For different linear dimension reduction methods like principal components analysis (PCA), independent components analysis (ICA) and supervised linear dimension reduction tests and estimates for the number of interesting components (ICs) are provided.

This package infers a topology of relationships between different datasets, such as multi-omics and phenotypic data recorded on the same samples. We based this methodology on the RV coefficient (Robert & Escoufier, 1976, <doi:10.2307/2347233>), a measure of matrix correlation, which we have extended for partial matrix correlations and binary data (Aben et al., 2018, <doi:10.1101/293993>).

Graphical visualization tools for analyzing the data produced by irace'. The iraceplot package enables users to analyze the performance and the parameter space data sampled by the configuration during the search process. It provides a set of functions that generate different plots to visualize the configurations sampled during the execution of irace and their performance. The functions just require the log file generated by irace and, in some cases, they can be used with user-provided data.

The Iterative Cumulative Sum of Squares (ICSS) algorithm by Inclan/Tiao (1994) <https://www.jstor.org/stable/2290916> detects multiple change points, i.e. structural break points, in the variance of a sequence of independent observations. For series of moderate size (i.e. 200 observations and beyond), the ICSS algorithm offers results comparable to those obtained by a Bayesian approach or by likelihood ration tests, without the heavy computational burden required by these approaches.

This package provides functions to access real-time infectious disease data from the disease.sh API', including COVID-19 global, US states, continent, and country statistics, vaccination coverage, influenza-like illness data from the Centers for Disease Control and Prevention (CDC), and more. Also includes curated datasets on a variety of infectious diseases such as influenza, measles, dengue, Ebola, tuberculosis, meningitis, AIDS, and others. The package supports epidemiological research and data analysis by combining API access with high-quality historical and survey datasets on infectious diseases. For more details on the disease.sh API', see <https://disease.sh/>.

This package provides functions read a dataframe containing one or more International Classification of Diseases Tenth Revision codes per subject. They return original data with injury categorizations and severity scores added.

This package provides a collection of wrapper functions for common variable and dataset manipulation workflows primarily used by iNZight', a graphical user interface providing easy exploration and visualisation of data for students of statistics, available in both desktop and online versions. Additionally, many of the functions return the tidyverse code used to obtain the result in an effort to bridge the gap between GUI and coding.

This package provides six modules for tumor microenvironment (TME) analysis based on multi-omics data. These modules cover data preprocessing, TME estimation, TME infiltrating patterns, cellular interactions, genome and TME interaction, and visualization for TME relevant features, as well as modelling based on key features. It integrates multiple microenvironmental analysis algorithms and signature estimation methods, simplifying the analysis and downstream visualization of the TME. In addition to providing a quick and easy way to construct gene signatures from single-cell RNA-seq data, it also provides a way to construct a reference matrix for TME deconvolution from single-cell RNA-seq data. The analysis pipeline and feature visualization are user-friendly and provide a comprehensive description of the complex TME, offering insights into tumour-immune interactions (Zeng D, et al. (2024) <doi:10.1016/j.crmeth.2024.100910>. Fang Y, et al. (2025) <doi:10.1002/mdr2.70001>).

Fits a double logistic function to NDVI time series and calculates instantaneous rate of green (IRG) according to methods described in Bischoff et al. (2012) <doi:10.1086/667590>.

Combining genomic prediction with Monte Carlo simulation, three different strategies are implemented to select parental lines for multiple traits in plant breeding. The selection strategies include (i) GEBV-O considers only genomic estimated breeding values (GEBVs) of the candidate individuals; (ii) GD-O considers only genomic diversity (GD) of the candidate individuals; and (iii) GEBV-GD considers both GEBV and GD. The above method can be seen in Chung PY, Liao CT (2020) <doi:10.1371/journal.pone.0243159>. Multi-trait genomic best linear unbiased prediction (MT-GBLUP) model is used to simultaneously estimate GEBVs of the target traits, and then a selection index is adopted to evaluate the composite performance of an individual.

You can access to open data published in Instituto Canario De Estadistica (ISTAC) APIs at <https://datos.canarias.es/api/estadisticas/>.

This package provides functions to simulate baseline characteristics, reconstruct overall survival data from published Kaplan-Meier curves, and generate publication-ready tables and forest plots reproducing the IMpower133 clinical trial results (Horn et al., 2018, <doi:10.1056/NEJMoa1809064>). The IPD reconstruction method is based on Liu et al.(2021, <doi:10.1186/s12874-021-01308-8>).

