This package provides a streamlined cross-referencing system for R Markdown documents generated with knitr'. R Markdown is an authoring format for generating dynamic content from R. kfigr provides a hook for anchoring code chunks and a function to cross-reference document elements generated from said chunks, e.g. figures and tables.

Adds support for the English language to the koRpus package. To ask for help, report bugs, suggest feature improvements, or discuss the global development of the package, please consider subscribing to the koRpus-dev mailing list (<https://korpusml.reaktanz.de>).

Rank-based tests for enrichment of KOG (euKaryotic Orthologous Groups) classes with up- or down-regulated genes based on a continuous measure. The meta-analysis is based on correlation of KOG delta-ranks across datasets (delta-rank is the difference between mean rank of genes belonging to a KOG class and mean rank of all other genes). With binary measure (1 or 0 to indicate significant and non-significant genes), one-tailed Fisher's exact test for over-representation of each KOG class among significant genes will be performed.

Analysis of DNA copy number in single cells using custom genome-wide targeted DNA sequencing panels for the Mission Bio Tapestri platform. Users can easily parse, manipulate, and visualize datasets produced from the automated Tapestri Pipeline', with support for normalization, clustering, and copy number calling. Functions are also available to deconvolute multiplexed samples by genotype and parsing barcoded reads from exogenous lentiviral constructs.

Produce Kaplanâ Meier plots in the style recommended following the KMunicate study by Morris et al. (2019) <doi:10.1136/bmjopen-2019-030215>. The KMunicate style consists of Kaplan-Meier curves with confidence intervals to quantify uncertainty and an extended risk table (per treatment arm) depicting the number of study subjects at risk, events, and censored observations over time. The resulting plots are built using ggplot2 and can be further customised to a certain extent, including themes, fonts, and colour scales.

Fits keyword assisted topic models (keyATM) using collapsed Gibbs samplers. The keyATM combines the latent dirichlet allocation (LDA) models with a small number of keywords selected by researchers in order to improve the interpretability and topic classification of the LDA. The keyATM can also incorporate covariates and directly model time trends. The keyATM is proposed in Eshima, Imai, and Sasaki (2024) <doi:10.1111/ajps.12779>.

Kernel Machine Score Test for Pathway Analysis in the Presence of Semi-Competing Risks. Method is detailed in: Neykov, Hejblum & Sinnott (2018) <doi: 10.1177/0962280216653427>.

Gaussian process regression with an emphasis on kernels. Quantitative and qualitative inputs are accepted. Some pre-defined kernels are available, such as radial or tensor-sum for quantitative inputs, and compound symmetry, low rank, group kernel for qualitative inputs. The user can define new kernels and composite kernels through a formula mechanism. Useful methods include parameter estimation by maximum likelihood, simulation, prediction and leave-one-out validation.

This package implements k-means like blockmodeling of one-mode and linked networks as presented in Žiberna (2020) <doi:10.1016/j.socnet.2019.10.006>. The development of this package is financially supported by the Slovenian Research Agency (<https://www.arrs.si/>) within the research programs P5-0168 and the research projects J7-8279 (Blockmodeling multilevel and temporal networks) and J5-2557 (Comparison and evaluation of different approaches to blockmodeling dynamic networks by simulations with application to Slovenian co-authorship networks).

An implementation of the k-means-- algorithm proposed by Chawla and Gionis, 2013 in their paper, "k-means-- : A unified approach to clustering and outlier detection. SIAM International Conference on Data Mining (SDM13)", <doi:10.1137/1.9781611972832.21> and using ordering described by Howe, 2013 in the thesis, Clustering and anomaly detection in tropical cyclones". Useful for creating (potentially) tighter clusters than standard k-means and simultaneously finding outliers inexpensively in multidimensional space.

This package infers relative kinase activity from phosphoproteomics data using the method described by Casado et al. (2013) <doi:10.1126/scisignal.2003573>.

This package provides methods for inference about/under complex relationships using peak height data from DNA mixtures: the most basic example would be testing whether a contributor to a mixture is the father of a child of known genotype. This provides most of the functionality of the KinMix package, but with some loss of efficiency and restriction on problem size, as the latter uses RHugin as the Bayes net engine, while this package uses gRain'. The package implements the methods introduced in Green, P. J. and Mortera, J. (2017) <doi:10.1016/j.fsigen.2017.02.001> and Green, P. J. and Mortera, J. (2021) <doi:10.1111/rssc.12498>.

Caches and then connects to a sqlite database containing half a million pediatric drug safety signals. The database is part of a family of resources catalogued at <https://nsides.io>. The database contains 17 tables where the description table provides a map between the fields the field's details. The database was created by Nicholas Giangreco during his PhD thesis which you can read in Giangreco (2022) <doi:10.7916/d8-5d9b-6738>. The observations are from the Food and Drug Administration's Adverse Event Reporting System. Generalized additive models estimated drug effects across child development stages for the occurrence of an adverse event when exposed to a drug compared to other drugs. Read more at the methods detailed in Giangreco (2022) <doi:10.1016/j.medj.2022.06.001>.

Retrieve data from kintone (<https://www.kintone.com/>) via its API. kintone is an enterprise application platform.

Assign and listen to keyboard shortcuts in shiny using the Mousetrap Javascript library.

