This package provides tools for calculating coordinate representations of hypocycloids, epicyloids, hypotrochoids, and epitrochoids (altogether called cycloids here) with different scaling and positioning options. The cycloids can be visualised with any appropriate graphics function in R.

This package provides a flexible, extendable representation of an ecological community and a range of functions for analysis and visualisation, focusing on food web, body mass and numerical abundance data. Allows inter-web comparisons such as examining changes in community structure over environmental, temporal or spatial gradients.

Data recorded as paths or trajectories may be suitably described by curves, which are independent of their parametrization. For the space of such curves, the package provides functionalities for reading curves, sampling points on curves, calculating distance between curves and for computing Tukey curve depth of a curve w.r.t. to a bundle of curves. For details see Lafaye De Micheaux, Mozharovskyi, and Vimond (2021) <doi:10.48550/arXiv.1901.00180>.

Tests convergence in macro-financial panels combining Dynamic Factor Models (DFM) and mean-reverting Ornstein-Uhlenbeck (OU) processes. Provides: (i) static/approximate DFMs for large panels with VAR/VECM stability checks, Portmanteau tests and rolling out-of-sample R^2, following Stock and Watson (2002) <doi:10.1198/073500102317351921> and the Generalized Dynamic Factor Model of Forni, Hallin, Lippi and Reichlin (2000) <doi:10.1162/003465300559037>; (ii) cointegration analysis à la Johansen (1988) <doi:10.1016/0165-1889(88)90041-3>; (iii) OU-based convergence and half-life summaries grounded in Uhlenbeck and Ornstein (1930) <doi:10.1103/PhysRev.36.823> and Vasicek (1977) <doi:10.1016/0304-405X(77)90016-2>; (iv) robust inference via sandwich HC/HAC estimators (Zeileis (2004) <doi:10.18637/jss.v011.i10>) and regression diagnostics ('lmtest'); and (v) optional PLS-based factor preselection (Mevik and Wehrens (2007) <doi:10.18637/jss.v018.i02>). Functions emphasize reproducibility and clear, publication-ready summaries.

Generates a visualization of binary classifier performance as a grid of diagnostic plots with just one function call. Includes ROC curves, prediction density, accuracy, precision, recall and calibration plots, all using ggplot2 for easy modification. Debug your binary classifiers faster and easier!

To optimize clinical trial designs and data analysis methods consistently through trial simulation, we need to simulate multivariate mixed-type virtual patient data independent of designs and analysis methods under evaluation. To make the outcome of optimization more realistic, relevant empirical patient level data should be utilized when itâ s available. However, a few problems arise in simulating trials based on small empirical data, where the underlying marginal distributions and their dependence structure cannot be understood or verified thoroughly due to the limited sample size. To resolve this issue, we use the copula invariance property, which can generate the joint distribution without making a strong parametric assumption. The function copula.sim can generate virtual patient data with optional data validation methods that are based on energy distance and ball divergence measurement. The function compare.copula.sim can conduct comparison of marginal mean and covariance of simulated data. To simulate patient-level data from a hypothetical treatment arm that would perform differently from the observed data, the function new.arm.copula.sim can be used to generate new multivariate data with the same dependence structure of the original data but with a shifted mean vector.

We present corto (Correlation Tool), a simple package to infer gene regulatory networks and visualize master regulators from gene expression data using DPI (Data Processing Inequality) and bootstrapping to recover edges. An initial step is performed to calculate all significant edges between a list of source nodes (centroids) and target genes. Then all triplets containing two centroids and one target are tested in a DPI step which removes edges. A bootstrapping process then calculates the robustness of the network, eventually re-adding edges previously removed by DPI. The algorithm has been optimized to run outside a computing cluster, using a fast correlation implementation. The package finally provides functions to calculate network enrichment analysis from RNA-Seq and ATAC-Seq signatures as described in the article by Giorgi lab (2020) <doi:10.1093/bioinformatics/btaa223>.

This package provides a framework that facilitates spatio-temporal analysis of climate dynamics through exploring and measuring different dimensions of climate change in space and time.

This package implements the uniform scaled beta distribution and the continuous convolution kernel density estimator.

This package provides tools for working with observational health data in the Observational Medical Outcomes Partnership (OMOP) Common Data Model format with a pipe friendly syntax. Common data model database table references are stored in a single compound object along with metadata.

