Algorithms to detect high-dimensional outliers. The minimum diagonal product of Ro, Zou, Wang and Yin (2015) <doi:10.1093/biomet/asv021>, the algorithm of Wilkinson (2018) <doi:10.1109/TVCG.2017.2744685>, and the distances of distances of Lee and Jeon (2025) <doi:10.48550/arXiv.2511.02199>.

This package provides details such as Morphine Equivalent Dose (MED), brand name and opioid content which are calculated of all oral opioids authorized for sale by Health Canada and the FDA based on their Drug Identification Number (DIN) or National Drug Code (NDC). MEDs are calculated based on recommendations by Canadian Institute for Health Information (CIHI) and Von Korff et al (2008) and information obtained from Health Canada's Drug Product Database's monthly data dump or FDA Daily database for Canadian and US databases respectively. Please note in no way should output from this package be a substitute for medical advise. All medications should only be consumed on prescription from a licensed healthcare provider.

Functionality to handle and project lat-long coordinates, easily download background maps and add a correct scale bar to OpenStreetMap plots in any map projection.

Ordination comprises several multivariate exploratory and explanatory techniques with theoretical foundations in geometric data analysis; see Podani (2000, ISBN:90-5782-067-6) for techniques and applications and Le Roux & Rouanet (2005) <doi:10.1007/1-4020-2236-0> for foundations. Greenacre (2010, ISBN:978-84-923846) shows how the most established of these, including principal components analysis, correspondence analysis, multidimensional scaling, factor analysis, and discriminant analysis, rely on eigen-decompositions or singular value decompositions of pre-processed numeric matrix data. These decompositions give rise to a set of shared coordinates along which the row and column elements can be measured. The overlay of their scatterplots on these axes, introduced by Gabriel (1971) <doi:10.1093/biomet/58.3.453>, is called a biplot. ordr provides inspection, extraction, manipulation, and visualization tools for several popular ordination classes supported by a set of recovery methods. It is inspired by and designed to integrate into Tidyverse workflows provided by Wickham et al (2019) <doi:10.21105/joss.01686>.

Detect the number and locations of change points. The locations can be either exact or in terms of ranges, depending on the available computational resource. The method is based on Jie Ding, Yu Xiang, Lu Shen, Vahid Tarokh (2017) <doi:10.1109/TSP.2017.2711558>.

Optimal scaling of a data vector, relative to a set of targets, is obtained through a least-squares transformation subject to appropriate measurement constraints. The targets are usually predicted values from a statistical model. If the data are nominal level, then the transformation must be identity-preserving. If the data are ordinal level, then the transformation must be monotonic. If the data are discrete, then tied data values must remain tied in the optimal transformation. If the data are continuous, then tied data values can be untied in the optimal transformation.

This package provides a unified object-oriented framework for numerical optimizers in R. Supports minimization and maximization with any optimizer, optimization over more than one function argument, computation time measurement, and time limits for long optimization tasks.

The OLStrajr package provides comprehensive functions for ordinary least squares (OLS) trajectory analysis and case-by-case OLS regression as outlined in Carrig, Wirth, and Curran (2004) <doi:10.1207/S15328007SEM1101_9> and Rogosa and Saner (1995) <doi:10.3102/10769986020002149>. It encompasses two primary functions, OLStraj() and cbc_lm(). The OLStraj() function simplifies the estimation of individual growth curves over time via OLS regression, with options for visualizing both group-level and individual-level growth trajectories and support for linear and quadratic models. The cbc_lm() function facilitates case-by-case OLS estimates and provides unbiased mean population intercept and slope estimators by averaging OLS intercepts and slopes across cases. It further offers standard error calculations across bootstrap replicates and computation of 95% confidence intervals based on empirical distributions from the resampling processes.

The identity provider ['OneLogin']<http://onelogin.com> is used for authentication via Single Sign On (SSO). This package provides an R interface to their API.

An implementation of the Rapid Assessment Method for Older People or RAM-OP <https://www.helpage.org/resource/rapid-assessment-method-for-older-people-ramop-manual/>. It provides various functions that allow the user to design and plan the assessment and analyse the collected data. RAM-OP provides accurate and reliable estimates of the needs of older people.

