iNEXT package. Refer to the iNEXT package for details. This package is mainly focusing on the computation for STEPs 1 and 4. See Chao et al. (2020) <doi:10.1111/1440-1703.12102> for statistical background.

This is the central location for data and tools for the development, maintenance, analysis, and deployment of the International Soil Radiocarbon Database (ISRaD). ISRaD was developed as a collaboration between the U.S. Geological Survey Powell Center and the Max Planck Institute for Biogeochemistry. This R package provides tools for accessing and manipulating ISRaD data, compiling local data using the ISRaD data structure, and simple query and reporting functions for ISRaD. For more detailed information visit the ISRaD website at: <https://soilradiocarbon.org/>.