Enables: (1) plotting two-dimensional confidence regions, (2) coverage analysis of confidence region simulations, (3) calculating confidence intervals and the associated actual coverage for binomial proportions, (4) calculating the support values and the probability mass function of the Kaplan-Meier product-limit estimator, and (5) plotting the actual coverage function associated with a confidence interval for the survivor function from a randomly right-censored data set. Each is given in greater detail next. (1) Plots the two-dimensional confidence region for probability distribution parameters (supported distribution suffixes: cauchy, gamma, invgauss, logis, llogis, lnorm, norm, unif, weibull) corresponding to a user-given complete or right-censored dataset and level of significance. The crplot() algorithm plots more points in areas of greater curvature to ensure a smooth appearance throughout the confidence region boundary. An alternative heuristic plots a specified number of points at roughly uniform intervals along its boundary. Both heuristics build upon the radial profile log-likelihood ratio technique for plotting confidence regions given by Jaeger (2016) <doi:10.1080/00031305.2016.1182946>, and are detailed in a publication by Weld et al. (2019) <doi:10.1080/00031305.2018.1564696>. (2) Performs confidence region coverage simulations for a random sample drawn from a user- specified parametric population distribution, or for a user-specified dataset and point of interest with coversim(). (3) Calculates confidence interval bounds for a binomial proportion with binomTest(), calculates the actual coverage with binomTestCoverage(), and plots the actual coverage with binomTestCoveragePlot(). Calculates confidence interval bounds for the binomial proportion using an ensemble of constituent confidence intervals with binomTestEnsemble(). Calculates confidence interval bounds for the binomial proportion using a complete enumeration of all possible transitions from one actual coverage acceptance curve to another which minimizes the root mean square error for n <= 15 and follows the transitions for well-known confidence intervals for n > 15 using binomTestMSE(). (4) The km.support() function calculates the support values of the Kaplan-Meier product-limit estimator for a given sample size n using an induction algorithm described in Qin et al. (2023) <doi:10.1080/00031305.2022.2070279>. The km.outcomes() function generates a matrix containing all possible outcomes (all possible sequences of failure times and right-censoring times) of the value of the Kaplan-Meier product-limit estimator for a particular sample size n. The km.pmf() function generates the probability mass function for the support values of the Kaplan-Meier product-limit estimator for a particular sample size n, probability of observing a failure h at the time of interest expressed as the cumulative probability percentile associated with X = min(T, C), where T is the failure time and C is the censoring time under a random-censoring scheme. The km.surv() function generates multiple probability mass functions of the Kaplan-Meier product-limit estimator for the same arguments as those given for km.pmf(). (5) The km.coverage() function plots the actual coverage function associated with a confidence interval for the survivor function from a randomly right-censored data set for one or more of the following confidence intervals: Greenwood, log-minus-log, Peto, arcsine, and exponential Greenwood. The actual coverage function is plotted for a small number of items on test, stated coverage, failure rate, and censoring rate. The km.coverage() function can print an optional table containing all possible failure/censoring orderings, along with their contribution to the actual coverage function.

Estimation and inference methods for the continuous threshold expectile regression. It can fit the continuous threshold expectile regression and test the existence of change point, for the paper, "Feipeng Zhang and Qunhua Li (2016). A continuous threshold expectile regression, submitted.".

Fit continuous-time correlated random walk models with time indexed covariates to animal telemetry data. The model is fit using the Kalman-filter on a state space version of the continuous-time stochastic movement process.

Fast and memory-efficient (or cheap') tools to facilitate efficient programming, saving time and memory. It aims to provide cheaper alternatives to common base R functions, as well as some additional functions.

Copula-based regression models for multivariate censored data, including bivariate right-censored data, bivariate interval-censored data, and right/interval-censored semi-competing risks data. Currently supports Clayton, Gumbel, Frank, Joe, AMH and Copula2 copula models. For marginal models, it supports parametric (Weibull, Loglogistic, Gompertz) and semiparametric (Cox and transformation) models. Includes methods for convenient prediction and plotting. Also provides a bivariate time-to-event simulation function and an information ratio-based goodness-of-fit test for copula. Method details can be found in Sun et.al (2019) Lifetime Data Analysis, Sun et.al (2021) Biostatistics, Sun et.al (2022) Statistical Methods in Medical Research, Sun et.al (2022) Biometrics, and Sun et al. (2023+) JRSSC.

