This package provides a finite-population significance test of the sharp causal null hypothesis that treatment exposure X has no effect on final outcome Y, within the principal stratum of Compliers. A generalized likelihood ratio test statistic is used, and the resulting p-value is exact. Currently, it is assumed that there are only Compliers and Never Takers in the population.

Given any graph, the node2vec algorithm can learn continuous feature representations for the nodes, which can then be used for various downstream machine learning tasks.The techniques are detailed in the paper "node2vec: Scalable Feature Learning for Networks" by Aditya Grover, Jure Leskovec(2016),available at <arXiv:1607.00653>.

This package provides a Software Development Kit for working with Nixtla''s TimeGPT', a foundation model for time series forecasting. API is an acronym for application programming interface'; this package allows users to interact with TimeGPT via the API'. You can set and validate API keys and generate forecasts via API calls. It is compatible with tsibble and base R. For more details visit <https://docs.nixtla.io/>.

This package implements the framework presented in Cucci, D. A., Voirol, L., Khaghani, M. and Guerrier, S. (2023) <doi:10.1109/TIM.2023.3267360> which allows to analyze the impact of sensor error modeling on the performance of integrated navigation (sensor fusion) based on inertial measurement unit (IMU), Global Positioning System (GPS), and barometer data. The framework relies on Monte Carlo simulations in which a Vanilla Extended Kalman filter is coupled with realistic and user-configurable noise generation mechanisms to recover a reference trajectory from noisy measurements. The evaluation of several statistical metrics of the solution, aggregated over hundreds of simulated realizations, provides reasonable estimates of the expected performances of the system in real-world conditions.

In shotgun proteomics, shared peptides (i.e., peptides that might originate from different proteins sharing homology, from different proteoforms due to alternative mRNA splicing, post-translational modifications, proteolytic cleavages, and/or allelic variants) represent a major source of ambiguity in protein identifications. The net4pg package allows to assess and handle ambiguity of protein identifications. It implements methods for two main applications. First, it allows to represent and quantify ambiguity of protein identifications by means of graph connected components (CCs). In graph theory, CCs are defined as the largest subgraphs in which any two vertices are connected to each other by a path and not connected to any other of the vertices in the supergraph. Here, proteins sharing one or more peptides are thus gathered in the same CC (multi-protein CC), while unambiguous protein identifications constitute CCs with a single protein vertex (single-protein CCs). Therefore, the proportion of single-protein CCs and the size of multi-protein CCs can be used to measure the level of ambiguity of protein identifications. The package implements a strategy to efficiently calculate graph connected components on large datasets and allows to visually inspect them. Secondly, the net4pg package allows to exploit the increasing availability of matched transcriptomic and proteomic datasets to reduce ambiguity of protein identifications. More precisely, it implement a transcriptome-based filtering strategy fundamentally consisting in the removal of those proteins whose corresponding transcript is not expressed in the sample-matched transcriptome. The underlying assumption is that, according to the central dogma of biology, there can be no proteins without the corresponding transcript. Most importantly, the package allows to visually inspect the effect of the filtering on protein identifications and quantify ambiguity before and after filtering by means of graph connected components. As such, it constitutes a reproducible and transparent method to exploit transcriptome information to enhance protein identifications. All methods implemented in the net4pg package are fully described in Fancello and Burger (2022) <doi:10.1186/s13059-022-02701-2>.

Offers a rich and diverse collection of datasets focused on the brain, nervous system, and related disorders. The package includes clinical, experimental, neuroimaging, behavioral, cognitive, and simulated data on conditions such as Parkinson's disease, Alzheimer's disease, dementia, epilepsy, schizophrenia, autism spectrum disorder, attention deficit, hyperactivity disorder, Tourette's syndrome, traumatic brain injury, gliomas, migraines, headaches, sleep disorders, concussions, encephalitis, subarachnoid hemorrhage, and mental health conditions. Datasets cover structural and functional brain data, cross-sectional and longitudinal MRI imaging studies, neurotransmission, gene expression, cognitive performance, intelligence metrics, sleep deprivation effects, treatment outcomes, brain-body relationships across species, neurological injury patterns, and acupuncture interventions. Data sources include peer-reviewed studies, clinical trials, military health records, sports injury databases, and international comparative studies. Designed for researchers, neuroscientists, clinicians, psychologists, data scientists, and students, this package facilitates exploratory data analysis, statistical modeling, and hypothesis testing in neuroscience and neuroepidemiology.

Macros to generate nimble code from a concise syntax. Included are macros for generating linear modeling code using a formula-based syntax and for building for() loops. For more details review the nimble manual: <https://r-nimble.org/html_manual/cha-writing-models.html#subsec:macros>.

This allows you to generate reporting workflows around nlmixr2 analyses with outputs in Word and PowerPoint. You can specify figures, tables and report structure in a user-definable YAML file. Also you can use the internal functions to access the figures and tables to allow their including in other outputs (e.g. R Markdown).

Nonparametric methods for analysis of covariance (ANCOVA) are distribution-free and provide a flexible statistical framework for situations where the assumptions of parametric ANCOVA are violated or when the response variable is ordinal. This package implements several well-known nonparametric ANCOVA procedures, including Quade, Puri and Sen, McSweeney and Porter, Burnett and Barr, Hettmansperger and McKean, Shirley, and Puri-Sen-Harwell-Serlin. The package provides user-friendly functions to apply these methods in practice. These methods are described in Olejnik et al. (1985) <doi:10.1177/0193841X8500900104> and Harwell et al. (1988) <doi:10.1037/0033-2909.104.2.268>.

