This package provides a collection of moment-matching methods for computing the cumulative distribution function of a positively-weighted sum of chi-squared random variables. Methods include the Satterthwaite-Welch method, Hall-Buckley-Eagleson method, Wood's F method, and the Lindsay-Pilla-Basak method.

This package provides a fast and general method for restructuring classical longitudinal observational data into augmented transition data suitable for multi-state modeling with the msm package. Works with any longitudinal data where subjects accumulate repeated observations with start and end times and an optional terminal outcome. Methods are described in Grossetti, Ieva and Paganoni (2018) <doi:10.1007/s10729-017-9400-z>.

Selecting the optimal multidimensional scaling (MDS) procedure for metric data via metric MDS (ratio, interval, mspline) and nonmetric MDS (ordinal). Selecting the optimal multidimensional scaling (MDS) procedure for interval-valued data via metric MDS (ratio, interval, mspline).Selecting the optimal multidimensional scaling procedure for interval-valued data by varying all combinations of normalization and optimization methods.Selecting the optimal MDS procedure for statistical data referring to the evaluation of tourist attractiveness of Lower Silesian counties. (Borg, I., Groenen, P.J.F., Mair, P. (2013) <doi:10.1007/978-3-642-31848-1>, Walesiak, M. (2016) <doi:10.15611/ekt.2016.2.01>, Walesiak, M. (2017) <doi:10.15611/ekt.2017.3.01>).

Discover OpenID Connect endpoints and authenticate using device flow. Used by MOLGENIS packages.

Facilitate frequentist and Bayesian meta-analysis of diagnosis and prognosis research studies. It includes functions to summarize multiple estimates of prediction model discrimination and calibration performance (Debray et al., 2019) <doi:10.1177/0962280218785504>. It also includes functions to evaluate funnel plot asymmetry (Debray et al., 2018) <doi:10.1002/jrsm.1266>. Finally, the package provides functions for developing multivariable prediction models from datasets with clustering (de Jong et al., 2021) <doi:10.1002/sim.8981>.

This package provides a method for the multiresolution analysis of spatial fields and images to capture scale-dependent features. mrbsizeR is based on scale space smoothing and uses differences of smooths at neighbouring scales for finding features on different scales. To infer which of the captured features are credible, Bayesian analysis is used. The scale space multiresolution analysis has three steps: (1) Bayesian signal reconstruction. (2) Using differences of smooths, scale-dependent features of the reconstructed signal can be found. (3) Posterior credibility analysis of the differences of smooths created. The method has first been proposed by Holmstrom, Pasanen, Furrer, Sain (2011) <DOI:10.1016/j.csda.2011.04.011> and extended in Flury, Gerber, Schmid and Furrer (2021) <DOI:10.1016/j.spasta.2020.100483>.

This package provides a range of functions for computing both global and local mark correlation functions for spatial point patterns in either Euclidean spaces or on linear networks, with points carrying either real-valued or function-valued marks. For a review of mark correlation functions, see Eckardt and Moradi (2024) <doi:10.1007/s13253-024-00605-1>.

This package provides tools to compute depth measures and implementations of related tasks such as outlier detection, data exploration and classification of multivariate, regression and functional data.

This package provides a variety of functions useful for data analysis, selection, manipulation, and graphics.

The nonparametric two-stage Bayesian adaptive design is a novel phase II clinical trial design for finding the minimum effective dose (MinED). This design is motivated by the top priority and concern of clinicians when testing a new drug, which is to effectively treat patients and minimize the chance of exposing them to subtherapeutic or overly toxic doses. It is used to design single-agent trials.

Multidimensional unfolding using Schoenemann's algorithm for metric and Procrustes rotation of unfolding results.

This package provides functions provide comprehensive treatments for estimating, inferring, testing and model selecting in linear regression models with structural breaks. The tests, estimation methods, inference and information criteria implemented are discussed in Bai and Perron (1998) "Estimating and Testing Linear Models with Multiple Structural Changes" <doi:10.2307/2998540>.

Mixed model-based genome-wide association analysis that accommodate population membership information, variance adjustment, and correlated responses.

This package provides functions of marginal mean and quantile regression models are used to analyze environmental exposure and biomonitoring data with repeated measurements and non-detects (i.e., values below the limit of detection (LOD)), as well as longitudinal exposure data that include non-detects and time-dependent covariates. For more details see Chen IC, Bertke SJ, Curwin BD (2021) <doi:10.1038/s41370-021-00345-1>, Chen IC, Bertke SJ, Estill CF (2024) <doi:10.1038/s41370-024-00640-7>, Chen IC, Bertke SJ, Dahm MM (2024) <doi:10.1093/annweh/wxae068>, and Chen IC (2025) <doi:10.1038/s41370-025-00752-8>.

Estimates the precision of transdimensional Markov chain Monte Carlo (MCMC) output, which is often used for Bayesian analysis of models with different dimensionality (e.g., model selection). Transdimensional MCMC (e.g., reversible jump MCMC) relies on sampling a discrete model-indicator variable to estimate the posterior model probabilities. If only few switches occur between the models, precision may be low and assessment based on the assumption of independent samples misleading. Based on the observed transition matrix of the indicator variable, the method of Heck, Overstall, Gronau, & Wagenmakers (2019, Statistics & Computing, 29, 631-643) <doi:10.1007/s11222-018-9828-0> draws posterior samples of the stationary distribution to (a) assess the uncertainty in the estimated posterior model probabilities and (b) estimate the effective sample size of the MCMC output.

