Pooling, backward and forward selection of linear, logistic and Cox regression models in multiply imputed datasets. Backward and forward selection can be done from the pooled model using Rubin's Rules (RR), the D1, D2, D3, D4 and the median p-values method. This is also possible for Mixed models. The models can contain continuous, dichotomous, categorical and restricted cubic spline predictors and interaction terms between all these type of predictors. The stability of the models can be evaluated using (cluster) bootstrapping. The package further contains functions to pool model performance measures as ROC/AUC, Reclassification, R-squared, scaled Brier score, H&L test and calibration plots for logistic regression models. Internal validation can be done across multiply imputed datasets with cross-validation or bootstrapping. The adjusted intercept after shrinkage of pooled regression coefficients can be obtained. Backward and forward selection as part of internal validation is possible. A function to externally validate logistic prediction models in multiple imputed datasets is available and a function to compare models. For Cox models a strata variable can be included. Eekhout (2017) <doi:10.1186/s12874-017-0404-7>. Wiel (2009) <doi:10.1093/biostatistics/kxp011>. Marshall (2009) <doi:10.1186/1471-2288-9-57>.

This package provides functions to perform paternity exclusion via allele matching, in autopolyploid species having ploidy 4, 6, or 8. The marker data used can be genotype data (copy numbers known) or allelic phenotype data (copy numbers not known).

This package provides a collection of functions to simulate, estimate and forecast a wide range of regression based dynamic models for positive time series. This package implements the results presented in Prass, T.S.; Pumi, G.; Taufemback, C.G. and Carlos, J.H. (2025). "Positive time series regression models: theoretical and computational aspects". Computational Statistics 40, 1185â 1215. <doi:10.1007/s00180-024-01531-z>.

This package provides tools to process legacy format summary redistricting data files produced by the United States Census Bureau pursuant to P.L. 94-171. These files are generally available earlier but are difficult to work with as-is.

Sequential Monte Carlo (SMC) inference for fully Bayesian Gaussian process (GP) regression and classification models by particle learning (PL) following Gramacy & Polson (2011) <doi:10.48550/arXiv.0909.5262>. The sequential nature of inference and the active learning (AL) hooks provided facilitate thrifty sequential design (by entropy) and optimization (by improvement) for classification and regression models, respectively. This package essentially provides a generic PL interface, and functions (arguments to the interface) which implement the GP models and AL heuristics. Functions for a special, linked, regression/classification GP model and an integrated expected conditional improvement (IECI) statistic provide for optimization in the presence of unknown constraints. Separable and isotropic Gaussian, and single-index correlation functions are supported. See the examples section of ?plgp and demo(package="plgp") for an index of demos.

This package provides tools for analyzing differential abundance in proteomics experiments. Implements S3 classes for data management and supports Generalized Linear Models (GLM; Nelder and Wedderburn (1972) <doi:10.2307/2344614>), Aligned Rank Transform (ART; Wobbrock et al. (2011) <doi:10.1145/1978942.1978963>), and pairwise test methods for statistical analysis. Includes visualization functions for Principal Component Analysis (PCA), volcano plots, and heatmaps.

Price volatility refers to the degree of variation in series over a certain period of time. This volatility is especially noticeable in agricultural commodities, adding uncertainty for farmers, traders, and others in the agricultural supply chain. Commonly and popularly used four volatility models viz, GARCH, Glosten Jagannatan Runkle-GARCH (GJR-GARCH) model, exponentially weighted moving average (EWMA) model and Multiplicative Error Model (MEM) are selected and implemented. PWAVE, weighted ensemble model based on particle swarm optimization (PSO) is proposed to combine the forecast obtained from all the candidate models. This package has been developed using algorithm of Paul et al. <doi:10.1007/s40009-023-01218-x> and Yeasin and Paul (2024) <doi:10.1007/s11227-023-05542-3>.

This package provides tools for fitting periodic coefficients regression models to data where periodicity plays a crucial role. It allows users to model and analyze relationships between variables that exhibit cyclical or seasonal patterns, offering functions for estimating parameters and testing the periodicity of coefficients in linear regression models. For simple periodic coefficient regression model see Regui et al. (2024) <doi:10.1080/03610918.2024.2314662>.

This package provides functions and graphics for projecting daily incidence based on past incidence, and estimates of the serial interval and reproduction number. Projections are based on a branching process using a Poisson-distributed number of new cases per day, similar to the model used for estimating R in EpiEstim or in earlyR', and described by Nouvellet et al. (2017) <doi:10.1016/j.epidem.2017.02.012>. The package provides the S3 class projections which extends matrix', with accessors and additional helpers for handling, subsetting, merging, or adding these objects, as well as dedicated printing and plotting methods.

Simple method of purging independent variables of mediating effects. First, regress the direct variable on the indirect variable. Then, used the stored residuals as the new purged (direct) variable in the updated specification. This purging process allows for use of a new direct variable uncorrelated with the indirect variable. Please cite the method and/or package using Waggoner, Philip D. (2018) <doi:10.1177/1532673X18759644>.

This package provides a simple interface for extracting various elements from the publicly available PubMed XML files, incorporating PubMed's regular updates, and combining the data with the NIH Open Citation Collection. See Schoenbachler and Hughey (2021) <doi:10.7717/peerj.11071>.

This package provides a secure and user-friendly interface to interact with the Plug <https://plugbytpf.com.br> API'. It enables developers to store and manage tokens securely using the keyring package, retrieve data from API endpoints with the httr2 package, and handle large datasets with chunked data fetching. Designed for simplicity and security, the package facilitates seamless integration with Plug ecosystem.

