This package implements the Scout method for regression, described in "Covariance-regularized regression and classification for high-dimensional problems", by Witten and Tibshirani (2008), Journal of the Royal Statistical Society, Series B 71(3): 615-636.

Substitution matrices are important parameters in protein alignment algorithms. These matrices represent the likelihood that an amino acid will be substituted for another during mutation. This tool allows users to apply predefined and custom matrices and then explore the resulting alignments with interactive visualizations. SubVis requires the availability of a web browser.

The most important function of the R package is the genetic effects analysis of small RNA in hybrid plants via two methods, and at the same time, it provides various forms of graph related to data characteristics and expression analysis. In terms of two classification methods, one is the calculation of the additive (a) and dominant (d), the other is the evaluation of expression level dominance by comparing the total expression of the small RNA in progeny with the expression level in the parent species.

Estimate necessary sample sizes for comparing the location of data from two groups or categories when the distribution of the data is skewed. The package offers a non-parametric method for a Wilcoxon Mann-Whitney test of location shift as well as methods for several generalized linear models, for instance, Gamma regression.

Species sensitivity distributions are cumulative probability distributions which are fitted to toxicity concentrations for different species as described by Posthuma et al.(2001) <isbn:9781566705783>. The ssdtools package uses Maximum Likelihood to fit distributions such as the gamma, log-logistic, log-normal and log-normal log-normal mixture. Multiple distributions can be averaged using Akaike Information Criteria. Confidence intervals on hazard concentrations and proportions are produced by bootstrapping.

This package provides a suite of statistical methods for analysis of single-cell omics data including linear model-based methods for differential abundance analysis for individual level single-cell RNA-seq data. For more details see Zhang, et al. (Submitted to Bioinformatics)<https://github.com/Lujun995/DiSC_Replication_Code>.

Based on the illness-death model a large number of clinical trials with oncology endpoints progression-free survival (PFS) and overall survival (OS) can be simulated, see Meller, Beyersmann and Rufibach (2019) <doi:10.1002/sim.8295>. The simulation set-up allows for random and event-driven censoring, an arbitrary number of treatment arms, staggered study entry and drop-out. Exponentially, Weibull and piecewise exponentially distributed survival times can be generated. The correlation between PFS and OS can be calculated.

This package implements tidy syllabification of transcription. Based on @kylebgorman's python implementation <https://github.com/kylebgorman/syllabify>.

Semi-distance and mean-variance (MV) index are proposed to measure the dependence between a categorical random variable and a continuous variable. Test of independence and feature screening for classification problems can be implemented via the two dependence measures. For the details of the methods, see Zhong et al. (2023) <doi:10.1080/01621459.2023.2284988>; Cui and Zhong (2019) <doi:10.1016/j.csda.2019.05.004>; Cui, Li and Zhong (2015) <doi:10.1080/01621459.2014.920256>.

Datasets and functions for the book "Statistiques pour lâ économie et la gestion", "Théorie et applications en entreprise", F. Bertrand, Ch. Derquenne, G. Dufrénot, F. Jawadi and M. Maumy, C. Borsenberger editor, (2021, ISBN:9782807319448, De Boeck Supérieur, Louvain-la-Neuve). The first chapter of the book is dedicated to an introduction to statistics and their world. The second chapter deals with univariate exploratory statistics and graphics. The third chapter deals with bivariate and multivariate exploratory statistics and graphics. The fourth chapter is dedicated to data exploration with Principal Component Analysis. The fifth chapter is dedicated to data exploration with Correspondance Analysis. The sixth chapter is dedicated to data exploration with Multiple Correspondance Analysis. The seventh chapter is dedicated to data exploration with automatic clustering. The eighth chapter is dedicated to an introduction to probability theory and classical probability distributions. The ninth chapter is dedicated to an estimation theory, one-sample and two-sample tests. The tenth chapter is dedicated to an Gaussian linear model. The eleventh chapter is dedicated to an introduction to time series. The twelfth chapter is dedicated to an introduction to probit and logit models. Various example datasets are shipped with the package as well as some new functions.

