This package provides plotting functions for visualizing pedigrees and family trees. The package complements a behavior genetics package BGmisc [Garrison et al. (2024) <doi:10.21105/joss.06203>] by rendering pedigrees using the ggplot2 framework. Features include support for duplicated individuals, complex mating structures, integration with simulated pedigrees, and layout customization. Due to the impending deprecation of kinship2, version 1.0 incorporates the layout helper functions from kinship2. The pedigree alignment algorithms are adapted from kinship2 [Sinnwell et al. (2014) <doi:10.1159/000363105>]. We gratefully acknowledge the original authors: Jason Sinnwell, Terry Therneau, Daniel Schaid, and Elizabeth Atkinson for their foundational work.

This package creates ideal data for all distributions in the generalized linear model framework.

Interface for extra smooth functions including tensor products, neural networks and decision trees.

This package provides a framework to detect Differential Item Functioning (DIF) in Generalized Partial Credit Models (GPCM) and special cases of the GPCM as proposed by Schauberger and Mair (2019) <doi:10.3758/s13428-019-01224-2>. A joint model is set up where DIF is explicitly parametrized and penalized likelihood estimation is used for parameter selection. The big advantage of the method called GPCMlasso is that several variables can be treated simultaneously and that both continuous and categorical variables can be used to detect DIF.

This package provides methods to analyse experimental agriculture data, from data synthesis to model selection and visualisation. The package is named after W.S. Gosset aka â Studentâ , a pioneer of modern statistics in small sample experimental design and analysis.

Computes experimental designs for two-arm experiments with covariates using multiple methods, including: (0) complete randomization and randomization with forced-balance; (1) greedy optimization of a balance objective function via pairwise switching; (2) numerical optimization via gurobi'; (3) rerandomization; (4) Karp's method for one covariate; (5) exhaustive enumeration for small sample sizes; (6) binary pair matching using nbpMatching'; (7) binary pair matching plus method (1) to further optimize balance; (8) binary pair matching plus method (3) to further optimize balance; (9) Hadamard designs; and (10) simultaneous multiple kernels. For the greedy, rerandomization, and related methods, three objective functions are supported: Mahalanobis distance, standardized sums of absolute differences, and kernel distances via the kernlab library. This package is the result of a stream of research that can be found in Krieger, A. M., Azriel, D. A., and Kapelner, A. (2019). "Nearly Random Designs with Greatly Improved Balance." Biometrika 106(3), 695-701 <doi:10.1093/biomet/asz026>. Krieger, A. M., Azriel, D. A., and Kapelner, A. (2023). "Better experimental design by hybridizing binary matching with imbalance optimization." Canadian Journal of Statistics, 51(1), 275-292 <doi:10.1002/cjs.11685>.

An implementation of ggplot2'-methods to present the composition of Solvency II Solvency Capital Requirement (SCR) as a series of concentric circle-parts. Solvency II (Solvency 2) is European insurance legislation, coming in force by the delegated acts of October 10, 2014. <https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=OJ%3AL%3A2015%3A012%3ATOC>. Additional files, defining the structure of the Standard Formula (SF) method of the SCR-calculation are provided. The structure files can be adopted for localization or for insurance companies who use Internal Models (IM). Options are available for combining smaller components, horizontal and vertical scaling, rotation, and plotting only some circle-parts. With outlines and connectors several SCR-compositions can be compared, for example in ORSA-scenarios (Own Risk and Solvency Assessment).

Analyze small-sample clustered or longitudinal data using modified generalized estimating equations with bias-adjusted covariance estimator. The package provides any combination of three modified generalized estimating equations and 11 bias-adjusted covariance estimators.

Using an approach based on similarity graph to estimate change-point(s) and the corresponding p-values. Can be applied to any type of data (high-dimensional, non-Euclidean, etc.) as long as a reasonable similarity measure is available.

Create a user-friendly plotting GUI for R'. In addition, one purpose of creating the R package is to facilitate third-party software to call R for drawing, for example, Phoenix WinNonlin software calls R to draw the drug concentration versus time curve.

Functionalities for modelling functional data with multidimensional inputs, multivariate functional data, and non-separable and/or non-stationary covariance structure of function-valued processes. In addition, there are functionalities for functional regression models where the mean function depends on scalar and/or functional covariates and the covariance structure depends on functional covariates. The development version of the package can be found on <https://github.com/gpfda/GPFDA-dev>.

Integer programming models to assign students to groups by maximising diversity within groups, or by maximising preference scores for topics.

Conducts causal inference with interactive fixed-effect models. It imputes counterfactuals for each treated unit using control group information based on a linear interactive fixed effects model that incorporates unit-specific intercepts interacted with time-varying coefficients. This method generalizes the synthetic control method to the case of multiple treated units and variable treatment periods, and improves efficiency and interpretability.