This package provides an estimator for generalized linear models with incomplete data for discrete covariates. The estimation is based on the EM algorithm by the method of weights by Ibrahim (1990) <DOI:10.2307/2290013>.

API wrapper that contains functions to retrieve data from the IsoMemo partnership databases. Web services for API: <https://isomemodb.com/api/v1/iso-data>.

Implementation of two multi-criteria decision making methods (MCDM): Intuitionistic Fuzzy Synthetic Measure (IFSM) and Intuitionistic Fuzzy Technique for Order of Preference by Similarity to Ideal Solution (IFTOPSIS) for intuitionistic fuzzy data sets for multi-criteria decision making problems. References describing the methods: JefmaÅ ski (2020) <doi:10.1007/978-3-030-52348-0_4>; JefmaÅ ski, Roszkowska, Kusterka-JefmaÅ ska (2021) <doi:10.3390/e23121636>.

Simulation of chromosomal segments shared identical-by-descent (IBD) among pedigree members. Using sex-specific recombination rates along the human genome (Halldorsson et al. (2019) <doi:10.1126/science.aau1043>), phased chromosomes are simulated for all pedigree members. Applications include calculation of realised relatedness coefficients and IBD segment distributions. ibdsim2 is part of the pedsuite collection of packages for pedigree analysis. A detailed presentation of the pedsuite', including a separate chapter on ibdsim2', is available in the book Pedigree analysis in R (Vigeland, 2021, ISBN:9780128244302). A Shiny app for visualising and comparing IBD distributions is available at <https://magnusdv.shinyapps.io/ibdsim2-shiny/>.

Creation of tables of summary statistics or counts for clinical data (for TLFs'). These tables can be exported as in-text table (with the flextable package) for a Clinical Study Report (Word format) or a topline presentation (PowerPoint format), or as interactive table (with the DT package) to an html document for clinical data review.

Helps with the thoughtful saving, reading, and management of result files (using rds files). The core functions take a list of parameters that are used to generate a unique hash to save results under. Then, the same parameter list can be used to read those results back in. This is helpful to avoid clunky file naming when running a large number of simulations. Additionally, helper functions are available for compiling a flat file of parameters of saved results, monitoring result usage, and cleaning up unwanted or unused results. For more information, visit the indexr homepage <https://lharris421.github.io/indexr/>.

An implementation of generalized linear models (GLMs) for studying relationships among attributes in connected populations, where responses of connected units can be dependent, as introduced by Fritz et al. (2025) <doi:10.1080/01621459.2025.2565851>. igml extends GLMs for independent responses to dependent responses and can be used for studying spillover in connected populations and other network-mediated phenomena.

Facilitates the calculation of validated pancreatic islet hormone-release indices from fasting and oral glucose tolerance test (OGTT) measurements. Provides beta-cell insulin release indices (including HOMA-beta, corrected insulin response, Stumvoll first-phase index, BIGTT-AIR, and disposition indices) as described in Madsen (2024) <doi:10.1038/s42255-024-01140-6>, alongside alpha-cell glucagon release and glucagon resistance indices derived from the glucagon-suppression and liver-alpha-cell-axis literature. Enables reproducible assessment of beta-cell and alpha-cell function for metabolic and endocrine research.

Converts character vectors between phonetic representations. Supports IPA (International Phonetic Alphabet), X-SAMPA (Extended Speech Assessment Methods Phonetic Alphabet), and ARPABET (used by the CMU Pronouncing Dictionary).

Implementation of some Individual Based Models (IBMs, sensu Grimm and Railsback 2005) and methods to create new ones, particularly for population dynamics models (reproduction, mortality and movement). The basic operations for the simulations are implemented in Rcpp for speed.

Iterator for generating permutations and combinations. They can be either drawn with or without replacement, or with distinct/ non-distinct items (multiset). The generated sequences are in lexicographical order (dictionary order). The algorithms to generate permutations and combinations are memory efficient. These iterative algorithms enable users to process all sequences without putting all results in the memory at the same time. The algorithms are written in C/C++ for faster performance. Note: iterpc is no longer being maintained. Users are recommended to switch to arrangements'.

IRT-M is a semi-supervised approach based on Bayesian Item Response Theory that produces theoretically identified underlying dimensions from input data and a constraints matrix. The methodology is fully described in Morucci et al. (2024), "Measurement That Matches Theory: Theory-Driven Identification in Item Response Theory Models"'. Details are available at <https://www.cambridge.org/core/journals/american-political-science-review/article/measurement-that-matches-theory-theorydriven-identification-in-item-response-theory-models/395DA1DFE3DCD7B866DC053D7554A30B>.