An input controller for R Shiny: a matrix with radio buttons, where only one option per row can be selected.

Use behavioural variables to score activity and infer sleep from bouts of immobility. It is primarily designed to score sleep in fruit flies from Drosophila Activity Monitor (TriKinetics) and Ethoscope data. It implements sleep scoring using the "five-minute rule" (Hendricks et al. (2000) <DOI:10.1016/S0896-6273(00)80877-6>), activity classification for Ethoscopes (Geissmann et al. (2017) <DOI:10.1371/journal.pbio.2003026>) and a new algorithm to detect when animals are dead.

Given a list of substance compositions, a list of substances involved in a process, and a list of constraints in addition to mass conservation of elementary constituents, the package contains functions to build the substance composition matrix, to analyze the uniqueness of process stoichiometry, and to calculate stoichiometric coefficients if process stoichiometry is unique. (See Reichert, P. and Schuwirth, N., A generic framework for deriving process stoichiometry in enviromental models, Environmental Modelling and Software 25, 1241-1251, 2010 for more details.).

Univariate and multivariate normal data simulation. They also supply a brief summary of the analysis for each experiment/design: - Independent samples. - One-way and two-way Anova. - Paired samples (T-Test & Regression). - Repeated measures (Anova & Multiple Regression). - Clinical Assay.

Sudoku designs (Bailey et al., 2008<doi:10.1080/00029890.2008.11920542>) can be used as experimental designs which tackle one extra source of variation than conventional Latin square designs. Although Sudoku designs are similar to Latin square designs, only addition is the region concept. Some very important functions related to row-column designs as well as block designs along with basic functions are included in this package.

Flexible multidimensional scaling (MDS) methods and extensions to the package smacof'. This package contains various functions, wrappers, methods and classes for fitting, plotting and displaying a large number of different flexible MDS models. These are: Torgerson scaling (Torgerson, 1958, ISBN:978-0471879459) with powers, Sammon mapping (Sammon, 1969, <doi:10.1109/T-C.1969.222678>) with ratio and interval optimal scaling, Multiscale MDS (Ramsay, 1977, <doi:10.1007/BF02294052>) with ratio and interval optimal scaling, s-stress MDS (ALSCAL; Takane, Young & De Leeuw, 1977, <doi:10.1007/BF02293745>) with ratio and interval optimal scaling, elastic scaling (McGee, 1966, <doi:10.1111/j.2044-8317.1966.tb00367.x>) with ratio and interval optimal scaling, r-stress MDS (De Leeuw, Groenen & Mair, 2016, <https://rpubs.com/deleeuw/142619>) with ratio, interval, splines and nonmetric optimal scaling, power-stress MDS (POST-MDS; Buja & Swayne, 2002 <doi:10.1007/s00357-001-0031-0>) with ratio and interval optimal scaling, restricted power-stress (Rusch, Mair & Hornik, 2021, <doi:10.1080/10618600.2020.1869027>) with ratio and interval optimal scaling, approximate power-stress with ratio optimal scaling (Rusch, Mair & Hornik, 2021, <doi:10.1080/10618600.2020.1869027>), Box-Cox MDS (Chen & Buja, 2013, <https://jmlr.org/papers/v14/chen13a.html>), local MDS (Chen & Buja, 2009, <doi:10.1198/jasa.2009.0111>), curvilinear component analysis (Demartines & Herault, 1997, <doi:10.1109/72.554199>), curvilinear distance analysis (Lee, Lendasse & Verleysen, 2004, <doi:10.1016/j.neucom.2004.01.007>), nonlinear MDS with optimal dissimilarity powers functions (De Leeuw, 2024, <https://github.com/deleeuw/smacofManual/blob/main/smacofPO(power)/smacofPO.pdf>), sparsified (power) MDS and sparsified multidimensional (power) distance analysis aka extended curvilinear (power) component analysis and extended curvilinear (power) distance analysis (Rusch, 2024, <doi:10.57938/355bf835-ddb7-42f4-8b85-129799fc240e>). Some functions are suitably flexible to allow any other sensible combination of explicit power transformations for weights, distances and input proximities with implicit ratio, interval, splines or nonmetric optimal scaling of the input proximities. Most functions use a Majorization-Minimization algorithm. Currently the methods are only available for one-mode two-way data (symmetric dissimilarity matrices).

