Equivalence tests and related confidence intervals for the comparison of two treatments, simultaneously for one or many normally distributed, primary response variables (endpoints). The step-up procedure of Quan et al. (2001) is both applied for differences and extended to ratios of means. A related single-step procedure is also available.

Website generator with HTML summaries for predictive models. This package uses DALEX explainers to describe global model behavior. We can see how well models behave (tabs: Model Performance, Auditor), how much each variable contributes to predictions (tabs: Variable Response) and which variables are the most important for a given model (tabs: Variable Importance). We can also compare Concept Drift for pairs of models (tabs: Drifter). Additionally, data available on the website can be easily recreated in current R session. Work on this package was financially supported by the NCN Opus grant 2017/27/B/ST6/01307 at Warsaw University of Technology, Faculty of Mathematics and Information Science.

Mixture model with overlapping clusters for binary actor-event data. Parameters are estimated in a Bayesian framework. Model and inference are described in Ranciati, Vinciotti, Wit (2017) Modelling actor-event network data via a mixture model under overlapping clusters. Submitted.

Sampling and evaluation methods to apply Monetary Unit Sampling (or in older literature Dollar Unit Sampling) during an audit of financial statements.

Fits multivariate Ornstein-Uhlenbeck types of models to continues trait data from species related by a common evolutionary history. See K. Bartoszek, J, Pienaar, P. Mostad, S. Andersson, T. F. Hansen (2012) <doi:10.1016/j.jtbi.2012.08.005> and K. Bartoszek, and J. Tredgett Clarke, J. Fuentes-Gonzalez, V. Mitov, J. Pienaar, M. Piwczynski, R. Puchalka, K. Spalik, K. L. Voje (2024) <doi:10.1111/2041-210X.14376>. The suggested PCMBaseCpp package (which significantly speeds up the likelihood calculations) can be obtained from <https://github.com/venelin/PCMBaseCpp/>.

Calculate morphine milligram equivalents (MME) for opioid dose comparison using standardized methods. Can directly call the NIH HEAL MME Online Calculator <https://research-mme.wakehealth.edu/api> API or replicate API calculations on the user's local machine from the comfort of R'. Creation of the NIH HEAL MME Online Calculator and the MME calculations implemented in this package are described in Adams MCB, Sward KA, Perkins ML, Hurley RW (2025) <doi:10.1097/j.pain.0000000000003529>.

Maximum likelihood estimation for series systems where the component cause of failure is masked. Implements analytical log-likelihood, score, and Hessian functions for exponential, homogeneous Weibull, and heterogeneous Weibull component lifetimes under masked cause conditions (C1, C2, C3). Supports exact, right-censored, left-censored, and interval-censored observations via composable observation functors. Provides random data generation, model fitting, and Fisher information for asymptotic inference. See Lin, Loh, and Bai (1993) <doi:10.1109/24.257799> and Craiu and Reiser (2006) <doi:10.1111/j.1541-0420.2005.00498.x>.

Transforms, calculates, and presents results from the Mental Health Quality of Life Questionnaire (MHQoL), a measure of health-related quality of life for individuals with mental health conditions. Provides scoring functions, summary statistics, and visualization tools to facilitate interpretation. For more details see van Krugten et al.(2022) <doi:10.1007/s11136-021-02935-w>.

The latest guidelines proposed by International Expert Consensus are used for the clinical diagnosis of Metabolic Associated Fatty Liver Disease (MAFLD). The new definition takes hepatic steatosis (determined by elastography or histology or biomarker-based fatty liver index) as a major criterion. In addition, race, gender, body mass index (BMI), waist circumference (WC), fasting plasma glucose (FPG), systolic blood pressure (SBP), diastolic blood pressure (DBP), triglycerides (TG), high-density lipoprotein cholesterol (HDLC), homeostatic model assessment of insulin resistance (HOMAIR), high sensitive c-reactive protein (HsCRP) for the diagnosis of MAFLD. Each parameter has to be interpreted based on the proposed cut-offs, making the diagnosis slightly complex and error-prone. This package is developed by incorporating the latest international expert consensus guidelines, and it will aid in the easy and quick diagnosis of MAFLD based on FibroScan in busy healthcare settings and also for research purposes. The new definition for MAFLD as per the International Consensus Statement is described by Eslam M et al (2020). <doi:10.1016/j.jhep.2020.03.039>.

Biodiversity areas, especially primary forest, serve a multitude of functions for local economy, regional functionality of the ecosystems as well as the global health of our planet. Recently, adverse changes in human land use practices and climatic responses to increased greenhouse gas emissions, put these biodiversity areas under a variety of different threats. The present package helps to analyse a number of biodiversity indicators based on freely available geographical datasets. It supports computational efficient routines that allow the analysis of potentially global biodiversity portfolios. The primary use case of the package is to support evidence based reporting of an organization's effort to protect biodiversity areas under threat and to identify regions were intervention is most duly needed.

Procedures for simulating biomes by equilibrium vegetation models, with a special focus on paleoenvironmental applications. Three widely used equilibrium biome models are currently implemented in the package: the Holdridge Life Zone (HLZ) system (Holdridge 1947, <doi:10.1126/science.105.2727.367>), the Köppen-Geiger classification (KGC) system (Köppen 1936, <https://koeppen-geiger.vu-wien.ac.at/pdf/Koppen_1936.pdf>) and the BIOME model (Prentice et al. 1992, <doi:10.2307/2845499>). Three climatic forest-steppe models are also implemented. An approach for estimating monthly time series of relative sunshine duration from temperature and precipitation data (Yin 1999, <doi:10.1007/s007040050111>) is also adapted, allowing process-based biome models to be combined with high-resolution paleoclimate simulation datasets (e.g., CHELSA-TraCE21k v1.0 dataset: <https://chelsa-climate.org/chelsa-trace21k/>).

