Uses multiple AUCs to select a combination of predictors when the outcome has multiple (ordered) levels and the focus is discriminating one particular level from the others. This method is most naturally applied to settings where the outcome has three levels. (Meisner, A, Parikh, CR, and Kerr, KF (2017) <http://biostats.bepress.com/uwbiostat/paper423/>.).

An implementation of Multi-Task Logistic Regression (MTLR) for R. This package is based on the method proposed by Yu et al. (2011) which utilized MTLR for generating individual survival curves by learning feature weights which vary across time. This model was further extended to account for left and interval censored data.

Conduct random forests-based meta-analysis, obtain partial dependence plots for metaforest and classic meta-analyses, and cross-validate and tune metaforest- and classic meta-analyses in conjunction with the caret package. A requirement of classic meta-analysis is that the studies being aggregated are conceptually similar, and ideally, close replications. However, in many fields, there is substantial heterogeneity between studies on the same topic. Classic meta-analysis lacks the power to assess more than a handful of univariate moderators. MetaForest, by contrast, has substantial power to explore heterogeneity in meta-analysis. It can identify important moderators from a larger set of potential candidates (Van Lissa, 2020). This is an appealing quality, because many meta-analyses have small sample sizes. Moreover, MetaForest yields a measure of variable importance which can be used to identify important moderators, and offers partial prediction plots to explore the shape of the marginal relationship between moderators and effect size.

Addressing a central challenge encountered in Mendelian randomization (MR) studies, where MR primarily focuses on discerning the effects of individual exposures on specific outcomes and establishes causal links between them. Using a network-based methodology, the intricacy involving interdependent outcomes due to numerous factors has been tackled through this routine. Based on Ni et al. (2018) <doi:10.1214/17-BA1087>, MR.RGM extends to a broader exploration of the causal landscape by leveraging on network structures and involves the construction of causal graphs that capture interactions between response variables and consequently between responses and instrument variables. The resulting Graph visually represents these causal connections, showing directed edges with effect sizes labeled. MR.RGM facilitates the navigation of various data availability scenarios effectively by accommodating three input formats, i.e., individual-level data and two types of summary-level data. The method also optionally incorporates measured covariates (when available) and allows flexible modeling of the error variance structure, including correlated errors that may reflect unmeasured confounding among responses. In the process, causal effects, adjacency matrices, and other essential parameters of the complex biological networks, are estimated. Besides, MR.RGM provides uncertainty quantification for specific network structures among response variables. Parts of the Inverse Wishart sampler are adapted from the econ722 repository by DiTraglia (GPL-2.0).

Core functions as well as diagnostic and calibration tools for combining matching and linear regression for causal inference in observational studies.

Regularly spaced grids containing continuous data are transformed to contour polygons. A grid can be defined by a data.frame (x, y, value), an sf object or a raster from terra'.

This package provides functions to perform all steps of genome-wide association meta-analysis for studying Genotype x Environment interactions, from collecting the data to the manhattan plot. The procedure accounts for the potential correlation between studies. In addition to the Fixed and Random models, one can investigate the relationship between QTL effects and some qualitative or quantitative covariate via the test of contrast and the meta-regression, respectively. The methodology is available from: (De Walsche, A., et al. (2025) \doi10.1371/journal.pgen.1011553).

This package implements the computation of discrepancy statistics summarizing differences between the density of imputed and observed values and the construction of weights to balance covariates that are part of the missing data mechanism as described in Marbach (2021) <arXiv:2107.05427>.

This package provides a color palette generator inspired by Mexican politics, with colors ranging from red on the left to gray in the middle and green on the right. Palette options range from only a few colors to several colors, but with discrete and continuous options to offer greatest flexibility to the user. This package allows for a range of applications, from mapping brief discrete scales (e.g., four colors for Morena, PRI, and PAN) to continuous interpolated arrays including dozens of shades graded from red to green.

We provide the framework to analyze multiresolution partitions (e.g. country, provinces, subdistrict) where each individual data point belongs to only one partition in each layer (e.g. i belongs to subdistrict A, province P, and country Q). We assume that a partition in a higher layer subsumes lower-layer partitions (e.g. a nation is at the 1st layer subsumes all provinces at the 2nd layer). Given N individuals that have a pair of real values (x,y) that generated from independent variable X and dependent variable Y. Each individual i belongs to one partition per layer. Our goal is to find which partitions at which highest level that all individuals in the these partitions share the same linear model Y=f(X) where f is a linear function. The framework deploys the Minimum Description Length principle (MDL) to infer solutions. The publication of this package is at Chainarong Amornbunchornvej, Navaporn Surasvadi, Anon Plangprasopchok, and Suttipong Thajchayapong (2021) <doi:10.1145/3424670>.

This package provides the facility to calculate non-isotropic accumulated cost surface, least-cost paths, least-cost corridors, least-cost networks using a number of human-movement-related cost functions that can be selected by the user. It just requires a Digital Terrain Model, a start location and (optionally) destination locations. See Alberti (2019) <doi:10.1016/j.softx.2019.100331>.

