The rdmulti package implements estimation, inference, and graphical procedures for regression discontinuity (RD) designs with multiple cutoffs or multiple scores. rdmc() provides point estimation and robust bias-corrected inference for multi-cutoff designs, rdmcplot() provides data-driven RD plots for multi-cutoff designs, and rdms() provides point estimation and robust bias-corrected inference for multi-score designs. See Cattaneo, Titiunik and Vazquez-Bare (2020) <https://rdpackages.github.io/references/Cattaneo-Titiunik-VazquezBare_2020_Stata.pdf> for further methodological details.

This package provides tools to perform randomization inference for RD designs under local randomization: rdrandinf() to perform hypothesis testing using randomization inference, rdwinselect() to select a window around the cutoff in which randomization is likely to hold, rdsensitivity() to assess the sensitivity of the results to different window lengths and null hypotheses and rdrbounds() to construct Rosenbaum bounds for sensitivity to unobserved confounders. See Cattaneo, Titiunik and Vazquez-Bare (2016) <https://rdpackages.github.io/references/Cattaneo-Titiunik-VazquezBare_2016_Stata.pdf> for further methodological details, and references.

Currently fully supports Enrichr, JASPAR, miEAA, PANTHER, Reactome, STRING, and UniProt! The goal of rbioapi is to provide a user-friendly and consistent interface to biological databases and services. In a way that insulates the user from the technicalities of using web services API and creates a unified and easy-to-use interface to biological and medical web services. This is an ongoing project; New databases and services will be added periodically. Feel free to suggest any databases or services you often use.

This is a collection of functions designed for simulating, estimating and forecasting seasonal functional autoregressive time series of order one. These methods are addressed in the manuscript: <https://www.monash.edu/business/ebs/research/publications/ebs/wp16-2019.pdf>.

Cross validate large genetic data while specifying clinical variables that should always be in the model using the function cv(). An ROC plot from the cross validation data with AUC can be obtained using rocplot(), which also can be used to compare different models. Framework was built to handle genetic data, but works for any data.

This package provides a complete seven-step workflow for copy number variation (CNV) analysis applicable to any disease or condition where samples with genomic copy number data is available. Supports built-in grading and risk stratification presets for seven major cancers (viz. prostate, breast, colorectal, lung, cervical, lymphoma, melanoma) based on clinically validated systems including ISUP Grade Groups, Nottingham Grading System, Dukes staging, IASLC TNM, FIGO, Ann Arbor/Lugano classification, and Breslow depth. Generalizable to other disease types. An automatic mode derives a normalised Risk Score from the data using min-max normalisation and adaptive binning. Custom user-defined thresholds are supported for any other disease type. Downstream functions for CNV aberration detection, recurrence analysis, gene annotation, CNV matrix generation, and CNV-RNA expression correlation are disease-type agnostic.

This package provides a unified framework for detecting regime changes (changepoints) in time series data. Implements both frequentist methods including Cumulative Sum (CUSUM, Page (1954) <doi:10.1093/biomet/41.1-2.100>), Pruned Exact Linear Time (PELT, Killick, Fearnhead, and Eckley (2012) <doi:10.1080/01621459.2012.737745>), Binary Segmentation, and Wild Binary Segmentation, as well as Bayesian methods such as Bayesian Online Changepoint Detection (BOCPD, Adams and MacKay (2007) <doi:10.48550/arXiv.0710.3742> and Shiryaev-Roberts. Supports offline analysis for retrospective detection and online monitoring for real-time surveillance. Provides rigorous uncertainty quantification through confidence intervals and posterior distributions. Handles univariate and multivariate series with detection of changes in mean, variance, trend, and distributional properties.

Floating Percentile Model with additional functions for optimizing inputs and evaluating outputs and assumptions.

Extend Rasch and Item Response Theory (IRT) analyses by providing tools for post-processing the output from five major IRT packages (i.e., eRm', psychotools', ltm', mirt', and TAM'). The current version provides the plotPIccc() function, which extracts from the return object of the originating package all information required to draw an extended Person-Item-Map (PIccc), showing any combination of * category characteristic curves (CCCs), * threshold characteristic curves (TCCs), * item characteristic curves (ICCs), * category information functions (CIFs), * item information functions (IIFs), * test information function (TIF), and the * standard error curve (S.E.). for uni- and multidimensional models (as far as supported by each package). It allows for selecting dimensions, items, and categories to plot and offers numerous options to adapt the output. The return object contains all calculated values for further processing.

Generate random positions (latitude/longitude), Well-known text ('WKT') points or polygons, or GeoJSON points or polygons.

This package provides robust statistical methods for analyzing numeric data, including robust estimation of location and scale using Huber M-estimators and a robust two-sample t-test. Methods are based on Huber (1981, ISBN:0471418056) "Robust Statistics" and Smyth (2004) <doi:10.2202/1544-6115.1027>.

An implementation of the WOFOST ("World Food Studies") crop growth model. WOFOST is a dynamic simulation model that uses daily weather data, and crop, soil and management parameters to simulate crop growth and development. See De Wit et al. (2019) <doi:10.1016/j.agsy.2018.06.018> for a recent review of the history and use of the model.

This package provides tools for large, sparse optimal matching of treated units and control units in observational studies. Provisions are made for refined covariate balance constraints, which include fine and near-fine balance as special cases. Matches are optimal in the sense that they are computed as solutions to network optimization problems rather than greedy algorithms. See Pimentel, et al.(2015) <doi:10.1080/01621459.2014.997879> and Pimentel (2016), Obs. Studies 2(1):4-23. The rrelaxiv package, which provides an alternative solver for the underlying network flow problems, carries an academic license and is not available on CRAN, but may be downloaded from Github at <https://github.com/josherrickson/rrelaxiv/>.