This is a tool to find the optimal rerandomization threshold in non-sequential experiments. We offer three procedures based on assumptions made on the residuals distribution: (1) normality assumed (2) excess kurtosis assumed (3) entire distribution assumed. Illustrations are included. Also included is a routine to unbiasedly estimate Frobenius norms of variance-covariance matrices. Details of the method can be found in "Optimal Rerandomization via a Criterion that Provides Insurance Against Failed Experiments" Adam Kapelner, Abba M. Krieger, Michael Sklar and David Azriel (2020) <arXiv:1905.03337>.

Obtain and evaluate various optimal designs for the 3, 4, and 5-parameter logistic models. The optimal designs are obtained based on the numerical algorithm in Hyun, Wong, Yang (2018) <doi:10.18637/jss.v083.i05>.

This package provides tools for collecting municipal-level data <http://www.transparencia.gov.br/swagger-ui.html> from several Brazilian governmental social programs.

This package provides a database management tool built as a shiny application. Connect to various databases to send queries, upload files, preview tables, and more.

This package provides a method that analyzes quality control metrics from multi-sample genomic sequencing studies and nominates poor quality samples for exclusion. Per sample quality control data are transformed into z-scores and aggregated. The distribution of aggregated z-scores are modelled using parametric distributions. The parameters of the optimal model, selected either by goodness-of-fit statistics or user-designation, are used for outlier nomination. Two implementations of the Cosine Similarity Outlier Detection algorithm are provided with flexible parameters for dataset customization.

Estimate the positron emission tomography (PET) neuroreceptor occupancies from the total volumes of distribution of a set of regions of interest. Fitting methods include the simple reference region', ordinary least squares (sometimes known as occupancy plot), and restricted maximum likelihood estimation'.

This package provides implementations of some of the most important outlier detection algorithms. Includes a tutorial mode option that shows a description of each algorithm and provides a step-by-step execution explanation of how it identifies outliers from the given data with the specified input parameters. References include the works of Azzedine Boukerche, Lining Zheng, and Omar Alfandi (2020) <doi:10.1145/3381028>, Abir Smiti (2020) <doi:10.1016/j.cosrev.2020.100306>, and Xiaogang Su, Chih-Ling Tsai (2011) <doi:10.1002/widm.19>.

The comprehensive knowledge of epigenetic modifications in plants, encompassing histone modifications in regulating gene expression, is not completely ingrained. It is noteworthy that histone deacetylation and histone H3 lysine 27 trimethylation (H3K27me3) play a role in repressing transcription in eukaryotes. In contrast, histone acetylation (H3K9ac) and H3K4me3 have been inevitably linked to the stimulation of gene expression, which significantly influences plant development and plays a role in plant responses to biotic and abiotic stresses. To our knowledge this the first multiclass classifier for predicting histone modification in plants. <doi:10.1186/s12864-019-5489-4>.

Design and analysis of confirmatory adaptive clinical trials using the optimal conditional error framework according to Brannath and Bauer (2004) <doi:10.1111/j.0006-341X.2004.00221.x>. An extension to the optimal conditional error function using interim estimates as described in Brannath and Dreher (2024) <doi:10.48550/arXiv.2402.00814> and functions to ensure that the resulting conditional error function is non-increasing are also available.

This package provides functions to test/check/verify/investigate the ordering of vectors. The is_[strictly_]* family of functions test vectors for sorted', monotonic', increasing', decreasing order; is_constant and is_incremental test for the degree of ordering. `ordering` provides a numeric indication of ordering -2 (strictly decreasing) to 2 (strictly increasing).

Open Location Codes <http://openlocationcode.com/> are a Google-created standard for identifying geographic locations. olctools provides utilities for validating, encoding and decoding entries that follow this standard.

Generate and analyze Optimal Channel Networks (OCNs): oriented spanning trees reproducing all scaling features characteristic of real, natural river networks. As such, they can be used in a variety of numerical experiments in the fields of hydrology, ecology and epidemiology. See Carraro et al. (2020) <doi:10.1002/ece3.6479> for a presentation of the package; Rinaldo et al. (2014) <doi:10.1073/pnas.1322700111> for a theoretical overview on the OCN concept; Furrer and Sain (2010) <doi:10.18637/jss.v036.i10> for the construct used.

Simplifies the creation of xlsx files by providing a high level interface to writing, styling and editing worksheets.

Given a certain coverage level, obtains simultaneous confidence bands for the survival and cumulative hazard functions such that the area between is minimized. Produces an approximate solution based on local time arguments.