The first major functionality is to compute the bias in regression coefficients of misspecified linear gene-environment interaction models. The most generalized function for this objective is GE_bias(). However GE_bias() requires specification of many higher order moments of covariates in the model. If users are unsure about how to calculate/estimate these higher order moments, it may be easier to use GE_bias_normal_squaredmis(). This function places many more assumptions on the covariates (most notably that they are all jointly generated from a multivariate normal distribution) and is thus able to automatically calculate many of the higher order moments automatically, necessitating only that the user specify some covariances. There are also functions to solve for the bias through simulation and non-linear equation solvers; these can be used to check your work. Second major functionality is to implement the Bootstrap Inference with Correct Sandwich (BICS) testing procedure, which we have found to provide better finite-sample performance than other inference procedures for testing GxE interaction. More details on these functions are available in Sun, Carroll, Christiani, and Lin (2018) <doi:10.1111/biom.12813>.

Trace plots and convergence diagnostics for Markov Chain Monte Carlo (MCMC) algorithms on highly multivariate or unordered spaces. Methods outlined in a forthcoming paper.

The Geocoordinate Validation Service (GVS) runs checks of coordinates in latitude/longitude format. It returns annotated coordinates with additional flags and metadata that can be used in data cleaning. Additionally, the package has functions related to attribution and metadata information. More information can be found at <https://github.com/ojalaquellueva/gvs/tree/master/api>.

This package implements the Rank In Similarity Graph Edge-count two-sample test (RISE) for high-dimensional and non-Euclidean data. The method constructs similarity-based graphs, such as k-nearest neighbor graph (k-NNG), k-minimum spanning tree (k-MST), and k-minimum distance non-bipartite pairing (k-MDP), and evaluates rank-based within-sample edge counts with asymptotic and permutation p-values. For methodological details, see Zhou and Chen (2023) <https://proceedings.mlr.press/v195/zhou23a.html>.

For plant physiologists, converts conductance (e.g. stomatal conductance) to different units: m/s, mol/m^2/s, and umol/m^2/s/Pa.

This package provides a ggplot2 extension that supports arbitrary hand-crafted colourable & fillable shapes. New shapes may be feature requested via a Github issue.

Description: For the risk, progression, and response to treatment of many complex diseases, it has been increasingly recognized that gene-environment interactions play important roles beyond the main genetic and environmental effects. In practical interaction analyses, outliers in response variables and covariates are not uncommon. In addition, missingness in environmental factors is routinely encountered in epidemiological studies. The developed package consists of five robust approaches to address the outliers problems, among which two approaches can also accommodate missingness in environmental factors. Both continuous and right censored responses are considered. The proposed approaches are based on penalization and sparse boosting techniques for identifying important interactions, which are realized using efficient algorithms. Beyond the gene-environment analysis, the developed package can also be adopted to conduct analysis on interactions between other types of low-dimensional and high-dimensional data. (Mengyun Wu et al (2017), <doi:10.1080/00949655.2018.1523411>; Mengyun Wu et al (2017), <doi:10.1002/gepi.22055>; Yaqing Xu et al (2018), <doi:10.1080/00949655.2018.1523411>; Yaqing Xu et al (2019), <doi:10.1016/j.ygeno.2018.07.006>; Mengyun Wu et al (2021), <doi:10.1093/bioinformatics/btab318>).

This package provides a simple and intuitive high-level language for music representation. Generates and embeds music scores and audio files in RStudio', R Markdown documents, and R Jupyter Notebooks'. Internally, uses MusicXML <https://github.com/w3c/musicxml> to represent music, and MuseScore <https://musescore.org/> to convert MusicXML'.

The accurate annotation of genes and Quantitative Trait Loci (QTLs) located within candidate markers and/or regions (haplotypes, windows, CNVs, etc) is a crucial step the most common genomic analyses performed in livestock, such as Genome-Wide Association Studies or transcriptomics. The Genomic Annotation in Livestock for positional candidate LOci (GALLO) is an R package designed to provide an intuitive and straightforward environment to annotate positional candidate genes and QTLs from high-throughput genetic studies in livestock. Moreover, GALLO allows the graphical visualization of gene and QTL annotation results, data comparison among different grouping factors (e.g., methods, breeds, tissues, statistical models, studies, etc.), and QTL enrichment in different livestock species including cattle, pigs, sheep, and chicken, among others.

This package provides probability functions (cumulative distribution and density functions), simulation function (Gumbel copula multivariate simulation) and estimation functions (Maximum Likelihood Estimation, Inference For Margins, Moment Based Estimation and Canonical Maximum Likelihood).

When comparing discrete data mini bubble plots allow displaying more information than traditional bubble plots via colour, shape or labels. Exact overlapping coordinates will be transformed so they surround the original point circularly without overlapping. This is implemented as a position_surround() function for ggplot2'.