Inverse normal transformation (INT) based genetic association testing. These tests are recommend for continuous traits with non-normally distributed residuals. INT-based tests robustly control the type I error in settings where standard linear regression does not, as when the residual distribution exhibits excess skew or kurtosis. Moreover, INT-based tests outperform standard linear regression in terms of power. These tests may be classified into two types. In direct INT (D-INT), the phenotype is itself transformed. In indirect INT (I-INT), phenotypic residuals are transformed. The omnibus test (O-INT) adaptively combines D-INT and I-INT into a single robust and statistically powerful approach. See McCaw ZR, Lane JM, Saxena R, Redline S, Lin X. "Operating characteristics of the rank-based inverse normal transformation for quantitative trait analysis in genome-wide association studies" <doi:10.1111/biom.13214>.

This package implements a series of robust Kalman filtering approaches. It implements the additive outlier robust filters of Ruckdeschel et al. (2014) <arXiv:1204.3358> and Agamennoni et al. (2018) <doi:10.1109/ICRA.2011.5979605>, the innovative outlier robust filter of Ruckdeschel et al. (2014) <arXiv:1204.3358>, as well as the innovative and additive outlier robust filter of Fisch et al. (2020) <arXiv:2007.03238>.

Flux (mass per unit time) and Load (mass) are computed from timeseries estimates of analyte concentration and discharge. Concentration timeseries are computed from regression between surrogate and user-provided analyte. Uncertainty in calculations is estimated using bootstrap resampling. Code for the processing of acoustic backscatter from horizontally profiling acoustic Doppler current profilers is provided. All methods detailed in Livsey et al (2020) <doi:10.1007/s12237-020-00734-z>, Livsey et al (2023) <doi:10.1029/2022WR033982>, and references therein.

This package implements a high performance C++ parser for ActiGraph GT3X'/'GT3X+ data format (with extension .gt3x') for accelerometer samples. Activity samples can be easily read into a matrix or data.frame. This allows for storing the raw accelerometer samples in the original binary format to reserve space.

Calculates and compares various reliability coefficients for unidimensional and multidimensional scales. Supported unidimensional estimators include coefficient alpha, congeneric reliability, the Gilmer-Feldt coefficient, Feldt's classical congeneric reliability, Hancock's H, Heise-Bohrnstedt's omega, Kaiser-Caffrey's alpha, and Ten Berge and Zegers mu series. Multidimensional estimators include stratified alpha, maximal reliability, correlated factors reliability, second-order factor reliability, and bifactor reliability. See Cho (2021) <doi:10.1007/s11336-021-09801-1>, Cho (2024) <doi:10.1037/met0000475>, Cho (2025) <doi:10.1037/met0000525>.

Calculates periodograms based on (robustly) fitting periodic functions to light curves (irregularly observed time series, possibly with measurement accuracies, occurring in astroparticle physics). Three main functions are included: RobPer() calculates the periodogram. Outlying periodogram bars (indicating a period) can be detected with betaCvMfit(). Artificial light curves can be generated using the function tsgen(). For more details see the corresponding article: Thieler, Fried and Rathjens (2016), Journal of Statistical Software 69(9), 1-36, <doi:10.18637/jss.v069.i09>.

Access data stored in REDCap databases using the Application Programming Interface (API). REDCap (Research Electronic Data CAPture; <https://projectredcap.org>, Harris, et al. (2009) <doi:10.1016/j.jbi.2008.08.010>, Harris, et al. (2019) <doi:10.1016/j.jbi.2019.103208>) is a web application for building and managing online surveys and databases developed at Vanderbilt University. The API allows users to access data and project meta data (such as the data dictionary) from the web programmatically. The redcapAPI package facilitates the process of accessing data with options to prepare an analysis-ready data set consistent with the definitions in a database's data dictionary.

Rectangle packing is a packing problem where rectangles are placed into a larger rectangular region (without overlapping) in order to maximise the use space. Rectangles are packed using the skyline heuristic as discussed in Lijun et al (2011) A Skyline-Based Heuristic for the 2D Rectangular Strip Packing Problem <doi:10.1007/978-3-642-21827-9_29>. A function is also included for determining a good small-sized box for containing a given set of rectangles.

This package provides a set of functions to analyze and print the development of a commodity using the Point and Figure (P&F) approach. A P&F processor can be used to calculate daily statistics for the time series. These statistics can be used for deeper investigations as well as to create plots. Plots can be generated as well known X/O Plots in plain text format, and additionally in a more graphical format.

This package provides functions for the calibration of radiocarbon dates, as well as options to calculate different radiocarbon-related timescales (cal BP, cal BC/AD, C14 age, F14C, pMC, D14C) and estimating the effects of contamination or local reservoir offsets (Reimer and Reimer 2001 <doi:10.1017/S0033822200038339>). Supporting publication: Blaauw, M., Reimer, P.J., 2026. An open-source toolkit for radiocarbon dating and calibration. Radiocarbon <doi:10.1017/RDC.2026.10221>. The methods follow long-established recommendations such as Stuiver and Polach (1977) <doi:10.1017/S0033822200003672> and Reimer et al. (2004) <doi:10.1017/S0033822200033154>. This package uses the calibration curves from the data package rintcal'.

This package provides a wrapper around the react-router-dom React library for use in Shiny applications and Quarto documents. Enables client-side routing with hash, memory, and browser history strategies, nested routes, dynamic segments, data loaders, actions, and navigation hooks.