This package implements statistical methods for detecting evolutionary shifts in both the optimal trait value (mean) and evolutionary diffusion variance. The method uses an L1-penalized optimization framework to identify branches where shifts occur, and the shift magnitudes. It also supports the inclusion of measurement error. For more details, see Zhang, Ho, and Kenney (2023) <doi:10.48550/arXiv.2312.17480>.

This package implements Bayesian inference in accelerated failure time (AFT) models for right-censored survival times assuming a log-logistic distribution. Details of the variational Bayes algorithms, with and without shared frailty, are described in Xian et al. (2024) <doi:10.1007/s11222-023-10365-6> and Xian et al. (2024) <doi:10.48550/arXiv.2408.00177>, respectively.

This package implements statistical methods for analyzing the counts of areal data, with a focus on the detection of spatial clusters and clustering. The package has a heavy emphasis on spatial scan methods, which were first introduced by Kulldorff and Nagarwalla (1995) <doi:10.1002/sim.4780140809> and Kulldorff (1997) <doi:10.1080/03610929708831995>.

Allows shiny developers to incorporate UI elements based on Google's Material design. See <https://material.io/guidelines/> for more information.

We propose a procedure for sample size calculation while controlling false discovery rate for RNA-seq experimental design. Our procedure depends on the Voom method proposed for RNA-seq data analysis by Law et al. (2014) <DOI:10.1186/gb-2014-15-2-r29> and the sample size calculation method proposed for microarray experiments by Liu and Hwang (2007) <DOI:10.1093/bioinformatics/btl664>. We develop a set of functions that calculates appropriate sample sizes for two-sample t-test for RNA-seq experiments with fixed or varied set of parameters. The outputs also contain a plot of power versus sample size, a table of power at different sample sizes, and a table of critical test values at different sample sizes. To install this package, please use source("http://bioconductor.org/biocLite.R"); biocLite("ssizeRNA")'. For R version 3.5 or greater, please use if(!requireNamespace("BiocManager", quietly = TRUE))install.packages("BiocManager"); BiocManager::install("ssizeRNA")'.

Perform survival simulation with parametric survival model generated from survreg function in survival package. In each simulation coefficients are resampled from variance-covariance matrix of parameter estimates to capture uncertainty in model parameters. Prediction intervals of Kaplan-Meier estimates and hazard ratio of treatment effect can be further calculated using simulated survival data.

This package provides a toolkit for Partially Observed Markov Decision Processes (POMDP). Provides bindings to C++ libraries implementing the algorithm SARSOP (Successive Approximations of the Reachable Space under Optimal Policies) and described in Kurniawati et al (2008), <doi:10.15607/RSS.2008.IV.009>. This package also provides a high-level interface for generating, solving and simulating POMDP problems and their solutions.

An updated and extended version of spm package, by introducing some further novel functions for modern statistical methods (i.e., generalised linear models, glmnet, generalised least squares), thin plate splines, support vector machine, kriging methods (i.e., simple kriging, universal kriging, block kriging, kriging with an external drift), and novel hybrid methods (228 hybrids plus numerous variants) of modern statistical methods or machine learning methods with mathematical and/or univariate geostatistical methods for spatial predictive modelling. For each method, two functions are provided, with one function for assessing the predictive errors and accuracy of the method based on cross-validation, and the other for generating spatial predictions. It also contains a couple of functions for data preparation and predictive accuracy assessment.