An implementation of the cross-validated difference in means (CVDM) test by Desmarais and Harden (2014) <doi:10.1007/s11135-013-9884-7> (see also Harden and Desmarais, 2011 <doi:10.1177/1532440011408929>) and the cross-validated median fit (CVMF) test by Desmarais and Harden (2012) <doi:10.1093/pan/mpr042>. These tests use leave-one-out cross-validated log-likelihoods to assist in selecting among model estimations. You can also utilize data from Golder (2010) <doi:10.1177/0010414009341714> and Joshi & Mason (2008) <doi:10.1177/0022343308096155> that are included to facilitate examples from real-world analysis.

This package provides a computationally efficient solution for generating optimal experimental designs in Accelerated Life Testing (ALT). Leveraging a Particle Swarm Optimization (PSO)-based hybrid algorithm, the package identifies optimal test plans that minimize estimation variance under specified failure models and stress profiles. For more detailed, see Lee et al. (2025), Optimal Robust Strategies for Accelerated Life Tests and Fatigue Testing of Polymer Composite Materials <doi:10.1214/25-AOAS2075>, and Hoang (2025), Model-Robust Minimax Design of Accelerated Life Tests via PSO-based Hybrid Algorithm, Master Thesis, Unpublished.

Mine metrics on common places on the web through the power of their APIs (application programming interfaces). It also helps make the data in a format that is easily used for a dashboard or other purposes. There is an associated dashboard template and tutorials that are underdevelopment that help you fully utilize metricminer'.

This package provides methods for Geographically Weighted Regression with spatial autocorrelation (Geniaux and Martinetti 2017) <doi:10.1016/j.regsciurbeco.2017.04.001>. Implements Multiscale Geographically Weighted Regression with Top-Down Scale approaches (Geniaux 2026) <doi:10.1007/s10109-025-00481-4>.

Fits the neighboring models of a fitted structural equation model and assesses the model uncertainty of the fitted model based on BIC posterior probabilities (BPP), using the method presented in Wu, Cheung, and Leung (2020) <doi:10.1080/00273171.2019.1574546>. See Pesigan, Cheung, Wu, Chang, and Leung (2026) <doi:10.3758/s13428-025-02921-x> for an introduction to the package.

This package provides utilities for reading and processing microdata from Spanish official statistics with R.

It finds Orthogonal Data Projections with Maximal Skewness. The first data projection in the output is the most skewed among all linear data projections. The second data projection in the output is the most skewed among all data projections orthogonal to the first one, and so on.

Randomization schedules are generated in the schemes with k (k>=2) treatment groups and any allocation ratios by minimization algorithms.

The routine twosample_test() in this package runs the two-sample test using various test statistic for multivariate data. The user can also run several tests and then find a p value adjusted for simultaneous inference. The p values are found via permutation or via the parametric bootstrap. The routine twosample_power() allows the estimation of the power of the tests. The routine run.studies() allows a user to quickly study the power of a new method and how it compares to those included in the package. For details of the methods and references see the included vignettes.

Chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq) is the premier technology for profiling genome-wide localization of chromatin-binding proteins, including transcription factors and histones with various modifications. This package provides a robust method for normalizing ChIP-seq signals across individual samples or groups of samples. It also designs a self-contained system of statistical models for calling differential ChIP-seq signals between two or more biological conditions as well as for calling hypervariable ChIP-seq signals across samples. Refer to Tu et al. (2021) <doi:10.1101/gr.262675.120> and Chen et al. (2022) <doi:10.1186/s13059-022-02627-9> for associated statistical details.

Compute correlation and other association matrices from small to high-dimensional datasets with relative simple functions and sensible defaults. Includes options for shrinkage and robustness to improve results in noisy or high-dimensional settings (p >= n), plus convenient print/plot methods for inspection. Implemented with optimised C++ backends using BLAS/OpenMP and memory-aware symmetric updates. Works with base matrices and data frames, returning standard R objects via a consistent S3 interface. Useful across genomics, agriculture, and machine-learning workflows. Supports Pearson, Spearman, Kendall, distance correlation, partial correlation, and robust biweight mid-correlation; Blandâ Altman analyses and Lin's concordance correlation coefficient (including repeated-measures extensions). Methods based on Ledoit and Wolf (2004) <doi:10.1016/S0047-259X(03)00096-4>; Schäfer and Strimmer (2005) <doi:10.2202/1544-6115.1175>; Lin (1989) <doi:10.2307/2532051>.

This package performs meta-analysis and meta-regression using standard and robust methods with confidence intervals based on the profile likelihood. Robust methods are based on alternative distributions for the random effect, either the t-distribution (Lee and Thompson, 2008 <doi:10.1002/sim.2897> or Baker and Jackson, 2008 <doi:10.1007/s10729-007-9041-8>) or mixtures of normals (Beath, 2014 <doi:10.1002/jrsm.1114>).

Train and make predictions from a multi-layer perceptron neural network with optional partial monotonicity constraints.