This package implements our Bayesian phase I repeated measurement design that accounts for multidimensional toxicity endpoints from multiple treatment cycles. The package also provides a novel design to account for both multidimensional toxicity endpoints and early-stage efficacy endpoints in the phase I design. For both designs, functions are provided to recommend the next dosage selection based on the data collected in the available patient cohorts and to simulate trial characteristics given design parameters. Yin, Jun, et al. (2017) <doi:10.1002/sim.7134>.

The function pointdensity returns a density count and the temporal average for every point in the original list. The dataframe returned includes four columns: lat, lon, count, and date_avg. The "lat" column is the original latitude data; the "lon" column is the original longitude data; the "count" is the density count of the number of points within a radius of radius*grid_size (the neighborhood); and the date_avg column includes the average date of each point in the neighborhood.

Normalization of numerical matrices by minimizing the mean/median/mode difference between all column pairs.

This package provides functions for working with primary event censored distributions and Stan implementations for use in Bayesian modeling. Primary event censored distributions are useful for modeling delayed reporting scenarios in epidemiology and other fields (Charniga et al. (2024) <doi:10.48550/arXiv.2405.08841>). It also provides support for arbitrary delay distributions, a range of common primary distributions, and allows for truncation and secondary event censoring to be accounted for (Park et al. (2024) <doi:10.1101/2024.01.12.24301247>). A subset of common distributions also have analytical solutions implemented, allowing for faster computation. In addition, it provides multiple methods for fitting primary event censored distributions to data via optional dependencies.

This package implements the Bayesian hierarchical model described by Wheldon, Raftery, Clark and Gerland (see: <doi:10.1080/01621459.2012.737729>) for simultaneously estimating age-specific population counts, fertility rates, mortality rates and net international migration flows, at the national level.

Construct parser combinator functions, higher order functions that parse input. Construction of such parsers is transparent and easy. Their main application is the parsing of structured text files like those generated by laboratory instruments. Based on a paper by Hutton (1992) <doi:10.1017/S0956796800000411>.

Estimation and inference for coefficients of linear EIV models with symmetric measurement errors. The measurement errors can be homoscedastic or heteroscedastic, for the latter, replication for at least some observations needs to be available. The estimation method and asymptotic inference are based on a generalised method of moments framework, where the estimating equations are formed from (1) minimising the distance between the empirical phase function (normalised characteristic function) of the response and that of the linear combination of all the covariates at the estimates, and (2) minimising a corrected least-square discrepancy function. Specifically, for a linear EIV model with p error-prone and q error-free covariates, if replicates are available, the GMM approach is based on a 2(p+q) estimating equations if some replicates are available and based on p+2q estimating equations if no replicate is available. The details of the method are described in Nghiem and Potgieter (2020) <doi:10.1093/biomet/asaa025> and Nghiem and Potgieter (2025) <doi:10.5705/ss.202022.0331>.

This package provides methods for building self-organizing maps (SOMs) with a number of distinguishing features such automatic centroid detection and cluster visualization using starbursts. For more details see the paper "Improved Interpretability of the Unified Distance Matrix with Connected Components" by Hamel and Brown (2011) in <ISBN:1-60132-168-6>. The package provides user-friendly access to two models we construct: (a) a SOM model and (b) a centroid based clustering model. The package also exposes a number of quality metrics for the quantitative evaluation of the map, Hamel (2016) <doi:10.1007/978-3-319-28518-4_4>. Finally, we reintroduced our fast, vectorized training algorithm for SOM with substantial improvements. It is about an order of magnitude faster than the canonical, stochastic C implementation <doi:10.1007/978-3-030-01057-7_60>.

Generation of a chosen number of count, binary, ordinal, and continuous random variables, with specified correlations and marginal properties. The details of the method are explained in Demirtas (2012) <DOI:10.1002/sim.5362>.

Implementation of the exact, normal approximation, and simulation-based methods for computing the probability mass function (pmf) and cumulative distribution function (cdf) of the Poisson-Multinomial distribution, together with a random number generator for the distribution. The exact method is based on multi-dimensional fast Fourier transformation (FFT) of the characteristic function of the Poisson-Multinomial distribution. The normal approximation method uses a multivariate normal distribution to approximate the pmf of the distribution based on central limit theorem. The simulation method is based on the law of large numbers. Details about the methods are available in Lin, Wang, and Hong (2022) <DOI:10.1007/s00180-022-01299-0>.

This package implements the Penalized Youden Index Estimator (PYE) and the Covariate-Adjusted Youden Index Estimator (covYI), providing a novel framework for feature and covariate selection and combination in high-dimensional binary classification problems. Methodologies are based on Salaroli and Pardo (2023) <doi:10.1016/j.chemolab.2023.104786> and an unpublished manuscript by Salaroli and Pardo (2026) under review.

Conduct simulation-based customized power calculation for clustered time to event data in a mixed crossed/nested design, where a number of cell lines and a number of mice within each cell line are considered to achieve a desired statistical power, motivated by Eckel-Passow and colleagues (2021) <doi:10.1093/neuonc/noab137> and Li and colleagues (2025) <doi:10.51387/25-NEJSDS76>. This package provides two commonly used models for powering a design, linear mixed effects and Cox frailty model. Both models account for within-subject (cell line) correlation while holding different distributional assumptions about the outcome. Alternatively, the counterparts of fixed effects model are also available, which produces similar estimates of statistical power.