This package provides a unified, programmatic interface for searching, browsing, and retrieving metadata from various international organization data repositories that use the National Data Archive ('NADA') software, such as the World Bank, FAO', and the International Household Survey Network ('IHSN'). Functions allow users to discover available data collections, country codes, and access types, perform complex searches using keyword and spatial/temporal filters, and retrieve detailed study information, including file lists and variable-level data dictionaries. It simplifies access to microdata for researchers and policy analysts globally.

It names the R Markdown chunks of files based on the filename.

This package provides a nested menu widget for usage in Shiny applications. This is useful for hierarchical choices (e.g. continent, country, city).

Snow water equivalent is modeled with the process based models delta.snow and HS2SWE and empirical regression, which use relationships between density and diverse at-site parameters. The methods are described in Winkler et al. (2021) <doi:10.5194/hess-25-1165-2021>, Magnusson et al. (2025) <doi:10.1016/j.coldregions.2025.104435>, Guyennon et al. (2019) <doi:10.1016/j.coldregions.2019.102859>, Pistocchi (2016) <doi:10.1016/j.ejrh.2016.03.004>, Jonas et al. (2009) <doi:10.1016/j.jhydrol.2009.09.021> and Sturm et al. (2010) <doi:10.1175/2010JHM1202.1>.

The purpose of this library is to to call different optimization solvers (such as Gonzalez Rodriguez et al. (2022) <doi:10.1007/s10898-022-01229-w>, Tawarmalani and Sahinidis (2005) <doi:10.1007/s10107-005-0581-8>, and Byrd et al. (2006) <doi:10.1007/0-387-30065-1_4>) to solve problems given by a standard nl file.

Perform a stratified weighted log-rank test in a randomized controlled trial. Tests can be visualized as a difference in average score on the two treatment arms. These methods are described in Magirr and Burman (2018) <doi:10.48550/arXiv.1807.11097>, Magirr (2020) <doi:10.48550/arXiv.2007.04767>, and Magirr and Jimenez (2022) <doi:10.48550/arXiv.2201.10445>.

This package performs Bayesian wavelet analysis using individual non-local priors as described in Sanyal & Ferreira (2017) <DOI:10.1007/s13571-016-0129-3> and non-local prior mixtures as described in Sanyal (2025) <DOI:10.48550/arXiv.2501.18134>.

Systematically creates and modifies NONMEM(R) control streams. Harvests NONMEM output, builds run logs, creates derivative data, generates diagnostics. NONMEM (ICON Development Solutions <https://www.iconplc.com/>) is software for nonlinear mixed effects modeling. See package?nonmemica'.

Analyzes data involving imprecise and vague information. Provides summary statistics and describes the characteristics of neutrosophic data, as defined by Florentin Smarandache (2013).<ISBN:9781599732749>.

Automated population pharmacokinetic modeling framework for data-driven initialisation, model evaluation, and metaheuristic optimization. Supports genetic algorithms, ant colony optimization, tabu search, and stepwise procedures for automated model selection and parameter estimation within the nlmixr2 ecosystem.

Implementation of forward selection based on cross-validated linear and logistic regression.

An efficient unified nonconvex penalized estimation algorithm for Gaussian (linear), binomial Logit (logistic), Poisson, multinomial Logit, and Cox proportional hazard regression models. The unified algorithm is implemented based on the convex concave procedure and the algorithm can be applied to most of the existing nonconvex penalties. The algorithm also supports convex penalty: least absolute shrinkage and selection operator (LASSO). Supported nonconvex penalties include smoothly clipped absolute deviation (SCAD), minimax concave penalty (MCP), truncated LASSO penalty (TLP), clipped LASSO (CLASSO), sparse ridge (SRIDGE), modified bridge (MBRIDGE) and modified log (MLOG). For high-dimensional data (data set with many variables), the algorithm selects relevant variables producing a parsimonious regression model. Kim, D., Lee, S. and Kwon, S. (2018) <arXiv:1811.05061>, Lee, S., Kwon, S. and Kim, Y. (2016) <doi:10.1016/j.csda.2015.08.019>, Kwon, S., Lee, S. and Kim, Y. (2015) <doi:10.1016/j.csda.2015.07.001>. (This research is funded by Julian Virtue Professorship from Center for Applied Research at Pepperdine Graziadio Business School and the National Research Foundation of Korea.).

Next-Generation Clustered Heat Maps (NG-CHMs) allow for dynamic exploration of heat map data in a web browser. NGCHM allows users to create both stand-alone HTML files containing a Next-Generation Clustered Heat Map, and .ngchm files to view in the NG-CHM viewer. See Ryan MC, Stucky M, et al (2020) <doi:10.12688/f1000research.20590.2> for more details.

Data sets and nonlinear regression models dedicated to predictive microbiology.

Loading NONMEM (NONlinear Mixed-Effect Modeling, <https://www.iconplc.com/solutions/technologies/nonmem/>) and PSN (Perl-speaks-NONMEM, <https://uupharmacometrics.github.io/PsN/>) output files to extract parameter estimates, provide visual predictive check (VPC) and goodness of fit (GOF) plots, and simulate with parameter uncertainty.