This package provides a method for modeling genetic data as a combination of discrete layers, within each of which relatedness may decay continuously with geographic distance. This package contains code for running analyses (which are implemented in the modeling language rstan') and visualizing and interpreting output. See the paper for more details on the model and its utility.

This package provides methods for analyzing (cell) motion in two or three dimensions. Available measures include displacement, confinement ratio, autocorrelation, straightness, turning angle, and fractal dimension. Measures can be applied to entire tracks, steps, or subtracks with varying length. While the methodology has been developed for cell trajectory analysis, it is applicable to anything that moves including animals, people, or vehicles. Some of the methodology implemented in this packages was described by: Beauchemin, Dixit, and Perelson (2007) <doi:10.4049/jimmunol.178.9.5505>, Beltman, Maree, and de Boer (2009) <doi:10.1038/nri2638>, Gneiting and Schlather (2004) <doi:10.1137/S0036144501394387>, Mokhtari, Mech, Zitzmann, Hasenberg, Gunzer, and Figge (2013) <doi:10.1371/journal.pone.0080808>, Moreau, Lemaitre, Terriac, Azar, Piel, Lennon-Dumenil, and Bousso (2012) <doi:10.1016/j.immuni.2012.05.014>, Textor, Peixoto, Henrickson, Sinn, von Andrian, and Westermann (2011) <doi:10.1073/pnas.1102288108>, Textor, Sinn, and de Boer (2013) <doi:10.1186/1471-2105-14-S6-S10>, Textor, Henrickson, Mandl, von Andrian, Westermann, de Boer, and Beltman (2014) <doi:10.1371/journal.pcbi.1003752>.

This package creates an HTML vertical timeline from a data frame as an input for rmarkdown documents and shiny applications.

This package provides a generic, easy-to-use and expandable implementation of a pharmacokinetic (PK) / pharmacodynamic (PD) model based on the S4 class system. This package allows the user to read/write a pharmacometric model from/to files and adapt it further on the fly in the R environment. For this purpose, this package provides an intuitive API to add, modify or delete equations, ordinary differential equations (ODE's), model parameters or compartment properties (like infusion duration or rate, bioavailability and initial values). Finally, this package also provides a useful export of the model for use with simulation packages rxode2 and mrgsolve'. This package is designed and intended to be used with package campsis', a PK/PD simulation platform built on top of rxode2 and mrgsolve'.

Calculates correlation of variables and displays the results graphically. Included panel functions can display points, shading, ellipses, and correlation values with confidence intervals. See Friendly (2002) <doi:10.1198/000313002533>.

This package provides functions and a workflow to easily and powerfully calculating specificity, sensitivity and ROC curves of biomarkers combinations. Allows to rank and select multi-markers signatures as well as to find the best performing sub-signatures, now also from single-cell RNA-seq datasets. The method used was first published as a Shiny app and described in Mazzara et al. (2017) <doi:10.1038/srep45477> and further described in Bombaci & Rossi (2019) <doi:10.1007/978-1-4939-9164-8_16>, and widely expanded as a package as presented in the bioRxiv pre print Ferrari et al. <doi:10.1101/2022.01.17.476603>.

Evaluation of default probability of sovereign and corporate entities based on structural or intensity based models and calibration on market Credit Default Swap quotes. References: Damiano Brigo, Massimo Morini, Andrea Pallavicini (2013) <doi:10.1002/9781118818589>. Print ISBN: 9780470748466, Online ISBN: 9781118818589. © 2013 John Wiley & Sons Ltd.

Fit continuous-time correlated random walk models with time indexed covariates to animal telemetry data. The model is fit using the Kalman-filter on a state space version of the continuous-time stochastic movement process.

Constrained ordinary least squares is performed. One constraint is that all beta coefficients (including the constant) cannot be negative. They can be either 0 or strictly positive. Another constraint is that the sum of the beta coefficients equals a constant. References: Hansen, B. E. (2022). Econometrics, Princeton University Press. <ISBN:9780691235899>.

Impute the survival times for censored observations based on their conditional survival distributions derived from the Kaplan-Meier estimator. CondiS can replace the censored observations with the best approximations from the statistical model, allowing for direct application of machine learning-based methods. When covariates are available, CondiS is extended by incorporating the covariate information through machine learning-based regression modeling ('CondiS_X'), which can further improve the imputed survival time.

Modeling periodic mortality (or other time-to event) processes from right-censored data. Given observations of a process with a known period (e.g. 365 days, 24 hours), functions determine the number, intensity, timing, and duration of peaks of periods of elevated hazard within a period. The underlying model is a mixed wrapped Cauchy function fitted using maximum likelihoods (details in Gurarie et al. (2020) <doi:10.1111/2041-210X.13305>). The development of these tools was motivated by the strongly seasonal mortality patterns observed in many wild animal populations. Thus, the respective periods of higher mortality can be identified as "mortality seasons".

