ClickHouse (<https://clickhouse.com/>) is an open-source, high performance columnar OLAP (online analytical processing of queries) database management system for real-time analytics using SQL. This DBI backend relies on the ClickHouse HTTP interface and support HTTPS protocol.

Create contour lines for a non regular series of points, potentially from a non-regular canvas.

Compute the certainty equivalents and premium risks as tools for risk-efficiency analysis. For more technical information, please refer to: Hardaker, Richardson, Lien, & Schumann (2004) <doi:10.1111/j.1467-8489.2004.00239.x>, and Richardson, & Outlaw (2008) <doi:10.2495/RISK080231>.

In many cases, experiments must be repeated across multiple seasons or locations to ensure applicability of findings. A single experiment conducted in one location and season may yield limited conclusions, as results can vary under different environmental conditions. In agricultural research, treatment à location and treatment à season interactions play a crucial role. Analyzing a series of experiments across diverse conditions allows for more generalized and reliable recommendations. The CANE package facilitates the pooled analysis of experiments conducted over multiple years, seasons, or locations. It is designed to assess treatment interactions with environmental factors (such as location and season) using various experimental designs. The package supports pooled analysis of variance (ANOVA) for the following designs: (1) PooledCRD()': completely randomized design; (2) PooledRBD()': randomized block design; (3) PooledLSD()': Latin square design; (4) PooledSPD()': split plot design; and (5) PooledStPD()': strip plot design. Each function provides the following outputs: (i) Individual ANOVA tables based on independent analysis for each location or year; (ii) Testing of homogeneity of error variances among distinct locations using Bartlettâ s Chi-Square test; (iii) If Bartlettâ s test is significant, Aitkenâ s transformation, defined as the ratio of the response to the square root of the error mean square, is applied to the response variable; otherwise, the data is used as is; (iv) Combined analysis to obtain a pooled ANOVA table; (v) Multiple comparison tests, including Tukey's honestly significant difference (Tukey's HSD) test, Duncanâ s multiple range test (DMRT), and the least significant difference (LSD) test, for treatment comparisons. The statistical theory and steps of analysis of these designs are available in Dean et al. (2017)<doi:10.1007/978-3-319-52250-0> and Ruà z et al. (2024)<doi:10.1007/978-3-031-65575-3>. By broadening the scope of experimental conclusions, CANE enables researchers to derive robust, widely applicable recommendations. This package is particularly valuable in agricultural research, where accounting for treatment à location and treatment à season interactions is essential for ensuring the validity of findings across multiple settings.

This package provides tools for the fitting and cross validation of exact conditional logistic regression models with lasso and elastic net penalties. Uses cyclic coordinate descent and warm starts to compute the entire path efficiently.

Load and analyze updated time series worldwide data of reported cases for the Novel Coronavirus Disease (COVID-19) from different sources, including the Johns Hopkins University Center for Systems Science and Engineering (JHU CSSE) data repository <https://github.com/CSSEGISandData/COVID-19>, "Our World in Data" <https://github.com/owid/> among several others. The datasets reporting the COVID-19 cases are available in two main modalities, as a time series sequences and aggregated data for the last day with greater spatial resolution. Several analysis, visualization and modelling functions are available in the package that will allow the user to compute and visualize total number of cases, total number of changes and growth rate globally or for an specific geographical location, while at the same time generating models using these trends; generate interactive visualizations and generate Susceptible-Infected-Recovered (SIR) model for the disease spread.

R interface for RAPIDS cuML (<https://github.com/rapidsai/cuml>), a suite of GPU-accelerated machine learning libraries powered by CUDA (<https://en.wikipedia.org/wiki/CUDA>).

This package provides easy and consistent time conversion for public health purposes. The time conversion functions provided here are between date, ISO week, ISO yearweek, ISO year, calendar month/year, season, season week.

Maps one of the viridis colour palettes, or a user-specified palette to values. Viridis colour maps are created by Stéfan van der Walt and Nathaniel Smith, and were set as the default palette for the Python Matplotlib library <https://matplotlib.org/>. Other palettes available in this library have been derived from RColorBrewer <https://CRAN.R-project.org/package=RColorBrewer> and colorspace <https://CRAN.R-project.org/package=colorspace> packages.

Nonparametric rank based tests (rank-sum tests and signed-rank tests) for clustered data, especially useful for clusters having informative cluster size and intra-cluster group size.

An algorithm for identifying candidate driver combinations in cancer. CRSO is based on a theoretical model of cancer in which a cancer rule is defined to be a collection of two or more events (i.e., alterations) that are minimally sufficient to cause cancer. A cancer rule set is a set of cancer rules that collectively are assumed to account for all of ways to cause cancer in the population. In CRSO every event is designated explicitly as a passenger or driver within each patient. Each event is associated with a patient-specific, event-specific passenger penalty, reflecting how unlikely the event would have happened by chance, i.e., as a passenger. CRSO evaluates each rule set by assigning all samples to a rule in the rule set, or to the null rule, and then calculating the total statistical penalty from all unassigned event. CRSO uses a three phase procedure find the best rule set of fixed size K for a range of Ks. A core rule set is then identified from among the best rule sets of size K as the rule set that best balances rule set size and statistical penalty. Users should consult the crso vignette for an example walk through of a full CRSO run. The full description, of the CRSO algorithm is presented in: Klein MI, Cannataro V, Townsend J, Stern DF and Zhao H. "Identifying combinations of cancer driver in individual patients." BioRxiv 674234 [Preprint]. June 19, 2019. <doi:10.1101/674234>. Please cite this article if you use crso'.