This function allows to generate two biological conditions synthetic microarray dataset which has similar behavior to those currently observed with common platforms. User provides a subset of parameters. Available default parameters settings can be modified.

Matching longitudinal methodology models with complex sampling design. It fits fixed and random effects models and covariance structured models so far. It also provides tools to perform statistical tests considering these specifications as described in : Pacheco, P. H. (2021). "Modeling complex longitudinal data in R: development of a statistical package." <https://repositorio.ufjf.br/jspui/bitstream/ufjf/13437/1/pedrohenriquedemesquitapacheco.pdf>.

Supports visual interpretation of hierarchical composite endpoints (HCEs). HCEs are complex constructs used as primary endpoints in clinical trials, combining outcomes of different types into ordinal endpoints, in which each patient contributes the most clinically important event (one and only one) to the analysis. See Karpefors M et al. (2022) <doi:10.1177/17407745221134949>.

Estimates exponential-family random graph models for multilevel network data, assuming the multilevel structure is observed. The scope, at present, covers multilevel models where the set of nodes is nested within known blocks. The estimation method uses Monte-Carlo maximum likelihood estimation (MCMLE) methods to estimate a variety of canonical or curved exponential family models for binary random graphs. MCMLE methods for curved exponential-family random graph models can be found in Hunter and Handcock (JCGS, 2006). The package supports parallel computing, and provides methods for assessing goodness-of-fit of models and visualization of networks.

Includes functions for conducting univariate and multivariate meta-analysis. This includes the estimation of the asymptotic variance-covariance matrix of effect sizes. For more details see Becker (1992) <doi:10.2307/1165128>, Cooper, Hedges, and Valentine (2019) <doi:10.7758/9781610448864>, and Schmid, Stijnen, and White (2020) <doi:10.1201/9781315119403>.

This package contains the Maddison Project 2018 database, which provides estimates of GDP per capita for all countries in the world between AD 1 and 2016. See <https://www.rug.nl/ggdc/historicaldevelopment/maddison/> for more information.

Evaluation and optimization of the Fisher Information Matrix in NonLinear Mixed Effect Models using Markov Chains Monte Carlo for continuous and discrete data.

This package provides a user-friendly tool for visualizing categorical or group movement.

The Markov Decision Processes (MDP) toolbox proposes functions related to the resolution of discrete-time Markov Decision Processes: finite horizon, value iteration, policy iteration, linear programming algorithms with some variants and also proposes some functions related to Reinforcement Learning.

Cooperative learning combines the usual squared error loss of predictions with an agreement penalty to encourage the predictions from different data views to agree. By varying the weight of the agreement penalty, we get a continuum of solutions that include the well-known early and late fusion approaches. Cooperative learning chooses the degree of agreement (or fusion) in an adaptive manner, using a validation set or cross-validation to estimate test set prediction error. In the setting of cooperative regularized linear regression, the method combines the lasso penalty with the agreement penalty (Ding, D., Li, S., Narasimhan, B., Tibshirani, R. (2021) <doi:10.1073/pnas.2202113119>).

This package provides a comprehensive framework for analyzing agricultural nutrient balances across multiple spatial scales (county, HUC8', HUC2') with integration of wastewater treatment plant ('WWTP') effluent loads for both nitrogen and phosphorus. Supports classification of spatial units as nutrient sources, sinks, or balanced areas based on agricultural surplus and deficit calculations. Includes visualization tools, spatial transition probability analysis, and nutrient flow network mapping. Built-in datasets include agricultural nutrient balance data from the Nutrient Use Geographic Information System ('NuGIS'; The Fertilizer Institute and Plant Nutrition Canada, 1987-2016) <https://nugis.tfi.org/tabular_data/> and U.S. Environmental Protection Agency ('EPA') wastewater discharge data from the ECHO Discharge Monitoring Report ('DMR') Loading Tool (2007-2016) <https://echo.epa.gov/trends/loading-tool/water-pollution-search>. Data are downloaded on demand from the Open Science Framework ('OSF') repository to minimize package size while maintaining full functionality. The integrated manureshed framework methodology is described in Akanbi et al. (2025) <doi:10.1016/j.resconrec.2025.108697>. Designed for nutrient management planning, environmental analysis, and circular economy research at watershed/administrative to national scales. This material is based upon financial support by the National Science Foundation, EEC Division of Engineering Education and Centers, NSF Engineering Research Center for Advancing Sustainable and Distributed Fertilizer Production (CASFER), NSF 20-553 Gen-4 Engineering Research Centers award 2133576. We thank Dr. Robert D. Sabo (U.S. Environmental Protection Agency) for his valuable contributions to the conceptual development and review of this work.

Framework for the Item Response Theory analysis of dichotomous and ordinal polytomous outcomes under the assumption of multidimensionality and discreteness of the latent traits. The fitting algorithms allow for missing responses and for different item parameterizations and are based on the Expectation-Maximization paradigm. Individual covariates affecting the class weights may be included in the new version (since 2.1).

Routines to generate fully randomized moodle quizzes. It also contains 15 examples and a shiny app.