This package provides a device closing function which is able to crop graphics (e.g., PDF, PNG files) on Unix-like operating systems with the required underlying command-line tools installed.

This package provides a flexible interface for interacting with Large Language Model ('LLM') providers including OpenAI', Groq', Anthropic', DeepSeek', DashScope', Gemini', Grok and GitHub Models'. Supports both synchronous and asynchronous chat-completion APIs, with features such as retry logic, dynamic model selection, customizable parameters, and multi-message conversation handling. Designed to streamline integration with state-of-the-art LLM services across multiple platforms.

Model-free selection of covariates under unconfoundedness for situations where the parameter of interest is an average causal effect. This package is based on model-free backward elimination algorithms proposed in de Luna, Waernbaum and Richardson (2011). Marginal co-ordinate hypothesis testing is used in situations where all covariates are continuous while kernel-based smoothing appropriate for mixed data is used otherwise.

Implementations of threshold regression approaches for linear regression models with a covariate subject to random censoring, including deletion threshold regression and completion threshold regression. Reverse survival regression, which flip the role of response variable and the covariate, is also considered.

This package provides a dynamic programming algorithm for optimal clustering multidimensional data with sequential constraint. The algorithm minimizes the sum of squares of within-cluster distances. The sequential constraint allows only subsequent items of the input data to form a cluster. The sequential constraint is typically required in clustering data streams or items with time stamps such as video frames, GPS signals of a vehicle, movement data of a person, e-pen data, etc. The algorithm represents an extension of Ckmeans.1d.dp to multiple dimensional spaces. Similarly to the one-dimensional case, the algorithm guarantees optimality and repeatability of clustering. Method clustering.sc.dp() can find the optimal clustering if the number of clusters is known. Otherwise, methods findwithinss.sc.dp() and backtracking.sc.dp() can be used. See Szkaliczki, T. (2016) "clustering.sc.dp: Optimal Clustering with Sequential Constraint by Using Dynamic Programming" <doi: 10.32614/RJ-2016-022> for more information.

Computation of Multiscale Codependence Analysis and spatial eigenvector maps.

It provides functions to bootstrap Credit Curves from market quotes (Credit Default Swap - CDS - spreads) and price Credit Default Swaps - CDS.

The COSSO regularization method automatically estimates and selects important function components by a soft-thresholding penalty in the context of smoothing spline ANOVA models. Implemented models include mean regression, quantile regression, logistic regression and the Cox regression models.

Calculating crude sequence ratio, adjusted sequence ratio and confidence intervals using data mapped to the Observational Medical Outcomes Partnership Common Data Model.

Developed as a collaboration between Earth lab and the North Central Climate Adaptation Science Center to help users gain insights from available climate data. Includes tools and instructions for downloading climate data via a USGS API and then organizing those data for visualization and analysis that drive insight. Web interface for USGS API can be found at <http://thredds.northwestknowledge.net:8080/thredds/reacch_climate_CMIP5_aggregated_macav2_catalog.html>.

This package provides functions to assess complex heterogeneity in the strength of a surrogate marker with respect to multiple baseline covariates, in either a randomized treatment setting or observational setting. For a randomized treatment setting, the functions assess and test for heterogeneity using both a parametric model and a semiparametric two-step model. More details for the randomized setting are available in: Knowlton, R., Tian, L., & Parast, L. (2025). "A General Framework to Assess Complex Heterogeneity in the Strength of a Surrogate Marker," Statistics in Medicine, 44(5), e70001 <doi:10.1002/sim.70001>. For an observational setting, functions in this package assess complex heterogeneity in the strength of a surrogate marker using meta-learners, with options for different base learners. More details for the observational setting will be available in the future in: Knowlton, R., Parast, L. (2025) "Assessing Surrogate Heterogeneity in Real World Data Using Meta-Learners." A tutorial for this package can be found at <https://www.laylaparast.com/cohetsurr>.

This package provides a consistent interface for connecting R to various data sources including file systems and databases. Designed for clinical research, connector streamlines access to ADAM', SDTM for example. It helps to deal with multiple data formats through a standardized API and centralized configuration.

Solving the problem of project management using CPM (Critical Path Method), PERT (Program Evaluation and Review Technique) and LESS (Least Cost Estimating and Scheduling) methods. The package sets the critical path, schedule and Gantt chart. In addition, it allows to draw a graph even with marked critical activities. For more information about project management see: Taha H. A. "Operations Research. An Introduction" (2017, ISBN:978-1-292-16554-7), Rama Murthy P. "Operations Research" (2007, ISBN:978-81-224-2944-2), Yuval Cohen & Arik Sadeh (2006) "A New Approach for Constructing and Generating AOA Networks", Journal of Engineering, Computing and Architecture 1. 1-13, Konarzewska I., Jewczak M., Kucharski A. (2020, ISBN:978-83-8220-112-3), MiszczyÅ ska D., MiszczyÅ ski M. "Wybrane metody badaÅ operacyjnych" (2000, ISBN:83-907712-0-9).