Learning, manipulation and evaluation of mixtures of truncated basis functions (MoTBFs), which include mixtures of polynomials (MOPs) and mixtures of truncated exponentials (MTEs). MoTBFs are a flexible framework for modelling hybrid Bayesian networks (I. Pérez-Bernabé, A. Salmerón, H. Langseth (2015) <doi:10.1007/978-3-319-20807-7_36>; H. Langseth, T.D. Nielsen, I. Pérez-Bernabé, A. Salmerón (2014) <doi:10.1016/j.ijar.2013.09.012>; I. Pérez-Bernabé, A. Fernández, R. Rumà , A. Salmerón (2016) <doi:10.1007/s10618-015-0429-7>). The package provides functionality for learning univariate, multivariate and conditional densities, with the possibility of incorporating prior knowledge. Structural learning of hybrid Bayesian networks is also provided. A set of useful tools is provided, including plotting, printing and likelihood evaluation. This package makes use of S3 objects, with two new classes called motbf and jointmotbf'.

This package provides a model designed to be a reliable testbed where various gene drive interventions for mosquito-borne diseases control. It is being developed to accommodate the use of various mosquito-specific gene drive systems within a population dynamics framework that allows migration of individuals between patches in landscape. Previous work developing the population dynamics can be found in Deredec et al. (2001) <doi:10.1073/pnas.1110717108> and Hancock & Godfray (2007) <doi:10.1186/1475-2875-6-98>, and extensions to accommodate CRISPR homing dynamics in Marshall et al. (2017) <doi:10.1038/s41598-017-02744-7>.

Implementation of the Monothetic Clustering algorithm (Chavent, 1998 <doi:10.1016/S0167-8655(98)00087-7>) on continuous data sets. A lot of extensions are included in the package, including applying Monothetic clustering on data sets with circular variables, visualizations with the results, and permutation and cross-validation based tests to support the decision on the number of clusters.

An implementation of multiple maps t-distributed stochastic neighbor embedding (t-SNE). Multiple maps t-SNE is a method for projecting high-dimensional data into several low-dimensional maps such that non-metric space properties are better preserved than they would be by a single map. Multiple maps t-SNE with only one map is equivalent to standard t-SNE. When projecting onto more than one map, multiple maps t-SNE estimates a set of latent weights that allow each point to contribute to one or more maps depending on similarity relationships in the original data. This implementation is a port of the original Matlab library by Laurens van der Maaten. See Van der Maaten and Hinton (2012) <doi:10.1007/s10994-011-5273-4>. This material is based upon work supported by the United States Air Force and Defense Advanced Research Project Agency (DARPA) under Contract No. FA8750-17-C-0020. Any opinions, findings and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the United States Air Force and Defense Advanced Research Projects Agency. Distribution Statement A: Approved for Public Release; Distribution Unlimited.

Sample size estimations for MRMC studies based on the Obuchowski-Rockette (OR) methodology is implemented. The function can calculate sample sizes where the endpoint of interest in the study is either ROC AUC (Area-Under-the-Receiver-Operating-Characteristics-Curve) or sensitivity. The package can also return sample sizes for studies expected to have clustering effect (e.g.- multiple pulmonary nodules per patient). All calculations assume that the study design is fully crossed (paired-reader, paired-case) where each reader reads/interprets each case and that there are two interventions/imaging-modalities/techniques in the study. In addition to MRMC, it can also be used to estimate sample sizes for standalone studies where sensitivity or AUC are the primary endpoints. The methods implemented are based on the methods described in Zhou et.al. (2011) <doi:10.1002/9780470906514> and Obuchowski (2000) <doi:10.1097/EDE.0b013e3181a663cc>.

Exploratory and predictive methods for the analysis of several blocks of variables measured on the same individuals.

Fits latent Dirichlet allocation (LDA), supervised topic models, and multilevel supervised topic models for text data with multiple outcome variables. Core estimation routines are implemented in C++ using the Rcpp ecosystem. For topic models, see Blei et al. (2003) <https://www.jmlr.org/papers/volume3/blei03a/blei03a.pdf>. For supervised topic models, see Blei and McAuliffe (2007) <https://papers.nips.cc/paper_files/paper/2007/hash/d56b9fc4b0f1be8871f5e1c40c0067e7-Abstract.html>.

This package provides a set of core functions for handling medical device event data in the context of post-market surveillance, pharmacovigilance, signal detection and trending, and regulatory reporting. Primary inputs are data on events by device and data on exposures by device. Outputs include: standardized device-event and exposure datasets, defined analyses, and time series.

To test whether the missing data mechanism, in a set of incompletely observed data, is one of missing completely at random (MCAR). For detailed description see Jamshidian, M. Jalal, S., and Jansen, C. (2014). "MissMech: An R Package for Testing Homoscedasticity, Multivariate Normality, and Missing Completely at Random (MCAR)", Journal of Statistical Software, 56(6), 1-31. <https://www.jstatsoft.org/v56/i06/> <doi:10.18637/jss.v056.i06>.