This package provides a wrapper for the Clockify API <https://docs.clockify.me/>, making it possible to query, insert and update time keeping data.

This package implements the regression approach of Zuber and Strimmer (2011) "High-dimensional regression and variable selection using CAR scores" SAGMB 10: 34, <DOI:10.2202/1544-6115.1730>. CAR scores measure the correlation between the response and the Mahalanobis-decorrelated predictors. The squared CAR score is a natural measure of variable importance and provides a canonical ordering of variables. This package provides functions for estimating CAR scores, for variable selection using CAR scores, and for estimating corresponding regression coefficients. Both shrinkage as well as empirical estimators are available.

This package provides the facility to perform the chi-square and G-square test of independence, calculates the retrospective power of the traditional chi-square test, compute permutation and Monte Carlo p-value, and provides measures of association for tables of any size such as Phi, Phi corrected, odds ratio with 95 percent CI and p-value, Yule Q and Y, adjusted contingency coefficient, Cramer's V, V corrected, V standardised, bias-corrected V, W, Cohen's w, Goodman-Kruskal's lambda, and tau. It also calculates standardised, moment-corrected standardised, and adjusted standardised residuals, and their significance, as well as the Quetelet Index, IJ association factor, and adjusted standardised counts. It also computes the chi-square-maximising version of the input table. Different outputs are returned in nicely formatted tables.

An implementation of the Chrome DevTools Protocol', for controlling a headless Chrome web browser.

Computes and visualize the results of the 0-1 test for chaos proposed by Gottwald and Melbourne (2004) <DOI:10.1137/080718851>. The algorithm is available in parallel for the independent values of parameter c. Additionally, fast RQA is added to distinguish chaos from noise.

In clinical practice and research settings in medicine and the behavioral sciences, it is often of interest to quantify the correlation of a continuous endpoint that was repeatedly measured (e.g., test-retest correlations, ICC, etc.). This package allows for estimating these correlations based on mixed-effects models. Part of this software has been developed using funding provided from the European Union's 7th Framework Programme for research, technological development and demonstration under Grant Agreement no 602552.

Simplifies the execution of command line interface (CLI) tools within isolated and reproducible environments. It enables users to effortlessly manage Conda environments, execute command line tools, handle dependencies, and ensure reproducibility in their data analysis workflows.

Cluster analysis is performed using pairwise distance information and a random partition distribution. The method is implemented for two random partition distributions. It draws samples and then obtains and plots clustering estimates. An implementation of a selection algorithm is provided for the mass parameter of the partition distribution. Since pairwise distances are the principal input to this procedure, it is most comparable to the hierarchical and k-medoids clustering methods. The method is Dahl, Andros, Carter (2022+) <doi:10.1002/sam.11602>.

This package provides a feasible framework for mutation analysis and reverse transcription polymerase chain reaction (RT-PCR) assay evaluation of COVID-19, including mutation profile visualization, statistics and mutation ratio of each assay. The mutation ratio is conducive to evaluating the coverage of RT-PCR assays in large-sized samples. Mercatelli, D. and Giorgi, F. M. (2020) <doi:10.20944/preprints202004.0529.v1>.

An algorithm developed to efficiently and accurately process complex and variable cardiac data with three key features: 1. employing autocorrelation to identify recurrent heartbeats and use their periods to compute heart rates; 2. incorporating a genetic algorithm framework to minimize data loss due to noise interference and accommodate within-sequence variations; and 3. introducing a tracking index as a moving reference to reduce errors. Lau, Wong, & Gu (2026) <https://ssrn.com/abstract=5153081>.

An implementation of efficiency first conformal prediction (EFCP) and validity first conformal prediction (VFCP) that demonstrates both validity (coverage guarantee) and efficiency (width guarantee). To learn how to use it, check the vignettes for a quick tutorial. The package is based on the work by Yang Y., Kuchibhotla A.,(2021) <arxiv:2104.13871>.

This package provides a time series usually does not have a uniform growth rate. Compound Annual Growth Rate measures the average annual growth over a given period. More details can be found in Bardhan et al. (2022) <DOI:10.18805/ag.D-5418>.

Engines for survival models from the parsnip package. These include parametric models (e.g., Jackson (2016) <doi:10.18637/jss.v070.i08>), semi-parametric (e.g., Simon et al (2011) <doi:10.18637/jss.v039.i05>), and tree-based models (e.g., Buehlmann and Hothorn (2007) <doi:10.1214/07-STS242>).