This package provides functions to identify plausible and replicable factor structures for a set of variables via k-fold cross validation. The process combines the exploratory and confirmatory factor analytic approach to scale development (Flora & Flake, 2017) <doi:10.1037/cbs0000069> with a cross validation technique that maximizes the available data (Hastie, Tibshirani, & Friedman, 2009) <isbn:978-0-387-21606-5>. Also available are functions to determine k by drawing on power analytic techniques for covariance structures (MacCallum, Browne, & Sugawara, 1996) <doi:10.1037/1082-989X.1.2.130>, generate model syntax, and summarize results in a report.

Tests the homogeneity of intraclass kappa statistics obtained from independent studies or a stratified study with binary results. It is desired to compare the kappa statistics obtained in multi-center studies or in a single stratified study to give a common or summary kappa using all available information. If the homogeneity test of these kappa statistics is not rejected, then it is possible to make inferences over a single kappa statistic that summarizes all the studies. Muammer Albayrak, Kemal Turhan, Yasemin Yavuz, Zeliha Aydin Kasap (2019) <doi:10.1080/03610918.2018.1538457> Jun-mo Nam (2003) <doi:10.1111/j.0006-341X.2003.00118.x> Jun-mo Nam (2005) <doi:10.1002/sim.2321>Mousumi Banerjee, Michelle Capozzoli, Laura McSweeney,Debajyoti Sinha (1999) <doi:10.2307/3315487> Allan Donner, Michael Eliasziw, Neil Klar (1996) <doi:10.2307/2533154>.

Metadata about populations and data about samples from the 1000 Genomes Project, including the 2,504 samples sequenced for the Phase 3 release and the expanded collection of 3,202 samples with 602 additional trios. The data is described in Auton et al. (2015) <doi:10.1038/nature15393> and Byrska-Bishop et al. (2022) <doi:10.1016/j.cell.2022.08.004>, and raw data is available at <http://ftp.1000genomes.ebi.ac.uk/vol1/ftp/>. See Turner (2022) <doi:10.48550/arXiv.2210.00539> for more details.

This is a stochastic framework that combines biochemical reaction networks with extended Kalman filter and Rauch-Tung-Striebel smoothing. This framework allows to investigate the dynamics of cell differentiation from high-dimensional clonal tracking data subject to measurement noise, false negative errors, and systematically unobserved cell types. Our tool can provide statistical support to biologists in gene therapy clonal tracking studies for a deeper understanding of clonal reconstitution dynamics. Further details on the methods can be found in L. Del Core et al., (2022) <doi:10.1101/2022.07.08.499353>.

Aids in identifying the Koeppen-Geiger (KG) climatic zone for a given location. The Koeppen-Geiger climate zones were first published in 1884, as a system to classify regions of the earth by their relative heat and humidity through the year, for the benefit of human health, plant and agriculture and other human activity [1]. This climate zone classification system, applicable to all of the earths surface, has continued to be developed by scientists up to the present day. Recently one of use (FZ) has published updated, higher accuracy KG climate zone definitions [2]. In this package we use these updated high-resolution maps as the data source [3]. We provide functions that return the KG climate zone for a given longitude and lattitude, or for a given United States zip code. In addition the CZUncertainty() function will check climate zones nearby to check if the given location is near a climate zone boundary. In addition an interactive shiny app is provided to define the KG climate zone for a given longitude and lattitude, or United States zip code. Digital data, as well as animated maps, showing the shift of the climate zones are provided on the following website <http://koeppen-geiger.vu-wien.ac.at>. This work was supported by the DOE-EERE SunShot award DE-EE-0007140. [1] W. Koeppen, (2011) <doi:10.1127/0941-2948/2011/105>. [2] F. Rubel and M. Kottek, (2010) <doi:10.1127/0941-2948/2010/0430>. [3] F. Rubel, K. Brugger, K. Haslinger, and I. Auer, (2016) <doi:10.1127/metz/2016/0816>.

Detect and test for changes in covariance structures of functional data, as well as changepoint detection for multivariate data more generally. Method for detecting non-stationarity in resting state functional Magnetic Resonance Imaging (fMRI) scans as seen in Ramsay, K., & Chenouri, S. (2025) <doi:10.1080/10485252.2025.2503891> is implemented in fmri_changepoints(). Also includes depth- and rank-based implementation of the wild binary segmentation algorithm for detecting multiple changepoints in multivariate data.

Multi-modal magnetic resonance imaging ('MRI') data from the Kirby21 reproducibility study <https://www.nitrc.org/projects/multimodal/>, including functional and structural imaging.

This is a C++ mutual information (MI) library based on the k-nearest neighbor (KNN) algorithm. There are three functions provided for computing MI for continuous values, mixed continuous and discrete values, and conditional MI for continuous values. They are based on algorithms by A. Kraskov, et. al. (2004) <doi:10.1103/PhysRevE.69.066138>, BC Ross (2014)<doi:10.1371/journal.pone.0087357>, and A. Tsimpiris (2012) <doi:10.1016/j.eswa.2012.05.014>, respectively.

The format KVH is a lightweight format that can be read/written both by humans and machines. It can be useful in situations where XML or alike formats seem to be an overkill. We provide an ability to parse KVH files in R pretty fast due to Rcpp use.