Assesses the quality of estimates made by complex sample designs, following the methodology developed by the National Institute of Statistics Chile (Household Survey Standard 2020, <https://www.ine.cl/docs/default-source/institucionalidad/buenas-pr%C3%A1cticas/clasificaciones-y-estandares/est%C3%A1ndar-evaluaci%C3%B3n-de-calidad-de-estimaciones-publicaci%C3%B3n-27022020.pdf>), (Economics Survey Standard 2024, <https://www.ine.gob.cl/docs/default-source/buenas-practicas/directrices-metodologicas/estandares/documentos/est%C3%A1ndar-evaluaci%C3%B3n-de-calidad-de-estimaciones-econ%C3%B3micas.pdf?sfvrsn=201fbeb9_2>) and by Economic Commission for Latin America and Caribbean (2020, <https://repositorio.cepal.org/bitstream/handle/11362/45681/1/S2000293_es.pdf>), (2024, <https://repositorio.cepal.org/server/api/core/bitstreams/f04569e6-4f38-42e7-a32b-e0b298e0ab9c/content>).

Simple, fast, and automatic encodings for category data using a data.table backend. Most of the methods are an implementation of "Sufficient Representation for Categorical Variables" by Johannemann, Hadad, Athey, Wager (2019) <arXiv:1908.09874>, particularly their mean, sparse principal component analysis, low rank representation, and multinomial logit encodings.

This package provides a comprehensive interface to access diverse public data about Colombia through multiple APIs and curated datasets. The package integrates four different APIs: API-Colombia for Colombian-specific data including geography, culture, tourism, and government information; World Bank API for economic and demographic indicators; Nager.Date for public holidays; and REST Countries API for general country information. The package enables users to explore various aspects of Colombia such as geographic locations, cultural attractions, economic indicators, demographic data, and public holidays. Additionally, ColombiAPI includes curated datasets covering Bogota air stations, business and holiday dates, public schools, Colombian coffee exports, cannabis licenses, Medellin rainfall, malls in Bogota, as well as datasets on indigenous languages, student admissions and school statistics, forest liana mortality, municipal and regional data, connectivity and digital infrastructure, program graduates, vehicle counts, international visitors, and GDP projections. These datasets provide users with a rich and multifaceted view of Colombian social, economic, environmental, and technological information, making ColombiAPI a comprehensive tool for exploring Colombia's diverse data landscape. For more information on the APIs, see: API-Colombia <https://api-colombia.com/>, Nager.Date <https://date.nager.at/Api>, World Bank API <https://datahelpdesk.worldbank.org/knowledgebase/articles/889392>, and REST Countries API <https://restcountries.com/>.

Clustering, or cluster analysis, is a widely used technique in bioinformatics to identify groups of similar biological data points. Consensus clustering is an extension to clustering algorithms that aims to construct a robust result from those clustering features that are invariant under different sources of variation. For the reference, please cite the following paper: Yousefi, Melograna, et. al., (2023) <doi:10.3389/fmicb.2023.1170391>.

Nonparametric change point estimation for survival data based on p-values of exact binomial tests.

Different methods to conduct causal inference for multiple treatments with a binary outcome, including regression adjustment, vector matching, Bayesian additive regression trees, targeted maximum likelihood and inverse probability of treatment weighting using different generalized propensity score models such as multinomial logistic regression, generalized boosted models and super learner. For more details, see the paper by Hu et al. <doi:10.1177/0962280220921909>.

An algorithm for identifying candidate driver combinations in cancer. CRSO is based on a theoretical model of cancer in which a cancer rule is defined to be a collection of two or more events (i.e., alterations) that are minimally sufficient to cause cancer. A cancer rule set is a set of cancer rules that collectively are assumed to account for all of ways to cause cancer in the population. In CRSO every event is designated explicitly as a passenger or driver within each patient. Each event is associated with a patient-specific, event-specific passenger penalty, reflecting how unlikely the event would have happened by chance, i.e., as a passenger. CRSO evaluates each rule set by assigning all samples to a rule in the rule set, or to the null rule, and then calculating the total statistical penalty from all unassigned event. CRSO uses a three phase procedure find the best rule set of fixed size K for a range of Ks. A core rule set is then identified from among the best rule sets of size K as the rule set that best balances rule set size and statistical penalty. Users should consult the crso vignette for an example walk through of a full CRSO run. The full description, of the CRSO algorithm is presented in: Klein MI, Cannataro V, Townsend J, Stern DF and Zhao H. "Identifying combinations of cancer driver in individual patients." BioRxiv 674234 [Preprint]. June 19, 2019. <doi:10.1101/674234>. Please cite this article if you use crso'.

Assembles two or more gene copies from short-read Next-Generation Sequencing data. Works best when there are only two gene copies and read length >=250 base pairs. High and relatively even coverage are important.

Access the Cumulocity API and retrieve data on devices, measurements, and events. Documentation for the API can be found at <https://www.cumulocity.com/guides/reference/rest-implementation/>.